-
1
المؤلفون: Meena V, Patel, Hillary M, Peltier, Mark A, Matulenko, John R, Koenig, Marc J, C Scanio, Rebecca J, Gum, Odile F, El-Kouhen, Meagan M, Fricano, Greta L, Lundgaard, Torben, Neelands, Xu-Feng, Zhang, Cenchen, Zhan, Madhavi, Pai, Nayereh, Ghoreishi-Haack, Thomas, Hudzik, Gary, Gintant, Ruth, Martin, Steve, McGaraughty, Jun, Xu, Daniel, Bow, John C, Kalvass, Philip R, Kym, David A, DeGoey, Michael E, Kort
المصدر: Bioorganicmedicinal chemistry. 63
مصطلحات موضوعية: Structure-Activity Relationship, Humans, Pain, Pain Management, Protein Isoforms, Sodium Channels
-
2
المؤلفون: Meena V. Patel, Hillary M. Peltier, Mark A. Matulenko, John R. Koenig, Marc J. C. Scanio, Rebecca J. Gum, Odile F. El-Kouhen, Meagan M. Fricano, Greta L. Lundgaard, Torben Neelands, Xu-Feng Zhang, Cenchen Zhan, Madhavi Pai, Nayereh Ghoreishi-Haack, Thomas Hudzik, Gary Gintant, Ruth Martin, Steve McGaraughty, Jun Xu, Daniel Bow, John C. Kalvass, Philip R. Kym, David A. DeGoey, Michael E. Kort
المصدر: Bioorganic & Medicinal Chemistry. 63:116743
مصطلحات موضوعية: Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Biochemistry
-
3
المؤلفون: Lei Shi, Madhavi Pai, David A. Degoey, Jerome F. Daanen, Gin C. Hsieh, Cenchen Zhan, Nayereh S Ghoreishi-Haack, Meagan M. Fricano, Jennifer M. Frost, Kort Michael E, Greta L. Lundgaard, Mark A. Matulenko, Torben R. Neelands, Odile F. El-Kouhen, Xu-Feng Zhang, Rebecca J. Gum
المصدر: Journal of Medicinal Chemistry. 59:3373-3391
مصطلحات موضوعية: Drug, Indazoles, media_common.quotation_subject, Pain, Osteoarthritis, Pharmacology, Imidazolidines, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Structure–activity relationship, Pyrroles, Dosing, Evoked Potentials, Pain Measurement, media_common, Analgesics, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, NAV1.7 Voltage-Gated Sodium Channel, medicine.disease, In vitro, Iodoacetic Acid, Rats, 0104 chemical sciences, Electrophysiology, Disease Models, Animal, Molecular Medicine, 030217 neurology & neurosurgery, Sodium Channel Blockers
-
4
المؤلفون: Cele Abad-Zapatero, Yong Jia, David J. Burns, Timothy E. Cloutier, Zhili Xin, Douglas Marcotte, Hua Tang, Kenneth M. Comess, Teresa I. Ng, David W. Borhani, Michael L. Coen, Sanyi Wang, Harriet T. Smith, Eric R. Goedken, Danying Song, Jill E. Clampit, Bo Liu, Philip J. Hajduk, Xueheng Cheng, Maria A. Argiriadi, David Banach, Chaohong Sun, Duncan R. Groebe, Elizabeth H. Fry, Christopher Quinn, Gang Liu, David J. Calderwood, Deanna L. Haasch, Vincent S. Stoll, Rebecca J. Gum
المصدر: ACS Chemical Biology. 6:234-244
مصطلحات موضوعية: Models, Molecular, Molecular Sequence Data, Biology, Crystallography, X-Ray, p38 Mitogen-Activated Protein Kinases, Biochemistry, MAP2K7, Small Molecule Libraries, Structure-Activity Relationship, Adenosine Triphosphate, Drug Discovery, Humans, Mitogen-Activated Protein Kinase 8, ASK1, c-Raf, Protein kinase A, Protein Kinase Inhibitors, Binding Sites, Molecular Structure, Cyclin-dependent kinase 2, Stereoisomerism, General Medicine, Protein kinase R, High-Throughput Screening Assays, Cell biology, Cyclin-dependent kinase complex, biology.protein, Molecular Medicine, Cyclin-dependent kinase 9
-
5
المؤلفون: Deanna L. Haasch, Hing L. Sham, Rebecca J. Gum, James M. Trevillyan, Elizabeth H. Fry, Cele Abad-Zapatero, Gang Liu, Mei Liu, Jill E. Clampit, Sanyi Wang, Cristina M. Rondinone
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:668-672
مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Enzyme Inhibitors, Protein kinase A, Molecular Biology, chemistry.chemical_classification, Aniline Compounds, biology, Kinase, Organic Chemistry, JNK Mitogen-Activated Protein Kinases, Aromatic amine, Pyrimidines, Enzyme, chemistry, Mitogen-activated protein kinase, biology.protein, Molecular Medicine, Indicators and Reagents, Signal transduction
-
6
المؤلفون: Hing L. Sham, Zhili Xin, Christi Kosogof, Terry Pederson, Hongyu Zhao, Cele Abad-Zapatero, Bo Liu, Michael D. Serby, Bruce G. Szczepankiewicz, Gang Liu, Cristina M. Rondinone, Nelson Lissa T, Deanna L. Haasch, Jill E. Clampit, Sanyi Wang, Rebecca J. Gum, James M. Trevillyan, Elizabeth H. Fry, Eric F. Johnson, Mei Liu
المصدر: Journal of Medicinal Chemistry. 49:4455-4458
مصطلحات موضوعية: Models, Molecular, Cell signaling, Pyridines, medicine.drug_class, Administration, Oral, Biological Availability, Carboxamide, In Vitro Techniques, Pharmacology, Crystallography, X-Ray, Mice, Structure-Activity Relationship, Microsomes, Drug Discovery, medicine, Animals, Humans, Protein kinase A, chemistry.chemical_classification, biology, Kinase, JNK Mitogen-Activated Protein Kinases, Amides, Rats, Enzyme, chemistry, Enzyme inhibitor, Mitogen-activated protein kinase, biology.protein, Thermodynamics, Molecular Medicine, Signal transduction
-
7
المؤلفون: James M. Trevillyan, Elizabeth H. Fry, Eric F. Johnson, Chaohong Sun, Hing L. Sham, Charles W. Hutchins, Thomas H. Lubben, Bruce G. Szczepankiewicz, Edward T. Olejniczak, Michael A. Stashko, Cele Abad-Zapatero, Michael D. Serby, Rebecca J. Gum, Hongyu Zhao, Kristi Haskins, Zhili Xin, Bo Liu, Sarah A Dorwin, Jill E. Clampit, Nelson Lissa T, Gang Liu, Mei Liu, Christi Kosogof, Cristina M. Rondinone, Sanyi Wang, Deanna L. Haasch
المصدر: Journal of Medicinal Chemistry. 49:3563-3580
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Aminopyridines, Biological Availability, Crystallography, X-Ray, MAP2K7, Rats, Sprague-Dawley, Mitogen-Activated Protein Kinase 10, Cell Line, Tumor, Drug Discovery, Animals, Humans, Mitogen-Activated Protein Kinase 9, Mitogen-Activated Protein Kinase 8, ASK1, Phosphorylation, Kinase activity, Protein kinase A, MAPK14, biology, Kinase, Chemistry, c-jun, Rats, Biochemistry, Mitogen-activated protein kinase, biology.protein, Molecular Medicine, Half-Life
-
8
المؤلفون: Gang Liu, Zhili Xin, James M. Trevillyan, Elizabeth H. Fry, Deanna L. Haasch, Rebecca J. Gum, Cele Abad-Zapatero, Jill E. Clampit, Sanyi Wang, Mei Liu, Hing L. Sham
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:2590-2594
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Quinolones, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Drug Discovery, Transferase, Enzyme Inhibitors, Protein kinase A, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Chemistry, Kinase, Organic Chemistry, c-jun, JNK Mitogen-Activated Protein Kinases, Enzyme, Enzyme inhibitor, Mitogen-activated protein kinase, biology.protein, Molecular Medicine
-
9
المؤلفون: Celerino Abad-Zapatero, Melissa M. Daly, Rebecca J. Gum, Thomas W. von Geldern, Elizabeth H. Fry, Chaohong Sun, Chunqiu Lai
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:1811-1815
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Allosteric regulation, Fructose 1,6-bisphosphatase, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Allosteric Regulation, Drug Discovery, Hydrolase, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Benzoxazoles, Sulfonamides, Biological studies, biology, Organic Chemistry, Biological activity, General Medicine, Benzoxazole, Fructose-Bisphosphatase, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Protein Binding
-
10
المؤلفون: Denise Wilcox, Cristina M. Rondinone, Lori L. Gaede, Jeffrey F. Waring, Matthew Heindel, Margery E. Stark, James M. Trevillyan, Rebecca J. Gum, Roger G. Ulrich, Michael R. Jirousek, Bradley A. Zinker
المصدر: Molecular Endocrinology. 17:1131-1143
مصطلحات موضوعية: Blood Glucose, medicine.medical_specialty, FGF21, Phosphatase, Protein tyrosine phosphatase, p38 Mitogen-Activated Protein Kinases, Mice, Random Allocation, Endocrinology, Internal medicine, Diabetes Mellitus, medicine, Animals, Insulin, Protein phosphorylation, Obesity, Protein Phosphatase 2, Phosphorylation, Cyclic AMP Response Element-Binding Protein, Molecular Biology, Protein Tyrosine Phosphatase, Non-Receptor Type 1, biology, Tumor Necrosis Factor-alpha, Kinase, JNK Mitogen-Activated Protein Kinases, Dual Specificity Phosphatase 2, General Medicine, Protein phosphatase 2, Oligonucleotides, Antisense, Mice, Inbred C57BL, Insulin receptor, Liver, biology.protein, Mitogen-Activated Protein Kinases, Protein Tyrosine Phosphatases
-
11
المؤلفون: Leigh Frost, Cathy Berg, Jill E. Clampit, Brett P. Monia, Rebecca J. Gum, Roger G. Ulrich, Madeline M. Butler, Michael R. Jirousek, Cristina M. Rondinone, Paul E. Kroeger, James M. Trevillyan, Bradley A. Zinker, Jeffrey F. Waring, Regina M. Reilly
المصدر: Diabetes. 51:2405-2411
مصطلحات موضوعية: medicine.medical_specialty, Time Factors, FGF21, Endocrinology, Diabetes and Metabolism, Mice, Obese, Adipose tissue, Protein tyrosine phosphatase, Polymerase Chain Reaction, Oligodeoxyribonucleotides, Antisense, Mice, Phosphatidylinositol 3-Kinases, chemistry.chemical_compound, Adipocyte, Internal medicine, Weight Loss, Adipocytes, Internal Medicine, medicine, Animals, Homeostasis, Insulin, Protein kinase B, Triglycerides, DNA Primers, Protein Tyrosine Phosphatase, Non-Receptor Type 1, biology, GRB10, Intracellular Signaling Peptides and Proteins, Genetic Variation, Phosphoproteins, Lipids, Isoenzymes, Alternative Splicing, Insulin receptor, Endocrinology, Adipose Tissue, Gene Expression Regulation, chemistry, Hyperglycemia, Lipogenesis, Insulin Receptor Substrate Proteins, biology.protein, Protein Tyrosine Phosphatases, hormones, hormone substitutes, and hormone antagonists
-
12
المؤلفون: Steven K. Davidsen, Jane A. Fagerland, Michael R. Michaelides, Matthew Heindel, Roger G. Ulrich, James M. Schmidt, Gerard D. Gagne, Rebecca J. Gum, Dean Hickman
المصدر: Biochemical Pharmacology. 62:1661-1673
مصطلحات موضوعية: Pharmacology, Phospholipidosis, biology, Matrix metalloproteinase inhibitor, Metabolite, Phospholipid, Biochemistry, In vitro, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Enzyme inhibitor, In vivo, Hepatocyte, medicine, biology.protein
-
13
المؤلفون: Rebecca J. Gum, Peter Young
المصدر: Biochemical and Biophysical Research Communications. 266:284-289
مصطلحات موضوعية: Models, Molecular, Recombinant Fusion Proteins, Mitogen-activated protein, p38 mitogen-activated protein kinases, Molecular Sequence Data, Biophysics, Protein Serine-Threonine Kinases, Biology, Transfection, p38 Mitogen-Activated Protein Kinases, Biochemistry, Substrate Specificity, Mitogen-Activated Protein Kinase 13, Structure-Activity Relationship, Humans, Amino Acid Sequence, Phosphorylation, Cyclic AMP Response Element-Binding Protein, Molecular Biology, Alanine, Binding Sites, Activating Transcription Factor 2, Kinase, Mutagenesis, Intracellular Signaling Peptides and Proteins, Substrate (chemistry), Myelin Basic Protein, Cell Biology, Alanine scanning, Precipitin Tests, Cell biology, Mutation, Mitogen-Activated Protein Kinases, HeLa Cells, Transcription Factors
-
14
المؤلفون: Lisa A. Marshall, Michael J. Hansbury, Brian J. Bolognese, Rebecca J. Gum, Peter R. Young, Ruth J. Mayer
المصدر: The Journal of Immunology. 161:6005-6013
مصطلحات موضوعية: Immunology, Immunology and Allergy
-
15
المؤلفون: John C. Lee, Peter R. Young, Annalisa T. Hand, Peter C. McDonnell, Rebecca J. Gum, Sanjay Kumar
المصدر: Biochemical and Biophysical Research Communications. 235:533-538
مصطلحات موضوعية: Male, Pyridines, SB 203580, p38 mitogen-activated protein kinases, Molecular Sequence Data, Biophysics, Biology, Transfection, p38 Mitogen-Activated Protein Kinases, Biochemistry, Substrate Specificity, chemistry.chemical_compound, Intestine, Small, Testis, Animals, Humans, Amino Acid Sequence, Cloning, Molecular, Enzyme Inhibitors, Kinase activity, Pancreas, Molecular Biology, chemistry.chemical_classification, Activating Transcription Factor 2, Sequence Homology, Amino Acid, Kinase, Imidazoles, Myelin Basic Protein, Cell Biology, Molecular biology, Recombinant Proteins, Amino acid, Enzyme Activation, Alternative Splicing, Kinetics, chemistry, Mitogen-activated protein kinase, Calcium-Calmodulin-Dependent Protein Kinases, DNA Transposable Elements, biology.protein, Sorbitol, Mitogen-Activated Protein Kinases, Sequence Alignment, HeLa Cells
-
16
المؤلفون: Yao Wang, C Simon, Hongmei Wang, Ernst Lengyel, Douglas D. Boyd, Rebecca J. Gum
المصدر: Oncogene. 14:2563-2573
مصطلحات موضوعية: Cancer Research, Time Factors, Receptor expression, MAP Kinase Kinase 1, Cell Cycle Proteins, Receptors, Cell Surface, Protein Serine-Threonine Kinases, Biology, Immediate-Early Proteins, Receptors, Urokinase Plasminogen Activator, Plasminogen Activators, Protein Phosphatase 1, Proto-Oncogene Proteins, Phosphoprotein Phosphatases, Tumor Cells, Cultured, Genetics, medicine, Extracellular, Enzyme Inhibitors, Receptor, Molecular Biology, Flavonoids, Mitogen-Activated Protein Kinase Kinases, Urokinase, Mitogen-Activated Protein Kinase 3, Activator (genetics), Kinase, Dual Specificity Phosphatase 1, Transfection, Protein-Tyrosine Kinases, Cell biology, Proto-Oncogene Proteins c-raf, Genes, ras, Biochemistry, Calcium-Calmodulin-Dependent Protein Kinases, Colonic Neoplasms, Laminin, Mitogen-Activated Protein Kinases, Protein Tyrosine Phosphatases, Vanadates, Plasminogen activator, Signal Transduction, medicine.drug
-
17
المؤلفون: Rebecca J. Gum, Ernst Lengyel, Heng Wang, Jose Juarez, Evan Stepp, Douglas D. Boyd
المصدر: Journal of Cellular Biochemistry. 61:430-443
مصطلحات موضوعية: Transcription, Genetic, Proto-Oncogene Proteins c-jun, Plasmin, Blotting, Western, Protein Serine-Threonine Kinases, Transfection, Biochemistry, Transactivation, Genes, jun, Proto-Oncogene Proteins, Tumor Cells, Cultured, medicine, Humans, c-Raf, Promoter Regions, Genetic, Molecular Biology, Transcription factor, Urokinase, Chemistry, Kinase, Cell Biology, Urokinase-Type Plasminogen Activator, Cell biology, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins c-raf, Transcription Factor AP-1, Oncogene Proteins v-fos, Mutagenesis, Calcium-Calmodulin-Dependent Protein Kinases, Signal transduction, Plasminogen activator, Signal Transduction, Transcription Factors, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022d962e07d796680b636c984537c677
https://doi.org/10.1002/(sici)1097-4644(19960601)61:3<430::aid-jcb10>3.0.co;2-n -
18
المؤلفون: Jose Juarez, Hiroshi Sato, Motoharu Seiki, Rebecca J. Gum, Ernst Lengyel, Douglas D. Boyd, Ji Hshiung Chen
المصدر: Journal of Biological Chemistry. 271:10672-10680
مصطلحات موضوعية: Chloramphenicol O-Acetyltransferase, Transcriptional Activation, Molecular Sequence Data, Biology, Mitogen-activated protein kinase kinase, Proto-Oncogene Mas, Biochemistry, Fibroblast activation protein, alpha, Tumor Cells, Cultured, Humans, Collagenases, Promoter Regions, Genetic, Protein kinase A, Molecular Biology, Mitogen-Activated Protein Kinase Kinases, Binding Sites, Expression vector, Base Sequence, Kinase, Wild type, Cell Biology, Molecular biology, Transcription Factor AP-1, DNA binding site, Genes, ras, Matrix Metalloproteinase 9, Oligodeoxyribonucleotides, Signal transduction, Protein Kinases, Transcription Factors
-
19
المؤلفون: Rebecca J. Gum, Ernst Lengyel, Evan Stepp, Douglas D. Boyd
المصدر: Journal of Biological Chemistry. 270:23007-23012
مصطلحات موضوعية: Plasmin, Mitogen-Activated Protein Kinase 3, Restriction Mapping, Biochemistry, Epitopes, Transactivation, Tumor Cells, Cultured, Promoter Regions, Genetic, Mitogen-Activated Protein Kinase 1, Ovarian Neoplasms, biology, Chemistry, Protein-Tyrosine Kinases, Recombinant Proteins, Mitogen-activated protein kinase, Female, Mitogen-Activated Protein Kinases, Signal transduction, Signal Transduction, medicine.drug, Chloramphenicol O-Acetyltransferase, Transcriptional Activation, Molecular Sequence Data, Adenocarcinoma, Protein Serine-Threonine Kinases, Transfection, Gene Expression Regulation, Enzymologic, Cell Line, Genes, jun, Proto-Oncogene Proteins, medicine, Humans, Amino Acid Sequence, Codon, Protein kinase A, Molecular Biology, Urokinase, Binding Sites, Cell Biology, Urokinase-Type Plasminogen Activator, Molecular biology, Proto-Oncogene Proteins c-raf, Transcription Factor AP-1, Urokinase receptor, Genes, ras, Urinary Bladder Neoplasms, Calcium-Calmodulin-Dependent Protein Kinases, biology.protein, Transcription Factors
-
20
المؤلفون: Brian Wakefield, Rebecca J. Gum, Michael F. Jarvis
مصطلحات موضوعية: P2Y receptor, business.industry, Central nervous system, Chronic pain, Inflammation, Cell Biology, Pharmacology, P2 receptor, medicine.disease, Cellular and Molecular Neuroscience, Nociception, medicine.anatomical_structure, medicine, Noxious stimulus, Original Article, medicine.symptom, Receptor, business, Molecular Biology