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1
المؤلفون: Fanuel Mebrahtu, Leslie J. Street, Marine Barnabe, Rudolf Mueller, Nina Lawrence, Matthias Rottmann, Virsinha Reddy, Aloysius T. Nchinda, Ravinder Reddy Kondreddi, Dale Taylor, Lloyd Tanner, Charles J. Eyermann, Kelly Chibale, Suresh B. Lakshminarayana, Bin Zou
المصدر: ACS Omega
ACS Omega, Vol 5, Iss 12, Pp 6967-6982 (2020)مصطلحات موضوعية: Benzimidazole, integumentary system, biology, Lerisetron, medicine.drug_class, General Chemical Engineering, General Chemistry, Pharmacology, medicine.disease, biology.organism_classification, Article, chemistry.chemical_compound, Chemistry, chemistry, parasitic diseases, medicine, Parasite hosting, Structure–activity relationship, Antiemetic, Plasmodium berghei, Whole cell, QD1-999, Malaria, medicine.drug
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2
المؤلفون: Els J. Klooster, Oliver Simon, Thierry T. Diagana, Suresh B. Lakshminarayana, Bryan K. S. Yeung, Anne-Marie Zeeman, Christophe Bodenreider, Robert W. Sauerwein, Ravinder Reddy Kondreddi, Nicole van der Werff, Annemarie Voorberg-van der Wel, Clemens H. M. Kocken
المصدر: Antimicrobial Agents and Chemotherapy, 60, 2858-63
Antimicrobial Agents and Chemotherapy, 60, 5, pp. 2858-63
Antimicrobial Agents and Chemotherapyمصطلحات موضوعية: 0301 basic medicine, Secondary infection, 030106 microbiology, Plasmodium vivax, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Clinical Therapeutics, Pharmacology, Parasitemia, Plasmodium, Antimalarials, Mice, 03 medical and health sciences, Pharmacokinetics, In vivo, parasitic diseases, Malaria, Vivax, medicine, Animals, Pharmacology (medical), biology, Malaria prophylaxis, medicine.disease, biology.organism_classification, Macaca mulatta, In vitro, 030104 developmental biology, Infectious Diseases, Sporozoites, Immunology, Malaria
وصف الملف: application/pdf
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3
المؤلفون: Luis R. Camacho, Srinivasa P. S. Rao, Christian G. Noble, Ravinder Reddy Kondreddi, Thierry T. Diagana, Ujjini H. Manjunatha, Anne Goh, Maxime Herve, Paul W. Smith, Stefan Peukert, Pearly Shuyi Ng, Ngai Ling Ma
المصدر: European Journal of Medicinal Chemistry. 106:144-156
مصطلحات موضوعية: Models, Molecular, Drug, Pyridones, Phenotypic screening, media_common.quotation_subject, Antitubercular Agents, Biological Availability, Microbial Sensitivity Tests, Pharmacology, Mycobacterium tuberculosis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Stability, In vivo, Tuberculosis, Multidrug-Resistant, Drug Discovery, Animals, Humans, Structure–activity relationship, Potency, media_common, Dose-Response Relationship, Drug, Molecular Structure, biology, Organic Chemistry, General Medicine, biology.organism_classification, In vitro, Rats, chemistry, Microsomes, Liver, Lead compound
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4
المؤلفون: Thierry T. Diagana, Suresh B. Lakshminarayana, Susan Noh, Francesca Blasco, Carrie F. Brooks, Jennifer A. Zambriski, Laura B. Goodman, Gu Feng, Sumiti Vinayak, Gillian T. Herbert, Peter Gedeck, Lijun Zhang, Jayesh Tandel, Siau H. Lim, Christian G. Noble, F. Joel Leong, Alex Chao, Juergen Wagner, Bin Zou, Boris Striepen, Tracy Sy, Ravinder Reddy Kondreddi, Christophe Bodenreider, Ujjini H. Manjunatha, Ghislain M. C. Bonamy, Adam Sateriale
المصدر: Nature
مصطلحات موضوعية: 0301 basic medicine, Male, Pyridines, Cryptosporidiosis, Cryptosporidium, Communicable Diseases, Article, Microbiology, 03 medical and health sciences, Immunocompromised Host, Interferon-gamma, Mice, Cell Line, Tumor, parasitic diseases, Pyrazolopyridine, medicine, Animals, Humans, Interferon gamma, Rats, Wistar, 1-Phosphatidylinositol 4-Kinase, Mice, Knockout, Multidisciplinary, biology, Kinase, Drug discovery, business.industry, biology.organism_classification, Antiparasitic agent, Virology, 3. Good health, Rats, Disease Models, Animal, 030104 developmental biology, Cryptosporidium parvum, Animals, Newborn, Pyrazoles, Cattle, Female, business, Cryptosporidium hominis, medicine.drug
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5
المؤلفون: Wai Ling Chan, Bo Zhang, Thomas H. Keller, Wouter Schul, Min Qing, Pei Yong Shi, Andy Yip, Kristen A. Bernard, Gang Zou, Hao Ying Xu, Suresh B. Lakshminarayana, Gang Wang, Anne Goh, Wei Liu, Min Dong, Boping Liu, Hui Pen Tan, Handan He, Qing Yin Wang, Margaret Weaver, Feng Gu, Yen Liang Chen, Zheng Yin, Pornwaratt Niyomrattanakit, Chuan Young Ng, Arkadius Pichota, Christine E. Garrett, Véronique Dartois, Joanne Y.H. Lim, Ravinder Reddy Kondreddi, Jeyaraj Duraiswamy, Kai Lin, Chin Chin Lim, Karen Beltz
المصدر: Proceedings of the National Academy of Sciences. 106:20435-20439
مصطلحات موضوعية: Male, Adenosine, viruses, Hepatitis C virus, Enzyme-Linked Immunosorbent Assay, Dengue virus, medicine.disease_cause, Antiviral Agents, Virus, Dengue fever, Dengue, Mice, Dogs, Chlorocebus aethiops, medicine, Animals, Viremia, Vero Cells, No-Observed-Adverse-Effect Level, Multidisciplinary, Western equine encephalitis virus, Molecular Structure, biology, virus diseases, Nucleoside inhibitor, biochemical phenomena, metabolism, and nutrition, Biological Sciences, Dengue Virus, RNA-Dependent RNA Polymerase, biology.organism_classification, medicine.disease, Virology, Rats, Flavivirus, Vesicular stomatitis virus, Female
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6
المؤلفون: Wai Ling Chan, Shahul Nilar, Subhash G. Vasudevan, Wan Yen Lee, Sigmar Dressler, Gang Wang, Pei Yong Shi, Alex Chao, Ru Hui Ng, Hans Voshol, Thomas H. Keller, Daying Wen, Yen Liang Chen, J. Fraser Glickman, Joanne Y.H. Lim, Pornwaratt Niyomrattanakit, Zheng Yin, Ravinder Reddy Kondreddi, Duraiswamy Athisayamani Jeyaraj, Carsten Spanka, Dieter Mueller
المصدر: Journal of Medicinal Chemistry. 52:7934-7937
مصطلحات موضوعية: Models, Molecular, Allosteric regulation, Dengue virus, medicine.disease_cause, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, RNA polymerase, Drug Discovery, medicine, Humans, Structure–activity relationship, ortho-Aminobenzoates, Enzyme Inhibitors, Binding site, Polymerase, chemistry.chemical_classification, Binding Sites, biology, Chemistry, Dengue Virus, RNA-Dependent RNA Polymerase, Sulfinic Acids, biology.organism_classification, Flavivirus, Enzyme, Biochemistry, biology.protein, Molecular Medicine
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7
المؤلفون: Ujjini H. Manjunatha, Richard Glynne, John R. Walker, Bee Huat Tan, Paul W. Smith, Srinivasa P. S. Rao, Kelli Kuhen, Pearly Shuyi Ng, Christian G. Noble, Susan W. Barnes, Peter J. Tonge, Seow H. Ng, Suresh B. Lakshminarayana, Ng L. Ma, Ravinder Reddy Kondreddi, Francesca Blasco, Thierry T. Diagana, David Beer, Maxime Herve, Weixuan Yu, Luis R. Camacho
المصدر: Science Translational Medicine. 7
مصطلحات موضوعية: Models, Molecular, Tuberculosis, Pyridines, Antitubercular Agents, Biology, Reductase, Nicotinamide adenine dinucleotide, Pharmacology, Crystallography, X-Ray, Article, Biophysical Phenomena, Microbiology, Mycobacterium tuberculosis, chemistry.chemical_compound, Bacterial Proteins, In vivo, Oxidoreductase, Drug Resistance, Multiple, Bacterial, Tuberculosis, Multidrug-Resistant, medicine, Animals, Enzyme Inhibitors, chemistry.chemical_classification, Mice, Inbred BALB C, Drug discovery, INHA, Reproducibility of Results, Sequence Analysis, DNA, General Medicine, biology.organism_classification, medicine.disease, Disease Models, Animal, chemistry, Oxidoreductases
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8
المؤلفون: Kerstin Gagaring, Sindhu Ravindran, Pablo Bifani, Gu Feng, Peck Gee Seah, Kelli Kuhen, Zhong Chen, Sarath K. Kalapala, Maxime Herve, Pamela Thayalan, Thierry T. Diagana, Arnab K. Chatterjee, Jan Jiricek, Anne Goh, Seow H. Ng, Thomas Dick, Whitney Barnes, Francesca Blasco, Richard Glynne, Lijun Zhang, Véronique Dartois, Siao H. Lim, John R. Walker, Margaret Weaver, David Beer, Luis R. Camacho, Mahesh Nanjundappa, Kevin Pethe, Paul W. Smith, Ujjini H. Manjunatha, Boon H. Lee, Srinivasa P. S. Rao, Bee Huat Tan, Sreehari Babu, Suresh B. Lakshminarayana, Ng L. Ma, Ravinder Reddy Kondreddi
المصدر: Science translational medicine. 5(214)
مصطلحات موضوعية: Drug, Tuberculosis, Indoles, media_common.quotation_subject, hERG, Antitubercular Agents, Administration, Oral, Biological Availability, Drug resistance, Microbial Sensitivity Tests, Pharmacology, Mycobacterium tuberculosis, Mice, Dogs, Pharmacokinetics, Bacterial Proteins, Drug Resistance, Multiple, Bacterial, Tuberculosis, Multidrug-Resistant, Medicine, Animals, Humans, Dosing, Rats, Wistar, media_common, Mice, Inbred BALB C, biology, Dose-Response Relationship, Drug, business.industry, Membrane Transport Proteins, General Medicine, medicine.disease, biology.organism_classification, Rats, Multiple drug resistance, Disease Models, Animal, Injections, Intravenous, biology.protein, business
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9
المؤلفون: Ujjini H. Manjunatha, Maxime Herve, Luis R. Camacho, Thierry T. Diagana, Pablo Bifani, Kelli Kuhen, Anne Goh, Suresh B. Lakshminarayana, Ranga Rao, Arnab K. Chatterjee, Paul W. Smith, Thomas Dick, Ngai Ling Ma, Jan Jiricek, Ravinder Reddy Kondreddi, Srinivasa P. S. Rao
المصدر: Journal of medicinal chemistry. 56(21)
مصطلحات موضوعية: Indole test, Indoles, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Stereochemistry, Phenotypic screening, Antitubercular Agents, Computational biology, Microbial Sensitivity Tests, Mycobacterium tuberculosis, Class (biology), Rats, Mice, Structure-Activity Relationship, Design synthesis, Solubility, Drug Design, Drug Discovery, Microsomes, Liver, Molecular Medicine, Animals, Humans, Tuberculosis, Biological evaluation
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المؤلفون: Qing Yin Wang, Ravinder Reddy Kondreddi, Laura D. Kramer, Wouter Schul, Shahul Nilar, David C. Chang, Suresh B. Lakshminarayana, Anne Goh, Thomas H. Keller, Ranga Rao, Hao Ying Xu, Pei Yong Shi, Hongping Dong, Min Qing, Xuping Xie, Fumiaki Yokokawa
المصدر: Antimicrobial agents and chemotherapy. 55(9)
مصطلحات موضوعية: Cell Survival, Glucuronidation, Pharmacology, Biology, Antiviral Agents, Virus, Cell Line, chemistry.chemical_compound, Mice, Pharmacokinetics, In vivo, Cell Line, Tumor, Cricetinae, Chlorocebus aethiops, Animals, Humans, Pharmacology (medical), Vero Cells, Chromatography, High Pressure Liquid, Molecular Structure, RNA, Dengue Virus, Virology, In vitro, Benzomorphan, Rats, Infectious Diseases, chemistry, RNA, Viral, Female, Enantiomer
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المؤلفون: Min Qing, Wai Ling Chan, Boping Liu, Melissa Lo, Helen Gu, Hui Pen Tan, Wouter Schul, Handan He, Ranga Rao, Hao Ying Xu, Gang Wang, Jeyaraj Duraiswamy, Thomas H. Keller, Sarah Liung, Pei Yong Shi, Yen Liang Chen, Chin Chin Lim, Ravinder Reddy Kondreddi, Andy Yip, Zheng Yin
المصدر: Antimicrobial agents and chemotherapy. 54(7)
مصطلحات موضوعية: Male, Small interfering RNA, Adenosine, Adenosine kinase, Antiviral Agents, Polymerase Chain Reaction, Cell Line, Cell Line, Tumor, medicine, Animals, Humans, Pharmacology (medical), Replicon, Phosphorylation, RNA, Small Interfering, Rats, Wistar, Adenosine Kinase, Pharmacology, biology, Kinase, RNA, RNA virus, Dengue Virus, biology.organism_classification, Molecular biology, Rats, Infectious Diseases, Biochemistry, biology.protein, RNA, Viral, Nucleoside, medicine.drug