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1Academic Journal
المؤلفون: Alicia Y. Lim, Yuki Kato, Courtney Sakolish, Alan Valdiviezo, Gang Han, Piyush Bajaj, Jason Stanko, Stephen S. Ferguson, Remi Villenave, Philip Hewitt, Rhiannon N. Hardwick, Ivan Rusyn
المصدر: Bioengineering, Vol 10, Iss 10, p 1195 (2023)
مصطلحات موضوعية: microphysiological systems, liver, testing, tissue chip, Technology, Biology (General), QH301-705.5
وصف الملف: electronic resource
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2Academic Journal
المصدر: ADMET and DMPK, Vol 4, Iss 4, Pp 302-313 (2016)
مصطلحات موضوعية: ABC transporters, transport inhibition, Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
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المؤلفون: Ivan Rusyn, Courtney Sakolish, Yuki Kato, Clifford Stephan, Leoncio Vergara, Philip Hewitt, Vasanthi Bhaskaran, Myrtle Davis, Rhiannon N Hardwick, Stephen S Ferguson, Jason P Stanko, Piyush Bajaj, Karissa Adkins, Nisha S Sipes, E Sidney Hunter, Maria T Baltazar, Paul L Carmichael, Kritika Sadh, Richard A Becker
المصدر: Toxicol Sci
مصطلحات موضوعية: Lab-On-A-Chip Devices, Humans, In-Depth Reviews, Toxicology
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المؤلفون: Rhiannon N Hardwick, Patrick Brassil, Ilaria Badagnani, Kimberly Perkins, Glenmar P Obedencio, Andrea S Kim, Michael W Conner, David L Bourdet, Eric B Harstad
المصدر: Toxicological Sciences. 186:323-337
مصطلحات موضوعية: Male, Reproduction, Administration, Oral, Embryonic Development, Inflammatory Bowel Diseases, Toxicology, Healthy Volunteers, Rats, Dogs, Pregnancy, Nitriles, Toxicity Tests, Animals, Humans, Female, Rabbits, Naphthyridines, Janus Kinases
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المؤلفون: Xiaoting, Wang, Anna K, Kopec, Mark, Collinge, Rhiannon, David, Christian, Grant, Rhiannon N, Hardwick, Aaron, Navratil, Nirav, Patel, Wendy, Rowan, Nikki, Marshall
المصدر: ALTEX.
مصطلحات موضوعية: Pharmacology, Medical Laboratory Technology, General Medicine
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المؤلفون: Szczepan W, Baran, Paul C, Brown, Andreas R, Baudy, Suzanne C, Fitzpatrick, Christopher, Frantz, Aaron, Fullerton, Jinping, Gan, Rhiannon N, Hardwick, Kathleen M, Hillgren, Anna K, Kopec, Jennifer L, Liras, Donna L, Mendrick, Ryan, Nagao, William R, Proctor, Diane, Ramsden, Alexandre J S, Ribeiro, David, Stresser, Kyung E, Sung, Radhakrishna, Sura, Kazuhiro, Tetsuka, Lindsay, Tomlinson, Terry, Van Vleet, Matthew P, Wagoner, Qin, Wang, Sevim Yildiz, Arslan, Gorm, Yoder, Jason E, Ekert
المصدر: ALTEX.
مصطلحات موضوعية: Pharmacology, Medical Laboratory Technology, Drug Industry, Pharmaceutical Preparations, United States Food and Drug Administration, Lab-On-A-Chip Devices, Drug Evaluation, Preclinical, Animals, General Medicine, Animal Testing Alternatives, United States
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المؤلفون: Jessica Whritenour, Rhiannon N. Hardwick, Catherine J. Betts, Maike Thamsen, Radhakrishna Sura, Kristin M. Fabre, Elad H. Kaufman
المصدر: Lab on a Chip. 20:199-214
مصطلحات موضوعية: Drug, Cell type, Drug Industry, media_common.quotation_subject, Biomedical Engineering, Bioengineering, Computational biology, Models, Biological, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Lab-On-A-Chip Devices, Animals, Humans, Medicine, Model development, Skin, 030304 developmental biology, media_common, Pharmaceutical industry, 0303 health sciences, business.industry, General Chemistry, Skin toxicity, Pharmaceutical Preparations, Drug development, Preclinical testing, 030220 oncology & carcinogenesis, business, Phototoxicity
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المؤلفون: Adrian Roth, Rhiannon N. Hardwick, Peter Loskill
المصدر: Stem Cell Reports
مصطلحات موضوعية: Thought experiment, Process (engineering), Aside, Stem Cells, Cell Culture Techniques, Drug Evaluation, Preclinical, Cell Biology, Biology, Biochemistry, Data science, Pipeline (software), Drug Discovery, Genetics, Key (cryptography), Commentary, Humans, Developmental Biology
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9
المؤلفون: Nathan J. Cherrington, Rhiannon N. Hardwick, Jeremy K. Nicholson, Alexandros Pechlivanis, Lesley Hoyles, Ian D. Wilson, Kate Wolfer, Marine P.M. Letertre, Nyasha Munjoma, Muireann Coen, Julie A. K. McDonald, Jonathan R. Swann
المساهمون: Medical Research Council (MRC)
المصدر: Journal of Proteome Research
مصطلحات موضوعية: Male, 0301 basic medicine, PHARMACOKINETICS, Metabolite, gut microbiome, Urine, Gut flora, Pharmacology, Biochemistry, TOXICITY, ACETYLCHOLINE, Rats, Sprague-Dawley, Feces, chemistry.chemical_compound, Tandem Mass Spectrometry, RNA, Ribosomal, 16S, skin and connective tissue diseases, mass spectrometry, biology, PLASMA, amplicon sequencing, metabolic phenotyping mass spectrometry, Toxicity, 03 Chemical Sciences, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, metabolic phenotyping, INHIBITION, METABOLISM, Article, Biochemical Research Methods, methotrexate, Nephrotoxicity, Excretion, 03 medical and health sciences, Pharmacokinetics, Animals, gastrointestinal toxicity, RELEASE, Science & Technology, 030102 biochemistry & molecular biology, General Chemistry, RESCUE, 06 Biological Sciences, biology.organism_classification, Gastrointestinal Microbiome, Rats, 030104 developmental biology, chemistry, DISCOVERY, HIGH-DOSE METHOTREXATE, Chromatography, Liquid
وصف الملف: text; application/pdf
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المصدر: Liver International. 37:1074-1081
مصطلحات موضوعية: 0301 basic medicine, Glycosylation, Blotting, Western, Biology, Endoplasmic Reticulum, Article, 03 medical and health sciences, chemistry.chemical_compound, N-linked glycosylation, Non-alcoholic Fatty Liver Disease, Gene expression, medicine, Humans, Hepatology, Gene Expression Profiling, Multidrug resistance-associated protein 2, Fatty liver, Membrane Transport Proteins, Biological Transport, Transporter, medicine.disease, carbohydrates (lipids), 030104 developmental biology, Liver, Oligosaccharyltransferase complex, Biochemistry, chemistry, Case-Control Studies, Efflux, Transcriptome, Protein Processing, Post-Translational
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المؤلفون: Deborah G. Nguyen, Chad Viergever, Alice E. Chen, Rhiannon N. Hardwick
المصدر: Clinical Pharmacology & Therapeutics. 101:453-457
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Engineering, New horizons, Tissue Engineering, business.industry, Nanotechnology, Disease, Disease Models, Animal, 03 medical and health sciences, Imaging, Three-Dimensional, 030104 developmental biology, 0302 clinical medicine, Human disease, Chemical safety, 030220 oncology & carcinogenesis, Animals, Humans, Pharmacology (medical), Biochemical engineering, business, Physiological Phenomena, Physiological Phenomenon
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المؤلفون: Nathan J. Cherrington, Rhiannon N. Hardwick, Christopher P. Leamon, Philip S. Low, April D. Lake
مصطلحات موضوعية: 0301 basic medicine, Male, Toxicology, Rats, Sprague-Dawley, chemistry.chemical_compound, 0302 clinical medicine, Methionine, Non-alcoholic Fatty Liver Disease, Nonalcoholic fatty liver disease, Choline, education.field_of_study, Organotechnetium Compounds, Imaging agent, Choline Deficiency, Molecular Imaging, Liver, 030220 oncology & carcinogenesis, medicine.symptom, medicine.medical_specialty, Inflammation, Biology, Diet, High-Fat, digestive system, Article, 03 medical and health sciences, Folic Acid, Predictive Value of Tests, Internal medicine, medicine, Animals, Humans, Folate Receptor 2, education, Pharmacology, Tomography, Emission-Computed, Single-Photon, Folate receptor beta, Innate immune system, Macrophages, nutritional and metabolic diseases, medicine.disease, digestive system diseases, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Endocrinology, chemistry, Steatosis, Radiopharmaceuticals, Biomarkers
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المؤلفون: Stavra A. Xanthakos, Robert P. Erickson, Rhiannon N. Hardwick, Hassan H. A-Kader, Mark J. Canet, Nathan J. Cherrington, Amy M. Bataille, José E. Manautou, Daniel W. Ferreira, Sarah N. Campion, Matthew D. Merrell
المصدر: Drug Metabolism and Disposition. 43:829-835
مصطلحات موضوعية: Male, medicine.medical_specialty, Adolescent, Pharmaceutical Science, Pilot Projects, Biology, Chronic liver disease, digestive system, Cohort Studies, Non-alcoholic Fatty Liver Disease, Internal medicine, Nonalcoholic fatty liver disease, medicine, Humans, Child, Biotransformation, Acetaminophen, Pharmacology, Multidrug resistance-associated protein 2, Bile Canaliculi, digestive, oral, and skin physiology, Fatty liver, Transporter, Articles, Analgesics, Non-Narcotic, medicine.disease, Multidrug Resistance-Associated Protein 2, digestive system diseases, Up-Regulation, Fatty Liver, Protein Transport, Endocrinology, Liver, Female, Efflux, Multidrug Resistance-Associated Proteins, Steatosis, medicine.drug
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المؤلفون: Michael Goedken, John D. Clarke, Nathan J. Cherrington, Curtis D. Klaassen, April D. Lake, Rhiannon N. Hardwick, Andrew J. Lickteig
المصدر: Journal of Hepatology. 61:139-147
مصطلحات موضوعية: Male, Statin, Organic anion transporter 1, medicine.drug_class, Biological Transport, Active, Organic Anion Transporters, Organic Anion Transporters, Sodium-Independent, Pharmacology, Article, Choline, Mice, chemistry.chemical_compound, Methionine, Pharmacokinetics, Non-alcoholic Fatty Liver Disease, medicine, Animals, Humans, Pravastatin, Mice, Knockout, Hepatology, biology, Liver-Specific Organic Anion Transporter 1, Muscles, nutritional and metabolic diseases, Transporter, medicine.disease, Mice, Inbred C57BL, Organic anion-transporting polypeptide, Liver, chemistry, biology.protein, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Steatohepatitis, medicine.drug
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المصدر: Journal of Pharmacology and Experimental Therapeutics. 348:452-458
مصطلحات موضوعية: Male, Simvastatin, medicine.medical_specialty, Organic anion transporter 1, Down-Regulation, Organic Anion Transporters, Metabolism, Transport, and Pharmacogenomics, Rats, Sprague-Dawley, chemistry.chemical_compound, Non-alcoholic Fatty Liver Disease, Internal medicine, Nonalcoholic fatty liver disease, medicine, Animals, Myopathy, Pharmacology, Methionine, biology, Fatty liver, medicine.disease, digestive system diseases, Rats, Fatty Liver, Organic anion-transporting polypeptide, Endocrinology, Liver, chemistry, biology.protein, Molecular Medicine, Hydroxymethylglutaryl-CoA Reductase Inhibitors, medicine.symptom, SLCO1B1, medicine.drug
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المؤلفون: Kim L. R. Brouwer, Nathan D. Pfeifer, Brian C. Ferslew, Rhiannon N. Hardwick, Arlene S. Bridges
المصدر: Journal of Pharmacology and Experimental Therapeutics. 347:737-745
مصطلحات موضوعية: Male, medicine.medical_specialty, Abcg2, Metabolism, Transport, and Pharmacogenomics, Excretion, Tandem Mass Spectrometry, Internal medicine, medicine, Animals, Bile, Rosuvastatin, Rosuvastatin Calcium, Biliary Tract, Pentanoic Acids, Cells, Cultured, Chromatography, High Pressure Liquid, Mice, Knockout, Pharmacology, Sulfonamides, biology, Multidrug resistance-associated protein 2, Rats, Fluorobenzenes, Pyrimidines, Endocrinology, Liver, Hepatocytes, biology.protein, Molecular Medicine, ATP-Binding Cassette Transporters, Efflux, Hepatic Elimination, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Carrier Proteins, Perfusion, medicine.drug
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المؤلفون: Bohuslav Dvorak, Teresa E. Estrada, Mark J. Canet, Rhiannon N. Hardwick, Harrison A. Frisk, Katie Lux, Nathan J. Cherrington, Melissa D. Halpern
المصدر: American Journal of Physiology-Gastrointestinal and Liver Physiology. 304:G48-G56
مصطلحات موضوعية: medicine.medical_specialty, Physiology, Blotting, Western, Down-Regulation, Organic Anion Transporters, Sodium-Dependent, Ileum, Biology, Cholesterol 7 alpha-hydroxylase, digestive system, Proinflammatory cytokine, Bile Acids and Salts, Rats, Sprague-Dawley, Mice, Enterocolitis, Necrotizing, Physiology (medical), Internal medicine, CYP27A1, medicine, Animals, RNA, Messenger, Mice, Knockout, Symporters, Hepatology, Tumor Necrosis Factor-alpha, Multidrug resistance-associated protein 2, Interleukin-18, Gastroenterology, DNA, medicine.disease, Multidrug Resistance-Associated Protein 2, digestive system diseases, Rats, Liver and Biliary Tract, Enterocytes, medicine.anatomical_structure, Endocrinology, Liver, Necrotizing enterocolitis, Cholestanetriol 26-Monooxygenase, RNA, Tumor necrosis factor alpha, Interleukin 18, Multidrug Resistance-Associated Proteins, Carrier Proteins
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المؤلفون: Nathan J. Cherrington, Robert P. Erickson, Bita Maghsoodi, David Jelinek, Ivan A. Borbon, Rhiannon N. Hardwick
المصدر: Gene. 491:128-134
مصطلحات موضوعية: Male, Heterozygote, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Adipose Tissue, White, Caveolin 1, Adipose tissue, White adipose tissue, Biology, Caveolae, Article, Mice, PTRF, Niemann-Pick C1 Protein, hemic and lymphatic diseases, Internal medicine, Genetics, medicine, Animals, Bile, Obesity, Adiposity, Niemann-Pick Diseases, Mice, Inbred BALB C, Sex Characteristics, Intracellular Signaling Peptides and Proteins, Genetic Variation, Proteins, nutritional and metabolic diseases, Heterozygote advantage, General Medicine, medicine.disease, Disease Models, Animal, Endocrinology, Female, NPC1, Niemann–Pick disease
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المؤلفون: Nathan J. Cherrington, Rhiannon N. Hardwick, Mark J. Canet, Stephanie M. Street, Craig D. Fisher
المصدر: Drug Metabolism and Disposition. 40:450-460
مصطلحات موضوعية: Male, medicine.medical_specialty, medicine.drug_class, Metabolite, Pharmaceutical Science, Bile Acids and Salts, Rats, Sprague-Dawley, chemistry.chemical_compound, Methionine, Ezetimibe, Non-alcoholic Fatty Liver Disease, Internal medicine, medicine, Animals, Glucuronosyltransferase, Intestinal Mucosa, Biliary Tract, Cellular localization, Pharmacology, Bile acid, Chemistry, Anticholesteremic Agents, Multidrug resistance-associated protein 2, Fatty liver, Membrane Transport Proteins, Biological Transport, Articles, medicine.disease, Choline Deficiency, Diet, Rats, Fatty Liver, Endocrinology, Liver, Biliary tract, Azetidines, Efflux, Multidrug Resistance-Associated Proteins, medicine.drug
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المؤلفون: Rhiannon N. Hardwick, Nathan J. Cherrington, Craig D. Fisher, Mark J. Canet, April D. Lake
المصدر: Drug Metabolism and Disposition. 38:2293-2301
مصطلحات موضوعية: Adult, medicine.medical_specialty, Antioxidant, NF-E2-Related Factor 2, Glutamate-Cysteine Ligase, medicine.medical_treatment, Pharmaceutical Science, Inflammation, Biology, medicine.disease_cause, digestive system, Antioxidants, chemistry.chemical_compound, Internal medicine, Nonalcoholic fatty liver disease, NAD(P)H Dehydrogenase (Quinone), medicine, Humans, Glutathione Transferase, Pharmacology, Fatty liver, nutritional and metabolic diseases, Articles, Glutathione, Malondialdehyde, medicine.disease, digestive system diseases, Fatty Liver, Endocrinology, Biochemistry, chemistry, Disease Progression, medicine.symptom, Steatosis, Oxidative stress
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