المؤلفون: Li Jiang, Yiqian Yang, Lin Huang, Yan Zhou, Junwei An, Yuchun Zheng, Yiwei Chen, Yanhong Liu, Jianhui Huang, Ee Lui Ang, Suwen Zhao, Huimin Zhao, Rongzhen Liao, Yifeng Wei, Yan Zhang

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Molecular Biology, Developmental Biology, Cancer, Inorganic Chemistry, Infectious Diseases, Chemical Sciences not elsewhere classified, recent studies show, >- methyl c4l, >- methyl c4d, >- methyl, >‑ methyl, widely distributed, various isomers, unmethylated substrates, studied mechanisms, structural proteins, provided insights, n <, many organisms, key components, hplg ), enantioselective radical, distinct mechanisms, crystal structures, catalyze reduction, catalyze radical, c4hp enantiomers

Relation: https://figshare.com/articles/journal_contribution/Glycyl_Radical_Enzymes_Catalyzing_the_Dehydration_of_Two_Isomers_of_i_N_i_Methyl-4-hydroxyproline/25371265

الاتاحة: https://doi.org/10.1021/acscatal.4c00216.s001

المؤلفون: Alexandru Deac (6244373), Qingqing Qi (2092018), Anura S. Indulkar (7878455), Hitesh S. Purohit (14293517), Yi Gao (112914), Geoff G. Z. Zhang (7445384), Lynne S. Taylor (1349709)

مصطلحات موضوعية: Biophysics, Medicine, Pharmacology, Mental Health, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, traditional separation techniques, recent studies show, four chemical analogues, amorphous solid dispersions, asd particles suspended, weakly interacting systems, strongly interacting systems, thermodynamic driving force, release rates diverged, polymer released congruently, insoluble barrier contained, high drug loads, dilute aqueous phase, lower drug loads, insoluble barrier, aqueous phase, drug loads, dilute environment, asd compacts, aqueous solution, lower loc

Relation: https://figshare.com/articles/journal_contribution/Dissolution_Mechanisms_of_Amorphous_Solid_Dispersions_Role_of_Drug_Load_and_Molecular_Interactions/21769484

الاتاحة: https://doi.org/10.1021/acs.molpharmaceut.2c00892.s001

المؤلفون: Reeddhi Ray (11254573), Santu Ghosh (1445494), Nikhil R. Jana (1268586)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Physiology, Biotechnology, Developmental Biology, Computational Biology, Space Science, Physical Sciences not elsewhere classified, stability, delivery carriers, cell delivery mechanism, nonendocytic cell delivery, Recent studies show, Phosphate-Dependent Colloidal Stabi., arginine-terminated quantum dots, control experiments show, nonendocytic cell uptake, surface chemistry approach, phosphate-dependent precipitation issue, cell membrane phosphate, nonendocytic approach, arginine-terminated nanoparticles, QD

Relation: https://figshare.com/articles/journal_contribution/Phosphate-Dependent_Colloidal_Stability_Controls_Nonendocytic_Cell_Delivery_of_Arginine-Terminated_Nanoparticles/15141763

الاتاحة: https://doi.org/10.1021/acs.jpcb.1c05931.s001

المؤلفون: Shanshan Feng (1749145), Yue Yue (3618713), Mingna Zheng (11139122), Yanwei Li (167076), Qingzhu Zhang (1813216), Wenxing Wang (73363)

مصطلحات موضوعية: Biophysics, Biochemistry, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, MHETase-catalyzed cascade degradation, Recent studies show, Ideonella sakaiensis MHETase, Ideonella sakaiensis PETase, hydrogen network, Polyethylene Terephthalate Polyethy., noncovalent interaction analysis, Ser-His-Asp-initiated nucleophilic ., iv, MHETase-Catalyzed Cascade Degradati.

Relation: https://figshare.com/articles/journal_contribution/_i_Is_i_PETase-_and_i_Is_i_MHETase-Catalyzed_Cascade_Degradation_Mechanism_toward_Polyethylene_Terephthalate/14987939

الاتاحة: https://doi.org/10.1021/acssuschemeng.1c02420.s001

المؤلفون: Alena Klindziuk (10723965), Anatoly B. Kolomeisky (1340823)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Immunology, Mental Health, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Recent studies show, transcriptional dynamics, noise decreases, gyrase binding, supercoiling buildup, supercoiling-mediated RNAP cooperat., RNA synthesis, DNA strands, chemical-kinetic model, RNAP molecules, transcription dynamics, RNA transcripts, DNA supercoiling, transcription process, RNAP cooperation, torsional strain, RNA elongation speed, supercoiling-mediated interactions, Monte Carlo computer simulations, Long-Range Supercoiling-Mediated RN., RNA polymerase

Relation: https://figshare.com/articles/journal_contribution/Long-Range_Supercoiling-Mediated_RNA_Polymerase_Cooperation_in_Transcription/14511948

الاتاحة: https://doi.org/10.1021/acs.jpcb.1c01859.s001

المؤلفون: Xiaoliang Zhang (284283), Weiwei Li (364036), Hua Tian (220297), Junxiu Liu (644397), Cong Li (115171), Hongliang Dong (3765625), Jian Chen (15340), Meng Song (469216), Bin Chen (63682), Hongwei Sheng (4391563), Shanmin Wang (1444309), Dongzhou Zhang (4267552), Hengzhong Zhang (62987)

مصطلحات موضوعية: Evolutionary Biology, Biological Sciences not elsewhere classified, bulk moduli, dislocation interactions, Recent studies show, single-crystalline diamond, high-entropy borides, theory predictions, Ultra-incompressible High-Entropy D., phase stabilities, hardness, high-entropy diborides, high-entropy borides deform elastically

Relation: https://figshare.com/articles/online_resource/Ultra-incompressible_High-Entropy_Diborides/14268893

الاتاحة: https://doi.org/10.1021/acs.jpclett.1c00399.ls01

المؤلفون: Z Hu, JHN Yik, DD Cissell, PV Michelier, KA Athanasiou, DR Haudenschild

المصدر: European Cells & Materials, Vol 30, Pp 200-209 (2012)

مصطلحات موضوعية: which promote chondrocyte apoptosis and degrade cartilage to potentiate PTOA development. Recent studies show that the rate-limiting step for transcriptional activation of injury response genes is controlled by cyclin-dependent kinase 9 (CDK9), and thus it is an attractive target for limiting the injury response. Here, we determined the effects of CDK9 inhibition in suppressing the injury response in mechanically-injured cartilage explants. Bovine cartilage explants were injured by a single compressive load of 30 % strain at 100 %/s, and then treated with the CDK9 inhibitor Flavopiridol. To assess acute injury responses, we measured the mRNA expression of pro-inflammatory cytokines, catabolic enzymes, and apoptotic genes by RT-PCR, and chondrocyte viability and apoptosis by TUNEL staining. For long-term outcome, cartilage matrix degradation was assessed by soluble glycosaminoglycan release, and by determining the mechanical properties with instantaneous and relaxation moduli. Our data showed CDK9 inhibitor markedly reduced injury-induced inflammatory cytokine and catabolic gene expression. CDK9 inhibitor also attenuated chondrocyte apoptosis and reduced cartilage matrix degradation. Lastly, the mechanical properties of the injured explants were preserved by CDK9 inhibitor. Our results provide a temporal profile connecting the chain of events from mechanical impact, acute injury responses, to the subsequent induction of chondrocyte apoptosis and cartilage matrix deterioration. Thus, CDK9, Flavopiridol, inflammatory cytokines, chondrocytes, Diseases of the musculoskeletal system, RC925-935, Orthopedic surgery, RD701-811

وصف الملف: electronic resource

Relation: http://www.ecmjournal.org/papers/vol030/pdf/v030a14.pdf; https://doaj.org/toc/1473-2262

URL الوصول: https://doaj.org/article/8a17de5451f7492ab62cbade472e0cb0

المؤلفون: Takeru Kameda (8057195), Katsura Asano (1864450), Yuichi Togashi (122308)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, Recent studies show, CAU, codon, GUG, Free energy landscape, eukaryotic translation pre-initiation, method, AUG, CUG, RNA binding dynamics, base-pair, energy profiles

Relation: https://figshare.com/articles/figure/Binding_free_energy_for_individual_simulation_trials_/14781201

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009068.s002

المؤلفون: Takeru Kameda (8057195), Katsura Asano (1864450), Yuichi Togashi (122308)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, Recent studies show, CAU, codon, GUG, Free energy landscape, eukaryotic translation pre-initiation, method, AUG, CUG, RNA binding dynamics, base-pair, energy profiles

Relation: https://figshare.com/articles/figure/Estimated_free_energy_of_bound_and_unbound_states_/14781198

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009068.s001

المؤلفون: Takeru Kameda (8057195), Katsura Asano (1864450), Yuichi Togashi (122308)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, Recent studies show, CAU, codon, GUG, Free energy landscape, eukaryotic translation pre-initiation, method, AUG, CUG, RNA binding dynamics, base-pair, energy profiles

Relation: https://figshare.com/articles/figure/Binding_free_energy_/14781207

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009068.g002

المؤلفون: Takeru Kameda (8057195), Katsura Asano (1864450), Yuichi Togashi (122308)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, Recent studies show, CAU, codon, GUG, Free energy landscape, eukaryotic translation pre-initiation, method, AUG, CUG, RNA binding dynamics, base-pair, energy profiles

Relation: https://figshare.com/articles/figure/PIC_structure_models_and_reaction_coordinates_in_this_study_/14781204

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009068.g001

المؤلفون: Takeru Kameda (8057195), Katsura Asano (1864450), Yuichi Togashi (122308)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, Recent studies show, CAU, codon, GUG, Free energy landscape, eukaryotic translation pre-initiation, method, AUG, CUG, RNA binding dynamics, base-pair, energy profiles

Relation: https://figshare.com/articles/figure/Convergence_of_free_energy_profiles_with_time_evolution_/14781210

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009068.g003

المؤلفون: Takeru Kameda (8057195), Katsura Asano (1864450), Yuichi Togashi (122308)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, Recent studies show, CAU, codon, GUG, Free energy landscape, eukaryotic translation pre-initiation, method, AUG, CUG, RNA binding dynamics, base-pair, energy profiles

Relation: https://figshare.com/articles/figure/Schematics_of_the_base-pair_binding_dynamics_/14781219

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009068.g006

المؤلفون: Takeru Kameda (8057195), Katsura Asano (1864450), Yuichi Togashi (122308)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, Recent studies show, CAU, codon, GUG, Free energy landscape, eukaryotic translation pre-initiation, method, AUG, CUG, RNA binding dynamics, base-pair, energy profiles

Relation: https://figshare.com/articles/figure/Estimated_binding_free_energy_/14781213

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009068.g004

المؤلفون: Takeru Kameda (8057195), Katsura Asano (1864450), Yuichi Togashi (122308)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, Recent studies show, CAU, codon, GUG, Free energy landscape, eukaryotic translation pre-initiation, method, AUG, CUG, RNA binding dynamics, base-pair, energy profiles

Relation: https://figshare.com/articles/figure/Projected_free_energy_profiles_/14781216

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009068.g005

المؤلفون: Takeru Kameda (8057195), Katsura Asano (1864450), Yuichi Togashi (122308)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, Recent studies show, CAU, codon, GUG, Free energy landscape, eukaryotic translation pre-initiation, method, AUG, CUG, RNA binding dynamics, base-pair, energy profiles

Relation: https://figshare.com/articles/figure/Typical_bound_structures_/14781222

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009068.g007

المؤلفون: Takeru Kameda (8057195), Katsura Asano (1864450), Yuichi Togashi (122308)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, Recent studies show, CAU, codon, GUG, Free energy landscape, eukaryotic translation pre-initiation, method, AUG, CUG, RNA binding dynamics, base-pair, energy profiles

Relation: https://figshare.com/articles/dataset/Codons_modeled_in_our_simulation_/14781231

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009068.t001

المؤلفون: Takeru Kameda (8057195), Katsura Asano (1864450), Yuichi Togashi (122308)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biotechnology, Evolutionary Biology, Infectious Diseases, Biological Sciences not elsewhere classified, Recent studies show, CAU, codon, GUG, Free energy landscape, eukaryotic translation pre-initiation, method, AUG, CUG, RNA binding dynamics, base-pair, energy profiles

Relation: https://figshare.com/articles/figure/Binding_mechanism_conjectured_by_this_study_/14781228

الاتاحة: https://doi.org/10.1371/journal.pcbi.1009068.g008

المؤلفون: Yuka Honjo (10724890), Yuki Fujita (330873), Hitoshi Niwa (7709), Toshihide Yamashita (314734)

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Neuroscience, Physiology, Biotechnology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, nerve injury causes neuropathic pain, infraorbital nerve injury Neuropath., Netrin -4 expression, neuropathic pain, Netrin -4, 5B, anti-Netrin -4 antibodies, nerve block therapy, infraorbital nerve injury, trigeminal neuropathic pain model rats, maxillofacial region, formation, Recent studies show Netrin -4

Relation: https://figshare.com/articles/figure/Netrin-4_and_Unc5B_receptors_are_expressed_in_Vc-C1_/14514088

الاتاحة: https://doi.org/10.1371/journal.pone.0251013.g004

المؤلفون: Yuka Honjo (10724890), Yuki Fujita (330873), Hitoshi Niwa (7709), Toshihide Yamashita (314734)

مصطلحات موضوعية: Medicine, Cell Biology, Genetics, Neuroscience, Physiology, Biotechnology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, nerve injury causes neuropathic pain, infraorbital nerve injury Neuropath., Netrin -4 expression, neuropathic pain, Netrin -4, 5B, anti-Netrin -4 antibodies, nerve block therapy, infraorbital nerve injury, trigeminal neuropathic pain model rats, maxillofacial region, formation, Recent studies show Netrin -4

Relation: https://figshare.com/articles/figure/Effects_of_anti-Netrin-4_antibody_administration_on_pain_behavior_in_trigeminal_neuropathic_pain_model_rats_/14514082

الاتاحة: https://doi.org/10.1371/journal.pone.0251013.g002