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المؤلفون: Bernard L. Flynn, Ruth R Magaye, Xin Xiong, Peter J Meikle, Danny Liew, Feby Savira, Kevin Huynh, David M. Kaye, Bing Hui Wang, Christopher M. Reid
المصدر: International Journal of Cardiology. Heart & Vasculature
International Journal of Cardiology: Heart & Vasculature, Vol 35, Iss, Pp 100837-(2021)مصطلحات موضوعية: RPS6, ribosomal protein S6, S1PR1, sphingosine -1-phosphate receptor 1, MMP2, matrix metalloproteinase 2, Sphingolipid, MA3PK, mitogen activated protein kinase kinase kinase, chemistry.chemical_compound, S1P, sphingosine-1 Phosphate, Sph, sphingosine, TIMP1, tissue inhibitor of metalloproteinase 1, TGFβ, transforming growth factor β, Medicine, S1PR1, Cardiac fibroblasts, biology, Dihydrosphingosine, Cell biology, S1PRs, sphingosine 1 phosphate receptor 1-5, Collagen synthesis, Sphingosine kinase 1, Coll1a1, collagen 1a1, mTOR, mammalian target for rapamycin, d7dhSph, deuterated dihydrosphingosine, lipids (amino acids, peptides, and proteins), MAPK, mitogren activated protein kinase, Cardiology and Cardiovascular Medicine, Ceramide, Cer, ceramide, SK1, sphingosine kinase 1, TAK1, transforming growth factor β activating kinase 1, CTGF, connective tissue growth factor, TGFβ, TGF beta signaling pathway, Diseases of the circulatory (Cardiovascular) system, Cer1P, ceramide 1 phosphate, Sphingosine-1-phosphate, NCF, neonatal cardiac fibroblasts, ComputingMethodologies_COMPUTERGRAPHICS, Original Paper, dhCer, dihydroceramide, Sphingosine, business.industry, dhS1P, dihydrosphingosine 1 phosphate, Degs1, dihydroceramide desaturase 1 gene, chemistry, RC666-701, ECM, extracellular matrix inhibitor of nuclear kappa B (NFKβ) kinase alpha and beta (IKKα/β), Akt, protein kinase B, biology.protein, MI, myocardial infarct, business, Des-1, dihydroceramide desaturase 1 enzyme, Transforming growth factor
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المؤلفون: Ruixia Dong, Pingping Chen, Chung S. Yang, Xiaoxiao Wang, Ke Zhang, Jinsong Zhang, Dongxu Wang
المصدر: Redox Biology, Vol 10, Iss C, Pp 221-232 (2016)
Redox Biologyمصطلحات موضوعية: 0301 basic medicine, Antioxidant, medicine.medical_treatment, Thioredoxin reductase, NQO1, NAD(P)H:quinone oxidoreductase 1, Clinical Biochemistry, Glutathione reductase, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, RIPA, tissue fluid of fast pyrolysis, AST, aspartate aminotransferase, Nrf2 response, Biochemistry, Nrf2, nuclear factor erythroid 2-related factor 2, Antioxidants, Catechin, GST, glutathione S-transferase, RT-PCR, reverse transcriptase polymerase chain reaction, chemistry.chemical_compound, Mice, EDTA, ethylene diamine tetraacetic acid, Thioredoxins, Glutaredoxin, GSH, glutathione, GR, glutathione reductase, Trx, thioredoxin, heterocyclic compounds, IL-6, interleukin-6, lcsh:QH301-705.5, HO1, heme oxygenase 1, EGCG, epigallocatechin-3-gallate, lcsh:R5-920, GPx, glutathione peroxidase, Epigallocatechin-3-gallate, GSSG, oxidized glutathione, food and beverages, BSO, buthionine sulfoximine, IL-10, interleukin-10, FoxO, Forkhead box class O, Thioredoxin system, Glutathione, CDNB, 1-chloro-2, 4-dinitrobenzene, Glutathione Reductase, Grx, glutaredoxin, H2O2, hydrogen peroxide, PBS, phosphate buffer solution, qPCR, quantitative polymerase chain reaction, RT, room temperature, Thioredoxin, ECL, enhanced chemiluminescense, lcsh:Medicine (General), Signal Transduction, Research Paper, inorganic chemicals, TrxR, thioredoxin reductase, Glutathione system, Thioredoxin-Disulfide Reductase, PVDF, polyvinylidene fluoride, SDS, sodium dodecyl sulfate, NF-E2-Related Factor 2, Rps6, ribosomal protein S6, UPLC, ultra-high performance liquid chromatography, Biology, complex mixtures, RNS, reactive nitrogen species, Se, selenium, 03 medical and health sciences, Selenium, ROS, reactive oxygen species, Sp1/Sp3, specificity protein 1/3, Thioredoxin Reductase 1, IL-2, interleukin-2, ALT, alanine aminotransferase, 4-HNE, 4-hydroxynonenal, SOD, superoxide dismutase, medicine, Animals, Glutaredoxins, Organic Chemistry, γ-H2AX, phosphorylated histone 2AX, NADHP, nicotinamide-adenine dinucleotide phosphate, SelP, selenoprotein P, 030104 developmental biology, chemistry, Gene Expression Regulation, lcsh:Biology (General), Sec, selenocysteine, Keap1, kelch-like ECH-associated protein 1, Prx, peroxiredoxin, NAD+ kinase, QQQ-MS/MS, triple quadrupole mass spectrometer, sense organs, Reactive Oxygen Species, TBS-T, tris-buffered saline with 0.05% Tween 20
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المصدر: EBioMedicine
مصطلحات موضوعية: 0301 basic medicine, Keratinocytes, Research paper, TF, transcription factor, TA, transactivation, 4EBP1, eukaryotic initiation factor 4E binding protein 1, Human skin, Glucocorticoid receptor, Wortmannin, chemistry.chemical_compound, Mice, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, ChIP, Chromatin immunoprecipitation, DEG, differentially expressed gene, GR, Glucocorticoid receptor, DDIT4, DNA damage inducible transcript 4, Medicine, Phosphorylation, TR, transrepression, Cells, Cultured, NF-κB, nuclear factor kappa B, Transrepression, Phosphoinositide-3 Kinase Inhibitors, Skin, SEGRAM, selective glucocorticoid receptor agonist or modulator, DDIT4, biology, TOR Serine-Threonine Kinases, REDD1, General Medicine, REDD1, regulated in development and DNA damage response 1, 3. Good health, FKBP51, FK506-binding protein, 030220 oncology & carcinogenesis, mTOR, WM, Wortmannin, rpS6, ribosomal protein S6, Glucocorticoid, medicine.drug, Skin atrophy, Cell Survival, CO, croton oil, FA, Fluocinolone acetonide, General Biochemistry, Genetics and Molecular Biology, Tacrolimus Binding Proteins, 03 medical and health sciences, Receptors, Glucocorticoid, Animals, Humans, Protein kinase B, Glucocorticoids, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, GRE, glucocorticoid responsive element, business.industry, PI3K/mTOR/Akt inhibitor, FC, fold change, Mice, Inbred C57BL, 030104 developmental biology, FKBP51, chemistry, biology.protein, Cancer research, mTOR, mammalian target of Rapamycin, Atrophy, business, Transcriptome, Proto-Oncogene Proteins c-akt, Transcription Factors
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المؤلفون: Xiu-Fen Ming, Gautham Yepuri, Michael Forbiteh, Zhihong Yang, Jean-Pierre Montani, Yuyan Xiong, Yi Yu
المصدر: Autophagy
مصطلحات موضوعية: Baf A1, bafilomycin A1, WT, wild type, RPS6, ribosomal protein S6, senescence, AMP-Activated Protein Kinases, ARGINASE, mTORC2, ARG1, arginase 1, 0302 clinical medicine, ARG2, arginase 2, LC3, microtubule-associated protein 1 light chain 3, LDL, low-density lipoprotein, SA-ß-gal, senescence-associated-β-gal, AKT/PKB, v-akt murine thymoma viral oncogene homolog 1, ANOVA, analysis of variance, Cellular Senescence, 0303 health sciences, BECN1, Beclin 1, autophagy-related, NOS3/eNOS, nitric oxide synthase 3 (endothelial cell), MTOR, Three-MA, 3-methyladenine, nor-NOHA, Nω-hydroxy-nor-Arginine, TOR Serine-Threonine Kinases, endothelial cells, RPS6KB1/S6K1, ribosomal protein S6 kinase, 70kDa, polypeptide 1, Atg, autophagy-related, 030220 oncology & carcinogenesis, Ribosomal protein s6, shRNA, short hairpin RNA, AR, aortic roots, SMC, smooth muscle cells, HAEC, human aortic endothelial cells, PtdIns3K, phosphatidylinositol 3-kinase, Signal Transduction, VWF, von Willebrand factor, autophagy, Basic Research Papers, MTOR, mechanistic target of rapamycin, Mice, Transgenic, P70-S6 Kinase 1, Mechanistic Target of Rapamycin Complex 2, Mechanistic Target of Rapamycin Complex 1, Biology, PE, phosphatidylethanolamine, Diet, High-Fat, apoe−/−, Apolipoprotein E-deficient, TP53/p53, tumor protein 53, 03 medical and health sciences, HUVEC, human umbilical vein endothelial cells, Animals, Humans, Protein kinase A, Molecular Biology, Mechanistic target of rapamycin, SQSTM1/p62, sequestosome 1, PI3K/AKT/mTOR pathway, H160F, inactive mutant of mouse ARG2, 030304 developmental biology, PRKAA/AMPK, protein kinase, AMP-activated, α catalytic subunit, EC, endothelial cell, Autophagy, arg2−/−, arginase type II deficient, AMPK, CMV, cytomegalovirus, Cell Biology, Atherosclerosis, BEC, S-12 bromoethyl-L-cystine-HCl, ULK1, unc-51 like autophagy activating kinase 1, Multiprotein Complexes, Cancer research, biology.protein, PRKAA
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المؤلفون: Brian K. Law, Jae-Sung Kim, Pouran Habibzadegah-Tari, Xiao Ming Yin, Min Li, S. Keisin Wang, Nicole A. Horenstein, David A. Ostrov, William A. Dunn, Debra Akin
المصدر: Autophagy
مصطلحات موضوعية: DMEM, Dulbecco's modified Eagle medium, RPS6, ribosomal protein S6, BECN1, beclin 1, autophagy related, ULK1/2, unc-51-like autophagy activating kinase 1/2, Aminopyridines, Autophagy-Related Proteins, IC50, half maximal inhibitory concentration, Vacuole, ECL, enhanced chemiluminescence, Translational Research Papers, GST, glutathione S-transferase, PVDF, polyvinylidene difluoride, RFP, red fluorescent protein, Mice, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, ATG, autophagy-related, Catalytic Domain, LC3B, GFP, green fluorescent protein, MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3beta, Osteosarcoma, 0303 health sciences, Kinase, TOR Serine-Threonine Kinases, dNGLUC, Gaussia luciferase, HRP, horseradish peroxidase, ACTB, actin, beta, Lipids, 3. Good health, ATG4B, Gene Expression Regulation, Neoplastic, Cysteine Endopeptidases, FYVE, zinc-finger domain named after 4 cysteine-rich proteins: FAB1, YOTB, VAC1, and EEA1, and xenografts, 030220 oncology & carcinogenesis, CMPase, cytidine monophosphatase, Female, PtdIns3P, phosphatidylinositol 3-phosphate, IP, intraperitoneal, MTOR, mechanistic target of rapamycin, Green Fluorescent Proteins, ATG4B, autophagy-related 4B, cysteine protease, Mice, Nude, Cysteine Proteinase Inhibitors, Protein degradation, Biology, SEM, standard error of the mean, MP, melting point, 03 medical and health sciences, NCI, National Cancer Institute, antiautophagy compounds, In vivo, Cell Line, Tumor, Autophagy, medicine, Animals, Humans, Computer Simulation, RPS6KB1, ribosomal protein S6 kinase, 70kDa, polypeptide 1, NMR, nuclear magnetic resonance, Molecular Biology, PI3K/AKT/mTOR pathway, 030304 developmental biology, GABARAPL2, GABA(A) receptor-associated protein-like 2, PtdIns3K, phosphatidylinositol 3-kinase class III, PLA2, phospholipase A2, Cell Biology, in silico docking, medicine.disease, Molecular biology, In vitro, HEK293 Cells, AV, autophagic vacuole, RLU, relative luciferase units, Cancer research, Neoplasm Transplantation, 3MA, 3-methyladenine
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المؤلفون: Grasso, Silvina, Tristante, Elena, Saceda, Miguel, Carbonell, Pablo, Mayor-López, Leticia, Carballo-Santana, Mar, Carrasco-García, Estefanía, Rocamora-Reverte, Lourdes, García-Morales, Pilar, Carballo, Fernando, Ferragut, José A., Martínez-Lacaci, Isabel
المصدر: Neoplasia (New York, N.Y.)
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, RPS6, ribosomal protein S6, Class I Phosphatidylinositol 3-Kinases, Article, Piperazines, Proto-Oncogene Proteins p21(ras), Phosphatidylinositol 3-Kinases, ERK, extracellular signal-regulated kinase, Cell Line, Tumor, Proto-Oncogene Proteins, Antineoplastic Combined Chemotherapy Protocols, Humans, Molecular Targeted Therapy, Phosphorylation, Protein Kinase Inhibitors, Cell Proliferation, Mitogen-Activated Protein Kinase 1, Ribosomal Protein S6, Mitogen-Activated Protein Kinase 3, Cell Cycle, p70S6K, p70 S6 kinase, Imidazoles, Ribosomal Protein S6 Kinases, 70-kDa, RSK, p90 ribosomal S6 kinase, Enzyme Activation, Drug Resistance, Neoplasm, CRC, colorectal cancer, Mutation, Quinolines, ras Proteins, Benzimidazoles, Colorectal Neoplasms, MEK, mitogen-activated protein kinase
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المؤلفون: Grasso S, Tristante E, Saceda M, Carbonell P, Mayor-López L, Carballo-Santana M, Carrasco-García E, Rocamora-Reverte L, García-Morales P, Carballo F, Ferragut JA, Martínez-Lacaci I
المصدر: Neoplasia
r-FISABIO. Repositorio Institucional de Producción Científica
instname
Europe PubMed Central
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) -
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المؤلفون: Calum C. Bain, Foo Y. Liew, Ananda S. Mirchandani, Anne-Gaelle Besnard, Neil C. Thomson, Robert J. Salmond
المصدر: The Journal of Allergy and Clinical Immunology
مصطلحات موضوعية: S6K1, Ribosomal protein S6 kinase 1, AHR, Airway hyperresponsiveness, medicine.medical_treatment, Mice, 0302 clinical medicine, PI3K, Phosphoinositide 3-kinase, Immunology and Allergy, TSLP, Thymic stromal lymphopoietin, Cells, Cultured, Mice, Knockout, 0303 health sciences, Immunity, Cellular, Mice, Inbred BALB C, Interleukin-13, TOR Serine-Threonine Kinases, Innate lymphoid cell, rpS6, Ribosomal protein S6, 3. Good health, ICOS, Inducible costimulator, Class Ia Phosphatidylinositol 3-Kinase, TH2, Cytokine, Interleukin 13, mTOR(C1/2), Mammalian target of rapamycin (complex 1/2), Mechanisms of Allergy and Clinical Immunology, medicine.symptom, Signal Transduction, BAL, Bronchoalveolar lavage, WT, Wild-type, APC, Allophycocyanin, Immunology, innate lymphoid cells, P70-S6 Kinase 1, Inflammation, Biology, 03 medical and health sciences, Th2 Cells, ILC, Innate lymphoid cell, medicine, Animals, Humans, PI3K/AKT/mTOR pathway, 030304 developmental biology, mammalian target of rapamycin, Phosphoinositide 3-kinase, rapamycin, Interleukins, Ribosomal Protein S6 Kinases, PE, Phycoerythrin, Pneumonia, Receptors, Interleukin, asthma, Interleukin-33, Interleukin-1 Receptor-Like 1 Protein, Immunity, Innate, TCR, T-cell receptor, Cancer research, biology.protein, IL-33, Cytokine secretion, Interleukin-5, Lin, Lineage-specific marker, 030215 immunology
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المؤلفون: Zakaria, Albatoul, Berthault, Claire, Cosson, Bertrand, Jung, Vincent, Guerrera, Ida Chiara, Rachdi, Latif, Scharfmann, Raphael
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: SUnSET, surface sensing of translation, insulin, glucose metabolism, TCA, tricarboxylic acid, mTOR, mammalian target of rapamycin, translation regulation, eIF, eukaryotic initiation factor, Cell Line, FACS, fluorescence-activated cell sorting, Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit, Insulin-Secreting Cells, 4EBP1, 4E-binding protein 1, Insulin Secretion, Humans, RNA, Messenger, TOR Serine-Threonine Kinases, human beta cell (β-cell), PCSK1, proprotein convertase subtilisin/kexin type 1, RAPA, rapamycin, tricarboxylic acid cycle (TCA cycle/Krebs cycle), Glucose, Proprotein Convertase 1, Protein Biosynthesis, PKA, protein kinase A, Puromycin, Mitogen-Activated Protein Kinases, Energy Metabolism, rpS6, ribosomal protein S6, MAPK, mitogen-activated protein kinase, Research Article, PRKAR2A, protein kinase type II-alpha regulatory subunit 1, Signal Transduction