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المؤلفون: Jennifer M. Johnston, Karen O. Akinsanya, Jason E. Imbriglio, Noel Byrne, Hratch J. Zokian, Sookhee Ha, Scott P. Salowe, Hyewon Youm, George H. Addona, JeanMarie Lisnock, Vijayalakshmi Agnani, Deborah L. Zink, Kake Zhao, Gregory C. Adam, Yusheng Xiong, Brian K. Hubbard, Pravien Abeywickrema, John P. Caldwell, Yongcheng Huang, Jen Baysarowich, Peter Orth, Wonsuk Chang, Juncai Meng, Michael Kavana, James R. Tata, Whitney Lane Petrilli, Rui Liang, Gopal Parthasarathy, Xi Ai, Rachael E. Ford, Zhe Feng, Oksana C. Palyha, Edward DiNunzio, Stephen M. Soisson, Alison M. Strack, Jennifer M. Shipman, Roman S. Erdmann, Zhijian Lu, Sujata Sharma, Jun Lu
مصطلحات موضوعية: Models, Molecular, Thermal shift assay, Serine Proteinase Inhibitors, Clinical Biochemistry, Allosteric regulation, Drug Evaluation, Preclinical, Protein degradation, Ligands, 01 natural sciences, Biochemistry, Small Molecule Libraries, Drug Discovery, Humans, Molecular Biology, Pharmacology, Serine protease, biology, Molecular Structure, 010405 organic chemistry, Chemistry, PCSK9, Proprotein convertase, Ligand (biochemistry), Small molecule, 0104 chemical sciences, Proteolysis, biology.protein, Molecular Medicine, Kexin, Proprotein Convertase 9
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المؤلفون: Nathaniel L. Elsen, Zangwei Xu, Peter J. Dandliker, Peter Saradjian, Keith W. Rickert, Berengere Sauvagnat, Nadya Smotrov, Dawn L. Hall, Elliott B. Nickbarg, Yiping Chen, Sujata Sharma, Kevin J. Lumb, Maria Kornienko, Noel Byrne, Chad Chamberlin, Christine Andrews, Samantha J Allen, Ilona Kariv, Jennifer M. Shipman, Patrick J. Curran, Kevin G. Coleman, Beutel Bruce A, Rachael E. Ford, Victoria Kutilek, Andrew Hashke, Rafael Fernandez, Tianxiao Sun, Matthew Richards, Ryan Boinay
المصدر: SLAS Discovery. 21:608-619
مصطلحات موضوعية: 0301 basic medicine, High-throughput screening, Phenotypic screening, Cell, Druggability, Computational biology, Biology, Ligands, Bioinformatics, 01 natural sciences, Biochemistry, Mass Spectrometry, Analytical Chemistry, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, medicine, TNF Receptor-Associated Factor 5, Reverse pharmacology, 010405 organic chemistry, Drug discovery, NF-kappa B, Transcription Factor RelA, Ligand (biochemistry), Phenotype, High-Throughput Screening Assays, 0104 chemical sciences, 030104 developmental biology, medicine.anatomical_structure, Molecular Medicine, Protein Binding, Signal Transduction, Biotechnology
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المؤلفون: Kevin J. Lumb, Stephen M. Soisson, Jennifer M. Shipman, Gopal Parthasarathy, Dawn L. Hall, Scott A. Johnson, Keith W. Rickert, Rachael E. Ford, Ronald E. Diehl, Samantha J Allen, Paul Zuck, Paul L. Darke, Sanjeev Munshi, John C. Reid
المصدر: Journal of Biological Chemistry. 290:20360-20373
مصطلحات موضوعية: inorganic chemicals, Models, Molecular, G-Protein-Coupled Receptor Kinase 4, Protein Conformation, Molecular Sequence Data, Mitogen-activated protein kinase kinase, Biology, Crystallography, X-Ray, environment and public health, Biochemistry, Substrate Specificity, MAP2K7, Humans, Amino Acid Sequence, Phosphorylation, Kinase activity, Molecular Biology, Sequence Homology, Amino Acid, MAP kinase kinase kinase, Autophosphorylation, Cyclin-dependent kinase 2, Cyclin-dependent kinase 3, Cell Biology, Cell biology, enzymes and coenzymes (carbohydrates), Protein Structure and Folding, Hypertension, biology.protein, bacteria, Cyclin-dependent kinase 9, biological phenomena, cell phenomena, and immunity
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المؤلفون: Harold G. Selnick, Nathaniel L. Elsen, Sangita B. Patel, Dawn L. Hall, John C. Reid, Fred Hess, Maria Kornienko, Hari Kandula, Daniel J. Klein, Rachael E. Ford, Sujata Sharma, Kevin J. Lumb, Stephen M. Soisson, Jennifer M. Shipman
المصدر: Nature chemical biology. 13(6)
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Dimer, Crystal structure, Calorimetry, Crystallography, X-Ray, 01 natural sciences, Models, Biological, Acetylglucosamine, Substrate Specificity, Serine, 03 medical and health sciences, chemistry.chemical_compound, Protein structure, Catalytic Domain, Hydrolase, Humans, Binding site, Threonine, Enzyme Inhibitors, Molecular Biology, Binding Sites, 010405 organic chemistry, Drug discovery, Chemistry, Cell Biology, beta-N-Acetylhexosaminidases, 0104 chemical sciences, Protein Structure, Tertiary, Enzyme Activation, Crystallography, 030104 developmental biology
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المؤلفون: Rachael E. Ford, Ranabir SinhaRoy, Wayne M. Geissler, Sujata Sharma, Keith W. Rickert, Pravien D. Abeywickrema, Noel Byrne, Kelly Ann D. Pryor, John C. Reid, Dawn L. Hall, Ronald E. Diehl, Kevin J. Lumb, Stephen M. Soisson, Jennifer M. Shipman, Sangita B. Patel
المصدر: Acta Crystallographica Section F Structural Biology and Crystallization Communications. 66:702-705
مصطلحات موضوعية: Glycosylation, genetic structures, Biophysics, Gene Expression, macromolecular substances, CHO Cells, Carboxypeptidases, Crystallography, X-Ray, Biochemistry, law.invention, chemistry.chemical_compound, Cricetulus, Structural Biology, law, Cricetinae, Gene expression, Genetics, Animals, Humans, Proline, Crystallization, chemistry.chemical_classification, biology, Chinese hamster ovary cell, Condensed Matter Physics, biology.organism_classification, Carboxypeptidase, Amino acid, chemistry, Crystallization Communications, biology.protein
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6
المؤلفون: Kevin J. Lumb, David Joseph Guerin, Stephen M. Soisson, Jennifer M. Shipman, Kevin J. Wilson, Rachael E. Ford, Jun Lu, Sanjeev Munshi, John C. Reid, Jonathon R. Young, Sangita B. Patel, Maria Kornienko, Elizabeth Stanton, Timothy J. Allison, Dawn L. Hall, Paul L. Darke, Keith W. Rickert, Noel Byrne
المصدر: The Journal of biological chemistry. 286(13)
مصطلحات موضوعية: Conformational change, Receptor Protein-Tyrosine Kinases, C-Mer Tyrosine Kinase, Biology, Spodoptera, Crystallography, X-Ray, Biochemistry, Receptor tyrosine kinase, Protein Structure, Secondary, Cell Line, Structure-Activity Relationship, Protein structure, Proto-Oncogene Proteins, Animals, Humans, Phosphorylation, Molecular Biology, Protein Kinase Inhibitors, c-Mer Tyrosine Kinase, Autophosphorylation, Cell Biology, Small molecule, Protein Structure, Tertiary, Protein kinase domain, Drug Design, Protein Structure and Folding, biology.protein, Biophysics, Protein Binding
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المؤلفون: Sangita B. Patel, Kevin J. Lumb, Pravien D. Abeywickrema, Keith W. Rickert, Rachael E. Ford, Noel Byrne, Stephen M. Soisson, Ronald E. Diehl, Jennifer M. Shipman, Dawn L. Hall, John C. Reid, Sujata Sharma
المصدر: BMC Structural Biology
BMC Structural Biology, Vol 10, Iss 1, p 16 (2010)مصطلحات موضوعية: Molecular Sequence Data, Proline binding, Sequence alignment, Carboxypeptidases, Crystallography, X-Ray, Substrate Specificity, Protein structure, Structural Biology, Catalytic Domain, Hydrolase, Research article, Humans, Amino Acid Sequence, Binding site, lcsh:QH301-705.5, Binding Sites, biology, Sequence Homology, Amino Acid, Rational design, Active site, Carboxypeptidase, Recombinant Proteins, Protein Structure, Tertiary, Biochemistry, lcsh:Biology (General), biology.protein, Sequence Alignment