المؤلفون: Balpreet Bhogal, Barbara A. Weir, Ramona Crescenzo, Ann Marien, Min Chul Kwon, Ulrike Philippar, Glenn S. Cowley

المصدر: Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2399-3642

URL الوصول: https://doaj.org/article/4cb0bcf1331e411599809aa13de6b330

المؤلفون: Florencia Cayrol, Pannee Praditsuktavorn, Tharu M. Fernando, Nicholas Kwiatkowski, Rosella Marullo, M. Nieves Calvo-Vidal, Jude Phillip, Benet Pera, Shao Ning Yang, Kaipol Takpradit, Lidia Roman, Marcello Gaudiano, Ramona Crescenzo, Jia Ruan, Giorgio Inghirami, Tinghu Zhang, Graciela Cremaschi, Nathanael S. Gray, Leandro Cerchietti

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/d9b0eca4497a40c1b2e964a28298864d

المؤلفون: Florencia Cayrol, Pannee Praditsuktavorn, Tharu M. Fernando, Nicholas Kwiatkowski, Rossella Marullo, M. Nieves Calvo-Vidal, Jude Phillip, Benet Pera, Shao Ning Yang, Kaipol Takpradit, Lidia Roman, Marcello Gaudiano, Ramona Crescenzo, Jia Ruan, Giorgio Inghirami, Tinghu Zhang, Graciela Cremaschi, Nathanael S Gray, Leandro Cerchietti

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/4f6d287b1b314c20bd2687a9811a5e95

المؤلفون: Balpreet Bhogal, Barbara A. Weir, Ramona Crescenzo, Ann Marien, Min Chul Kwon, Ulrike Philippar, Glenn S. Cowley

المصدر: Communications biology. 5(1)

مصطلحات موضوعية: Leukemia, Myeloid, Acute, Mutation, Medicine (miscellaneous), Humans, Methyltransferases, DNA (Cytosine-5-)-Methyltransferases, DNA, General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology, DNA Methyltransferase 3A

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75688cd0955d1f690bbb87f7d68fdebc
https://pubmed.ncbi.nlm.nih.gov/36329185

المؤلفون: Maria E. Riveiro, Heng Pan, Leandro Cerchietti, Ramona Crescenzo, Valentina Vurchio, Giorgio Inghirami, Francesco Bertoni, Mangeng Cheng, Olivier Elemento, Maria Todaro, Andrea Rinaldi, Ivo Kwee, Michela Boi, Shao Ning Yang, John Moon, Esteban Cvitkovic

المصدر: Oncotarget

مصطلحات موضوعية: 0301 basic medicine, Time Factors, BRD inhibitor, chemistry.chemical_compound, tyrosine kinase inhibitor, 0302 clinical medicine, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, Anaplastic lymphoma kinase, Anaplastic Lymphoma Kinase, Anaplastic large-cell lymphoma, biology, Large-cell lymphoma, Drug Synergism, Cell cycle, Gene Expression Regulation, Neoplastic, Phenotype, Oncology, anaplastic large cell lymphoma, 030220 oncology & carcinogenesis, Ibrutinib, Lymphoma, Large-Cell, Anaplastic, OTX015/MK-8628, Heterocyclic Compounds, 3-Ring, Signal Transduction, Research Paper, medicine.drug_class, Antineoplastic Agents, Inhibitory Concentration 50, 03 medical and health sciences, Cell Line, Tumor, Biomarkers, Tumor, gene expression profiling, medicine, Humans, Bruton's tyrosine kinase, Genetic Predisposition to Disease, Cell Proliferation, Dose-Response Relationship, Drug, business.industry, Receptor Protein-Tyrosine Kinases, Cell Cycle Checkpoints, medicine.disease, Lymphoma, ALK inhibitor, 030104 developmental biology, chemistry, Drug Resistance, Neoplasm, Immunology, biology.protein, Cancer research, Acetanilides, Transcriptome, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7911b4c2e9a1e2f01a62ddbb11a502c4
https://doi.org/10.18632/oncotarget.12876

المؤلفون: Ramona Crescenzo, Francesco Abate, Elena Lasorsa, Fabrizio Tabbo’, Marcello Gaudiano, Nicoletta Chiesa, Filomena Di Giacomo, Elisa Spaccarotella, Luigi Barbarossa, Elisabetta Ercole, Maria Todaro, Michela Boi, ACQUAVIVA, ANDREA, FICARRA, ELISA, Domenico Novero, Andrea Rinaldi, Thomas Tousseyn, Andreas Rosenwald, Lukas Kenner, Lorenzo Cerroni, Alexander Tzankov, Maurilio Ponzoni, Marco Paulli, Dennis Weisenburger, Wing C. Chan, Javeed Iqbal, Miguel A. Piris, Alberto Zamo’, Carmela Ciardullo, Davide Rossi, Gianluca Gaidano, Stefano Pileri, Enrico Tiacci, Brunangelo Falini, Leonard D. Shultz, Laurence Mevellec, Jorge E. Vialard, Roberto Piva, Francesco Bertoni, Raul Rabadan, Giorgio Inghirami

المساهمون: Ramona, Crescenzo, Francesco, Abate, Elena, Lasorsa, Fabrizio, Tabbo’, Marcello, Gaudiano, Nicoletta, Chiesa, Filomena Di, Giacomo, Elisa, Spaccarotella, Luigi, Barbarossa, Elisabetta, Ercole, Maria, Todaro, Michela, Boi, Acquaviva, Andrea, Ficarra, Elisa, Domenico, Novero, Andrea, Rinaldi, Thomas, Tousseyn, Andreas, Rosenwald, Lukas, Kenner, Lorenzo, Cerroni, Alexander, Tzankov, Maurilio, Ponzoni, Marco, Paulli, Dennis, Weisenburger, Wing C., Chan, Javeed, Iqbal, Miguel A., Piri, Alberto, Zamo’, Carmela, Ciardullo, Davide, Rossi, Gianluca, Gaidano, Stefano, Pileri, Enrico, Tiacci, Brunangelo, Falini, Leonard D., Shultz, Laurence, Mevellec, Jorge E., Vialard, Roberto, Piva, Francesco, Bertoni, Raul, Rabadan, Giorgio, Inghirami

مصطلحات موضوعية: RNA-Seq data, anaplastic large cell lymphoma (ALCL), driver genetic alteration, gene fusion, somatic point mutation, massive sequencing, copy number alterations

Relation: info:eu-repo/semantics/altIdentifier/pmid/25873174; info:eu-repo/semantics/altIdentifier/wos/WOS:000352962600013; volume:27; issue:4; firstpage:516; lastpage:532; numberofpages:17; journal:CANCER CELL; http://hdl.handle.net/11380/1240376; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84928015700; http://www.sciencedirect.com/science/article/pii/S153561081500094X

الاتاحة: http://hdl.handle.net/11380/1240376
https://doi.org/10.1016/j.ccell.2015.03.006
http://www.sciencedirect.com/science/article/pii/S153561081500094X

المؤلفون: Lorenzo Cerroni, Laurence Mevellec, Andreas Rosenwald, Giorgio Inghirami, Luigi Barbarossa, Elena Lasorsa, Enrico Tiacci, Miguel A. Piris, Francesco Bertoni, Davide Rossi, Elisabetta Ercole, Nicoletta Chiesa, Filomena Di Giacomo, Domenico Novero, Maria Todaro, Alberto Zamò, Jorge Vialard, Ramona Crescenzo, Alexander Tzankov, Andrea Rinaldi, Lukas Kenner, Leonard D. Shultz, Francesco Abate, Thomas Tousseyn, Raul Rabadan, Javeed Iqbal, Dennis D. Weisenburger, Brunangelo Falini, Carmela Ciardullo, Elisa Ficarra, Wing C. Chan, Gianluca Gaidano, Elisa Spaccarotella, Andrea Acquaviva, Roberto Piva, Stefano Pileri, Fabrizio Tabbò, Marcello Gaudiano, Michela Boi, Marco Paulli, Maurilio Ponzoni

المساهمون: Crescenzo, Ramona, Abate, Francesco, Lasorsa, Elena, Tabbo', Fabrizio, Gaudiano, Marcello, Chiesa, Nicoletta, Di Giacomo, Filomena, Spaccarotella, Elisa, Barbarossa, Luigi, Ercole, Elisabetta, Todaro, Maria, Boi, Michela, Acquaviva, Andrea, Ficarra, Elisa, Novero, Domenico, Rinaldi, Andrea, Tousseyn, Thoma, Rosenwald, Andrea, Kenner, Luka, Cerroni, Lorenzo, Tzankov, Alexander, Ponzoni, Maurilio, Paulli, Marco, Weisenburger, Denni, Chan, Wing C, Iqbal, Javeed, Piris, Miguel A, Zamo', Alberto, Ciardullo, Carmela, Rossi, Davide, Gaidano, Gianluca, Pileri, Stefano, Tiacci, Enrico, Falini, Brunangelo, Shultz, Leonard D, Mevellec, Laurence, Vialard, Jorge E, Piva, Roberto, Bertoni, Francesco, Rabadan, Raul, Inghirami, Giorgio, Ramona Crescenzo, Francesco Abate, Elena Lasorsa, Fabrizio Tabbo’, Marcello Gaudiano, Nicoletta Chiesa, Filomena Di Giacomo, Elisa Spaccarotella, Luigi Barbarossa, Elisabetta Ercole, Maria Todaro, Michela Boi, ACQUAVIVA, ANDREA, FICARRA, ELISA, Domenico Novero, Andrea Rinaldi, Thomas Tousseyn, Andreas Rosenwald, Lukas Kenner, Lorenzo Cerroni, Alexander Tzankov, Maurilio Ponzoni, Marco Paulli, Dennis Weisenburger, Wing C. Chan, Javeed Iqbal, Miguel A. Piri, Alberto Zamo’, Carmela Ciardullo, Davide Rossi, Gianluca Gaidano, Stefano Pileri, Enrico Tiacci, Brunangelo Falini, Leonard D. Shultz, Laurence Mevellec, Jorge E. Vialard, Roberto Piva, Francesco Bertoni, Raul Rabadan, Giorgio Inghirami

مصطلحات موضوعية: Cancer Research, Lymphoma, Somatic cell, massive sequencing, Activating Transcription Factor 3, Animals, Cell Line, Tumor, HEK293 Cells, Humans, Janus Kinase 1, Lymphoma, Large-Cell, Anaplastic, Mice, Mutant Chimeric Proteins, NF-kappa B, Phosphorylation, Proto-Oncogene Proteins, Receptor Protein-Tyrosine Kinases, STAT3 Transcription Factor, Signal Transduction, TYK2 Kinase, Gene Expression Regulation, Neoplastic, Cell Biology, Oncology, Medicine (all), Anaplastic Large Cell Lymphoma, JAK/STAT3 pathway, Oncogenic STAT3 Activation, gene fusions, 0302 clinical medicine, hemic and lymphatic diseases, RNA-Seq data, anaplastic large cell lymphoma (ALCL), driver genetic alterations, somatic point mutations, copy number alterations, Anaplastic, Anaplastic lymphoma kinase, Anaplastic large-cell lymphoma, 0303 health sciences, Tumor, Janus kinase 1, Kinase, Large-Cell, 3. Good health, driver genetic alteration, somatic point mutation, Tyrosine kinase 2, 030220 oncology & carcinogenesis, Tyrosine kinase, Biology, Article, Cell Line, 03 medical and health sciences, ROS1, medicine, 030304 developmental biology, Stat3 activation, Neoplastic, Point mutation, gene fusion, medicine.disease, Molecular biology, Gene Expression Regulation, Cancer cell, Cancer research

وصف الملف: STAMPA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a9d987f67c88511b8a93dfda4325af
http://hdl.handle.net/11583/2598380

المؤلفون: Pannee Praditsuktavorn, Leandro Cerchietti, Tinghu Zhang, Ramona Crescenzo, Rossella Marullo, Nicholas Kwiatkowski, Tharu M. Fernando, Kaipol Takpradit, Nathanael S. Gray, Giorgio Inghirami, Benet Pera, Marcello Gaudiano, Shao Ning Yang, Florencia Cayrol, Jia Ruan, M. Nieves Calvo-Vidal, Graciela Cremaschi, Lidia Roman, Jude M. Phillip

المصدر: Nature Communications
Nature Communications. 2017;8:14290
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

مصطلحات موضوعية: 0301 basic medicine, Male, T Cell Lymphoma, Indoles, Transcription, Genetic, General Physics and Astronomy, Apoptosis, Mice, SCID, Pharmacology, Phenylenediamines, chemistry.chemical_compound, Mice, Mice, Inbred NOD, immune system diseases, MEDICINA BASICA, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, T-cell lymphoma, STAT3, Multidisciplinary, biology, PROTEINAS, Chromatin binding, Otras Medicina Básica, purl.org/becyt/ford/3.1 [https], Corrigenda, Chromatin, Cyclin-Dependent Kinases, humanities, 3. Good health, Gene Expression Regulation, Neoplastic, Medicina Básica, medicine.anatomical_structure, Treatment Outcome, Proto-Oncogene Proteins c-bcl-2, Gain of Function Mutation, Female, purl.org/becyt/ford/3 [https], Signal Transduction, STAT3 Transcription Factor, Bcl2, CIENCIAS MÉDICAS Y DE LA SALUD, Cell Survival, T cell, Science, Cdk7, PIM1, Lymphoma, T-Cell, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, Humans, Pyrroles, Protein Kinase Inhibitors, General Chemistry, INMUNOLOGIA, medicine.disease, Xenograft Model Antitumor Assays, Lymphoma, SANGRE, 030104 developmental biology, Pyrimidines, chemistry, Cell culture, Cancer research, biology.protein, Cyclin-Dependent Kinase-Activating Kinase, Obatoclax

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8163cfcb4091b44cbed66dfff4fe549d
http://europepmc.org/articles/PMC5290269

المؤلفون: Min Chul Kwon, Glenn S. Cowley, Ramona Crescenzo, Ricardo Attar, Balpreet Bhogal, Barbara A. Weir, David Pocalyko, Ulrike Philippar

المصدر: Cancer Research. 78:1383-1383

مصطلحات موضوعية: Cancer Research, Oncology, embryonic structures, DNA methylation, DNMT3B, DNMT1, Mutagenesis (molecular biology technique), CRISPR, Methylation, Computational biology, Biology, Genomic imprinting, DNA methyltransferase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::14d1a961844cc529ec9c9a32e937e7cf
https://doi.org/10.1158/1538-7445.am2018-1383

المؤلفون: Ramona Crescenzo, Giorgio Inghirami

المصدر: Current opinion in pharmacology. 23

مصطلحات موضوعية: Pharmacology, Crizotinib, biology, Receptor Protein-Tyrosine Kinases, SUPERFAMILY, Antineoplastic Agents, Food and drug administration, Clinical trial, Chimera (genetics), Insulin receptor, hemic and lymphatic diseases, Neoplasms, Drug Discovery, medicine, biology.protein, Cancer research, Anaplastic lymphoma kinase, Animals, Humans, Anaplastic Lymphoma Kinase, Protein Kinase Inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6597bc865c4197a3516cd844231d84
https://pubmed.ncbi.nlm.nih.gov/26051994

المؤلفون: Tabbó F, Barreca A, Piva R, Inghirami G, The European T-Cell Lymphoma Study Group (, Riccardo Bruna, Daniele Corino, Diego Cortese, Ramona Crescenzo, Giuditta Cuccuru, Filomena di Giacomo, Alessandro Fioravanti, Marco Ladetto, Indira Landra, Katia Messana, Rodolfo Machiorlatti, Barbara Martinoglio, Enzo Medico, Marta Mossino, Elisa Pellegrino, Maria Todaro, Paola Campisi, Luigi Chiusa, Annalisa Chiappella, Domenico Novero, Umberto Vitolo, Francesco Abate, Andrea Acquaviva, Elisa Ficarra, Roberto Freilone, Marco Chilosi, Alberto Zamó, Fabio Facchetti, Silvia Lonardi, Anna De Chiara, Franco Fulciniti, Claudio Doglioni, Maurilio Ponzoni, Luca Agnelli, Antonino Neri, Katia Todoerti, Claudio Agostinelli, Pier Paolo Piccaluga, Stefano Pileri, Brunangelo Falini, Enrico Tiacci, Peter Van Loo, Thomas Tousseyn, Christiane De Wolf-Peeters, Eva Geissinger, Hans Konrad Muller-Hermelink, Andreas Rosenwald, Miguel Angel Piris, Maria E. Rodriguez, Francesco Bertoni, Michela Boi, Ivo Kwee

المساهمون: F, Tabbó, A, Barreca, R, Piva, G, Inghirami, (, The European T-Cell Lymphoma Study Group, Bruna, Riccardo, Corino, Daniele, Cortese, Diego, Crescenzo, Ramona, Cuccuru, Giuditta, di Giacomo, Filomena, Fioravanti, Alessandro, Ladetto, Marco, Landra, Indira, Messana, Katia, Machiorlatti, Rodolfo, Martinoglio, Barbara, Medico, Enzo, Mossino, Marta, Pellegrino, Elisa, Todaro, Maria, Campisi, Paola, Chiusa, Luigi, Chiappella, Annalisa, Novero, Domenico, Vitolo, Umberto, Abate, Francesco, Acquaviva, Andrea, Ficarra, Elisa, Freilone, Roberto, Chilosi, Marco, Zamó, Alberto, Facchetti, Fabio, Lonardi, Silvia, De Chiara, Anna, Fulciniti, Franco, Doglioni, Claudio, Ponzoni, Maurilio, Agnelli, Luca, Neri, Antonino, Todoerti, Katia, Agostinelli, Claudio, Paolo Piccaluga, Pier, Pileri, Stefano, Falini, Brunangelo, Tiacci, Enrico, Van Loo, Peter, Tousseyn, Thoma, De Wolf-Peeters, Christiane, Geissinger, Eva, Konrad Muller-Hermelink, Han, Rosenwald, Andrea, Angel Piris, Miguel, Rodriguez, Maria E., Bertoni, Francesco, Boi, Michela, Kwee, Ivo

Relation: info:eu-repo/semantics/altIdentifier/pmid/22649787; volume:2; firstpage:41_1; lastpage:41_12; numberofpages:12; journal:FRONTIERS IN ONCOLOGY; http://hdl.handle.net/11579/120616; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84872363571

الاتاحة: http://hdl.handle.net/11579/120616
https://doi.org/10.3389/fonc.2012.00041

المؤلفون: Sabina Chiaretti, Robin Foà, Valentina Gianfelici, Lydia Roman-Gonzalez, Xujun Wang, Anna Guarini, Shahin Rafii, José Gabriel Barcia Durán, Jude M. Phillip, Jesus Maria Gomez Salinero, Ramona Crescenzo, Giorgio Inghirami, Rohan Bareja, Olivier Elemento, Marcello Gaudiano, Lorena Consolino, Ginsberg Michael, Filomena Di Giacomo, Danilo Fiore, Leandro Cerchietti

المصدر: Blood. 128:279-279

مصطلحات موضوعية: T cell, Immunology, Cell, Cell Biology, Hematology, Biology, medicine.disease, Biochemistry, Haematopoiesis, Leukemia, Cell killing, medicine.anatomical_structure, Cell culture, medicine, Bone marrow, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5d22a8990ebdfb7f7b9afe7d0a8e7c59
https://doi.org/10.1182/blood.v128.22.279.279

المؤلفون: Marco Pizzi, Giorgio Inghirami, Ramona Crescenzo, Marcello Gaudiano, Valentina Fragliasso

المصدر: Cancer Research. 76:2885-2885

مصطلحات موضوعية: Genetics, Cancer Research, T-cell receptor, GATA3, CD28, Biology, Germline mutation, Oncology, RAR-related orphan receptor gamma, biology.protein, Cancer research, Ectopic expression, IL-2 receptor, STAT3

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7af5e19b070bf43651fc16e411202fa4
https://doi.org/10.1158/1538-7445.am2016-2885

المؤلفون: Michela Boi, Raul Rabadan, Laurence Mevellec, Francesco Abate, Fabrizio Tabbò, Marcello Gaudiano, Andreas Rosenwald, Davide Rossi, Maria Todaro, Giorgio Inghirami, Luigi Barbarossa, Elena Lasorsa, Thomas Tousseyn, Filomena Di Giacomo, Elisa Spaccarotella, Nicoletta Chiesa, Francesco Bertoni, Ramona Crescenzo, Jorge Vialard, Lukas Kenner

المصدر: Blood. 124:781-781

مصطلحات موضوعية: Chemistry, medicine.drug_class, Immunology, Cell Biology, Hematology, Transfection, medicine.disease, Biochemistry, Molecular biology, Phenotype, Stat3 Signaling Pathway, Transcriptome, ALK inhibitor, Aldesleukin, hemic and lymphatic diseases, medicine, Anaplastic large-cell lymphoma, Tyrosine kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a9701d5ad8547906a543418d84377a36
https://doi.org/10.1182/blood.v124.21.781.781

المؤلفون: TABBO', FABRIZIO, INGHIRAMI, Giorgio, Maurilio Ponzoni, Raul Rabadan, Francesco Bertoni, European T. cell Lymphoma Study Group

المساهمون: Fabrizio Tabbò, Maurilio Ponzoni, Raul Rabadan, Francesco Bertoni, Giorgio Inghirami, European T-cell Lymphoma Study Group, (Sabrina Aliberti, Antonella Barreca, Luca Bessone, Ramona Crescenzo, Filomena Di Giacomo, Marcello Gaudiano, Indira Landra, Elena Lasorsa, Rodolfo Machiorlatti, Elisabetta Mereu, Katia Messana, Domenico Novero, Elisa Pellegrino, Achille Pich, Roberto Piva, Irene Scarfo’, Elisa Spaccarotella, Maria Todaro, Ivana Ubezzi, Susanna Urigu, Francesco Vittone, Francesco Abate, Elisa Ficarra, Andrea Acquaviva, Carmelo Carlo-Stella, Claudio Agostinelli, Pier Paolo Piccaluga, Stefano Pileri, Brunangelo Falini, Enrico Tiacci, Michela Boi, Ivo Kwee)

Relation: info:eu-repo/semantics/altIdentifier/pmid/23673339; info:eu-repo/semantics/altIdentifier/wos/WOS:000326748400017; volume:20; issue:4; firstpage:374; lastpage:381; numberofpages:8; journal:CURRENT OPINION IN HEMATOLOGY; http://hdl.handle.net/2318/136676; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84880223497

الاتاحة: http://hdl.handle.net/2318/136676
https://doi.org/10.1097/MOH.0b013e3283623c07