المؤلفون: Tomáš Otava (11002064), Michal Šála (1398271), Fengling Li (176389), Jindřich Fanfrlík (1265010), Kanchan Devkota (1822468), Sumera Perveen (9974693), Irene Chau (2276365), Paknoosh Pakarian (171283), Pavel Hobza (1279320), Masoud Vedadi (210076), Evzen Boura (302259), Radim Nencka (808341)

مصطلحات موضوعية: Biochemistry, Microbiology, Molecular Biology, Pharmacology, Infectious Diseases, Plant Biology, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, methyl group, homology model, SARS-CoV nsp 14, crystal structure, SARS-CoV -2 nsp 14, SARS-CoV -2 methyltransferases, SAM, guanosine triphosphate moiety, docking studies, Structure-Based Design, adenine nucleobase, MTase catalyzes, position 7, novel SAH derivatives, 7- deaza analogues, inhibitor, RNA

Relation: https://figshare.com/articles/journal_contribution/The_Structure-Based_Design_of_SARS-CoV_2_nsp14_Methyltransferase_Ligands_Yields_Nanomolar_Inhibitors/14818016

الاتاحة: https://doi.org/10.1021/acsinfecdis.1c00131.s001

المؤلفون: Markéta Pimková Polidarová (8052770), Petra Břehová (2259607), Martin Maxmilian Kaiser (10843630), Miroslav Smola (7135004), Martin Dračínský (1398268), Joshua Smith (734814), Aleš Marek (1860241), Milan Dejmek (1600816), Michal Šála (1398271), Ondrej Gutten (1455745), Lubomír Rulíšek (1263147), Barbora Novotná (8052761), Andrea Brázdová (8052773), Zlatko Janeba (1585501), Radim Nencka (808341), Evzen Boura (302259), Ondřej Páv (1546600), Gabriel Birkuš (2325874)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Physiology, Immunology, Cancer, Computational Biology, Chemical Sciences not elsewhere classified, Q STING, WT, proinflammatory cytokines, Biological Evaluation, peak intracellular concentration, 2 h, STING allelic forms, Phosphorothioate Prodrugs, phosphorothioate analogues, REF, CDNs results, parent CDN, parent CDNs, reporter-cell-based assays, intracellular cleavage, pivaloyloxymethyl prodrugs, type, X-ray crystallography, isopropyloxycarbonyl phosphoester p., interferon genes

Relation: https://figshare.com/articles/journal_contribution/Synthesis_and_Biological_Evaluation_of_Phosphoester_and_Phosphorothioate_Prodrugs_of_STING_Agonist_3_3_-c-Di_2_F_2_dAMP_/14639956

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00301.s003

المؤلفون: Markéta Pimková Polidarová (8052770), Petra Břehová (2259607), Martin Maxmilian Kaiser (10843630), Miroslav Smola (7135004), Martin Dračínský (1398268), Joshua Smith (734814), Aleš Marek (1860241), Milan Dejmek (1600816), Michal Šála (1398271), Ondrej Gutten (1455745), Lubomír Rulíšek (1263147), Barbora Novotná (8052761), Andrea Brázdová (8052773), Zlatko Janeba (1585501), Radim Nencka (808341), Evzen Boura (302259), Ondřej Páv (1546600), Gabriel Birkuš (2325874)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Physiology, Immunology, Cancer, Computational Biology, Chemical Sciences not elsewhere classified, Q STING, WT, proinflammatory cytokines, Biological Evaluation, peak intracellular concentration, 2 h, STING allelic forms, Phosphorothioate Prodrugs, phosphorothioate analogues, REF, CDNs results, parent CDN, parent CDNs, reporter-cell-based assays, intracellular cleavage, pivaloyloxymethyl prodrugs, type, X-ray crystallography, isopropyloxycarbonyl phosphoester p., interferon genes

Relation: https://figshare.com/articles/dataset/Synthesis_and_Biological_Evaluation_of_Phosphoester_and_Phosphorothioate_Prodrugs_of_STING_Agonist_3_3_-c-Di_2_F_2_dAMP_/14639950

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00301.s001