نتائج البحث - "Rebecca Freilich"

المصدر: Nature structural & molecular biology
Nature Structural and Molecular Biology
Nature structural & molecular biology 25(5), 384-393 (2018). doi:10.1038/s41594-018-0057-1
Nature structural & molecular biology, vol 25, iss 5

مصطلحات موضوعية: 0301 basic medicine, Aging, Regulator, protein-protein interactions, Neurodegenerative, Alzheimer's Disease, Medical and Health Sciences, Biochemistry, purified proteins, metabolism [HSP40 Heat-Shock Proteins], 0302 clinical medicine, Structural Biology, protein folding, 2.1 Biological and endogenous factors, Aetiology, biology, Brain, Biological Sciences, Protein folding, physiology [Protein Binding], Protein Binding, Tau pathology, Tau protein, Biophysics, MAPT protein, human, tau Proteins, Computational biology, DNAJA2 protein, human, Protein Aggregation, Pathological, prevention & control [Protein Aggregation, Pathological], Article, protein aggregation, 03 medical and health sciences, Protein Aggregates, Pathological, ddc:570, mental disorders, Acquired Cognitive Impairment, Humans, physiology [Protein Aggregates], protein quality control, Molecular Biology, tauopathy, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), HSP40 Heat-Shock Proteins, Protein Aggregation, metabolism [tau Proteins], Brain Disorders, 030104 developmental biology, metabolism [Brain], Chaperone (protein), Chemical Sciences, heat shock proteins, biology.protein, Proteostasis, Dementia, 030217 neurology & neurosurgery, Developmental Biology, Neuroscience

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3599a70c0b3cd7e1a62eb1d691ffda3f
http://europepmc.org/articles/PMC5942583

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5

Direct targeting of RAS in pancreatic ductal adenocarcinoma with RMC-6236, a first-in-class, RAS-selective, orally bioavailable, tri-complex RASMULTI(ON) inhibitor

المصدر: Journal of Clinical Oncology. 40:591-591

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::63569a7e33ebcfcd5a727482c9276c2f
https://doi.org/10.1200/jco.2022.40.4_suppl.591

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6

Abstract 1260: First-in-class, orally bioavailable KRASG12V(ON) tri-complex inhibitors, as single agents and in combinations, drive profound anti-tumor activity in preclinical models of KRASG12V mutant cancers

المصدر: Cancer Research. 81:1260-1260

مصطلحات موضوعية: Antitumor activity, Cancer Research, Class (computer programming), Oncology, business.industry, Cancer research, Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ab77b27f6edb9b24c1b85ee6b626c5f4
https://doi.org/10.1158/1538-7445.am2021-1260

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7

Protein-Protein Interactions in the Molecular Chaperone Network

المؤلفون: Jason E. Gestwicki, Rebecca Freilich, Jennifer L. Abrams, Taylor Arhar

المصدر: Accounts of chemical research. 51(4)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e60286b6f8e9f0217713bbaadf7f5a
https://pubmed.ncbi.nlm.nih.gov/29613769

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8

Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis

المؤلفون: Ke Xu, Erik D. Roberson, Rui Yan, Shiaoching Gong, Celeste M. Karch, Kelly M. Montgomery, Kenneth S. Kosik, Manni He, Cindy Tzu-Ling Huang, Rebecca Freilich, Carolina M. Camargo, Sue-Ann Mok, Tara E. Tracy, Li Fan, Peter Dongmin Sohn, Justin Baik, Taylor Arhar, Li Gan, Jason E. Gestwicki

المصدر: Neuron, vol 104, iss 3

مصطلحات موضوعية: Aging, Neurodegenerative, Alzheimer's Disease, medicine.disease_cause, axon initial segment, neuronal activity, homeostasis, Homeostasis, 2.1 Biological and endogenous factors, Psychology, Premovement neuronal activity, tau, Aetiology, Induced pluripotent stem cell, Cytoskeleton, Alzheimer's Disease Related Dementias (ADRD), Neurons, Mutation, Neuronal Plasticity, Stem Cell Research - Induced Pluripotent Stem Cell - Human, General Neuroscience, EB3, FTD, Depolarization, Frontotemporal Dementia (FTD), Frontotemporal Dementia, Neurological, Cognitive Sciences, Microtubule-Associated Proteins, Frontotemporal dementia, Induced Pluripotent Stem Cells, tau Proteins, Biology, Protein Aggregation, Pathological, Rare Diseases, Pathological, mental disorders, Acquired Cognitive Impairment, Genetics, medicine, Extracellular, Humans, Axon Initial Segment, Neurology & Neurosurgery, Stem Cell Research - Induced Pluripotent Stem Cell, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Stem Cell Research, medicine.disease, Protein Aggregation, Axon initial segment, Electrophysiological Phenomena, Brain Disorders, Dementia, Extracellular Space, Neuroscience

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8559dcab8194ff737a4e2392dbe5b923
https://doi.org/10.1016/j.neuron.2019.08.008

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9

BAG3 is a modular, scaffolding protein that physically links heat shock protein 70 (Hsp70) to the small heat shock proteins

المؤلفون: Daniel R. Southworth, Jennifer N. Rauch, Sue-Ann Mok, Leah N. Makley, Eric Tse, Jason E. Gestwicki, Rebecca Freilich

المصدر: Journal of molecular biology, vol 429, iss 1

مصطلحات موضوعية: 0301 basic medicine, Scaffold protein, Biochemistry & Molecular Biology, 1.1 Normal biological development and functioning, DNA Mutational Analysis, Plasma protein binding, Biology, BAG3, Intrinsically disordered proteins, Small, Microbiology, Article, 03 medical and health sciences, Medicinal and Biomolecular Chemistry, Structural Biology, Underpinning research, protein folding, chaperones, 2.1 Biological and endogenous factors, Humans, HSP70 Heat-Shock Proteins, Hsp27, Aetiology, Molecular Biology, Heat-Shock Proteins, Adaptor Proteins, Signal Transducing, proteostasis, Signal Transducing, Adaptor Proteins, Hsp70, Cell biology, Heat-Shock Proteins, Small, 030104 developmental biology, Proteostasis, Biochemistry, Chaperone (protein), biology.protein, Protein folding, intrinsically disordered proteins, Generic health relevance, Biochemistry and Cell Biology, Apoptosis Regulatory Proteins, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8b056472329db337f49c2b3bfedfac
https://europepmc.org/articles/PMC5186407/

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