المؤلفون: Fink, Elissa A, Bardine, Conner, Gahbauer, Stefan, Singh, Isha, Detomasi, Tyler C, White, Kris, Gu, Shuo, Wan, Xiaobo, Chen, Jun, Ary, Beatrice, Glenn, Isabella, O'Connell, Joseph, O'Donnell, Henry, Fajtová, Pavla, Lyu, Jiankun, Vigneron, Seth, Young, Nicholas J, Kondratov, Ivan S, Alisoltani, Arghavan, Simons, Lacy M, Lorenzo‐Redondo, Ramon, Ozer, Egon A, Hultquist, Judd F, O'Donoghue, Anthony J, Moroz, Yurii S, Taunton, Jack, Renslo, Adam R, Irwin, John J, García‐Sastre, Adolfo, Shoichet, Brian K, Craik, Charles S

المصدر: Protein Science. 32(8)

مصطلحات موضوعية: Medicinal and Biomolecular Chemistry, Chemical Sciences, Emerging Infectious Diseases, Infectious Diseases, Coronaviruses, 5.1 Pharmaceuticals, Good Health and Well Being, Humans, COVID-19, SARS-CoV-2, Pandemics, Protease Inhibitors, Molecular Docking Simulation, Viral Nonstructural Proteins, Antiviral Agents, major protease, SARS-COV-2, structure-based inhibitor, discoverydockinganti-viral, Biochemistry and Cell Biology, Computation Theory and Mathematics, Other Information and Computing Sciences, Biophysics, Biochemistry and cell biology, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/61h336z6
https://escholarship.org/content/qt61h336z6/qt61h336z6.pdf

المؤلفون: Togo, Takaya, Tram, Linh, Denton, Laura G, ElHilali-Pollard, Xochina, Gu, Jun, Jiang, Jinglei, Liu, Chenglei, Zhao, Yan, Zhao, Yanlong, Zheng, Yinzhe, Zheng, Yunping, Yang, Jingjing, Fan, Panpan, Arkin, Michelle R, Härmä, Harri, Sun, Deqian, Canan, Stacie S, Wheeler, Steven E, Renslo, Adam R

المصدر: Journal of medicinal chemistry. 66(14)

مصطلحات موضوعية: Models, Molecular, Ligands, Proteins, Tyrosine, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5pv0w92r

المؤلفون: Van Horn, Kurt S, Wang, Dongju, Medina-Cleghorn, Daniel, Lee, Peter S, Bryant, Clifford, Altobelli, Chad, Jaishankar, Priyadarshini, Leung, Kevin K, Ng, Raymond A, Ambrose, Andrew J, Tang, Yinyan, Arkin, Michelle R, Renslo, Adam R

المصدر: Journal of the American Chemical Society. 145(18)

مصطلحات موضوعية: Rare Diseases, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Humans, Caspase 6, Cysteine, Caspases, Apoptosis, Cysteine Proteinase Inhibitors, Chemical Sciences, General Chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5z17x94z
https://escholarship.org/content/qt5z17x94z/qt5z17x94z.pdf

المؤلفون: Gahbauer, Stefan, Correy, Galen J, Schuller, Marion, Ferla, Matteo P, Doruk, Yagmur Umay, Rachman, Moira, Wu, Taiasean, Diolaiti, Morgan, Wang, Siyi, Neitz, R Jeffrey, Fearon, Daren, Radchenko, Dmytro S, Moroz, Yurii S, Irwin, John J, Renslo, Adam R, Taylor, Jenny C, Gestwicki, Jason E, von Delft, Frank, Ashworth, Alan, Ahel, Ivan, Shoichet, Brian K, Fraser, James S

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 120(2)

مصطلحات موضوعية: Theory Of Computation, Biochemistry and Cell Biology, Biological Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, Built Environment and Design, Information and Computing Sciences, Design, Emerging Infectious Diseases, Bioengineering, Infectious Diseases, Coronaviruses, 5.1 Pharmaceuticals, Generic health relevance, Humans, SARS-CoV-2, COVID-19, Crystallography, Pandemics, Ligands, Molecular Docking Simulation, Protease Inhibitors, Antiviral Agents, coronavirus, macrodomain, virtual screening, fragment-based drug discovery

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3qr8j49t
https://escholarship.org/content/qt3qr8j49t/qt3qr8j49t.pdf

المؤلفون: Hulce, Kaitlin R, Jaishankar, Priyadarshini, Lee, Gregory M, Bohn, Markus-Frederik, Connelly, Emily J, Wucherer, Kristin, Ongpipattanakul, Chayanid, Volk, Regan F, Chuo, Shih-Wei, Arkin, Michelle R, Renslo, Adam R, Craik, Charles S

المصدر: Cell Chemical Biology. 29(5)

مصطلحات موضوعية: Biochemistry and Cell Biology, Medicinal and Biomolecular Chemistry, Chemical Sciences, Biological Sciences, Emerging Infectious Diseases, Infectious Diseases, 5.1 Pharmaceuticals, 2.2 Factors relating to the physical environment, Infection, Cysteine, Cytomegalovirus, Cytomegalovirus Infections, Humans, Peptide Hydrolases, Viral Proteases, allostery, antiviral, conformational dynamics, covalent inhibitor, cytomegalovirus, dimerization, herpesvirus, irreversible electrophile, non-catalytic cysteine, protease

URL الوصول: https://escholarship.org/uc/item/6903b62c

المؤلفون: Jiang, Honglin, Muir, Ryan K, Gonciarz, Ryan L, Olshen, Adam B, Yeh, Iwei, Hann, Byron C, Zhao, Ning, Wang, Yung-hua, Behr, Spencer C, Korkola, James E, Evans, Michael J, Collisson, Eric A, Renslo, Adam R

المصدر: Journal of Experimental Medicine. 219(4)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, 6.1 Pharmaceuticals, 5.1 Pharmaceuticals, Good Health and Well Being, Animals, Cell Line, Tumor, Iron, Mutation, Neoplasms, Protein Kinase Inhibitors, Proto-Oncogene Proteins p21(ras), Signal Transduction, Medical and Health Sciences, Immunology, Biomedical and clinical sciences, Health sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5tq885td
https://escholarship.org/content/qt5tq885td/qt5tq885td.pdf

المؤلفون: Chen, Jun, Gonciarz, Ryan L, Renslo, Adam R

المصدر: RSC Advances. 11(58)

مصطلحات موضوعية: Chemical Sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0nd156q4
https://escholarship.org/content/qt0nd156q4/qt0nd156q4.pdf

المؤلفون: Chen, Jun, Gonciarz, Ryan L, Renslo, Adam R

المصدر: RSC Advances. 11(54)

مصطلحات موضوعية: Chemical Sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8fd582kp

المؤلفون: Kim, Gha-Hyun J, Mo, Han, Liu, Harrison, Wu, Zhihao, Chen, Steven, Zheng, Jiashun, Zhao, Xiang, Nucum, Daryl, Shortland, James, Peng, Longping, Elepano, Mannuel, Tang, Benjamin, Olson, Steven, Paras, Nick, Li, Hao, Renslo, Adam R, Arkin, Michelle R, Huang, Bo, Lu, Bingwei, Sirota, Marina, Guo, Su

مصطلحات موضوعية: D. melanogaster, electronic health records, genetics, genomics, glucocerebrosidase, human, neuroscience, nitroreductase (NTR)-metronidazole, parkin, pink1, a-synuclein, dj-1, phenotypic screening, time to Levodopa, zebrafish, Angiotensin II Type 1 Receptor Blockers, Angiotensin-Converting Enzyme Inhibitors, Animals, Animals, Genetically Modified, Antiparkinson Agents, Case-Control Studies, Databases, Factual, Disease Models, Animal, Dopaminergic Neurons, Drosophila Proteins, Drosophila melanogaster, Gaucher Disease, High-Throughput Screening Assays, Humans, Mitochondria, Neuroprotective Agents, Parkinson Disease, Receptor, Angiotensin, Type 1, Renin-Angiotensin System, Zebrafish, Zebrafish Proteins, parkin, pink1, a-synuclein, dj-1, D, melanogaster, Human, Parkinson's Disease, Hypertension, Neurodegenerative, Neurosciences, Aging, Brain Disorders, 5.1 Pharmaceuticals, Neurological, Biochemistry and Cell Biology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/18n217jf

المؤلفون: Zhao, Ning, Huang, Yangjie, Wang, Yung-Hua, Muir, Ryan K, Chen, Ying-Chu, Wei, Junnian, Hooshdaran, Nima, Viswanath, Pavithra, Seo, Youngho, Ruggero, Davide, Renslo, Adam R, Evans, Michael J

المصدر: Journal of Nuclear Medicine. 62(7)

مصطلحات موضوعية: Cancer, Biotechnology, Rare Diseases, Animals, Cell Line, Tumor, Female, Male, Mice, Molecular Imaging, Radiopharmaceuticals, labile iron pool, theranostics, PET, Clinical Sciences, Nuclear Medicine & Medical Imaging

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/2xz9c8r0

المؤلفون: Gonciarz, Ryan L, Renslo, Adam R

مصطلحات موضوعية: Microbiology, Biological Sciences, Infectious Diseases, Aetiology, 2.2 Factors relating to the physical environment, Infection, Anti-Bacterial Agents, Bacteria, Host-Pathogen Interactions, Humans, Iron, Gram-negative bacteria, Host?pathogen interaction, Iron metabolism, Iron speciation, Labile iron pool, Activity-based probes, Reactivity-based probes, Antibacterial agents, Anti-infectives, Host–pathogen interaction, Medicinal and Biomolecular Chemistry, Biochemistry and Cell Biology, Organic Chemistry, Biochemistry and cell biology, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/92h152cg

المؤلفون: Klope, Matthew T., Tapia Cardona, Juan A., Chen, Jun, Gonciarz, Ryan L., Cheng, Ke, Jaishankar, Priyadarshini, Kim, Julie, Legac, Jenny, Rosenthal, Philip J., Renslo, Adam R.

المساهمون: Division of Microbiology and Infectious Diseases

المصدر: ACS Medicinal Chemistry Letters ; volume 15, issue 10, page 1764-1770 ; ISSN 1948-5875 1948-5875

الاتاحة: http://dx.doi.org/10.1021/acsmedchemlett.4c00365
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.4c00365

المؤلفون: Gonciarz, Ryan L, Collisson, Eric A, Renslo, Adam R

المصدر: Trends in Pharmacological Sciences. 42(1)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Good Health and Well Being, Cell Death, Ferroptosis, Iron, Oxidation-Reduction, activity-based probes, ferritinophagy, ferroptosis, iron homeostasis, reactivity-based probes, targeted prodrugs, Biological Sciences, Medical and Health Sciences, Pharmacology & Pharmacy, Pharmacology and pharmaceutical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6sr173t6

المؤلفون: Huff, Tyler C, Camarena, Vladimir, Sant, David W, Wilkes, Zachary, Van Booven, Derek, Aron, Allegra T, Muir, Ryan K, Renslo, Adam R, Chang, Christopher J, Monje, Paula V, Wang, Gaofeng

المصدر: Life Science Alliance. 3(1)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, 2.1 Biological and endogenous factors, Animals, Cells, Cultured, Cyclic AMP, Demethylation, Ferrous Compounds, Gene Silencing, Histones, Jumonji Domain-Containing Histone Demethylases, Ligands, Methylation, Oxidoreductases, N-Demethylating, Protein Processing, Post-Translational, Rats, Receptors, G-Protein-Coupled, Schwann Cells, Signal Transduction, Thionucleotides, Transfection, Biological sciences, Biomedical and clinical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/74k787q9
https://escholarship.org/content/qt74k787q9/qt74k787q9.pdf

المؤلفون: Pemberton, Orville A, Jaishankar, Priyadarshini, Akhtar, Afroza, Adams, Jessie L, Shaw, Lindsey N, Renslo, Adam R, Chen, Yu

المصدر: Journal of Medicinal Chemistry. 62(18)

مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Biodefense, Emerging Infectious Diseases, Antimicrobial Resistance, Infectious Diseases, 5.1 Pharmaceuticals, Anti-Bacterial Agents, Bacterial Proteins, Crystallography, X-Ray, Drug Design, Enterobacter cloacae, Escherichia coli, HEK293 Cells, Humans, Imipenem, Klebsiella pneumoniae, Ligands, Microsomes, Liver, Molecular Conformation, Organophosphonates, Pseudomonas aeruginosa, beta-Lactamase Inhibitors, beta-Lactamases, beta-Lactams, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, Pharmacology and pharmaceutical sciences, Medicinal and biomolecular chemistry, Organic chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9gz7885v
https://escholarship.org/content/qt9gz7885v/qt9gz7885v.pdf

المؤلفون: Ehrnhoefer, Dagmar E, Skotte, Niels H, Reinshagen, Jeanette, Qiu, Xiaofan, Windshügel, Björn, Jaishankar, Priyadarshini, Ladha, Safia, Petina, Olga, Khankischpur, Mehdi, Nguyen, Yen TN, Caron, Nicholas S, Razeto, Adelia, Meyer Zu Rheda, Matthias, Deng, Yu, Huynh, Khuong T, Wittig, Ilka, Gribbon, Philip, Renslo, Adam R, Geffken, Detlef, Gul, Sheraz, Hayden, Michael R

المصدر: Cell Chemical Biology. 26(9)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Neurodegenerative, Rare Diseases, Huntington's Disease, Brain Disorders, Neurosciences, Allosteric Regulation, Animals, Apoptosis, COS Cells, Caspase 6, Chlorocebus aethiops, Huntingtin Protein, Huntington Disease, Molecular Docking Simulation, Nerve Tissue Proteins, Neurons, Nuclear Proteins, Huntington disease, allosteric, caspase-6, inhibitor, non-apoptotic, Biochemistry and cell biology, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3pm9n7x7

المؤلفون: Muir, Ryan K, Zhao, Ning, Wei, Junnian, Wang, Yung-Hua, Moroz, Anna, Huang, Yangjie, Chen, Ying-Chu, Sriram, Renuka, Kurhanewicz, John, Ruggero, Davide, Renslo, Adam R, Evans, Michael J

المصدر: ACS central science. 5(4)

مصطلحات موضوعية: Chemical Sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9pw662p3

المؤلفون: Griffin, Aliesha L, Jaishankar, Priyadarshini, Grandjean, Jean-Marc, Olson, Steven H, Renslo, Adam R, Baraban, Scott C

المصدر: Brain communications. 1(1)

مصطلحات موضوعية: Chemical biology, drug development, electrophysiology, epilepsy, serotonin, Epilepsy, Brain Disorders, Neurodegenerative, Neurosciences, Development of treatments and therapeutic interventions, Aetiology, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Good Health and Well Being

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4d87j9h5
https://escholarship.org/content/qt4d87j9h5/qt4d87j9h5.pdf

المؤلفون: Pope, Lianne, Arrigoni, Cristina, Lou, Hubing, Bryant, Clifford, Gallardo-Godoy, Alejandra, Renslo, Adam R, Minor, Daniel L

المصدر: ACS Chemical Neuroscience. 9(12)

مصطلحات موضوعية: Analytical Chemistry, Biochemistry and Cell Biology, Biological Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, Brain Disorders, Neurosciences, Chronic Pain, Pain Research, Animals, HEK293 Cells, Humans, Nerve Tissue Proteins, Oocytes, Patch-Clamp Techniques, Potassium Channels, Potassium Channels, Tandem Pore Domain, Tetrahydronaphthalenes, Tetrazoles, Xenopus laevis, K-2P channel, TREK channel, electrophysiology, ion channel chemical biology, K2P channel, Biochemistry and cell biology, Analytical chemistry, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/24p3t7bk
https://escholarship.org/content/qt24p3t7bk/qt24p3t7bk.pdf

المؤلفون: Raleigh, David R, Sever, Navdar, Choksi, Pervinder K, Sigg, Monika Abedin, Hines, Kelly M, Thompson, Bonne M, Elnatan, Daniel, Jaishankar, Priyadarshini, Bisignano, Paola, Garcia-Gonzalo, Francesc R, Krup, Alexis Leigh, Eberl, Markus, Byrne, Eamon FX, Siebold, Christian, Wong, Sunny Y, Renslo, Adam R, Grabe, Michael, McDonald, Jeffrey G, Xu, Libin, Beachy, Philip A, Reiter, Jeremy F

المصدر: Molecular Cell. 72(2)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Pediatric, Brain Disorders, Brain Cancer, Rare Diseases, Cancer, Animals, Cell Line, Cilia, HEK293 Cells, Hedgehog Proteins, Humans, Mice, NIH 3T3 Cells, Oxysterols, Signal Transduction, CBP, HSD11β2, Hedgehog, Smoothened, cilia, lipid, medulloblastoma, oxysterol, primary cilium, sterol, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Health sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8hg474xb