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1
المؤلفون: Alexey A. Lugovskoy, Ulrik B. Nielsen, Birgit Schoeberl, Kenneth J. Olivier, Brian D. Harms, Yang Jiao, Maja Razlog, Rachel Rennard, Neeraj Kohli, Lihui Xu, Victoria Rimkunas, Jian Tang, Sergio Iadevaia, Sharlene Adams, Jason Baum, Bryan W. Johnson, Jonathan B. Fitzgerald
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2
المؤلفون: Alexey A. Lugovskoy, Ulrik B. Nielsen, Birgit Schoeberl, Kenneth J. Olivier, Brian D. Harms, Yang Jiao, Maja Razlog, Rachel Rennard, Neeraj Kohli, Lihui Xu, Victoria Rimkunas, Jian Tang, Sergio Iadevaia, Sharlene Adams, Jason Baum, Bryan W. Johnson, Jonathan B. Fitzgerald
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3
المؤلفون: Alexey A. Lugovskoy, Ulrik B. Nielsen, Birgit Schoeberl, Kenneth J. Olivier, Brian D. Harms, Yang Jiao, Maja Razlog, Rachel Rennard, Neeraj Kohli, Lihui Xu, Victoria Rimkunas, Jian Tang, Sergio Iadevaia, Sharlene Adams, Jason Baum, Bryan W. Johnson, Jonathan B. Fitzgerald
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4
المؤلفون: Alexey A. Lugovskoy, Ulrik B. Nielsen, Birgit Schoeberl, Kenneth J. Olivier, Brian D. Harms, Yang Jiao, Maja Razlog, Rachel Rennard, Neeraj Kohli, Lihui Xu, Victoria Rimkunas, Jian Tang, Sergio Iadevaia, Sharlene Adams, Jason Baum, Bryan W. Johnson, Jonathan B. Fitzgerald
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5
المؤلفون: Ulrik B. Nielsen, Lihui Xu, Kathy Zhang, Daryl C. Drummond, Tad Kornaga, Alexey Lugovskoy, Neeraj Kohli, Yang Jiao, Melissa Geddie, Dmitri B. Kirpotin, Rachel Rennard
المصدر: mAbs. 7:42-52
مصطلحات موضوعية: Antibody-drug conjugate, Antibodies, Neoplasm, media_common.quotation_subject, Immunology, Yeast display, Mice, Drug Delivery Systems, Antigen, Cell Line, Tumor, Neoplasms, Animals, Humans, Immunology and Allergy, Single-chain variable fragment, Cytotoxic T cell, Internalization, media_common, Cytotoxins, Chemistry, Ligand (biochemistry), Molecular biology, Recombinant Proteins, Amino Acid Substitution, Biophysics, Nanoparticles, Linker, Reports, Single-Chain Antibodies
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6
المؤلفون: Pearl Bakhru, Girish Hemashettar, Allison Nelson, Monia Draghi, Thomas Daly, Robert Tighe, Michael Schmidt, Wilson Guzman, Samantha Ottinger, Sara M. Haserlat, Rachel Rennard, Ugur Eskiocak, Benjamin Wolf, Jason Lajoie, Amanda Oliphant, Alan Leung, Lucy Liu
المصدر: Cancer Research. 79:3239-3239
مصطلحات موضوعية: Cancer Research, biology, business.industry, medicine.medical_treatment, CD47, CD137, Antigen presentation, Immunotherapy, Tumor antigen, Blockade, Oncology, Cancer immunotherapy, Cancer research, medicine, biology.protein, Antibody, business
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7
المؤلفون: Victoria Rimkunas, Jian Tang, Alexey Lugovskoy, Rachel Rennard, Kenneth J. Olivier, Lihui Xu, Sergio Iadevaia, Birgit Schoeberl, Bryan Johnson, Jonathan Fitzgerald, Neeraj Kohli, Brian Harms, Jason Baum, Yang Jiao, Sharlene Adams, Ulrik B. Nielsen, Maja Razlog
المصدر: Molecular Cancer Therapeutics. 13:410-425
مصطلحات موضوعية: Cancer Research, Receptor, ErbB-3, Blotting, Western, Mice, Nude, Docetaxel, Mice, SCID, Biology, Pharmacology, Antibodies, Monoclonal, Humanized, Deoxycytidine, Receptor, IGF Type 1, Phosphatidylinositol 3-Kinases, chemistry.chemical_compound, Mice, Inbred NOD, Cell Line, Tumor, Neoplasms, Antibodies, Bispecific, Antineoplastic Combined Chemotherapy Protocols, medicine, Animals, Humans, ERBB3, Everolimus, Receptor, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, Sirolimus, TOR Serine-Threonine Kinases, Xenograft Model Antitumor Assays, Gemcitabine, Tumor Burden, Oncology, chemistry, Cancer cell, Female, Taxoids, Signal transduction, Growth inhibition, Proto-Oncogene Proteins c-akt, Signal Transduction, medicine.drug
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8
المؤلفون: Lihui Xu, Neeraj Kohli, Bryan Johnson, Ulrik B. Nielsen, Jonathan Fitzgerald, Maja Razlog, Rachel Rennard, Kathy Zhang, Jason Baum, Yang Jiao, Jian Tang, Alexey Lugovskoy, Birgit Schoeberl
المصدر: mAbs
مصطلحات موضوعية: Receptor, ErbB-3, High-throughput screening, Immunology, Catumaxomab, CHO Cells, Computational biology, Yeast display, Biology, Protein Engineering, scFv, Receptor, IGF Type 1, ErbB3, Cricetulus, Growth factor receptor, Report, Antibodies, Bispecific, medicine, Animals, Humans, Immunology and Allergy, Avidity, ERBB3, yeast display, Gene Library, library, Antibodies, Monoclonal, Protein engineering, Combinatorial chemistry, High-Throughput Screening Assays, HEK293 Cells, Drug Design, bispecific antibodies, IGF-1R, Single-Chain Antibodies, high throughput screening, medicine.drug
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9
المؤلفون: Alexey Lugovskoy, Rachel Rennard, Dmitri B. Kirpotin, Melissa Geddie, Tad Kornaga, Birgit Schoerberl, James D. Marks, Maja Razlog, Lihui Xu, Neeraj Kohli, Yang Jiao, Daryl C. Drummond
المصدر: mAbs, vol 9, iss 1
مصطلحات موضوعية: 0301 basic medicine, Immunoconjugates, Immunoglobulin Variable Region, Nanoparticle, protein A binding, Protein Engineering, 0302 clinical medicine, Drug Delivery Systems, Immunology and Allergy, Nanotechnology, Thermostability, Cancer, Pediatric, biology, antibody engineering, Chemistry, Protein Stability, Receptor, EphA2, Ephrin-A2, Pharmacology and Pharmaceutical Sciences, 5.1 Pharmaceuticals, 030220 oncology & carcinogenesis, Drug delivery, liposome, Public Health and Health Services, manufacturability, Development of treatments and therapeutic interventions, Receptor, Biotechnology, Antibody-drug conjugate, Immunology, Bioengineering, antibody fragment, EphA2, 03 medical and health sciences, Affinity chromatography, Fragment (logic), Report, developability, Single-chain variable fragment, Animals, Humans, stability, Combinatorial chemistry, 030104 developmental biology, biology.protein, Nanoparticles, Immunization, Protein A, Single-Chain Antibodies
وصف الملف: application/pdf
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10
المؤلفون: Veronica Gabarra, Anne Cheung, Xianjun Cao, Miriam Ramirez, Karen Mclachlan, Yan Ren, Rachel Rennard, Samuel Cho, Ling Ling Chen, Christilyn Graff, Kelsey R Unruh, Heather Huet, Beth Browning
المصدر: Cancer Biology & Therapy. 9:437-445
مصطلحات موضوعية: Integrins, Cancer Research, Integrin, Apoptosis, Breast Neoplasms, Antibodies, Epitope, Cell Line, Breast cancer, Neoplasms, Cell Adhesion, medicine, Humans, Epidermal growth factor receptor, Cell adhesion, PI3K/AKT/mTOR pathway, Integrin alpha6beta4, Pharmacology, biology, medicine.disease, Cell biology, ErbB Receptors, Oncology, Tumor progression, biology.protein, Molecular Medicine, Female, Signal transduction, Signal Transduction
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11
المؤلفون: Kandasamy Hariharan, Melissa Levesque, Angelina Altshuler, William B. Snyder, Christopher L. Reyes, Eric Ailor, Michael Favis, Hon Tran, Flora Huang, Rachel Rennard, Steffan Ho, Michael Shields, Stephen Demarest, Tracey Murphy, C Hession, David Gregson, Scott Glaser, Albert Flavier, Lisa Berquist, Xianjun Cao, Adam Doern, Tracey Snipas, William S. Shestowsky, Susan Tamraz, Xiufeng Wu, Jianying Dong, Ellen Garber, Mitchell Reff, Christilyn Graff, Arlene Sereno, Lindsay J. Cole
المصدر: Journal of Biological Chemistry. 284:10254-10267
مصطلحات موضوعية: Allosteric regulation, Cell Biology, Insulin-Like Growth Factor Receptor, Biology, Ligand (biochemistry), Biochemistry, Epitope, Epitope mapping, Growth factor receptor, Mechanism of action, medicine, medicine.symptom, Receptor, Molecular Biology
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12
المؤلفون: Zhifang Li, Steven D. Miklasz, Joseph V. Bonventre, Takaharu Ichimura, Lourdes Pablo, Patricia Mccoon, Irene Sizing, Veronique Bailly, Paul D. Rennert, Leticia Tarilonte, Rachel Rennard
المصدر: The Journal of Immunology. 177:4311-4321
مصطلحات موضوعية: Adoptive cell transfer, Ovalbumin, Recombinant Fusion Proteins, T-Lymphocytes, T cell, Cellular differentiation, Immunology, Cell, Inflammation, Biology, Mice, Th2 Cells, Immune system, medicine, Animals, Immunology and Allergy, Lung, Mice, Inbred BALB C, Reverse Transcriptase Polymerase Chain Reaction, Effector, Membrane Proteins, Cell Differentiation, Flow Cytometry, Phenotype, Asthma, Mice, Mutant Strains, Rats, Disease Models, Animal, medicine.anatomical_structure, medicine.symptom
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13
المؤلفون: Matt Miller, Kristin Backstrom, Yan Hu, Rachel Rennard, Chuansong Wang, Thomas J. Sferra
المصدر: Molecular Therapy. 10(3):478-491
مصطلحات موضوعية: Genetic enhancement, Transgene, Mucopolysaccharidosis, Genetic Vectors, Mucopolysaccharidosis VII, Spleen, Biology, medicine.disease_cause, Adenoviridae, Injections, 03 medical and health sciences, Mice, 0302 clinical medicine, Peptide Elongation Factor 1, Microscopy, Electron, Transmission, Drug Discovery, Lysosomal storage disease, medicine, Genetics, Animals, Promoter Regions, Genetic, Adeno-associated virus, Molecular Biology, 030304 developmental biology, Glucuronidase, Pharmacology, 0303 health sciences, Gene Transfer Techniques, Genetic Therapy, medicine.disease, Virology, Molecular biology, beta-N-Acetylhexosaminidases, 3. Good health, medicine.anatomical_structure, Liver, Organ Specificity, alpha-Galactosidase, biology.protein, Molecular Medicine, Lysosomes, 030217 neurology & neurosurgery, Acid hydrolase
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14
المؤلفون: Rachel Rennard, Warren D. Lo, Philip R. Johnson, Thomas J. Sferra, K. Reed Clark, Guang Qu, David McNeely
المصدر: Human Gene Therapy. 11:507-519
مصطلحات موضوعية: Central Nervous System, Male, Mucopolysaccharidosis, Genetic enhancement, Genetic Vectors, Biology, Recombinant virus, medicine.disease_cause, Virus, Mice, Lysosome, Genetics, medicine, Lysosomal storage disease, Animals, Humans, Molecular Biology, Adeno-associated virus, DNA Primers, Glucuronidase, Glycosaminoglycans, Recombination, Genetic, Base Sequence, Genetic transfer, Mucopolysaccharidosis VII, Genetic Therapy, Dependovirus, medicine.disease, Virology, medicine.anatomical_structure, Molecular Medicine, Female, Lysosomes, HeLa Cells
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15
المؤلفون: Birgit Schoeberl, Sergio Iadevaia, Jason Baum, Neeraj Kohli, Yang Jiao, Jian Tang, Lihui Xu, Rachel Rennard, Jonathan Fitzgerald, Pragalath Sundararajan, Sharlene Adams, Ulrik B. Nielsen, Alexey Lugovskoy, Bryan Johnson
المصدر: Therapy.
مصطلحات موضوعية: business.industry, Pancreatic tumor, Pancreatic cancer, Medicine, Cancer, P70-S6 Kinase 1, ERBB3, Pharmacology, business, medicine.disease, Autocrine signalling, Protein kinase B, PI3K/AKT/mTOR pathway
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16
المؤلفون: Brian Robert Miller, Rachel Rennard, Flora Huang, Michael Favis, Emma Langley, Arlene Sereno, Eric Chan, Steffan Ho, Cyrus Virata, Ying Zhang, Stephen Demarest, Grace Yco, Antonio Boccia, Kandasamy Hariharan, Sharon X. Gao, James Gamez, Ellen Rohde, Qin Wang, Ronald Morena, Xiufeng Wu, Christilyn Graff, Ingrid B.J.K. Joseph, Jianying Dong, William B. Snyder, Dikran Aivazian, Reff Mitchell E, Scott Glaser, Lisa Berquist, Matt Cantele
المصدر: mAbs. 3(3)
مصطلحات موضوعية: Cell Survival, Immunology, Blotting, Western, Antibody Affinity, Mice, Nude, CHO Cells, Mice, SCID, Insulin-Like Growth Factor Receptor, Biology, Receptor, IGF Type 1, Mice, Cricetulus, Growth factor receptor, Cell surface receptor, Antibody Specificity, Cell Line, Tumor, Cricetinae, Neoplasms, Report, Antibodies, Bispecific, Immunology and Allergy, Animals, Humans, Growth factor receptor inhibitor, ERBB3, Epidermal growth factor receptor, Phosphorylation, Dose-Response Relationship, Drug, Antibodies, Monoclonal, Molecular biology, Xenograft Model Antitumor Assays, Tumor Burden, ErbB Receptors, Tumor progression, Immunoglobulin G, biology.protein, Tyrosine kinase, Signal Transduction, Single-Chain Antibodies
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17
المؤلفون: Wenjie Chang, Lourdes Pablo, Steven D. Miklasz, Meghan E. Walsh, Zhifang Li, Max Dobles, Mohammad Zafari, Martin L. Scott, Rachel Rennard, Irene Sizing, Sambasiva P. Rao, Patricia Mccoon, Leticia Tarilonte, Kevin Godbout, Paul D. Rennert, Gerard R. Majeau, Veronique Bailly
المصدر: Journal of immunology (Baltimore, Md. : 1950). 178(4)
مصطلحات موضوعية: medicine.drug_class, Ovalbumin, T cell, Immunology, Quantitative Trait Loci, Inflammation, Biology, Monoclonal antibody, Epitope, Epitopes, Mice, Immune system, Th2 Cells, medicine, Immunology and Allergy, Animals, Humans, Allele, Lung, Cells, Cultured, Mice, Inbred BALB C, Mucin, Antibodies, Monoclonal, Membrane Proteins, Pneumonia, Asthma, Protein Structure, Tertiary, medicine.anatomical_structure, Cytokines, Female, medicine.symptom, Ex vivo, Epitope Mapping
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18
المصدر: Journal of molecular biology. 307(1)
مصطلحات موضوعية: Protein Conformation, RNA Splicing, Molecular Sequence Data, Exonic splicing enhancer, Neurospora crassa, Structural Biology, Tyrosine-tRNA Ligase, Group I catalytic intron, Amino Acid Sequence, Molecular Biology, Genetics, biology, Sequence Homology, Amino Acid, Ribozyme, Intron, Group II intron, biology.organism_classification, Adenosine Monophosphate, Introns, Recombinant Proteins, Protein Structure, Tertiary, Kinetics, Transfer RNA, RNA splicing, biology.protein, RNA, Tyrosine, Gene Deletion
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19
المؤلفون: Bryan Johnson, Jason Baum, Yang Jiao, Jonathan Fitzgerald, Rachel Rennard, Lihui Xu, Pragalath Sundararajan, Birgit Schoeberl, Alexey Lugovskoy, Jian Tang, Neeraj Kohli, Sharlene Adams, Ulrik B. Nielsen
المصدر: Cancer Research. 72:2719-2719
مصطلحات موضوعية: Antitumor activity, Cancer Research, Bispecific antibody, Oncology, Chemistry, Cancer research, ERBB3, Ligand (biochemistry)
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20
المؤلفون: Ulrik Nilesen, Lihui Xu, Neeraj Kohli, Alexey Lugovskoy, Jonathan Fitzgerald, Jian Tang, Jason Baum, Yang Jiao, Bryan Johnson, Rachel Rennard, Sharlene Adams
المصدر: Molecular Cancer Therapeutics. 10:B205-B205
مصطلحات موضوعية: Cancer Research, business.industry, medicine.drug_class, Growth factor, medicine.medical_treatment, Cancer, Pharmacology, medicine.disease, Monoclonal antibody, Oncology, DU145, Pancreatic cancer, Neuregulin, Medicine, ERBB3, business, Protein kinase B