المؤلفون: Po Hu, Hongzheng Wang, Xiaoxuan Yu, Wenzhuo Sun, Hui Hui, Hui Li, Mengyuan Zhu, Zhanyu Wang, Jingyan Xu, Qinglong Guo, Yingjie Qing

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3178-3192 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: NPC, Niemann-Pick type disease C, Cathepsin D, ATG, autophagy related, NH4Cl, ammonium chloride, Lysosomal damage, Calcium in biology, Hematological malignancies, 0302 clinical medicine, RAB7A, RAS-related protein RAB-7a, K48, lysine 48, LC3, microtubule-associated protein 1 light chain 3, TFEB, transcription factor EB, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, RT-qPCR, real time quantitative PCR, Chemistry, LCD, lysosome-dependent cell death, CaN, calcineurin, P62/SQSTM1, sequestosome 1, Cell biology, TRPML1, transient receptor potential mucolipin 1, medicine.anatomical_structure, Cholesterol, 030220 oncology & carcinogenesis, shRNA, short hairpin RNA, Original Article, CsA, cyclosporine A, DAPI, 4′,6-diamidino-2-phenylindole dihydrochloride, Programmed cell death, AO, acridine orange, CTSD, cathepsin D, LW-218, PBS, phosphate-buffered saline, CTSB, cathepsin B, LMP, lysosome membrane permeabilization, EGTA, ethylene glycol-bis(2-aminoethyl ether)-N,N,N′,N′-tetraacetic acid, RM1-950, Lysosome-dependent cell death, 03 medical and health sciences, Dex, dexamethasone, ROS, reactive oxygen species, FBS, fetal bovine serum, Lysosome, NPC1, NPC intracellular cholesterol transporter 1, medicine, BAF A1, bafilomycin A1, 030304 developmental biology, Cathepsin, PBMCs, peripheral blood mononuclear cells, Lysosomal membrane permeabilization, K63, lysine 63, Cell growth, DCFH-DA, 2,7-dichlorodi-hydrofluorescein diacetate, Autophagy, BID, BH3-interacting domain death agonist, Lysophagy, OD, optical density, TFEB, CCK8, Cell Counting Kit, Therapeutics. Pharmacology, LAMPs, lysosomal-associated membrane proteins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2bc1bb062d92dcf545995a174a1320
http://www.sciencedirect.com/science/article/pii/S2211383521000411

المؤلفون: Liming Chen, Junjie Zhu, Lirong Zhang, Xiaochao Ma, Xueyan Shao, Pei Wang, Xiao-bo Zhong, Yifan Bao

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 171-185 (2020)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: HFD, high-fat diet, HNF4α, hepatocyte nuclear factor 4 alpha, O-18-LA, offspring from parental mice fed with 18 weeks LFD, BMI, body mass index, Overweight, O-18-HA, offspring from parental mice fed with 18 weeks HFD, 0302 clinical medicine, 4-HA, adult mice fed with 4 weeks HFD, Nuclear receptors, EFV, efavirenz, O-8-LA, offspring from parental mice fed with 8 weeks LFD, SULT1A1, sulfotransferase 1A1, General Pharmacology, Toxicology and Pharmaceutics, 2. Zero hunger, 0303 health sciences, MPA, mobile phase A, PXR, pregnane X receptor, Diet-induced obesity, CYP2E1, cytochrome P450 2E1, 18-HA, adult mice fed with 18 weeks HFD, 7-ER, 7-ethoxyresorufin, 3. Good health, Drug metabolizing enzymes, High-fat diet, 18-LA, adult mice fed with 18 weeks LFD, AhR, aryl hydrocarbon receptor, 030220 oncology & carcinogenesis, 4-LA, adult mice fed with 4 weeks LFD, MDZ, midazolam, DMEs, drug-metabolizing enzymes, medicine.symptom, Drug-metabolizing enzymes, CAR, constitutive androstane receptor, Original article, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, RSF, resorufin, Ontogenic expression, MPB, mobile phase B, O-4-LA, offspring from parental mice fed with 4 weeks LFD, Offspring, PBS, phosphate-buffered saline, 8-HA, adult mice fed with 8 weeks HFD, Gapdh, glyceraldehyde-3-phosphate dehydrogenase, O-8-HA, offspring from parental mice fed with 8 weeks HFD, 03 medical and health sciences, Internal medicine, medicine, 030304 developmental biology, PPARα, peroxisome proliferator-activated receptor alpha, business.industry, lcsh:RM1-950, DIO, diet-induced obesity, RT-qPCR, real-time quantitative PCR, NADPH, nicotinamide adenine dinucleotide phosphate, Severe obesity, medicine.disease, Differential effects, Obesity, LFD, low-fat diet, Endocrinology, lcsh:Therapeutics. Pharmacology, Nuclear receptor, CHZ, chlorzoxazone, UGT1A1, uridine diphosphate glucuronosyltransferase 1A1, O-4-HA, offspring from parental mice fed with 4 weeks HFD, NRs, nuclear receptors, SD, standard deviation, business, 8-LA, adult mice fed with 8 weeks LFD, Ahr aryl hydrocarbon receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cf0a5fdc606267df866d8be623f019
http://www.sciencedirect.com/science/article/pii/S2211383519308585

المؤلفون: Pengbo Zhou, Chenyi Yang, Arleen B. Rifkind, Silvia Diani-Moore, Mercedes Paz Rijo

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Polychlorinated Dibenzodioxins, NES, nuclear export signal, TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin, Biochemistry, cytochrome P450 (CYP450), Mice, +siTiPARP, silencing TiPARP by siRNA, AHR, aryl hydrocarbon receptor, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), Basic Helix-Loop-Helix Transcription Factors, mouse embryonic fibroblasts (MEFs), Cells, Cultured, biology, Chemistry, respiratory system, Cullin Proteins, Ubiquitin ligase, Cell biology, E3 ubiquitin ligase, Gene Knockdown Techniques, Infb1, interferon beta 1, Environmental Pollutants, nuclear export, Poly(ADP-ribose) Polymerases, Research Article, Proteasome Endopeptidase Complex, Aryl hydrocarbon receptor nuclear translocator, 3pRNA, 5'-triphosphate RNA, sgRNA, single-guide RNA, CUL4B, cullin 4B, Protein degradation, 03 medical and health sciences, FBS, fetal bovine serum, TCDD-Inducible Poly [ADP-Ribose] Polymerase, Animals, MEFCul4b-null, MEF cell line in which the Cullin 4B gene had been knocked out, Nuclear export signal, Molecular Biology, Transcription factor, aryl hydrocarbon receptor (AHR), 030102 biochemistry & molecular biology, Cell Biology, RT-qPCR, real-time quantitative PCR, Aryl hydrocarbon receptor, MEF, mouse embryonic fibroblast, respiratory tract diseases, TCDD-inducible poly(ADP-ribose) polymerase (TiPARP, PARP7, ARTD14), TiPARP, TCDD-inducible poly(ADP-ribose) polymerase, 030104 developmental biology, Proteasome, Gene Expression Regulation, Receptors, Aryl Hydrocarbon, protein proteasomal degradation, Proteolysis, ARNT, aryl hydrocarbon receptor nuclear translocator, biology.protein, interferon beta 1 (Ifnb1), cullin 4B (CUL4B), LMB, leptomycin B

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e2b5476cf6c1e1f9ee2bcbc8cd8049
https://pubmed.ncbi.nlm.nih.gov/34146543

المؤلفون: Dan Xie, Wensu Wei, Zhen Li, Lijuan Jiang, Minhua Deng, Xiangdong Li, Fangjian Zhou, Pei Dong, Wenhua Lu, Zhiyong Li, Ning Wang, Zhuowei Liu, Zhen Xiang, Jian-ye Liu, Zhen-hua Liu, Chunping Yu, Kai Yao, Yulu Peng, Zhiling Zhang, Yunlin Ye

المصدر: Redox Biology
Redox Biology, Vol 48, Iss, Pp 102201-(2021)

مصطلحات موضوعية: Medicine (General), IHC, Immunohistochemistry, MIBC, muscle invasive bladder cancer, FISH, fluorescence in situ hybridization, OXPHOS, oxidative phosphorylation, Clinical Biochemistry, RNA-binding protein, Mitochondrion, medicine.disease_cause, Biochemistry, WB, western blot, fluids and secretions, Ubiquitin, miRNA, microRNA, circRNA, Biology (General), siRNA, short interfering RNA, RT-qPCR, real time quantitative PCR, biology, Urothelial carcinoma of the bladder, Chemistry, ROS, IP, immunoprecipitation, DEGs, The differentially expressed genes, PFS, progression-free survival, Cell biology, LRPPRC, embryonic structures, shRNA, short hairpin RNA, UCB, Urothelial carcinoma of the bladder, Research Paper, QH301-705.5, ETC, electron transport chain, circRNA, circular RNA, TCA, tricarboxylic acid, OS, overall survival, R5-920, ΔΨm, mitochondrial membrane potential, Downregulation and upregulation, medicine, NMIBC, non-muscle invasive bladder cancer, mt-mRNAs, mRNAs encoded by mitochondrial, Organic Chemistry, FOXM1, Cancer cell, biology.protein, TCGA, The Cancer Genome Atlas, Pentatricopeptide repeat, Carcinogenesis, ROS, Reactive oxygen species

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d6519110da67e6032cff8ea1984f5b
https://doi.org/10.1016/j.redox.2021.102201

المؤلفون: Ijssennagger, Noortje, van Rooijen, Kristel S., Magnúsdóttir, Stefanía, Ramos Pittol, José M., Willemsen, Ellen C.L., de Zoete, Marcel R., Baars, Matthijs J.D., Stege, Paul B., Colliva, Carolina, Pellicciari, Roberto, Youssef, Sameh A., de Bruin, Alain, Vercoulen, Yvonne, Kuipers, Folkert, van Mil, Saskia W.C., dI&I I&I-2, Dep Biomolecular Health Sciences, Pathobiologie, dPB RMSC

المساهمون: Center for Liver, Digestive and Metabolic Diseases (CLDM), dI&I I&I-2, Dep Biomolecular Health Sciences, Pathobiologie, dPB RMSC

المصدر: JHEP Reports, 3(5). Elsevier BV
JHEP reports : innovation in hepatology, 3(5):100344. Elsevier
JHEP Reports, Vol 3, Iss 5, Pp 100344-(2021)
JHEP Reports

مصطلحات موضوعية: medicine.medical_specialty, fpkm, fragments per kilobase of transcript per million mapped reads, medicine.drug_class, Colon, HID, high-iron diamine, RC799-869, KEGG, Kyoto Encyclopedia of Genes and Genomes, Liver-specific Fxr-KO mouse, Fxr-intKO, intestine-specific Fxr knockout, RT qPCR, real-time quantitative PCR, Liver–gut axis, Farnesoid X receptor, Internal medicine, GO, Gene Ontology, Gene expression, Internal Medicine, medicine, Immunology and Allergy, Mucus layer, DSS, dextran sodium sulfate, Fxr-livKO, liver-specific Fxr knockout, Microbiome, Colitis, Receptor, Barrier function, Gut microbiome, IBD, inflammatory bowel disease, Hepatology, Bile acid, Chemistry, BAs, bile acids, Fgfr4, fibroblast growth factor receptor 4, Gastroenterology, Diseases of the digestive system. Gastroenterology, medicine.disease, Fxr-totKO, whole body Fxr knockout, Mucus, Endocrinology, Fxr, farnesoid X receptor, Intestine-specific Fxr-KO mouse, FITC, fluorescein isothiocyanate, Liver-gut axis, Research Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72552e39408b54b1d6b3f7ac049c554
https://research.rug.nl/en/publications/6d114c7d-e702-4429-b4f3-185d79b7792b

المؤلفون: Yanting Xu, Taiyong Yu, Gongshe Yang, Xiaoge Zhou, Xiaochang Chen, Kuilong Huang, Xiaoyu Wang, Chen Zhao, Weijun Pang, Yulong Wang

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, HFD, high-fat diet, OXPHOS, oxidative phosphorylation, NAC, N-acetylcysteine, Adipose tissue, RER, respiratory exchange rate, medicine.disease_cause, Biochemistry, Mice, chemistry.chemical_compound, insulin resistance, LDL, low-density lipoprotein, Adipocyte, GM, growth medium, Brown adipose tissue, DMEM, Dulbecco’s modified Eagle medium, ROS production, TGF, transforming growth factor, Mice, Knockout, NOX4, Cell Differentiation, TG, triglycerides, NOX, NADPH oxidase, Cell biology, TNFα, tumor necrosis factor α, medicine.anatomical_structure, Adipose Tissue, Adipogenesis, Bone Morphogenetic Proteins, Research Article, HDL, high-density lipoprotein, Diet, High-Fat, Bone morphogenetic protein, MCP1, monocyte chemoattractant protein 1, adipogenesis, 03 medical and health sciences, ROS, reactive oxygen species, MCE, mitotic clonal expansion, medicine, Animals, Humans, Molecular Biology, BAMBI, 030102 biochemistry & molecular biology, CCAAT-Enhancer-Binding Protein-beta, NADPH oxidase 4, Membrane Proteins, BAMBI, bone morphogenetic protein and activin membrane-bound inhibitor, RT-qPCR, real-time quantitative PCR, Cell Biology, NADPH, nicotinamide adenine dinucleotide phosphate, Acetylcysteine, BAT, brown adipose tissue, Fatty Liver, 030104 developmental biology, chemistry, CD, chow diet, H&E, hematoxylin and eosin, Reactive Oxygen Species, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa01fa7d58c64d44260d6ff949f10acc
https://doi.org/10.1074/jbc.ra120.014793

المؤلفون: Stefano Braggion, Luca Goitre, Andrea Moglia, Lorenza Trabalzini, Michela Guglielmotto, Eliana Trapani, Marco Forni, Fiorella Biasi, Saverio Francesco Retta, Elisa De Luca

المصدر: Free Radical Biology & Medicine

مصطلحات موضوعية: Central Nervous System, Hemangioma, Cavernous, Central Nervous System, Redox signaling, Original Contributions, NAC, N-acetylcysteine, Free radicals, medicine.disease_cause, Biochemistry, Pathogenesis, KRIT1 Protein, siRNA, short interfering RNA, Regulation of gene expression, chemistry.chemical_classification, KRIT1, Cerebral Cavernous Malformations (CCM), CCM1, c-JUN, Reactive Oxygen Species, Cellular Antioxidant Defense Mechanisms, COX-2, Molecular Mechanisms of CCM Pathogenesis, c-jun, Cellular antioxidant defense mechanisms, Cavernous, Hemangioma, Microtubule-Associated Proteins, Biology, ROS, reactive oxygen species, Downregulation and upregulation, Proto-Oncogene Proteins, Physiology (medical), HUVEC, human umbilical vein endothelial cells, medicine, Animals, Humans, Transcription factor, Loss function, Reactive oxygen species, c-Jun, Cerebral cavernous malformations, JNK Mitogen-Activated Protein Kinases, RT-qPCR, real-time quantitative PCR, MEF, mouse embryonic fibroblast, Gene Expression Regulation, Mutation, Oxidative Stress, CCM, cerebral cavernous malformation, chemistry, Cancer research, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37cfe58d6ce868e505bb880df82f17f4
https://doi.org/10.1016/j.freeradbiomed.2013.11.020

المؤلفون: Yasunori Okada, Yuko Kitagawa, Koji Okabayashi, Tetsuya Tsukamoto, Aya Sasaki, Keisuke Horiuchi, Hirotoshi Hasegawa, Masayuki Shimoda

المصدر: EBioMedicine
EBioMedicine, Vol 5, Iss C, Pp 114-124 (2016)

مصطلحات موضوعية: 0301 basic medicine, PCNA, proliferation cell nuclear antigen, STAT3, signal transducer and activator of transcription 3, Cell, lcsh:Medicine, BrdU, bromodeoxyuridine, Mice, Epidermal growth factor, STAT3, TGF, transforming growth factor, Goblet cell, Epithelial barrier, ADAM, a disintegrin and metalloproteinase, lcsh:R5-920, TNF, tumor necrosis factor, IBD, inflammatory bowel disease, Dextran Sulfate, PI3K, phosphatidylinositol 3-kinase, General Medicine, ErbB Receptors, MMP, matrix metalloproteinase, medicine.anatomical_structure, pEGFR, phosphorylated EGFR, Goblet Cells, Signal transduction, lcsh:Medicine (General), Signal Transduction, Research Paper, A disintegrin and metalloproteinase 17 (ADAM17), Colon, Biology, ADAM17 Protein, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, DSS, dextran sulfate sodium, medicine, Animals, Humans, Colitis, Cell Proliferation, Inflammation, EGF, epidermal growth factor, Cell growth, Tumor Necrosis Factor-alpha, TGM, transglutaminase, lcsh:R, Epithelial Cells, RT-qPCR, real-time quantitative PCR, medicine.disease, Epidermal growth factor receptor (EGFR), pIpC, polyinosinic–polycytidylic acid, EGFR, epidermal growth factor receptor, Disease Models, Animal, UC, ulcerative colitis, 030104 developmental biology, Gene Expression Regulation, Ulcerative colitis, Cancer research, biology.protein, Colitis, Ulcerative, TACE, tumor necrosis factor-α converting enzyme, Transforming growth factor, MAPK, mitogen activated protein kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff524e5587d6f02d41dfbb60c0a6814b
https://pubmed.ncbi.nlm.nih.gov/27077118

المؤلفون: Adedamola, Olayanju, Ian M, Copple, Holly K, Bryan, George T, Edge, Rowena L, Sison, Min Wei, Wong, Zheng-Quan, Lai, Zhi-Xiu, Lin, Karen, Dunn, Christopher M, Sanderson, Ahmad F, Alghanem, Michael J, Cross, Ewa C, Ellis, Magnus, Ingelman-Sundberg, Hassan Z, Malik, Neil R, Kitteringham, Christopher E, Goldring, B Kevin, Park

المصدر: Free Radical Biology & Medicine

مصطلحات موضوعية: Keap1, Carcinoma, Hepatocellular, NF-E2-Related Factor 2, Blotting, Western, Apoptosis, Gclm, glutamate–cysteine ligase regulatory subunit, Brusatol, Free radicals, Cell defense, Real-Time Polymerase Chain Reaction, digestive system, environment and public health, Nrf2, nuclear factor erythroid 2-related factor 2, Nrf2, RT-qPCR, real-time quantitative PCR, Mice, Autophagy, Brucea, Animals, Humans, Hepatocyte, RNA, Messenger, RNA, Small Interfering, AMC, 7-amino-4-methylcoumarin, Cells, Cultured, DNCB, 2,4-dinitrochlorobenzene, Cell Proliferation, Quassins, Toxicity, Reverse Transcriptase Polymerase Chain Reaction, Liver Neoplasms, Original Contribution, respiratory system, Keap1, Kelch-like ECH-associated protein 1, Chemical stress, Oxidative Stress, Gene Expression Regulation, Hepatocytes, HIF-1α, hypoxia-inducible factor 1α, NEM, N-ethylmaleimide, Nqo1, NAD(P)H dehydrogenase quinone 1, IAA, iodoacetamide, NAPQI, N-acetyl-p-benzoquinone imine, Oxidation-Reduction, CDDO-Me, methyl-2-cyano-3,12-dioxooleana-1, 9(11)dien-28-oate, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::0120eae82a5a66da0ccda5377b1d32a8
https://pubmed.ncbi.nlm.nih.gov/25445704

المؤلفون: Alvin P. L. Kwan, Jason L. Johnson, Timothy Gordon Ashlin, Rebecca Claire Salter, Melanie Buckley, Dipak Purshottam Ramji

المصدر: The International Journal of Biochemistry & Cell Biology

مصطلحات موضوعية: Small interfering RNA, RM, Disintegrins, Cytokine action, medicine.medical_treatment, ADAMTS, Signal transduction, Biology, Biochemistry, Article, Small hairpin RNA, Mice, Phosphatidylinositol 3-Kinases, medicine, Animals, Humans, shRNA, small hairpin RNA, BMDM, bone marrow-derived macrophages, Extracellular Signal-Regulated MAP Kinases, ADAMTS, a disintegrin and metalloproteinase with thrombospondin motifs, Protein kinase B, Foam cell, HMDM, human monocyte-derived macrophages, Thrombospondin, DAB, 3,3′-diaminobenzidine, Interleukins, Macrophages, apoE, apolipoprotein E, JNK Mitogen-Activated Protein Kinases, RT-qPCR, real-time quantitative PCR, Cell Biology, Atherosclerosis, Cardiovascular disease, ECM, extracellular matrix, Cell biology, QR, MMP, matrix metalloproteinase, Cytokine, siRNA, small interfering RNA, QR180, Metalloproteases, Cytokines, Thrombospondins, IHC, immunohistochemistry

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968f7353be9b7a06a7a9e530fac905a0
https://orca.cardiff.ac.uk/id/eprint/65716/1/1-s2.0-S1357272513003464-main.pdf__tid=4994b224-5083-11e4-9240-00000aab0f6b&acdnat=1412948733_ab40ab8e9249049343d192644d816bb3

المؤلفون: Mary L. Nordberg, Ian F. Pollack, Ronald L. Hamilton, Marie E. Beckner

المصدر: BBA Clinical

مصطلحات موضوعية: 0301 basic medicine, SLC, solute carrier, HKG, housekeeping gene, ATP citrate lyase, DAPI, diaminephylindole, EGFR, Amplified oncogenes, Biology, WHO, World Health Organization, Pathology and Forensic Medicine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, XIAP, Physiology (medical), Carbonic anhydrase, Glycolysis, ddCt, delta-delta crossing threshold, MPNST, malignant peripheral nerve sheath tumor, Gene, CN, copy number, GOI, gene of interest, RT-qPCR, real time quantitative PCR, Oncogene, Glycogen, RNF139, Regular Article, MLPA, multiplex ligation-dependent probe amplification, REMBRANDT, Repository of Molecular Brain Neoplasia Database, Molecular biology, GB, glioblastoma, 030104 developmental biology, HIF1A, chemistry, IRES, internal ribosome entry site, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Molecular Medicine, NB, normal brain, MTB/GF, metabolic/growth factor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3b27277af7c35ec9cc2a84f2522647