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1Academic Journal
المؤلفون: Christopher R. Smith, Dan Chen, James G. Christensen, René Coulombe, James Féthière, Robin J. Gunn, Johan Hollander, Benjamin Jones, John M. Ketcham, Shilpi Khare, Jon Kuehler, J. David Lawson, Matthew A. Marx, Peter Olson, Kelly E. Pearson, Cynthia Ren, Denise Tsagris, Thirumalaiselvi Ulaganathan, Inge Van’t Veer, Xiaolun Wang, Anthony Ivetac
مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Cancer, Chemical Sciences not elsewhere classified, stimulated ras activation, ray cocrystal structures, binding modes determined, based screening strategy, sos1 inhibitor bi, kras ppi inhibitors, kras inhibitors, selective sos1, therapeutic interest, mediate rtk, mapk rebound, identify x, clinical investigation
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2
المؤلفون: Steven R. LaPlante, René Coulombe, Thao Trinh, Dominik Wernic, Rebekah J. Carson, Nathalie Rioux, Bruno Simoneau, Catherine Chabot, Youla S. Tsantrizos, Jianmin Duan, Simon Surprenant, Pierre R. Bonneau, Carl Thibeault, Stephen W. Mason, Serge Landry, Craig Fenwick, François Bilodeau, Araz Jakalian, Murray D. Bailey, Stephen H. Kawai, Clint James, Yves Bousquet, Bounkham Thavonekham, Michel Garneau, Eric Beaulieu, Sébastien Morin, Christiane Yoakim, Ted Halmos, Lee Fader, Jennifer Tsoung
المصدر: ACS Medicinal Chemistry Letters. 7:797-801
مصطلحات موضوعية: 0301 basic medicine, 010405 organic chemistry, Organic Chemistry, Integrase inhibitor, Biology, Pharmacology, 01 natural sciences, Biochemistry, Desymmetrization, Virus, Chemical space, 0104 chemical sciences, Integrase, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Pharmacokinetics, chemistry, Drug Discovery, Pyridine, biology.protein, Potency
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3
المؤلفون: Nathalie Rioux, Sonia Tremblay, Michel Garneau, Pierre R. Bonneau, René Coulombe, Marc-André Poupart, Bruno Simoneau, Steve Mason, Louie Lamorte, Patricia Schroeder, Stephen H. Kawai, Jianmin Duan, Ma’an Amad, Laibin Luo, Lee Fader, Anne-Marie Faucher, Steven R. LaPlante, Craig Fenwick, Araz Jakalian, Michael Bös, Youla S. Tsantrizos, Paul J. Edwards, Myriam Witvrouw, Murray D. Bailey, Michael G. Cordingley, Richard Bethell, Christiane Yoakim
المصدر: Antimicrobial Agents and Chemotherapy. 58:3233-3244
مصطلحات موضوعية: Serum, Anti-HIV Agents, Stereochemistry, Integrase inhibitor, HIV Integrase, Virus Replication, Antiviral Agents, Mice, Pharmacokinetics, Drug Resistance, Viral, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Pharmacology (medical), HIV Integrase Inhibitors, Cloning, Molecular, ADME, Pharmacology, chemistry.chemical_classification, biology, Cytochrome P450, Molecular biology, Long terminal repeat, Rats, Integrase, Bioavailability, Infectious Diseases, Enzyme, Amino Acid Substitution, chemistry, DNA, Viral, HIV-1, Hepatocytes, biology.protein, Caco-2 Cells
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4
المؤلفون: Murray D. Bailey, Rebekah J. Carson, Michel Garneau, François Bilodeau, Jianmin Duan, Stephen H. Kawai, Steven R. LaPlante, Christiane Yoakim, Araz Jakalian, René Coulombe, Sébastien Morin, Kevork Mekhssian, Catherine Chabot, Bruno Simoneau, Lee Fader, Youla S. Tsantrizos, Ted Halmos, Craig Fenwick, Stephen W. Mason
المصدر: ACS Medicinal Chemistry Letters. 5:711-716
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Quinoline, Integrase inhibitor, Biology, Biochemistry, In vitro, Integrase, Amino acid, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, biology.protein, Lead compound, ADME
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5
المؤلفون: Marc Pesant, Christian Brochu, Rebekah J. Carson, Bruno Simoneau, Patricia Schroeder, Murray D. Bailey, Pierre R. Bonneau, Michael G. Cordingley, Catherine Chabot, Michel Garneau, Anne-Marie Faucher, Michael Bös, René Coulombe, Mathieu Parisien, Stephen W. Mason, Araz Jakalian, Jianmin Duan, Marc-André Poupart, Dominik Wernic, Sébastien Morin, François Bilodeau, Serge Landry, Yves Bousquet, Eric Malenfant, Stephen H. Kawai, Punit Bhardwaj, Ma’an Amad, Lee Fader, Youla S. Tsantrizos, Richard Bethell, Christiane Yoakim, Steven R. LaPlante, Paul J. Edwards, Ted Halmos, Craig Fenwick
المصدر: ACS Medicinal Chemistry Letters. 5:422-427
مصطلحات موضوعية: biology, Organic Chemistry, Quinoline, Allosteric regulation, Substituent, Human immunodeficiency virus (HIV), Integrase inhibitor, Metabolic stability, medicine.disease_cause, Biochemistry, Combinatorial chemistry, Integrase, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, biology.protein, Potency
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6
المؤلفون: Rebekah J. Carson, Pierre L. Beaulieu, Norman Aubry, Pierre R. Bonneau, Claudio Sturino, Steven R. LaPlante, René Coulombe, Gordon Bolger
المصدر: Journal of Medicinal Chemistry. 56:7073-7083
مصطلحات موضوعية: Drug, Magnetic Resonance Spectroscopy, Aqueous solution, Chemistry, media_common.quotation_subject, In Vitro Techniques, Combinatorial chemistry, NMR spectra database, Partition coefficient, Molecular Probes, Drug Discovery, Lipophilicity, Proton NMR, Molecular Medicine, Molecule, Organic chemistry, Molecular probe, media_common
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7
المؤلفون: Rebekah J. Carson, Sylvain Bordeleau, Michael J. Little, Pierre L. Beaulieu, Steven R. LaPlante, Jeff A. O'Meara, James Gillard, Pierre R. Bonneau, Norman Aubry, René Coulombe
المصدر: Journal of Medicinal Chemistry. 56:5142-5150
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Aqueous medium, Chemistry, Drug discovery, Detergents, food and beverages, Nuclear magnetic resonance spectroscopy, Combinatorial chemistry, Pharmaceutical Preparations, Solubility, Drug Discovery, Proton NMR, Molecular Medicine, Molecule, Sample preparation
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8
المؤلفون: A. Pelletier, Stephen W. Mason, Daniel Rajotte, Claudio Sturino, Richard Bethell, Lise Bourgon, P. Salois, Sonia Tremblay, René Coulombe, Louie Lamorte
المصدر: Antimicrobial Agents and Chemotherapy. 57:2712-2718
مصطلحات موضوعية: Anti-HIV Agents, Microbial Sensitivity Tests, Pyrimidinones, Biology, Virus Replication, Recombinant virus, Antiviral Agents, Primer extension, Structure-Activity Relationship, Drug Resistance, Viral, medicine, Humans, Structure–activity relationship, Pharmacology (medical), Polymerase, Benzofurans, Pharmacology, Reverse-transcriptase inhibitor, Resistance mutation, Virology, Molecular biology, HIV Reverse Transcriptase, Reverse transcriptase, High-Throughput Screening Assays, Infectious Diseases, Viral replication, HIV-1, biology.protein, Reverse Transcriptase Inhibitors, medicine.drug
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9
المؤلفون: Anne-Marie Faucher, Bruno Simoneau, Yves Bousquet, Christopher T. Lemke, Jean‐François Mercier, Steve Titolo, Lee Fader, Eric Malenfant, Stephen W. Mason, Nathalie Goudreau, Chantal Grand-Maître, Jean-Eric Lacoste, René Coulombe
المصدر: ChemMedChem. 8:405-414
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, medicine.drug_class, Crystallography, X-Ray, Ligands, Biochemistry, Benzodiazepines, Drug Discovery, medicine, Humans, General Pharmacology, Toxicology and Pharmaceutics, Binding site, Binding selectivity, Pharmacology, Benzodiazepine, Binding Sites, Nitrogen Isotopes, Chemistry, Drug discovery, Organic Chemistry, Fluorine, Nuclear magnetic resonance spectroscopy, Ligand (biochemistry), In vitro, Protein Structure, Tertiary, Capsid, HIV-1, Molecular Medicine, Capsid Proteins, Protein Binding
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10
المؤلفون: Jeff A. O'Meara, Alexandre Gagnon, Sébastien Morin, Serge Landry, Michael Bös, Patrick Deroy, Christopher T. Lemke, Pierre R. Bonneau, Steve Titolo, Yves Bousquet, Stephen W. Mason, Bruno Simoneau, Eric Malenfant, Oliver Hucke, René Coulombe, Ingrid Guse, Richard Bethell, Chantal Grand-Maître, Anne-Marie Faucher, Jean-Eric Lacoste, Christiane Yoakim, Michael G. Cordingley, Stephen H. Kawai, Nathalie Goudreau, Lee Fader
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:398-404
مصطلحات موضوعية: Anti-HIV Agents, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Pyrazole, Biochemistry, Chemical synthesis, Enamine, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Molecular Biology, Benzodiazepinones, Bicyclic molecule, Reverse-transcriptase inhibitor, Organic Chemistry, Imidazoles, HIV Reverse Transcriptase, Diazepine, chemistry, Capsid, HIV-1, Pyrazoles, Reverse Transcriptase Inhibitors, Molecular Medicine, Capsid Proteins, Lead compound, medicine.drug
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11
المؤلفون: Alexandre Gagnon, René Coulombe, Michel Garneau, Araz Jakalian, Patrick Deroy, Bruno Simoneau, Jianmin Duan, Serge Landry, Eric Jolicoeur, Christiane Yoakim, Pierre R. Bonneau, Louise Doyon, Ingrid Guse, Eric Malenfant, Ma’an Amad
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:4437-4441
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Biological Availability, Pharmaceutical Science, Antiviral Agents, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Structure–activity relationship, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Reverse-transcriptase inhibitor, Chemistry, Organic Chemistry, Wild type, Nucleotidyltransferase, HIV Reverse Transcriptase, humanities, Rats, Enzyme, Enzyme inhibitor, Mutation, HIV-1, biology.protein, Reverse Transcriptase Inhibitors, Molecular Medicine, Acetanilides, Nucleoside, medicine.drug
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12
المؤلفون: Anne-Marie Faucher, René Coulombe, Jeff A. O'Meara, Pierre R. Bonneau, Bruno Simoneau, Araz Jakalian, Jennifer Racine, Steven R. LaPlante, Serge Landry, Ingrid Guse, Christiane Yoakim, Bounkham Thavonekham
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:3362-3366
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Molecular model, Anti-HIV Agents, Stereochemistry, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Virus Replication, Biochemistry, Nucleoside Reverse Transcriptase Inhibitor, Inhibitory Concentration 50, Structure-Activity Relationship, Thiocarbamates, Drug Resistance, Viral, Drug Discovery, medicine, Humans, Molecular Biology, Reverse-transcriptase inhibitor, biology, Chemistry, Organic Chemistry, Rational design, virus diseases, Nucleotidyltransferase, Amides, HIV Reverse Transcriptase, Thiocarbamate, Models, Chemical, Enzyme inhibitor, Drug Design, biology.protein, Reverse Transcriptase Inhibitors, Molecular Medicine, Carbamates, medicine.drug
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13
المؤلفون: Dale R. Cameron, Peter W. White, Yong Wang, Steve Titolo, Louise Thauvette, Lynn M. Amon, Christiane Yoakim, Jacques Archambault, Marie-Josée Massariol, Dominique Fink, Ewald Welchner, René Coulombe
المصدر: Journal of Biological Chemistry. 279:6976-6985
مصطلحات موضوعية: Models, Molecular, Transcriptional Activation, Materials science, DNA Mutational Analysis, Molecular Sequence Data, Glutamic Acid, Plasma protein binding, Calorimetry, Crystallography, X-Ray, Biochemistry, Viral Proteins, Transactivation, Protein structure, Leucine, Histidine, Amino Acid Sequence, Amino Acids, Binding site, Molecular Biology, Peptide sequence, Adenosine Triphosphatases, chemistry.chemical_classification, Binding Sites, Dose-Response Relationship, Drug, Sequence Homology, Amino Acid, biology, Circular Dichroism, Helicase, Cell Biology, Small molecule, Protein Structure, Tertiary, Amino acid, Models, Chemical, chemistry, Mutation, biology.protein, Biophysics, Tyrosine, Ultracentrifugation, Protein Binding
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14
المؤلفون: René Coulombe, Masoud Vedadi, Alice Vrielink, M. Delarge, Lei Zhang, Edward A. Meighen, Bijan Ahvazi
المصدر: Biochemical Journal. 349:853-861
مصطلحات موضوعية: chemistry.chemical_classification, biology, Protein Conformation, Vibrio harveyi, Stereochemistry, Aldehyde dehydrogenase, Active site, Dehydrogenase, Cell Biology, Aldehyde Dehydrogenase, Crystallography, X-Ray, biology.organism_classification, Biochemistry, Cofactor, Substrate Specificity, Enzyme, chemistry, Oxidoreductase, biology.protein, NAD+ kinase, Molecular Biology, NADP, Vibrio, Research Article
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15
المؤلفون: Anil Kumar Padyana, Xiang Li, Asitha Abeywardane, Pierre R. Bonneau, René Coulombe, Qiang Zhang, Araz Jakalian, Steven John Taylor, Peter W. White, Steven R. LaPlante, Shuang Liang, Ginette McKercher, Jessi Wildeson-Jones, Mireille Cartier
المصدر: Journal of medicinal chemistry. 57(5)
مصطلحات موضوعية: Drug, Models, Molecular, Magnetic Resonance Spectroscopy, media_common.quotation_subject, Hepatitis C virus, In silico, Computational biology, Hepacivirus, Viral Nonstructural Proteins, Ns3 helicase, medicine.disease_cause, Antiviral Agents, Structure-Activity Relationship, Drug Discovery, medicine, Enzyme Inhibitors, media_common, biology, Drug discovery, Serine Endopeptidases, Helicase, Surface Plasmon Resonance, Virology, Kinetics, biology.protein, Molecular Medicine, RNA Helicases
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16
المؤلفون: René Coulombe, Pierre L. Beaulieu, Oliver Hucke, George Kukolj, James Gillard, Marc-André Joly, Christopher T. Lemke, Pat Forgione, Steven R. LaPlante, Araz Jakalian, Timothy A. Stammers, Steve Titolo, Robert S. McCollum, Colette Boucher
المصدر: Journal of medicinal chemistry. 57(5)
مصطلحات موضوعية: Steric effects, Atropisomer, Magnetic Resonance Spectroscopy, biology, Stereochemistry, Chemistry, HIV, Stereoisomerism, Hepacivirus, Viral Nonstructural Proteins, Crystallography, X-Ray, Antiviral Agents, Allosteric Regulation, Covalent bond, Drug Discovery, biology.protein, Molecular Medicine, Enantiomer, Chirality (chemistry), Racemization, Polymerase, Chromatography, High Pressure Liquid
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17
المؤلفون: Michel Garneau, George Kukolj, Sylvie Goulet, Gulrez Fazal, Bounkham Thavonekham, Pierre L. Beaulieu, Dominik Wernic, Alexandre Gagnon, Araz Jakalian, Timothy A. Stammers, Jean Rancourt, Martin Duplessis, Steven R. LaPlante, René Coulombe
المصدر: Bioorganicmedicinal chemistry letters. 23(24)
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Virus Replication, Biochemistry, Antiviral Agents, Ns5b polymerase, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Anthranilic acid, Potency, ortho-Aminobenzoates, Replicon, Enzyme Inhibitors, Molecular Biology, IC50, EC50, chemistry.chemical_classification, Binding Sites, Organic Chemistry, Molecular biology, Protein Structure, Tertiary, Molecular Docking Simulation, Enzyme, chemistry, Cell culture, Drug Design, Molecular Medicine, Protein Binding
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18
المؤلفون: Olivier Lepage, Martin Poirier, Christian Brochu, René Coulombe, Martin Marquis, Timothy A. Stammers, Oliver Hucke, Megan Bertrand-Laperle, George Kukolj, Marc Pesant, James Gillard, Serge Landry, Maude Poirier, Montse Llinas-Brunet, Marc-André Joly, Pierre L. Beaulieu, Pierre R. Bonneau, Ginette McKercher
المصدر: Journal of medicinal chemistry. 57(5)
مصطلحات موضوعية: Chemistry, Stereochemistry, Allosteric regulation, Rational design, Hepacivirus, Molecular Dynamics Simulation, Viral Nonstructural Proteins, Crystallography, X-Ray, Antiviral Agents, Ns5b polymerase, Cell Line, chemistry.chemical_compound, Molecular dynamics, Structure-Activity Relationship, Allosteric Regulation, Drug Discovery, Molecular Medicine, Structure based, Potency, Replicon, Enzyme Inhibitors, NS5B
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19
المؤلفون: George Kukolj, Martin Poirier, Julie Naud, Jianmin Duan, René Coulombe, Marc-André Joly, Gulrez Fazal, Nathalie Rioux, Oliver Hucke, Bounkham Thavonekham, Cédrickx Godbout, Araz Jakalian, Timothy A. Stammers, Pierre L. Beaulieu, Olivier Lepage, Montse Llinas-Brunet
المصدر: Bioorganicmedicinal chemistry letters. 23(14)
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Allosteric regulation, Drug Evaluation, Preclinical, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Crystallography, X-Ray, Virus Replication, Biochemistry, Antiviral Agents, chemistry.chemical_compound, Structure-Activity Relationship, Protein structure, Allosteric Regulation, Drug Discovery, Anthranilic acid, Structure–activity relationship, Animals, ortho-Aminobenzoates, Molecular Biology, NS5B, Quinazolinone, Polymerase, ADME, Quinazolinones, Binding Sites, biology, Organic Chemistry, Protein Structure, Tertiary, Rats, Molecular Docking Simulation, chemistry, Drug Design, biology.protein, Molecular Medicine, Half-Life
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20
المؤلفون: René Coulombe, Robert Ménard, J. S. Mort, Miroslaw Cygler, J. Sivaraman, Pawel Grochulski
المصدر: The EMBO Journal. 15:5492-5503
مصطلحات موضوعية: Models, Molecular, Proteases, Protein Conformation, Cathepsin L, Molecular Sequence Data, Biology, Crystallography, X-Ray, General Biochemistry, Genetics and Molecular Biology, Cathepsin B, Protein structure, Endopeptidases, Hydrolase, Humans, pharmaceutical, Amino Acid Sequence, Molecular Biology, Peptide sequence, Conserved Sequence, Enzyme Precursors, General Immunology and Microbiology, General Neuroscience, Cathepsins, Cysteine protease, Cysteine Endopeptidases, Biochemistry, biology.protein, Sequence Alignment, Research Article, Cysteine