المؤلفون: Ulrich Bothe, Judith Günther, Reinhard Nubbemeyer, Holger Siebeneicher, Sven Ring, Ulf Bömer, Michaele Peters, Alexandra Rausch, Karsten Denner, Herbert Himmel, Andreas Sutter, Ildiko Terebesi, Martin Lange, Antje M. Wengner, Nicolas Guimond, Tobias Thaler, Johannes Platzek, Uwe Eberspächer, Martina Schäfer, Holger Steuber, Thomas M. Zollner, Andreas Steinmeyer, Nicole Schmidt

مصطلحات موضوعية: Biochemistry, Genetics, Pharmacology, Immunology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, innate inflammatory processes, house docking model, favorable dmpk profiles, associated kinase 4, bay1834845 , bay1830839 , unique combination, two compounds, good potency, critical role, compound library, clinical development, bayer ’, 1 receptor

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_IRAK4_Inhibitors_b_BAY1834845_b_Zabedosertib_and_b_BAY1830839_b_/25009497

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01714.s002
https://figshare.com/articles/journal_contribution/Discovery_of_IRAK4_Inhibitors_b_BAY1834845_b_Zabedosertib_and_b_BAY1830839_b_/25009497

المؤلفون: Roman C. Hillig, Ioana Neagoe, Andreas Steinmeyer, Thomas M. Zollner, Stefanie Mesch, Henrik Dahllöf, Julie Klint, Simone Schulz, Vera Puetter, Reinhard Nubbemeyer, Antonius Ter Laak, Stefan Werner, Alexis Laux-Biehlmann, Nico Bräuer, Michaela Bairlein

المصدر: Journal of Medicinal Chemistry. 62:11194-11217

مصطلحات موضوعية: 0303 health sciences, Pregnane X receptor, CYP3A4, biology, Drug discovery, Chemistry, Cell growth, Antagonist, Pharmacology, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, In vivo, Drug Discovery, biology.protein, Molecular Medicine, Enzyme inducer, Receptor, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4e3181b39b48ed7aca3777fb47bb1722
https://doi.org/10.1021/acs.jmedchem.9b01304

المؤلفون: Eckhard Bender, Olaf Prien, Reinhard Nubbemeyer, Stefan Bäurle, Norbert Schmees, Wilhelm Bone, Andreas Steinmeyer, Gernot Langer, Olaf Panknin, Thomas Mueller, Thomas M. Zollner, Katrin Nowak-Reppel, Martina Schäfer, Andrea Wagenfeld, Sven Ring, Amaury Ernesto Fernandez-Montalvan, Christian Friedrich

المصدر: Journal of medicinal chemistry. 63(20)

مصطلحات موضوعية: Indoles, medicine.drug_class, Administration, Oral, Pharmacology, 01 natural sciences, 03 medical and health sciences, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, Spiro Compounds, Rats, Wistar, Receptor, 030304 developmental biology, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Antagonist, 0104 chemical sciences, Rats, Postmenopause, 010404 medicinal & biomolecular chemistry, Tolerability, Hormone receptor, Estrogen, Hepatocytes, Microsomes, Liver, Molecular Medicine, Female, Caco-2 Cells, Luteinizing hormone, Gonadotropin-releasing hormone receptor, Receptors, LHRH, Hormone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426db565493e565bf916243aff255067
https://pubmed.ncbi.nlm.nih.gov/32960053

المؤلفون: Doi:mol Cell Biol, Franz Theuring, Ulrich Gottwald, Richard Ivell, Reinhard Nubbemeyer, Ben Davies, Claudia Baumann, Christiane Kirchhoff, Male Infertility

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://mcb.asm.org/content/24/19/8642.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.544.7629; http://mcb.asm.org/content/24/19/8642.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.544.7629
http://mcb.asm.org/content/24/19/8642.full.pdf

المؤلفون: Stefan, Werner, Stefanie, Mesch, Roman C, Hillig, Antonius, Ter Laak, Julie, Klint, Ioana, Neagoe, Alexis, Laux-Biehlmann, Henrik, Dahllöf, Nico, Bräuer, Vera, Puetter, Reinhard, Nubbemeyer, Simone, Schulz, Michaela, Bairlein, Thomas M, Zollner, Andreas, Steinmeyer

المصدر: Journal of medicinal chemistry. 62(24)

مصطلحات موضوعية: Inflammation, Male, Purinergic P2X Receptor Antagonists, Cytochrome P-450 CYP3A Inducers, Pain, Apoptosis, Ligands, Rats, Mice, Inbred C57BL, Mice, Gene Expression Regulation, Enzyme Induction, Acetamides, Drug Discovery, Animals, Cytochrome P-450 CYP3A, Humans, Female, Rats, Wistar, Receptors, Purinergic P2X4, Cells, Cultured, Cell Proliferation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::e16e87bc911e637cdb4a91a4540d5ba8
https://pubmed.ncbi.nlm.nih.gov/31746599

المؤلفون: Reinhard Nubbemeyer, Judith Günther, Federica Morandi, Gernot Langer, Dieter Moosmayer, Peter Muhn, Bernhard Lindenthal, Ulrich Lücking, Marcus Koppitz, Hilmar Weinmann, Martina Schäfer, Ronald Kühne, Dieter Heldmann, Anna K. Schrey, Alexander Walter, Ulrike Röhn, Lothar Sobek, Katrin Nowak-Reppel, Kuhnke Joachim, Lars Wortmann

المصدر: Journal of medicinal chemistry. 62(22)

مصطلحات موضوعية: Male, Ovulation, endocrine system, ERG1 Potassium Channel, Administration, Oral, Biological Availability, Pharmacology, Mice, Structure-Activity Relationship, Sex hormone-binding globulin, In vivo, hemic and lymphatic diseases, Drug Discovery, Animals, Humans, Testosterone, Naphthyridines, Rats, Wistar, Receptor, Progesterone, G protein-coupled receptor, Granulosa Cells, biology, Dose-Response Relationship, Drug, Estradiol, Chemistry, luteinizing hormone/choriogonadotropin receptor, Receptors, LH, Polycystic ovary, High-Throughput Screening Assays, biology.protein, Microsomes, Liver, Molecular Medicine, Receptors, FSH, Female, Luteinizing hormone, Hormone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c682e5fe6dba70d06105a046a496c9
https://pubmed.ncbi.nlm.nih.gov/31670515

المؤلفون: Hille Gieschen, Steffen Sandman, Dagmar Trummel, Dietrich Seidel, Christian Zurth, Reinhard Nubbemeyer

المصدر: Journal of Clinical Oncology. 37:156-156

مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, business.industry, Apalutamide, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Darolutamide, Endocrinology, Oncology, chemistry, 030220 oncology & carcinogenesis, Blood brain barrier penetration, Internal medicine, Enzalutamide, Medicine, Androgen receptor antagonist, business, Whole body, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::499e9019b3c75abccbd24a32cbf11f4c
https://doi.org/10.1200/jco.2019.37.7_suppl.156

المؤلفون: Franz von Nussbaum, Ulf Boemer, Michael Brands, Wolf-Dietrich Doecke, Nicole Schmidt, Reinhard Nubbemeyer, Holger Steuber, Eleni Lagkadinou, Oliver Politz, Ulrich Bothe, Andreas Steinmeyer, Holger Siebeneicher, Judith Guenther, Antje Margret Wengner, Dominik Mumberg, Lisette Potze, Thomas M. Zollner, Martin Lange, Karl Ziegelbauer

المصدر: Cancer Research. 78:1887-1887

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, biology, Chemistry, IRAK4, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Oncology, hemic and lymphatic diseases, 030220 oncology & carcinogenesis, Ibrutinib, biology.protein, Cancer research, Bruton's tyrosine kinase, Signal transduction, Protein kinase B, Tyrosine kinase, PI3K/AKT/mTOR pathway, Copanlisib

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ed9906a0dd171187036a294f5e6b5afc
https://doi.org/10.1158/1538-7445.am2018-1887

المؤلفون: Reinhard Nubbemeyer

المصدر: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 122:437-444

مصطلحات موضوعية: medicine.medical_specialty, Physiology, media_common.quotation_subject, Biology, Biochemistry, Estrus, Pregnancy, Internal medicine, Reproductive biology, medicine, Animals, Vaginal smear, Testosterone, Molecular Biology, Progesterone, media_common, Vaginal Smears, Estrous cycle, Arvicolinae, medicine.disease, biology.organism_classification, Endocrinology, Pregnancy, Animal, Female, Vole, Reproduction, Hormone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3219f1027056aea1556ce5190b35d32
https://doi.org/10.1016/s1095-6433(99)00029-x

المؤلفون: Christiane Otto, Iris Fuchs, Karl-Heinrich Fritzemeier, Beate Rohde-Schulz, Reinhard Nubbemeyer, Katja Prelle, Mario Klewer, Gilda Schwarz, Dominic E.A. Brittain, Gernot Langer, Benjamin Bader

المصدر: Endocrinology. 149(10)

مصطلحات موضوعية: medicine.medical_specialty, medicine.drug_class, Ovariectomy, Green Fluorescent Proteins, Estrogen receptor, Biology, Endoplasmic Reticulum, Transfection, Receptors, G-Protein-Coupled, Mice, Endocrinology, Mammary Glands, Animal, Internal medicine, Chlorocebus aethiops, medicine, Cyclic AMP, Animals, Humans, Receptor, G protein-coupled receptor, Estradiol, Endoplasmic reticulum, Uterus, Receptors, Estrogen, Estrogen, G-Protein Coupled Estrogen Receptor 1, COS Cells, Calcium, Female, Signal transduction, GPER, Protein Binding, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5500b067f30dfa60271e021e9e7d9181
https://pubmed.ncbi.nlm.nih.gov/18566127

المؤلفون: Ulrich Gottwald, Christiane Kirchhoff, Ursula-Friederike Habenicht, Claudia Baumann, Franz Theuring, Richard Ivell, Ben Davies, Reinhard Nubbemeyer

المصدر: Molecular and cellular biology. 24(19)

مصطلحات موضوعية: Male, medicine.medical_specialty, Efferent, Biology, Receptors, G-Protein-Coupled, Male infertility, Mice, Internal medicine, Testis, Mammalian Genetic Models with Minimal or Complex Phenotypes, medicine, Extracellular, Animals, Gene family, RNA, Messenger, Receptor, Molecular Biology, Infertility, Male, Epididymis, Mice, Knockout, Efferent ducts, Cell Biology, Blotting, Northern, medicine.disease, Cell biology, Endocrinology, medicine.anatomical_structure, Knockout mouse, Gene Deletion

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c04ead4dd6763d53e21fe1b03fe897
http://ora.ox.ac.uk/objects/uuid:19659325-9c48-486e-92a6-15bcf62df7a6

المؤلفون: Ursula Ganzer, Andrea Rotgeri, Susanne Schwenke, Thomas Steger-Hartmann, Michaele Peters, Bernhard Lindenthal, Katja Prelle, Reinhard Nubbemeyer, Margrit Hillmann, Thorsten Blume, Roland Reimann, Monika Lessl, Walter Klose

المصدر: Biology of Reproduction. 78:56-57

مصطلحات موضوعية: Genetics, Reproductive Medicine, Meiosis, media_common.quotation_subject, Fertility, Cell Biology, General Medicine, Biology, Sterol, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1e8e8b122772833a48686da1167f04d3
https://doi.org/10.1093/biolreprod/78.s1.56b

المؤلفون: Ludwig Zorn, Stephan Gründemann, Reinhard Nubbemeyer, Kristine Venstrom, Khusru Asadullah, Martina Schäfer, Alexandra Rausch, Bernd Buchmann, Ben Bader, Judith Günther, Arne von Bonin, Thomas Matthias Zollner

المصدر: Nature Medicine. 12:873-873

مصطلحات موضوعية: Chemistry, Immunology, General Medicine, General Biochemistry, Genetics and Molecular Biology, Efomycine M, Selectin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9a21f3b34334b4485baf41cf5d3fd0e3
https://doi.org/10.1038/nm0806-873a

المؤلفون: Antonius ter Laak, Carsten Moeller, Lars Wortmann, Ludwig Zorn, Reinhard Nubbemeyer, Rolf Bohlmann, Tim Wintermantel, Ulrich Bothe

المصدر: The Lens

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::499ac79b4c139ae54c02aa5ca7ce383f
https://www.lens.org/113-805-019-659-098