المؤلفون: Hoa Q. Nguyen, Andrea Iskenderian, David Ehmann, Paul Jasper, Zhiwei Zhang, Haojing Rong, Devin Welty, Rangaraj Narayanan

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 6, Pp 342-352 (2020)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2163-8306

URL الوصول: https://doaj.org/article/989002c80fa045f481784c21bfd34edd

المؤلفون: Kristine Holgersen, Xiaoyan Gao, Rangaraj Narayanan, Tripti Gaur, Galen Carey, Norman Barton, Xiaoyu Pan, Tik Muk, Thomas Thymann, Per Torp Sangild

المصدر: Frontiers in Pediatrics, Vol 8 (2021)

مصطلحات موضوعية: IGF-1, infant, intestine, preterm birth, gut, newborn, Pediatrics, RJ1-570

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fped.2020.602047/full; https://doaj.org/toc/2296-2360

URL الوصول: https://doaj.org/article/763117225fc245408709081efbf4015a

المؤلفون: Paul Jasper, David Ehmann, Andrea Iskenderian, Devin Welty, Zhiwei Zhang, Hoa Q. Nguyen, Haojing Rong, Rangaraj Narayanan

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 6, Pp 342-352 (2020)
CPT: Pharmacometrics & Systems Pharmacology

مصطلحات موضوعية: Follistatin, Activin Receptors, Type II, Recombinant Fusion Proteins, Duchenne muscular dystrophy, Myostatin, Ligands, Bioinformatics, Models, Biological, Article, Animals, Humans, Medicine, Drug Dosage Calculations, Pharmacology (medical), Muscle, Skeletal, biology, business.industry, Mechanism (biology), Research, Systems Biology, lcsh:RM1-950, Skeletal muscle, Articles, medicine.disease, Fusion protein, Muscular Dystrophy, Duchenne, medicine.anatomical_structure, lcsh:Therapeutics. Pharmacology, Neuromuscular Agents, Drug development, Modeling and Simulation, biology.protein, business, Signal Transduction, Systems pharmacology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72be8a4a714484e01d65c0117a1ee15d
https://doaj.org/article/989002c80fa045f481784c21bfd34edd

المؤلفون: Kristine Holgersen (10097569), Xiaoyan Gao (249733), Rangaraj Narayanan (2499475), Tripti Gaur (10097572), Galen Carey (2535706), Norman Barton (8539227), Xiaoyu Pan (31050), Tik Muk (7869236), Thomas Thymann (307795), Per Torp Sangild (307802)

مصطلحات موضوعية: Foetal Development and Medicine, Obstetrics and Gynaecology, Paediatrics, Paediatrics and Reproductive Medicine not elsewhere classified, IGF-1, infant, intestine, preterm birth, gut, newborn, growth restriction, fetus

Relation: https://figshare.com/articles/dataset/Table_3_Supplemental_Insulin-Like_Growth_Factor-1_and_Necrotizing_Enterocolitis_in_Preterm_Pigs_pdf/13713430

الاتاحة: https://doi.org/10.3389/fped.2020.602047.s004

المؤلفون: Kristine Holgersen (10097569), Xiaoyan Gao (249733), Rangaraj Narayanan (2499475), Tripti Gaur (10097572), Galen Carey (2535706), Norman Barton (8539227), Xiaoyu Pan (31050), Tik Muk (7869236), Thomas Thymann (307795), Per Torp Sangild (307802)

مصطلحات موضوعية: Foetal Development and Medicine, Obstetrics and Gynaecology, Paediatrics, Paediatrics and Reproductive Medicine not elsewhere classified, IGF-1, infant, intestine, preterm birth, gut, newborn, growth restriction, fetus

Relation: https://figshare.com/articles/figure/Image_1_Supplemental_Insulin-Like_Growth_Factor-1_and_Necrotizing_Enterocolitis_in_Preterm_Pigs_pdf/13713421

الاتاحة: https://doi.org/10.3389/fped.2020.602047.s001

المؤلفون: Venkatesh Pilla Reddy, Vaishali Dixit, Sibylle Neuhoff, Mohammed Ullah, Maud Beneton, Jan Snoeys, Felix Huth, Manthena V.S. Varma, Maria M. Posada, Dwaipayan Mukherjee, Arian Emami Riedmaier, Howard Burt, Xiaoyan Chu, Kenichi Umehara, Kunal S Taskar, Ming Zheng, Rangaraj Narayanan, Yuichi Sugiyama, Masanori Nakakariya, Yuan Chen

المصدر: Clinical Pharmacology and Therapeutics

مصطلحات موضوعية: Drug, Physiologically based pharmacokinetic modelling, Computer science, media_common.quotation_subject, Reviews, Review, 030226 pharmacology & pharmacy, Models, Biological, Food and drug administration, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Cytochrome P-450 Enzyme System, Continuous use, Humans, Pharmacology (medical), Drug Interactions, media_common, Pharmacology, Membrane Transport Proteins, Regulatory Submission, Drug development, Risk analysis (engineering), Pharmaceutical Preparations, 030220 oncology & carcinogenesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a97644b8b720f9be3b7137da1988f14e
https://pubmed.ncbi.nlm.nih.gov/31628859

المؤلفون: Matthew Hoffmann, Hong Liu, Sekhar Surapaneni, Rangaraj Narayanan

المصدر: Drug Metabolism Letters. 10:195-199

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, CYP2B6, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, Cytochrome P-450 CYP1A2, Indoxyl, medicine, Humans, Pharmacology (medical), Inducer, RNA, Messenger, Renal Insufficiency, Chronic, Cells, Cultured, Aged, Uremia, chemistry.chemical_classification, Dose-Response Relationship, Drug, Indoleacetic Acids, biology, Biochemistry (medical), CYP1A2, Cytochrome P450, medicine.disease, 030104 developmental biology, Enzyme, chemistry, Hepatocytes, biology.protein, Female, Indican, Omeprazole, Drug metabolism, Kidney disease

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935c161ea527407afd896fa432b3c7d6
https://doi.org/10.2174/1872312810666160719143703

المؤلفون: Gondi N. Kumar, Rangaraj Narayanan, Sekhar Surapaneni, Matthew Hoffmann

المصدر: Drug Metabolism Letters. 10:172-179

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Physiologically based pharmacokinetic modelling, Time Factors, Combination therapy, Midazolam, Clinical Biochemistry, Population, Cmax, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, Models, Biological, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, Prostate cancer, 0302 clinical medicine, Pharmacokinetics, Internal medicine, Nitriles, Phenylthiohydantoin, medicine, Cytochrome P-450 CYP3A, Humans, Enzalutamide, Computer Simulation, Drug Interactions, Pharmacology (medical), Dosing, education, education.field_of_study, Dose-Response Relationship, Drug, business.industry, Biochemistry (medical), Cytochrome P-450 CYP3A Inducers, Middle Aged, medicine.disease, 030104 developmental biology, chemistry, Area Under Curve, 030220 oncology & carcinogenesis, Benzamides, business, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8406b35c56007c566bd93afeadeac97
https://doi.org/10.2174/1872312810666160729124745

المؤلفون: Heidi J. Einolf, Susanna Tse, Tonika Bohnert, Sirimas Sudsakorn, Ying-Hong Wang, David Moore, Jim Keirns, Ling He, Robert L. Walsky, Rangaraj Narayanan, Wanping Geng, Aarti Patel, Louis Leung, W. George Lai, Xiaoqing Yang, Ralph Stearns, Dieter Lang, Michael Sinz, Yuan Chen, Chuang Lu, Jan Wahlstrom, Ian Templeton

المصدر: Drug Metabolism and Disposition. 44:1399-1423

مصطلحات موضوعية: Drug, Drug Industry, Computer science, media_common.quotation_subject, Population, Decision tree, Pharmaceutical Science, Pharmacology, Risk Assessment, 030226 pharmacology & pharmacy, Substrate Specificity, 03 medical and health sciences, 0302 clinical medicine, Species Specificity, New chemical entity, Drug Discovery, Animals, Humans, Computer Simulation, Drug Interactions, education, Biotransformation, media_common, education.field_of_study, Decision Trees, Perspective (graphical), Models, Theoretical, Enzymes, Kinetics, Identification (information), Drug metabolizing enzymes, Pharmaceutical Preparations, Risk analysis (engineering), 030220 oncology & carcinogenesis, Risk assessment

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ff752216b7095cfbd939b67f0dd8ae
https://doi.org/10.1124/dmd.115.069096

المؤلفون: Lei Zhao, Scott A. Shaw, Lynn M. Abell, Fred Lo, Gregory A. Locke, Meriah Neissel Valente, Xiaoqin Liu, Paul G. Sleph, Lisa M. Kopcho, Michael Basso, Andrew Quoc Viet, Rangaraj Narayanan, Nicholas R. Wurtz, Franck Duclos, Sutjano Jusuf, Ellen K. Kick, Dilger Andrew K, Ruth R. Wexler, Gayani Fernando, Javed Khan

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Reactive oxygen species, biology, Organic Chemistry, Rational design, Active site, Inflammation, Pharmacology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, Thioether, 030220 oncology & carcinogenesis, Myeloperoxidase, Drug Discovery, biology.protein, medicine, Triazolopyridine, medicine.symptom, Peroxidase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d146ac6bd8e0ed839899be07882101e6
https://europepmc.org/articles/PMC6295853/

المؤلفون: Yan Li, Jim Nissel, Sekhar Surapaneni, Rangaraj Narayanan, Hong Liu, Christian Atsriku, Xiaomin Wang, Zeen Tong

المصدر: Xenobiotica; the fate of foreign compounds in biological systems. 49(1)

مصطلحات موضوعية: Physiologically based pharmacokinetic modelling, Health, Toxicology and Mutagenesis, Drug-drug interaction, Pharmacology, Toxicology, 030226 pharmacology & pharmacy, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Animals, Humans, Drug Interactions, Prospective Studies, Sirolimus, Chemistry, Kinase, In vitro metabolism, TOR Serine-Threonine Kinases, Membrane Transport Proteins, Transporter, General Medicine, Metabolism, In vitro, Ketoconazole, 030220 oncology & carcinogenesis, Pyrazines, Microsomes, Liver, Cytochrome P-450 CYP3A Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afef4248cd359e781f4071f3043cff4e
https://pubmed.ncbi.nlm.nih.gov/29297772

المؤلفون: Edgar Schuck, Yang Xu, Arian Emami Riedmaier, Haojing Rong, Rangaraj Narayanan, Pradeep Sharma, Felix Huth, Maud Beneton, Jing Lin, Ming Zheng, Iain Gardner, Yuan Chen, Masoud Jamei, Venkatesh Pilla Reddy, Christiane Collins, Mohamad Shebley, Jun Chen, Punam Sandhu, Shinji Yamazaki, Loeckie de Zwart, Malcolm Rowland, Nassim Djebli, Faraz Kazmi, Sheila Annie Peters, Yumi Cleary, Aarti Patel, Shu Pei Wu, Chirag Patel, Francois Bouzom, Aleksandrs Odinecs, Feras Khalil, Gemma L. Dickinson, Heidi J. Einolf, Kenta Yoshida

المصدر: Shebley, M, Sandhu, P, Emami Riedmaier, A, Jamei, M, Narayanan, R, Patel, A, Peters, S A, Reddy, V P, Zheng, M, de Zwart, L, Beneton, M, Bouzom, F, Chen, J, Chen, Y, Cleary, Y, Collins, C, Dickinson, G L, Djebli, N, Einolf, H J, Gardner, I, Huth, F, Kazmi, F, Khalil, F, Lin, J, Odinecs, A, Patel, C, Rong, H, Schuck, E, Sharma, P, Wu, S P, Xu, Y, Yamazaki, S, Yoshida, K & Rowland, M 2018, ' Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions : A Consortium Perspective ', Clinical Pharmacology and Therapeutics . https://doi.org/10.1002/cpt.1013
Clinical Pharmacology and Therapeutics

مصطلحات موضوعية: Pharmacology, Physiologically based pharmacokinetic modelling, United States Food and Drug Administration, Computer science, Reviews, Review, Models, Biological, 030226 pharmacology & pharmacy, Regulatory Submission, United States, Europe, Food and drug administration, 03 medical and health sciences, Engineering management, 0302 clinical medicine, 030220 oncology & carcinogenesis, Humans, Computer Simulation, Pharmacokinetics, Pharmacology (medical), Drug Approval

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4695aa7ee7d1f810eac77f151fe62bd
https://doi.org/10.1002/cpt.1013

المؤلفون: Daniel J. Sexton, Zhiwei Zhang, Rangaraj Narayanan, Haobin Luo, Paul Jasper, Salome Juethner, Peng Lu

المصدر: Journal of Allergy and Clinical Immunology. 145:AB105

مصطلحات موضوعية: Pharmacokinetics, business.industry, Treatment adherence, Immunology, Kinetics, Hereditary angioedema, Immunology and Allergy, Medicine, Kallikrein, Pharmacology, business, medicine.disease, Target binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::817b687a5f2294bd9cb3c4e938d30267
https://doi.org/10.1016/j.jaci.2019.12.631

المؤلفون: Dietmar A. Seiffert, Bates J Alex, Pancras C. Wong, Rangaraj Narayanan, Joseph M. Luettgen, E. Scott Priestley, Alan R. Rendina, Jeremy M. Richter, Daniel L. Cheney, Timothy M. Harper, Anzhi Wei, Ruth R. Wexler

المصدر: ACS medicinal chemistry letters. 8(1)

مصطلحات موضوعية: 0301 basic medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, 030204 cardiovascular system & hematology, Metabolic stability, Factor VIIa, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f1ff4fd337f917536b6363b5574967
https://pubmed.ncbi.nlm.nih.gov/28105277

المؤلفون: William C. Stevens, John A. Lupisella, Venkataiah Bollu, Richard Martin, Denise Grimm, Rangaraj Narayanan, Max H. Nanao, Ruth R. Wexler, Raju Mohan, Xiaoping Hou, Meriah Neissel Valente, Brant Clayton Boren, Grace Yan, James Smalley, Brett B. Busch, Jacek Ostrowski, Paul G. Sleph, Yinong Xie, Barry Brock, Ira G. Schulman, A. David Rodrigues, Artur Plonowski, Glenn H. Cantor, Michael Charles Nyman, Huiping Zhang, Lam Nguyen, Ellen K. Kick, Todd G. Kirchgessner, Kamelia Behnia

المصدر: ACS medicinal chemistry letters. 7(12)

مصطلحات موضوعية: 0301 basic medicine, Agonist, biology, medicine.drug_class, Organic Chemistry, Liver X receptor alpha, Pharmacology, Biochemistry, Blood proteins, Sulfone, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, ABCG1, chemistry, ABCA1, Drug Discovery, biology.protein, medicine, lipids (amino acids, peptides, and proteins), Liver X receptor, Whole blood

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7f03cc7bbe62de8dff6d1806159952
https://pubmed.ncbi.nlm.nih.gov/27994765

المؤلفون: Mimi L. Quan, Ruth R. Wexler, Joseph E. Myers, Joseph M. Luettgen, Donald J. P. Pinto, Dietmar A. Seiffert, Yi-Xin Li, Steven Sheriff, Timothy W. Harper, Rangaraj Narayanan, Michael J. Orwat, Anzhi Wei, James R. Corte, Tianan Fang, Joanna J. Zheng, Karen A. Rossi, Vidhyashankar Ramamurthy, Alan R. Rendina

المصدر: Bioorganicmedicinal chemistry. 24(10)

مصطلحات موضوعية: Models, Molecular, Carbamate, Pyrimidine, Stereochemistry, Pyridines, medicine.medical_treatment, Clinical Biochemistry, Phenylcarbamates, Pharmaceutical Science, Administration, Oral, 030204 cardiovascular system & hematology, Ring (chemistry), Crystallography, X-Ray, 01 natural sciences, Biochemistry, Factor XIa, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dogs, Drug Discovery, Pyridine, medicine, Imidazole, Moiety, Animals, Humans, Molecular Biology, Blood Coagulation, Indazole, 010405 organic chemistry, Chemistry, Organic Chemistry, Anticoagulants, 0104 chemical sciences, Bioavailability, Pyrimidines, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ca33105fc2ef09c3a3fa90299ef468
https://pubmed.ncbi.nlm.nih.gov/27073051

المؤلفون: Evan B. Janovitz, Mary Ann Pelleymounter, Mary F. Malley, Eva Zuvich, Jeffrey G. Varnes, Xueying Cao, Chen-Pin Hung, Karen A. Rossi, Mary Jane Cullen, Thao Ung, William J. Keim, Sarah E. Malmstrom, Michael Thomas, Keith J. Miller, Ginger Wu, Kenneth W. Rohrbach, Ge Zhang, Rangaraj Narayanan, Qinling Qu, Lois D. Lehman-McKeeman, Jeffrey A. Robl, James Devenny, Dean A. Wacker

المصدر: Journal of Medicinal Chemistry. 50:1365-1379

مصطلحات موضوعية: Male, Agonist, Indoles, medicine.drug_class, Stereochemistry, Administration, Oral, Isoindoles, Pharmacology, Weight Gain, Chemical synthesis, Cell Line, Rats, Sprague-Dawley, Mice, Necrosis, Radioligand Assay, Parietal Cells, Gastric, Pharmacokinetics, Oral administration, In vivo, Drug Discovery, medicine, Functional selectivity, Animals, Humans, Chemistry, Antagonist, Stereoisomerism, Feeding Behavior, Rats, 5-HT2C receptor, Blood-Brain Barrier, Pyrazines, Conditioning, Operant, Molecular Medicine, Anti-Obesity Agents, Serotonin 5-HT2 Receptor Agonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9455a4be4dd87363342b50ad98d204
https://doi.org/10.1021/jm0612968

المؤلفون: Xiaoqin Liu, Yinong Xie, Paul G. Sleph, John A. Lupisella, Todd G. Kirchgessner, Rangaraj Narayanan, Denise Grimm, Ellen K. Kick, James Smalley, Jacek Ostrowski, Martin Richard, Glenn H. Cantor, Raju Mohan

المصدر: The Journal of pharmacology and experimental therapeutics. 352(2)

مصطلحات موضوعية: Agonist, Male, medicine.medical_specialty, Apolipoprotein B, medicine.drug_class, In vivo, Internal medicine, medicine, Animals, Sulfones, Liver X receptor, Triglycerides, Liver X Receptors, Pharmacology, biology, Dose-Response Relationship, Drug, Anticholesteremic Agents, Lipogenesis, Reverse cholesterol transport, Imidazoles, Orphan Nuclear Receptors, Lipids, Drug Partial Agonism, Macaca fascicularis, Endocrinology, ABCG1, Nuclear receptor, Liver, ABCA1, biology.protein, Molecular Medicine, lipids (amino acids, peptides, and proteins), ATP-Binding Cassette Transporters

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861e4be555317ae6e757933732ddf726
https://pubmed.ncbi.nlm.nih.gov/25467132

المؤلفون: David A. Williams, Rangaraj Narayanan, Barbara LeDuc

المصدر: Journal of Pharmaceutical and Biomedical Analysis. 22:527-540

مصطلحات موضوعية: Male, Clinical Biochemistry, Glucuronidation, Pharmaceutical Science, High-performance liquid chromatography, Colorimetry (chemical method), Substrate Specificity, Analytical Chemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, Glucuronides, Microsomes, Drug Discovery, Animals, Protein Isoforms, Testosterone, Glucuronosyltransferase, Intestinal Mucosa, Gonadal Steroid Hormones, Chromatography, High Pressure Liquid, Spectroscopy, Testosterone glucuronide, Hymecromone, Chromatography, Chemistry, Reproducibility of Results, Oxyquinoline, Glucuronic acid, Rats, Aglycone, Biochemistry, Microsomes, Liver, Indicators and Reagents, Glucuronide

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6337ffc8453dd1f4ac0e866cfb4633
https://doi.org/10.1016/s0731-7085(00)00241-7

المؤلفون: Rangaraj Narayanan

المصدر: Drug Metabolism and Pharmacokinetics. 32:S7

مصطلحات موضوعية: Pharmacology, Pathology, medicine.medical_specialty, Physiologically based pharmacokinetic modelling, business.industry, medicine, Pharmaceutical Science, Pharmacology (medical), Medical physics, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ddd72a531a498cc61f2ae624af6c4f23
https://doi.org/10.1016/j.dmpk.2016.10.039