المؤلفون: Felipe Fidalgo (642532), Giovana Tardin Torrezan (9075146), Bianca Costa Soares de Sá (12009028), Bruna Durães de Figueiredo Barros (12009031), Luciana Facure Moredo (10689512), Renan Valieris (548359), Sandro J. de Souza (9578582), João Pereira Duprat (12009034), Ana Cristina Victorino Krepischi (5453723), Dirce Maria Carraro (6830156)

مصطلحات موضوعية: Genetics, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, variant pathogenicity prediction, new putative candidates, genetic predisposition accounts, 2 affected individuals, potential candidate genes, prone families negative, prone families contributing, cutaneous melanoma susceptibility, cutaneous melanoma predisposition, including 7 loss, div >< p, prone families, putative role, genetic etiology, affected relatives, several genes, penetrance genes, melanoma risk, melanoma cases, brazilian melanoma, 5 melanoma, wrn <

Relation: https://figshare.com/articles/figure/Diagram_of_the_germline_sequencing_analysis_and_variant_prioritization_strategy_showing_the_main_technical_processes_/19079446

الاتاحة: https://doi.org/10.1371/journal.pone.0262419.g002

المؤلفون: Felipe Fidalgo (642532), Giovana Tardin Torrezan (9075146), Bianca Costa Soares de Sá (12009028), Bruna Durães de Figueiredo Barros (12009031), Luciana Facure Moredo (10689512), Renan Valieris (548359), Sandro J. de Souza (9578582), João Pereira Duprat (12009034), Ana Cristina Victorino Krepischi (5453723), Dirce Maria Carraro (6830156)

مصطلحات موضوعية: Genetics, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, variant pathogenicity prediction, new putative candidates, genetic predisposition accounts, 2 affected individuals, potential candidate genes, prone families negative, prone families contributing, cutaneous melanoma susceptibility, cutaneous melanoma predisposition, including 7 loss, div >< p, prone families, putative role, genetic etiology, affected relatives, several genes, penetrance genes, melanoma risk, melanoma cases, brazilian melanoma, 5 melanoma, wrn <

Relation: https://figshare.com/articles/dataset/Targeted_NGS_validated_variants_/19079428

الاتاحة: https://doi.org/10.1371/journal.pone.0262419.s003

المؤلفون: Felipe Fidalgo (642532), Giovana Tardin Torrezan (9075146), Bianca Costa Soares de Sá (12009028), Bruna Durães de Figueiredo Barros (12009031), Luciana Facure Moredo (10689512), Renan Valieris (548359), Sandro J. de Souza (9578582), João Pereira Duprat (12009034), Ana Cristina Victorino Krepischi (5453723), Dirce Maria Carraro (6830156)

مصطلحات موضوعية: Genetics, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, variant pathogenicity prediction, new putative candidates, genetic predisposition accounts, 2 affected individuals, potential candidate genes, prone families negative, prone families contributing, cutaneous melanoma susceptibility, cutaneous melanoma predisposition, including 7 loss, div >< p, prone families, putative role, genetic etiology, affected relatives, several genes, penetrance genes, melanoma risk, melanoma cases, brazilian melanoma, 5 melanoma, wrn <

Relation: https://figshare.com/articles/dataset/Probably_pathogenic_variants_algorithms_/19079434

الاتاحة: https://doi.org/10.1371/journal.pone.0262419.s005

المؤلفون: Felipe Fidalgo (642532), Giovana Tardin Torrezan (9075146), Bianca Costa Soares de Sá (12009028), Bruna Durães de Figueiredo Barros (12009031), Luciana Facure Moredo (10689512), Renan Valieris (548359), Sandro J. de Souza (9578582), João Pereira Duprat (12009034), Ana Cristina Victorino Krepischi (5453723), Dirce Maria Carraro (6830156)

مصطلحات موضوعية: Genetics, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, variant pathogenicity prediction, new putative candidates, genetic predisposition accounts, 2 affected individuals, potential candidate genes, prone families negative, prone families contributing, cutaneous melanoma susceptibility, cutaneous melanoma predisposition, including 7 loss, div >< p, prone families, putative role, genetic etiology, affected relatives, several genes, penetrance genes, melanoma risk, melanoma cases, brazilian melanoma, 5 melanoma, wrn <

Relation: https://figshare.com/articles/dataset/TVC_X_GATK_variant_calling_/19079422

الاتاحة: https://doi.org/10.1371/journal.pone.0262419.s001

المؤلفون: Felipe Fidalgo (642532), Giovana Tardin Torrezan (9075146), Bianca Costa Soares de Sá (12009028), Bruna Durães de Figueiredo Barros (12009031), Luciana Facure Moredo (10689512), Renan Valieris (548359), Sandro J. de Souza (9578582), João Pereira Duprat (12009034), Ana Cristina Victorino Krepischi (5453723), Dirce Maria Carraro (6830156)

مصطلحات موضوعية: Genetics, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, variant pathogenicity prediction, new putative candidates, genetic predisposition accounts, 2 affected individuals, potential candidate genes, prone families negative, prone families contributing, cutaneous melanoma susceptibility, cutaneous melanoma predisposition, including 7 loss, div >< p, prone families, putative role, genetic etiology, affected relatives, several genes, penetrance genes, melanoma risk, melanoma cases, brazilian melanoma, 5 melanoma, wrn <

Relation: https://figshare.com/articles/figure/Pedigrees_of_the_five_melanoma-prone_families_/19079443

الاتاحة: https://doi.org/10.1371/journal.pone.0262419.g001

المؤلفون: Felipe Fidalgo (642532), Giovana Tardin Torrezan (9075146), Bianca Costa Soares de Sá (12009028), Bruna Durães de Figueiredo Barros (12009031), Luciana Facure Moredo (10689512), Renan Valieris (548359), Sandro J. de Souza (9578582), João Pereira Duprat (12009034), Ana Cristina Victorino Krepischi (5453723), Dirce Maria Carraro (6830156)

مصطلحات موضوعية: Genetics, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, variant pathogenicity prediction, new putative candidates, genetic predisposition accounts, 2 affected individuals, potential candidate genes, prone families negative, prone families contributing, cutaneous melanoma susceptibility, cutaneous melanoma predisposition, including 7 loss, div >< p, prone families, putative role, genetic etiology, affected relatives, several genes, penetrance genes, melanoma risk, melanoma cases, brazilian melanoma, 5 melanoma, wrn <

Relation: https://figshare.com/articles/dataset/288_variants_prioritized_variants_/19079425

الاتاحة: https://doi.org/10.1371/journal.pone.0262419.s002

المؤلفون: Felipe Fidalgo (642532), Giovana Tardin Torrezan (9075146), Bianca Costa Soares de Sá (12009028), Bruna Durães de Figueiredo Barros (12009031), Luciana Facure Moredo (10689512), Renan Valieris (548359), Sandro J. de Souza (9578582), João Pereira Duprat (12009034), Ana Cristina Victorino Krepischi (5453723), Dirce Maria Carraro (6830156)

مصطلحات موضوعية: Genetics, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, variant pathogenicity prediction, new putative candidates, genetic predisposition accounts, 2 affected individuals, potential candidate genes, prone families negative, prone families contributing, cutaneous melanoma susceptibility, cutaneous melanoma predisposition, including 7 loss, div >< p, prone families, putative role, genetic etiology, affected relatives, several genes, penetrance genes, melanoma risk, melanoma cases, brazilian melanoma, 5 melanoma, wrn <

Relation: https://figshare.com/articles/dataset/VarElect_analysis_/19079431

الاتاحة: https://doi.org/10.1371/journal.pone.0262419.s004

المؤلفون: Felipe Fidalgo (642532), Giovana Tardin Torrezan (9075146), Bianca Costa Soares de Sá (12009028), Bruna Durães de Figueiredo Barros (12009031), Luciana Facure Moredo (10689512), Renan Valieris (548359), Sandro J. de Souza (9578582), João Pereira Duprat (12009034), Ana Cristina Victorino Krepischi (5453723), Dirce Maria Carraro (6830156)

مصطلحات موضوعية: Genetics, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, variant pathogenicity prediction, new putative candidates, genetic predisposition accounts, 2 affected individuals, potential candidate genes, prone families negative, prone families contributing, cutaneous melanoma susceptibility, cutaneous melanoma predisposition, including 7 loss, div >< p, prone families, putative role, genetic etiology, affected relatives, several genes, penetrance genes, melanoma risk, melanoma cases, brazilian melanoma, 5 melanoma, wrn <

Relation: https://figshare.com/articles/dataset/IPA_main_diseases_and_conditions_/19079437

الاتاحة: https://doi.org/10.1371/journal.pone.0262419.s006

المؤلفون: Felipe Fidalgo (642532), Giovana Tardin Torrezan (9075146), Bianca Costa Soares de Sá (12009028), Bruna Durães de Figueiredo Barros (12009031), Luciana Facure Moredo (10689512), Renan Valieris (548359), Sandro J. de Souza (9578582), João Pereira Duprat (12009034), Ana Cristina Victorino Krepischi (5453723), Dirce Maria Carraro (6830156)

مصطلحات موضوعية: Genetics, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, variant pathogenicity prediction, new putative candidates, genetic predisposition accounts, 2 affected individuals, potential candidate genes, prone families negative, prone families contributing, cutaneous melanoma susceptibility, cutaneous melanoma predisposition, including 7 loss, div >< p, prone families, putative role, genetic etiology, affected relatives, several genes, penetrance genes, melanoma risk, melanoma cases, brazilian melanoma, 5 melanoma, wrn <

Relation: https://figshare.com/articles/dataset/Published_melanoma_candidate_genes_/19079440

الاتاحة: https://doi.org/10.1371/journal.pone.0262419.s007

المؤلفون: Felipe Fidalgo (642532), Giovana Tardin Torrezan (9075146), Bianca Costa Soares de Sá (12009028), Bruna Durães de Figueiredo Barros (12009031), Luciana Facure Moredo (10689512), Renan Valieris (548359), Sandro J. de Souza (9578582), João Pereira Duprat (12009034), Ana Cristina Victorino Krepischi (5453723), Dirce Maria Carraro (6830156)

مصطلحات موضوعية: Genetics, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, variant pathogenicity prediction, new putative candidates, genetic predisposition accounts, 2 affected individuals, potential candidate genes, prone families negative, prone families contributing, cutaneous melanoma susceptibility, cutaneous melanoma predisposition, including 7 loss, div >< p, prone families, putative role, genetic etiology, affected relatives, several genes, penetrance genes, melanoma risk, melanoma cases, brazilian melanoma, 5 melanoma, wrn <

Relation: https://figshare.com/articles/figure/Network_of_13_genes_harboring_rare_germline_variants_identified_in_melanoma-prone_patients_/19079449

الاتاحة: https://doi.org/10.1371/journal.pone.0262419.g003

المؤلفون: Felipe Fidalgo (642532), Giovana Tardin Torrezan (9075146), Bianca Costa Soares de Sá (12009028), Bruna Durães de Figueiredo Barros (12009031), Luciana Facure Moredo (10689512), Renan Valieris (548359), Sandro J. de Souza (9578582), João Pereira Duprat (12009034), Ana Cristina Victorino Krepischi (5453723), Dirce Maria Carraro (6830156)

مصطلحات موضوعية: Genetics, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, variant pathogenicity prediction, new putative candidates, genetic predisposition accounts, 2 affected individuals, potential candidate genes, prone families negative, prone families contributing, cutaneous melanoma susceptibility, cutaneous melanoma predisposition, including 7 loss, div >< p, prone families, putative role, genetic etiology, affected relatives, several genes, penetrance genes, melanoma risk, melanoma cases, brazilian melanoma, 5 melanoma, wrn <

Relation: https://figshare.com/articles/dataset/Types_of_rare_non-synonymous_heterozygous_variants_co-segregating_in_both_affected_relatives_of_the_five_melanoma-prone_families_/19079458

الاتاحة: https://doi.org/10.1371/journal.pone.0262419.t003

المؤلفون: Felipe Fidalgo (642532), Giovana Tardin Torrezan (9075146), Bianca Costa Soares de Sá (12009028), Bruna Durães de Figueiredo Barros (12009031), Luciana Facure Moredo (10689512), Renan Valieris (548359), Sandro J. de Souza (9578582), João Pereira Duprat (12009034), Ana Cristina Victorino Krepischi (5453723), Dirce Maria Carraro (6830156)

مصطلحات موضوعية: Genetics, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, variant pathogenicity prediction, new putative candidates, genetic predisposition accounts, 2 affected individuals, potential candidate genes, prone families negative, prone families contributing, cutaneous melanoma susceptibility, cutaneous melanoma predisposition, including 7 loss, div >< p, prone families, putative role, genetic etiology, affected relatives, several genes, penetrance genes, melanoma risk, melanoma cases, brazilian melanoma, 5 melanoma, wrn <

Relation: https://figshare.com/articles/dataset/Detected_genes_associated_with_the_phenotypes_of_interest_and_their_respective_rare_non-synonymous_variants_/19079464

الاتاحة: https://doi.org/10.1371/journal.pone.0262419.t005

المؤلفون: Felipe Fidalgo (642532), Giovana Tardin Torrezan (9075146), Bianca Costa Soares de Sá (12009028), Bruna Durães de Figueiredo Barros (12009031), Luciana Facure Moredo (10689512), Renan Valieris (548359), Sandro J. de Souza (9578582), João Pereira Duprat (12009034), Ana Cristina Victorino Krepischi (5453723), Dirce Maria Carraro (6830156)

مصطلحات موضوعية: Genetics, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, variant pathogenicity prediction, new putative candidates, genetic predisposition accounts, 2 affected individuals, potential candidate genes, prone families negative, prone families contributing, cutaneous melanoma susceptibility, cutaneous melanoma predisposition, including 7 loss, div >< p, prone families, putative role, genetic etiology, affected relatives, several genes, penetrance genes, melanoma risk, melanoma cases, brazilian melanoma, 5 melanoma, wrn <

Relation: https://figshare.com/articles/dataset/Clinical_characteristics_of_melanoma_patients_/19079455

الاتاحة: https://doi.org/10.1371/journal.pone.0262419.t002

المؤلفون: Felipe Fidalgo (642532), Giovana Tardin Torrezan (9075146), Bianca Costa Soares de Sá (12009028), Bruna Durães de Figueiredo Barros (12009031), Luciana Facure Moredo (10689512), Renan Valieris (548359), Sandro J. de Souza (9578582), João Pereira Duprat (12009034), Ana Cristina Victorino Krepischi (5453723), Dirce Maria Carraro (6830156)

مصطلحات موضوعية: Genetics, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, variant pathogenicity prediction, new putative candidates, genetic predisposition accounts, 2 affected individuals, potential candidate genes, prone families negative, prone families contributing, cutaneous melanoma susceptibility, cutaneous melanoma predisposition, including 7 loss, div >< p, prone families, putative role, genetic etiology, affected relatives, several genes, penetrance genes, melanoma risk, melanoma cases, brazilian melanoma, 5 melanoma, wrn <

Relation: https://figshare.com/articles/dataset/Rare_germline_LoF_variants_identified_by_WES_in_the_5_melanoma-prone_families_/19079461

الاتاحة: https://doi.org/10.1371/journal.pone.0262419.t004

المؤلفون: Felipe Fidalgo (642532), Giovana Tardin Torrezan (9075146), Bianca Costa Soares de Sá (12009028), Bruna Durães de Figueiredo Barros (12009031), Luciana Facure Moredo (10689512), Renan Valieris (548359), Sandro J. de Souza (9578582), João Pereira Duprat (12009034), Ana Cristina Victorino Krepischi (5453723), Dirce Maria Carraro (6830156)

مصطلحات موضوعية: Genetics, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, variant pathogenicity prediction, new putative candidates, genetic predisposition accounts, 2 affected individuals, potential candidate genes, prone families negative, prone families contributing, cutaneous melanoma susceptibility, cutaneous melanoma predisposition, including 7 loss, div >< p, prone families, putative role, genetic etiology, affected relatives, several genes, penetrance genes, melanoma risk, melanoma cases, brazilian melanoma, 5 melanoma, wrn <

Relation: https://figshare.com/articles/dataset/Clinical_characteristics_of_cutaneous_melanoma_patients_/19079452

الاتاحة: https://doi.org/10.1371/journal.pone.0262419.t001

المؤلفون: Felipe Fidalgo (642532), Giovana Tardin Torrezan (9075146), Bianca Costa Soares de Sá (12009028), Bruna Durães de Figueiredo Barros (12009031), Luciana Facure Moredo (10689512), Renan Valieris (548359), Sandro J. de Souza (9578582), João Pereira Duprat (12009034), Ana Cristina Victorino Krepischi (5453723), Dirce Maria Carraro (6830156)

مصطلحات موضوعية: Genetics, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, variant pathogenicity prediction, new putative candidates, genetic predisposition accounts, 2 affected individuals, potential candidate genes, prone families negative, prone families contributing, cutaneous melanoma susceptibility, cutaneous melanoma predisposition, including 7 loss, div >< p, prone families, putative role, genetic etiology, affected relatives, several genes, penetrance genes, melanoma risk, melanoma cases, brazilian melanoma, 5 melanoma, wrn <

Relation: https://figshare.com/articles/dataset/Main_cellular_function_and_diseases_associated_with_91_prioritized_genes_/19079467

الاتاحة: https://doi.org/10.1371/journal.pone.0262419.t006