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1Academic Journal
المؤلفون: Liyuan Zhang, Rongze Tang, Dongli Liang, Wenfeng Wang, Kaijun Min, Tingrong Luo, Xiaoning Li
المصدر: Cells, Vol 13, Iss 13, p 1165 (2024)
مصطلحات موضوعية: CSFV (classical swine fever virus), TRAF1 (tumor necrosis factor receptor (TNF-R)-associated factor 1), RIG-I (retinoic acid-inducible gene I), MAVS (mitochondrial antiviral-signaling protein), IRF1 (interferon regulatory factor 1), ISG15 (interferon-stimulating gene 15), Cytology, QH573-671
وصف الملف: electronic resource
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المؤلفون: Maryam Meskini, Mojgan Sheikhpour, Seyed Davar Siadat, Mina Rezghi Rami, Soumya Ghosh, Parang Maroofi
المصدر: Journal of Infection and Public Health
Journal of Infection and Public Health, Vol 14, Iss 10, Pp 1284-1298 (2021)مصطلحات موضوعية: CRP, C reactive protein, Coronaviruses, Epidemiology, RIG-I, retinoic acid-inducible gene I, Infectious and parasitic diseases, RC109-216, medicine.disease_cause, Disease Outbreaks, MERS-CoV, middle east respiratory syndrome coronavirus, PRRs, pattern recognition receptors, TLR-3, toll-like receptors 3, PHEIC, public health emergency of international concern, COVID-19, coronavirus disease 2019, education.field_of_study, biology, ADE, antibody-dependent enhancement, FcγR, Fcγ receptors, Common cold, General Medicine, CXCL10, C-X-C motif chemokine 10, Europe, Infectious Diseases, Middle East Respiratory Syndrome Coronavirus, WHO, world health organization, Public aspects of medicine, RA1-1270, medicine.symptom, IP-10, interferon gamma-induced protein 10, MIP, macrophage inflammatory protein, medicine.medical_specialty, Middle East respiratory syndrome coronavirus, SARS-CoV, severe acute respiratory syndrome coronavirus, MCP-1, monocyte chemoattractant protein 1, HLH, hemophagocytic lymphohistiocytosis, Immunology, Population, ACE2, angiotensin-converting enzyme 2, MERS, middle east respiratory syndrome, PAMPs, pathogen-associated molecular patterns, medicine, Humans, SARS, severe acute respiratory syndrome, education, ARDS, acute respiratory distress syndrome, SARS-CoV-2, business.industry, C-reactive protein, Public Health, Environmental and Occupational Health, COVID-19, Outbreak, Original Articles, medicine.disease, Neutrophilia, MDA5, melanoma differentiation-associated protein 5, Africa, biology.protein, Middle East respiratory syndrome, business
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المؤلفون: Li Xue, Xue-Qin Yang, Jun-Rong Du, Dongke Yu, Hui Li
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 3, Pp 475-487 (2020)مصطلحات موضوعية: ved/biology.organism_classification_rank.species, Cognitive decline, Gut flora, TNF-α, tumor necrosis factor-α, NF-κB, law.invention, TLR4, toll-like receptor 4, ZO-1, zona occluden-1, RIG-I, Probiotic, 0302 clinical medicine, Lactobacillus acidophilus, law, TLR4, General Pharmacology, Toxicology and Pharmaceutics, F/B, Firmicutes/Bacteroidetes, BBB, blood–brain barrier, IL-6, interleukin-6, Microbiota–gut–brain axis, 0303 health sciences, biology, HE, hematoxylin and eosin, SYN, synaptophysin, ELISA, enzyme-linked immunosorbent assay, MCI, mild cognitive impairment, 030220 oncology & carcinogenesis, LPS, lipopolysaccharide, AD, Alzheimer's disease, SAMP8 mice, IHC, immunohistochemistry, NMDS, non-metric multidimensional scaling, PAMP, pathogen-associated molecular pattern, medicine.medical_specialty, Lactobacillus casei, Original article, Gut–brain axis, Iba-1, ionized calcium binding adaptor molecule-1, NF-κB, nuclear factor-κB, digestive system, CFU, colony-forming units, VE-cadherin, vascular endothelial-cadherin, 03 medical and health sciences, Internal medicine, medicine, OTU, operational taxonomic unit, TEM, transmission electron microscopy, 030304 developmental biology, Bifidobacterium bifidum, SAMP8, senescence-accelerated mouse prone 8, ved/biology, RIG-I, retinoic-acid-inducible gene-I, Probiotics, lcsh:RM1-950, GFAP, glial fibrillary acidic protein, biology.organism_classification, lcsh:Therapeutics. Pharmacology, Endocrinology, AAMI, age-associated memory impairment, 8-OHdG, 8-hydroxydesoxyguanosine
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المؤلفون: Kennosuke Ichikawa, Yuzuha Motoe, Hiroyuki Horiuchi, Ryo Ezaki, Mei Matsuzaki
المصدر: Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 27, Iss, Pp 101084-(2021)مصطلحات موضوعية: Innate immune response, animal structures, Knock-in, DSB, DNA double-strand break, QH301-705.5, animal diseases, viruses, AIV, avian influenza virus, Biophysics, chemical and pharmacologic phenomena, Avian influenza virus, RIG-I, retinoic acid-inducible gene I, QD415-436, Biology, Retinoic acid-inducible gene I, Biochemistry, IRF7, interferon regulatory factor 7, OASL, 2′-5′-oligoadenylate synthase-like protein, Immune system, Downregulation and upregulation, Gene knockin, Precise integration into target chromosome, ISG, interferon-stimulated gene, Biology (General), Receptor, Gene, Innate immune system, HPAIV, highly pathogenic avian influenza virus, RIG-I, RLR, RIG-I-like receptor, virus diseases, LPAIV, low pathogenic avian influenza virus, ISRE, IFN-stimulated response element, Molecular biology, IRF7, IFNs, interferons, Interferons, MMEJ, microhomology-mediated end-joining, Research Article, PITCh, precise integration into target chromosome
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المصدر: International Immunopharmacology
مصطلحات موضوعية: RhoB, Ras homolog gene family member B, M-CSF, Macrophage CSF, PPP2CA, Protein phosphatase 2 catalytic subunit alpha, RNA pol, RNA polymerase, medicine.medical_treatment, IRF, IFN regulatory factor, v-miRNA, Viral miRNA, DCs, Dendritic cells, MyD88, Myeloid differentiation factor 88, ISGs, IFN-stimulated genes, TLRs, Toll-like receptors, AT1R, Ang II receptor type 1, KCNQ1OT1, KCNQ1 overlapping transcript 1, CYLD, Cylindromatosis, IFNs-I, Type I IFNs, TNF-α, Tumor necrosis factor alpha, cPLA2, Cytoplasmic phospholipase A2, LPS, Lipopolysaccharide, Th cells, T helper cells, LPLs, Lysophospholipids, NLRP3, NOD-, LRR- and pyrin domain-containing protein 3, siRNAs, Small interfering RNAs, CNS, Central nervous system, pri-miRNAs, Primary miRNAs, MDA5, Melanoma differentiation-associated protein 5, ERK, Extracellular signal-regulated kinase, MERS-CoV, Middle East respiratory syndrome coronavirus, BBB, Blood-brain barrier, OxPLs, Oxidized phospholipids, MODS, Multiple organ dysfunction syndrome, mPGES-1, Microsomal prostaglandin E synthase-1, RNAi, RNA interference, ADAM17, A disintegrin and metalloproteinase 17, AGO, Argonaute, CRISPR, Cas13 family of clustered regularly interspaced short palindromic repeats, DAMPs, Damage-associated molecular patterns, circRNAs, Circular RNAs, CD, Cluster of differentiation, JAK, Janus kinase, TNFR, TNF receptor, Cytokine Release Syndrome, TRIM27, Tripartite motif-containing protein 27, gp130, Glycoprotein 130, MMP, Matrix metalloproteinase, 2019-nCoV, 2019 novel coronavirus, CCL, C-C motif chemokine ligand, SOCS3, Suppressor of cytokine signaling 3, Immunology, COX, Cyclooxygenase, Sry, Sex-determining region Y, Article, S protein, Spike protein, microRNA, Humans, K, Lysine, CSF, Colony-stimulating factor, RGMB-AS1, RGMB antisense RNA 1, TIMP-I, Tissue inhibitors of matrix metalloproteinases-I, S100A9, S100 calcium-binding protein A9, Pharmacology, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, NOXs, Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, CHD, Coronary heart disease, STAT, Signal transducer and activator of transcription, Virus Internalization, medicine.disease, Viral replication, NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells, miRNAs-based therapy, TBK1, TANK-binding kinase 1, ORF, Open reading frame, SOFA, Sequential organ failure assessment score, lncRNAs, Long non-coding RNAs, CatB/L, Cathepsin B/L, sIL-6R, Soluble IL-6R, ROS, Reactive oxygen species, EAE, Experimental autoimmune encephalomyelitis, RBCs, Red blood cells, MAPK, Mitogen-activated protein kinase, PBMCs, Peripheral blood mononuclear cells, N protein, Nucleocapsid protein, Ig, Immunoglobulin, Cytokine storm, Bioinformatics, Virus Replication, 3'-UTR, 3'-untranslated region, H3, Histone 3, AGEs, Advanced glycation end products, Renin-Angiotensin System, XPO5, Exportin-5, G-CSF, Granulocyte CSF, CXCL, C-X-C motif chemokine ligand, DIC, Disseminated intravascular coagulation, Immunology and Allergy, IL, Interleukin, PG, Prostaglandin, RAS, Renin-Angiotensin system, Amp, Amplifier, MCs, Mast cells, COVID-19, Coronavirus disease 2019, HSP, Heat shock protein, AA, Arachidonic acid, ASOs, Antisense oligonucleotides, IFN, Interferon, mRNA, Messenger RNA, ICU, Intensive care unit, Cytokine, RAGE, Receptor for advanced glycation end products, mIL-6R, Membrane IL-6 receptor, FOXO3, Forkhead box O3, miRNAs, LTs, Leukotrienes, miRISC, MicroRNA-induced silencing complex, IκB-ζ, Inhibitor of nuclear factor kappa B zeta, Signal transduction, me3, Trimethylation, M protein, Membrane protein, APJ, Apelin receptor, AP-1, Activator protein 1, TMPRSS2, Transmembrane serine protease 2, PRR, Pattern recognition receptor, GM-CSF, Granulocyte-macrophage CSF, RIG-I, Retinoic acid-inducible gene I, E protein, Envelope protein, Biology, hsa, Homo sapiens, TXs, Thromboxanes, LOXs, Lipoxygenases, Virus, ER, Endoplasmic reticulum, ARDS, Acute respiratory distress syndrome, Gene regulators, medicine, me2, Dimethylation, Animals, PKCα, Protein kinase C alpha, pre-miRNAs, Precursor miRNAs, DMVs, Double membrane vesicles, ceRNAs, Competing endogenous RNAs, nsp, Non-structural protein, Competing endogenous RNA, SARS-CoV-2, ALI, Acute lung injury, PaO2/FiO2, Pressure of arterial oxygen to fractional inspired oxygen concentration, COVID-19, ACE, Angiotensin-converting enzyme, ANRIL, Antisense noncoding RNA in the INK4 locus, miRNAs, MicroRNAs, MEG3, Maternally expressed gene 3, Review article, MicroRNAs, DMD, Dense matted deposits, TAB, Transforming growth factor β-activated kinase-1 (TAK1)-binding protein, HMGB1, High mobility group box protein 1, Ang, Angiotensin
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المؤلفون: Murat Kizil, Muhammad Akram, Ahmet Çağkan İnkaya, Aziz Rodan Sarohan, Shokhan Mahmud, Osman Cen
المساهمون: Dicle Üniversitesi, Fen Bilimleri Enstitüsü, Kimya Ana Bilim Dalı, Kızıl, Murat
المصدر: Cellular Signalling
مصطلحات موضوعية: CRABP-1, cytoplasmic retinoic acid binding protein 1, CRBP-I, cytoplasmic retinol binding protein 1, TRAF, TNF receptor (TNF-R)-associated factor, Autoimmunity, PPAR, peroxisome proliferator-activated receptor, T-Lymphocytes, Regulatory, NF-κB, nuclear factor kappa light chain enhancer of activated B cells, RIG-I, Medicine, ATRA, All-trans retinoic acid, CDC, Centers for Disease Control and Prevention, IRF, interferon-regulatory factors, COVID-19, coronavirus disease 2019, Retinol, RARE, retinoic acid response elements (regulatory DNA sequences bound by retinoic acid receptors), FOXP3, VitD, vitamin D, STAT, signal transducer and activator of transcription, Interferon Type I, RORγt, CYP450, Article, WHO, World Health Organization, VitA, vitamin A, FoxP3, Retinoic acid, Humans, Type-I IFN, Type I interferon (IFN-α and IFN-β), MDA5, melanoma differentiation-associated protein 5, Viral Tropism, GluR1, glutamate receptor 1, PRR, pattern recognition receptors, Immunology, Interferon type I, MAPK, mitogen-activated protein kinase, Central Nervous System, sTNFRSF1A, soluble TNF receptor superfamily member 1A, Erk, extracellular-signal-regulated kinase, medicine.disease_cause, TGF-β, transforming growth factor-beta, NF-κB, Pathogenesis, IL, interleukin cytokines, Interferon, PI3K, Phosphatidylinositol-3-Kinase, BALF, bronchoalveolar lavage fluid, RA, retinoic acid, FoxP3, Forkhead box P3 transcription factor, Retinoid, Receptors, Immunologic, Vitamin D, Vitamin A, RIG-I, retinoic acid-inducible gene-I, NCoA, nuclear receptor co-activators, IL2RA, interleukin 2 receptor-alpha subunit, Lyn, Lyn protein kinase, a member of Src family tyrosine kinases, RLR, RIG-I-like receptor, VAD, vitamin A deficiency, Treg, RDH, retinol dehydrogenase enzymes, Type-I IFN, RXR, retinoid X receptors, DEAD Box Protein 58, Th17, medicine.symptom, medicine.drug, Signal Transduction, Retinoid signaling, medicine.drug_class, Inflammation, cisRA, cis isomers of retinoic acid, CYP27, cytochrome P450 family 27, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, TLR, Toll-like receptors, Th17, T helper 17 cells, Immune system, Akt, serine/threonine specific protein kinase B, CXCL9, C-X-C motif chemokine ligand 9, Immune Tolerance, IFN, interferon, RORγt, Retinoic acid-related orphan receptor gT transcription factor, CYP26, cytochrome P450 family 26, NCoR, nuclear receptor co-repressors, business.industry, SARS-CoV-2, TNF, Tumor necrosis factor, COVID-19, Cell Biology, RALDH, retinaldehyde dehydrogenase enzyme, STRA6, signaling receptor and transporter of retinol, Treg, regulatory T cells, Jak, Janus kinases, sST2, soluble suppression of tumorigenicity 2, CYP450, cytochrome P450 superfamily of enzymes, business, RAR, retinoic acid receptors, RBP, retinol binding protein, c-Myc, cellular Myc proto-oncogene
وصف الملف: application/pdf
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المؤلفون: Min Zheng, Parimal Samir, Rajendra Karki, Benoit Briard, David E. Place, R. K. Subbarao Malireddi, Thirumala-Devi Kanneganti, Bhesh Raj Sharma, Sannula Kesavardhana, Peter Vogel
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, P-eIF2α, phosphorylation of eIF2α, Inflammasomes, NS1, CASP1, caspase-1, Biochemistry, P-IRF3, phosphorylation of IRF3, DEAD-box RNA Helicases, Mice, iBMDMs, immortalized BMDMs, Interferon, innate immunity, Ars, arsenite, MCMV, murine cytomegalovirus, NP, nucleoprotein, STAT1, signal transducer and activator of transcription 1, MOI, multiplicity of infection, Toll-like receptor, RIG-I, HRP, horseradish peroxidase, Inflammasome, CASP3, caspase-3, Cell biology, G3BP1, GTPase-activating protein-binding protein 1, host defense, Interferon Type I, DDX3X, medicine.drug, Research Article, TLR, Toll-like receptor, VSV, vesicular stomatitis virus, PR8, Puerto Rico/8/34, IRF1, interferon regulatory factor 1, Biology, stress granule, 03 medical and health sciences, Immune system, Stress granule, NLRP3, inflammasome, NLR Family, Pyrin Domain-Containing 3 Protein, CASP8, caspase-8, IAV, influenza A virus, medicine, Animals, influenza A virus, DDX3X, DEAD-box helicase 3 X-linked, IFN, interferon, Molecular Biology, immune evasion, NS1, nonstructural protein 1, Innate immune system, ΔNS1, NS1 deletion mutant, 030102 biochemistry & molecular biology, Cell Biology, ASC, apoptosis-associated speck-like protein containing a caspase recruitment domain, SG, stress granule, NLRP3, nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3, Immunity, Innate, IL, interleukin, RIG-I, retinoic acid–inducible gene I, 030104 developmental biology, IRF1, BMDM, bone marrow–derived macrophage, type I IFN
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المؤلفون: Meignié, Alice, Combredet, Chantal, Santolini, Marc, Kovács, István, Douché, Thibaut, Gianetto, Quentin Giai, Eun, Hyeju, Matondo, Mariette, Jacob, Yves, Grailhe, Regis, Tangy, Frédéric, Komarova, Anastassia
المساهمون: Génomique virale et vaccination, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7), Centre de Recherche Interdisciplinaire / Center for Research and Interdisciplinarity [Paris, France] (CRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Northeastern University [Boston], Northwestern University [Evanston], Central European University [Budapest, Hongrie] (CEU), Plateforme de Protéomique / Proteomics platform, Spectrométrie de Masse pour la Biologie – Mass Spectrometry for Biology (UTechS MSBio), Institut Pasteur [Paris]-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris]-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur Korea - Institut Pasteur de Corée, Réseau International des Instituts Pasteur (RIIP), Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), This work was supported by ANR 16 CE18 0016 01 Tangy ONCOMEVAX, the Institut Pasteur, and CNRS., We thank Dr Kaoru Takeuchi and Dr Chantal Rabourdin-Combe for anti-C rAb polyclonal antibody and anti-N monoclonal antibody, respectively. We thank Dr.Hervé Bourhy from Lyssavirus Epidemiology and Neuropathology Laboratory of Institut Pasteur for providing us pYFP-p65 plasmid that contains EYFP reporter gene fused to p65. We thank all members of the Viral Genomics and Vaccination Unit and Laboratory of Molecular Genetics of RNA Viruses for their critical discussion, Dr Atousa Arbabian for technical support with experiments, Dr Dmitry Trubetskoy for the help with data representation, and Dr Aleksandr Barinov and Dr Caroline Demeret for critical reading., ANR-16-CE18-0016,OncoMeVax,Un virus de la rougeole modifié pour traiter le cancer(2016), Matondo, Mariette, Un virus de la rougeole modifié pour traiter le cancer - - OncoMeVax2016 - ANR-16-CE18-0016 - AAPG2016 - VALID, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut Pasteur [Paris] (IP)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
المصدر: Molecular & Cellular Proteomics : MCP
Molecular and Cellular Proteomics
Molecular and Cellular Proteomics, American Society for Biochemistry and Molecular Biology, 2021, 20, pp.100049. ⟨10.1016/j.mcpro.2021.100049⟩
Molecular and Cellular Proteomics, 2021, 20, pp.100049. ⟨10.1016/j.mcpro.2021.100049⟩مصطلحات موضوعية: Proteomics, RIG-I, retinoic acid–inducible gene-I, FDR, false discovery rate, NF-kB, nuclear factor-kappa B, PPI, protein–protein interaction, virus-host protein-protein interactions, virulence factors, SOD1, superoxide dismutase 1, Viral Nonstructural Proteins, Virus Replication, Cell Line, PKR, protein kinase R, Chlorocebus aethiops, BRET, bioluminescence resonance energy Transfer, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Animals, Humans, AGC, automatic Gain Control, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, IFN, interferon, LCC, largest connected component, Protein Interaction Maps, NLR, normalized luminescence ratio, innate immunity, MOI, multiplicity of infection, FA, formic acid, DCA, dichloroacetic acid, Cell Death, Research, Y2H, yeast two-hybrid, Intracellular Signaling Peptides and Proteins, Transcription Factor RelA, ACN, acetonitrile, MV, measles virus, Repressor Proteins, ATU, additional transcription unit, Measles virus, Host-Pathogen Interactions, DI, defective interfering, PCA, protein complementation assay, Tumor Suppressor Protein p53, Nluc, nanoluciferase, Measles
وصف الملف: application/pdf
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المصدر: Life Sciences
مصطلحات موضوعية: Chemokine, ALI, acute lung injury, STAT, signal transducers and activators of transcription, viruses, medicine.medical_treatment, RIG-I, retinoic acid-inducible gene I, Pathogenesis, Severe Acute Respiratory Syndrome, Monocytes, pDCs, plasmacytoid dendritic cells, PRRs, pattern recognition receptors, Macrophage, Medicine, General Pharmacology, Toxicology and Pharmaceutics, Respiratory Distress Syndrome, biology, General Medicine, MCP-1, monocyte chemoattractant protein-1, MERS-CoV, Middle East respiratory syndrome-related coronavirus, SARS-CoV, severe acute respiratory syndrome-related coronavirus, Cytokine, CRP, C-reactive protein, Cytokines, NLRP3, Nod-like receptor protein 3, Chemokines, Coronavirus Infections, Pneumonia, Viral, CD, cluster of differentiation, NF-κB, nuclear factor-κB, mTOR, mammalian target of rapamycin, ACE2, angiotensin-converting enzyme 2, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, Article, WHO, World Health Organization, Virus, General Biochemistry, Genetics and Molecular Biology, Betacoronavirus, Immune system, PAMPs, pathogen-associated molecular patterns, Humans, MHC, major histocompatibility complex, IFN, interferon, ADAM17, ADAM metallopeptidase domain 17, Antigen-presenting cell, Pandemics, ARDS, acute respiratory distress syndrome, Inflammation, PBMCs, peripheral blood mononuclear cells, ADCC, antibody-dependent cellular cytotoxicity, SARS-CoV-2, business.industry, Macrophages, fungi, COVID-19, CTL, cytotoxic T lymphocyte, medicine.disease, MDA5, melanoma differentiation-associated protein 5, PRRSV, porcine reproductive and respiratory syndrome virus, Treg, regulatory T cells, siRNA, small interfering RNA, Immunology, biology.protein, TMPRSS2, transmembrane serine protease 2, business, Cytokine storm, IRF, interferon regulatory factor
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المصدر: Cytokine & Growth Factor Reviews
مصطلحات موضوعية: aIIb/b3, Glycoprotein IIb/IIIa, TNF-R, Tumor necrosis factor receptor, XO, Xanthine oxidase, Endocrinology, Diabetes and Metabolism, Gsk-3, Glycogen synthase kinase-3, vWF, von Willebrand factor, Systemic inflammation, NAD(P)H, Nicotinamide adenine dinucleotide phosphate hydrogen, Severity of Illness Index, Glycogen Synthase Kinase 3, 0302 clinical medicine, GSK-3, TIRAP, TIR-domain-containing adaptor protein, Medicine, Molecular Targeted Therapy, Coronavirus, TLR-3, Toll like receptor-3, Nucleocapsid protein, IFN-γ, Interferon-gamma, MIP1α, Macrophage inflammatory protein 1α, PPRPattern, recognition receptor, Kinase, PEDV, Porcine epidemic diarrhea virus, HDAC3, Histone deacetylase 3, OxPLs, Oxidized phospholipids, 030220 oncology & carcinogenesis, ATP, Adenosine triphosphate, MCP-1, Monocyte chemoattractant peptide, CBP, CREB binding protein, Immunology, Antiviral Agents, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, TRAF6, Tumour necrosis factor receptor associated factor 6, Humans, NLRP3, NOD-like receptors protein 3, NTD, N-terminal domain, Glycogen synthase, PD, Parkinson’s disease, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, IRAKs, Interleukin (IL)- 1R-associated kinase, TAK1, Transforming growth factor-β (TGF-β)-activated kinase 1, HO-1, Heme Oxygenase-1, 030104 developmental biology, Viral replication, PAMP, Pathogen associated molecular pattern, CREB, cAMP response element-binding protein, Keap1, Kelch-like ECH associated protein 1, BALF, Bronchoalveolar lavage, ROS, Reactive oxygen species, 0301 basic medicine, Myd88, Myeloid differentiation primary response 88, ASC, Apoptosis-associated speck-like protein containing a CARD, DAMP, Death associated molecular pattern, medicine.disease_cause, NF-κB, Gsk-3, GSH, Intracellular glutathione, bZIP, Basic leucine zipper, COVID-19, Coronavirus disease 19, Immunology and Allergy, O.−2, Superoxide anion, Phosphorylation, biology, TRS, Transcription regulating sequence, ARE, Antioxidant response elements, NOX, NADPH oxidase, O2, Oxygen molecule, NF-κB, Nuclear factor-κB, GPx, Glutathione peroxidase, medicine.symptom, PAR, Protease-activated receptors, Signal Transduction, RIG-I, Retinoic acid-inducible gene I, IKK, IkB Kinase, IκB, Inhibitor of kappa B, Inflammation, PSGL, P-Selectin glycoprotein ligand-1, AD, Alzheimer’s disease, N-protein, Nucleocapsid protein, ADP, Adenosine diphosphate, HCV, Hepatitis C virus, CATs, Catalase, Nrf2, Nuclear factor erythroid 2-related factor, ACE2, Angiotensin-converting enzyme 2, LiCl, Lithium chloride, ARDS, Acute respiratory distress syndrome, TNFα, Tumour necrosis factor-alpha, SODs, Superoxide dismutase, Pandemics, ComputingMethodologies_COMPUTERGRAPHICS, NLRP3, Nucleotide-binding domain (NOD)-like receptor protein 3, XOR, Xanthine oxidoreductase, Cul3, Cullin 3, business.industry, SARS-CoV-2, TNF, Tumor necrosis factor, COVID-19, IL-6, Interleukin -6, COVID-19 Drug Treatment, Oxidative Stress, sgmRNA, Sub genomic messenger RNA, TF, Tissue factor, biology.protein, G-CSF, Granulocyte colony stimulating factor, business, Oxidative stress
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المؤلفون: Masataka Kuwana, Toru Tanaka, Masahiro Seike, Nariaki Kokuho, Yoshinobu Saito, Hiroyuki Takoi, Hiroki Hayashi, Yasuhiro Terasaki, Takeru Kashiwada, Akihiko Gemma, Chika Yajima, Takahisa Gono, Junichi Aoyama, Shinji Abe, Ayumi Nishikawa
المصدر: Respiratory Medicine Case Reports, Vol 26, Iss, Pp 193-196 (2019)
Respiratory Medicine Case Reportsمصطلحات موضوعية: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Cyclophosphamide, medicine.medical_treatment, Anti-MDA5, anti-melanoma differentiation-associate gene, Case Report, IVCY, intravenous cyclophosphamide, Gastroenterology, Clinical amyopathic dermatomyositis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, CADM, clinically amyopathic dermatomyositis, RP-ILD, rapidly progressive interstitial lung disease, Extracorporeal membrane oxygenation, Medicine, lcsh:RC705-779, Inhalation, biology, Anti-melanoma differentiation-associated gene 5 antibody, business.industry, ARS, anti-aminoacyl-tRNA synthetase, Interstitial lung disease, lcsh:Diseases of the respiratory system, Dermatomyositis, medicine.disease, Tacrolimus, RIG-I, retinoic acid inducible gene-I, respiratory tract diseases, Rapidly progressive interstitial pneumonia, 030228 respiratory system, Methylprednisolone, 030220 oncology & carcinogenesis, biology.protein, HRCT, high-resolution computed tomography, Antibody, business, medicine.drug
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المؤلفون: Myung Hee Kim, Sunghoon Kim, Eun-Young Lee
المصدر: Biochemical Pharmacology
مصطلحات موضوعية: 0301 basic medicine, PTM, post-translational modification, Antiviral immunity, TNF-α, tumor necrosis factor-α, Biochemistry, Human health, chemistry.chemical_compound, Drug Delivery Systems, 0302 clinical medicine, Antibiotics, RIG-I, retinoic acid-inducible gene-I, MEK, MAPK kinase kinase, Multi-tRNA synthetase complex, ERK, extracellular-related kinase, ARS, aminoacyl-tRNA synthetase, BMDM, bone marrow-derived macrophage, Anti-Bacterial Agents, HIV, human immunodeficiency virus, HCV, hepatitis C virus, 030220 oncology & carcinogenesis, MAVS, mitochondrial antiviral signaling protein, CRP, C-reactive protein, LPS, lipopolysaccharide, EMAPII, endothelial monocyte-activating polypeptide II, Infection, Medical science, TH1, T-helper type 1, Signal Transduction, PBMC, peripheral blood mononuclear cell, TLS, tRNA-like structure, Cell signaling, IL-1β, interleukin-1β, ITCH, E3 ubiquitin-protein ligase Itchy homolog, IP-10, interferon-inducible protein 10, AA-AMP, aminoacyl-adenylate, MITF, microphthalmia-associated transcription factor, IFN-α, interferon-α, Microbial Sensitivity Tests, Computational biology, Biology, Antiviral Agents, Communicable Diseases, Article, Amino Acyl-tRNA Synthetases, 03 medical and health sciences, Immunity, TRAIL, tumor necrosis factor-related apoptosis-inducing ligand, BMDC, bone marrow-derived dendritic cell, Animals, Humans, IFN, interferon, TCID50, a median tissue culture infective dose, TLR, toll-like receptor, ComputingMethodologies_COMPUTERGRAPHICS, eEF1A, eukaryotic elongation factor 1 alpha, AIMP, ARS-interacting multifunctional protein, Pharmacology, Aminoacyl tRNA synthetase, PCBP2, poly(rC)-binding protein 2, Oas, 2′-5′-oligoadenylate synthase, WT, wild-type, MDA5, melanoma differentiation-associated protein 5, HMGB1, high mobility group box 1, 030104 developmental biology, chemistry, TGF-β, tumor growth factor-β, Protein Biosynthesis, Aminoacyl-tRNA synthetase, MSC, multi-tRNA synthetase complex, GAIT, IFN-γ-activated inhibition of translation, MAPK, mitogen-activated protein kinase
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المؤلفون: Frank Loganzo, Aaron Y. Chang, Kesha M. Shah, Yu Jerry Zhou, Seng-Ryong Woo, Heather Wheeler, Paula M. Loria, Piotr W. Pobiarzyn, Pavel Tishchenko, Yue-Ming Wang, Sharanya Iyengar
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: RNA splicing, THP-1 Cells, IFN-I, type I interferon, Biochemistry, Mice, hpRNA, hairpin RNA, RNA Precursors, cytokine, MDA5, melanoma differentiation–associated protein 5, anticancer drug, Receptors, Immunologic, innate immunity, HDR, homology-directed repair, Chemistry, RIG-I, interferon, Cell biology, RIG-I-like receptor, interferon regulatory factor, Stimulator of interferon genes, Interferon Type I, MAVS, mitochondrial antiviral signaling protein, DEAD Box Protein 58, RNA Splicing Factors, Research Article, Spliceosome, Plad B, pladienolide B, mRNA, sgRNA, single-guide RNA, Mutation, Missense, TNFα, tumor necrosis factor alpha, STING, stimulator of interferon genes, Proinflammatory cytokine, alternative splicing, cDNA, complementary DNA, HEK, human embryonic kidney, SF3B1, spliceosome splicing factor 3b subunit 1, Animals, Humans, Molecular Biology, IRF3, interferon regulatory factor 3, Cell Biology, Phosphoproteins, IL, interleukin, RIG-I, retinoic acid–inducible gene I, LU, light unit, NGS, next-generation sequencing, Amino Acid Substitution, A549 Cells, ISG54, interferon-stimulated gene 54, Spliceosomes, SEAP, secreted embryonic alkaline phosphatase, spliceosome, IRF3, Interferon regulatory factors
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المؤلفون: Assaf Potruch, Marc D. Berg, Samuel Agus, Yuval Ishay, Khurram Jamil, Yaron Ilan, Asaf Schwartz
المصدر: Biomedicine & Pharmacotherapy, Vol 143, Iss, Pp 112228-(2021)
Biomedicine & Pharmacotherapyمصطلحات موضوعية: ARDS, medicine.medical_treatment, CoV, coronavirus, IFNR, type I IFN receptor, RIG-I, retinoic acid-inducible gene I, PRM, patterns recognition molecules, Disease, Antiviral therapy, Severity of Illness Index, RT-PCR, reverse transcriptase polymerase chain reaction, NK cells, natural killer cells, Pandemic, TLR, toll-like receptors, MT, microtubules, SK1, sphingokinase 1, Th cells, T helper cells, NLR, neutrophil-lymphocyte ratio, COVID-19, coronavirus disease 2019, TNF, tumor necrosis factor, Immunity, Cellular, Disease Management, SphK, sphingosine kinase, General Medicine, ICU, intensive care unit, S-1P, sphingosine-1-phosphate, Chemotherapy, Adjuvant, Antiviral response, Tregs, regulatory T cells, Disease Progression, Digital health, Adjuvant, Algorithms, NF-κB, nuclear factor kappa-light-chain, medicine.medical_specialty, Myocarditis, JAK-STAT, Janus kinase signal transducer and activation of transcription, CD, cluster of differentiation, HLH, hemophagocytic lymphohistiocytosis, IG, immunoglobulin, IFNβ, interferon-beta, IP-10, IFN gamma-induced protein 10, RM1-950, HRV, heart rate variability, Antiviral Agents, Article, Immune system, Severity of illness, medicine, Humans, IFN, interferon, APC, antigen-presenting cells, NKT, NK T cells, HBC, hyperimmune bovine colostrum, SARS, severe acute respiratory syndrome, Intensive care medicine, ARDS, acute respiratory distress syndrome, Pharmacology, Hepatitis, business.industry, MERS, Middle East respiratory syndrome, COVID-19, CTL, cytotoxic T cells, MCP, monocyte chemoattractant protein, medicine.disease, IL, interleukin, Immunity, Humoral, COVID-19 Drug Treatment, Gastrointestinal Tract, Coronavirus, GC, glucosylceramide, RNA, ribonucleic acid, dsRNA, double-stranded RNA, Therapeutics. Pharmacology, HCC, hepatocellular carcinoma, business, Medical Informatics, IRF, interferon regulatory factor
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المؤلفون: Attila Bacsi, Tünde Fekete, Alíz Varga, Kitti Pazmandi, Hyelim Moon, Zsofia Agod, Attila Szabo, Tamás Bíró, Istvan Boldogh, Arpad Lanyi, Marietta Margit Budai
المصدر: Redox Biology, Vol 13, Iss C, Pp 633-645 (2017)
Redox Biologyمصطلحات موضوعية: 0301 basic medicine, Interferon Regulatory Factor-7, Clinical Biochemistry, PI3K, phosphatidylinositol-3-kinase, Biochemistry, pDCs, plasmacytoid dendritic cells, 0302 clinical medicine, Interferon, Elméleti orvostudományok, Receptors, Immunologic, lcsh:QH301-705.5, Cells, Cultured, lcsh:R5-920, Endosomal TLR signaling, RLR, RIG-I-like receptor, hemic and immune systems, Orvostudományok, Mitochondria, Cell biology, Antiviral response, 030220 oncology & carcinogenesis, Interferon Type I, DEAD Box Protein 58, Phosphorylation, Signal transduction, lcsh:Medicine (General), Signal Transduction, Research Paper, TLR, Toll-like receptor, medicine.drug, Biology, Cell Line, 03 medical and health sciences, Plasmacytoid dendritic cell, ROS, reactive oxygen species, medicine, Humans, IFN, interferon, Type I interferon, Transcription factor, AMA, Antimycin-A, RIG-I, retinoic-acid-inducible gene-I, Organic Chemistry, TLR9, Dendritic Cells, mtROS, mitochondrial reactive oxygen species, Mitochondrial ROS, 030104 developmental biology, lcsh:Biology (General), Toll-Like Receptor 9, MAVS, mitochondrial antiviral-signaling, IRF7, RIG-I signaling, Reactive Oxygen Species, 7-AAD, 7-aminoactinomycin-D, IRF3, IRF, interferon regulatory factor, Interferon regulatory factors
وصف الملف: application/pdf
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16
المؤلفون: Alexander F. Palazzo, Qingtang Shen, Yifan E. Wang
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, NES, nuclear export signal, CoV, coronavirus, DENV, dengue virus, ISGF3, interferon-stimulated gene factor 3, cGAS, cyclic GMP–AMP synthase, NXF1, nuclear RNA export factor 1, Viral Nonstructural Proteins, Virus Replication, Biochemistry, NF-κB, Vpr, viral protein R, NTF2, nuclear transport factor 2, Nup, nucleoporin, NXF1, nucleocytoplasmic trafficking, NSP, nonstructural protein, NXT1, NTF2-like export factor 1, TPR, translocated promoter region, Nuclear pore, IL-6, interleukin-6, CA, capsid, TNF-α, tumor necrosis factor α, COVID-19, coronavirus disease 2019, nuclear pore proteins, NF-kappa B, Pattern recognition receptor, VACV, vaccinia virus, Cell biology, STAT, signal transducer and activator of transcription, Virus Diseases, HCV, hepatitis C virus, viral immune evasion, EBV, Epstein–Barr virus, EBOV, Ebola virus, Nucleoporin, cGAMP, cyclic dinucleotide GMP–AMP, TMEV, Theiler's murine encephalomyelitis virus, PAMP, pathogen-associated molecular pattern, TLR, Toll-like receptor, VEEV, Venezuelan equine encephalitis virus, VSV, vesicular stomatitis virus, Active Transport, Cell Nucleus, IRF3, interferon-regulatory factor 3, PRR, pattern-recognition receptor, HPV, human papillomavirus, HRV, human rhinovirus, JEV, Japanese encephalitis virus, Host cell nucleoplasm, Biology, IRF9, interferon-regulatory factor 9, STATs, ER, endoplasmic reticulum, 03 medical and health sciences, STING, stimulator of IFN genes, IAV, influenza A virus, Humans, RNA Viruses, hnRNP, heterogenous nuclear ribonucleoprotein, IFN, interferon, IFN-1, type I interferon, SARS, severe acute respiratory syndrome, Nuclear export signal, ANE1, acute necrotizing encephalopathy 1, Molecular Biology, Immune Evasion, karyopherins, HHV, human herpesvirus, AdV, adenovirus, Nucleoplasm, M, matrix protein, ZIKV, Zika virus, 030102 biochemistry & molecular biology, JBC Reviews, CRM1, chromosomal maintenance 1, MERS, Middle East respiratory syndrome, DNA Viruses, EMCV, encephalomyocarditis virus, Cell Biology, IRF3, FG-Nups, Nups that contain phenylalanine–glycine repeats, Immunity, Innate, RIG-I, retinoic acid–inducible gene I, Nuclear Pore Complex Proteins, L, leader protein, HBV, hepatitis B virus, 030104 developmental biology, innate immune responses, NLS, nuclear localization signal, PV, poliovirus, KSHV, Kaposi's sarcoma–associated herpesvirus, Nuclear Pore, HSV, herpes simplex virus, mRNP, messenger ribonucleoprotein, Nuclear transport, TREX, transcription export
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المؤلفون: Raffaele Badolato, Rosaria Scaduto, Elisa Fazzi, Simona Orcesi, Jessica Galli, Manuela Cortesi, Sara Roversi, Silvia Giliani, Rosalba Monica Ferraro, Marco Cattalini
المصدر: Clinical Immunology (Orlando, Fla.)
مصطلحات موضوعية: Ruxolitinib, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, Review Article, MDA-5, melanoma differentiation-associated protein 5, PKR, protein kinase R, Nitriles, medicine, Humans, RIG-I, retinoic acid-inducible gene I, Immunology and Allergy, IFN, interferon, Letter to the Editor, Innate immunity, Viral infections, A-to-I RNA editing, SARS-CoV-2, business.industry, COVID-19, Virology, ISG, interferon stimulated genes, Pyrimidines, eIF-2a, Eukaryotic translation initiation factor 2 subunit 1, RNA editing, Pyrazoles, RNA Editing, business, Mutations, IRF, interferon regulatory factor, medicine.drug
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المؤلفون: Yin, Changchuan
المصدر: Journal of Theoretical Biology
مصطلحات موضوعية: Evolution fitness, NDU, the normalized distribution uniformity, 0301 basic medicine, Periodicity, viruses, RIG-I, retinoic acid-inducible gene I, Disease, medicine.disease_cause, Genome, 0302 clinical medicine, MERS, Middle-East respiratory syndrome, Pandemic, CD, a congruence derivative, Phylogeny, COVID-19, coronavirus disease 2019, Coronavirus, Virulence, ACE2, angiotensin converting enzyme 2, Applied Mathematics, virus diseases, Genomics, Period Circadian Proteins, General Medicine, Modeling and Simulation, 2019-nCoV, Dinucleotide, RNA, Viral, DMV, double-membrane vesicle, General Agricultural and Biological Sciences, Statistics and Probability, APOBEC, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like3, Genome, Viral, Computational biology, Biology, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, History, 21st Century, Article, General Biochemistry, Genetics and Molecular Biology, Virus, Evolution, Molecular, Open Reading Frames, 03 medical and health sciences, PAMPs, pathogen-associated molecular patterns, Phylogenetics, Modelling and Simulation, medicine, DNA Barcoding, Taxonomic, Humans, SARS, severe acute respiratory syndrome, Pandemics, Base Sequence, General Immunology and Microbiology, SARS-CoV-2, COVID-19, Sequence Analysis, DNA, Models, Theoretical, 030104 developmental biology, 030217 neurology & neurosurgery
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المؤلفون: Weijun Cao, Xiangle Zhang, Kangli Li, Shuying Chen, Shasha Li, Yi Ru, Zixiang Zhu, Zheng Haixue, Xiangtao Liu, Fan Yang
المصدر: Molecular & Cellular Proteomics : MCP
مصطلحات موضوعية: Swine, Picornaviridae, Virus Replication, RIG-I–like receptor signaling pathway, antiviral response, JAK-STAT, Janus kinase signal transducer and activator of transcription, Interferon, MDA5, melanoma differentiation–associated protein 5, Receptors, Immunologic, IL-6, interleukin-6, MOI, multiplicity of infection, DMEM, Dulbecco's modified Eagle's medium, IRF7, IFN regulatory factor 7, JAK-STAT signaling pathway, SVV, Seneca Valley virus, interferon, iTRAQ, isobaric tag for relative and absolute quantitation, TCID50, 50% tissue culture infective dose, General Medicine, senecavirus A, Cell biology, CPE, cytopathic effect, DEAD Box Protein 58, IBRS-2, Instituto Biologico-Rim Suino-2, Signal Transduction, medicine.drug, IRF3, IFN regulatory factor 3, FDR, false discovery rate, RLR, RIG-I–like receptor, MAVS, mitochondrial antiviral-signaling protein, PK-15, porcine kidney-15 cells, Biology, RIG-I-like receptor, KEGG, Kyoto Encyclopedia of Genes and Genomes, Cell Line, FBS, fetal bovine serum, GO, Gene Ontology, medicine, Animals, ISG, interferon-stimulated gene, IFN, interferon, hpi, hours post infection, Picornaviridae Infections, Innate immune system, foot-and-mouth disease virus, Research, CDS, coding sequence, ACN, acetonitrile, RIG-I, retinoic acid–inducible gene I, Oncolytic virus, SeV, Sendai virus, DEP, differentially expressed protein, TBK1, TANK-binding kinase 1, FMDV, foot-and-mouth disease virus, qPCR, quantitative PCR, RIG-I-Like Receptor Signaling Pathway, IRF3, Janus kinase, HA, hemagglutinin
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المؤلفون: Zhihai Zhou, Jingyun Ma, Tian Lan, Yao-Rong Tan, Li Qianniu, Xiaoling Yan, Yuan Sun, Xiaoyu Tang
المصدر: Virus Research
مصطلحات موضوعية: Cancer Research, Swine, viruses, RIG-I, retinoic acid-inducible gene I, medicine.disease_cause, PEDV, porcine epidemic diarrhea virus, RIG-I, PRRs, pattern recognition receptors, TANK-binding kinase 1, IRF-3, IFN regulatory factor 3, Phosphorylation, Promoter Regions, Genetic, MOI, multiplicity of infection, IPS-1, Coronavirus, 0303 health sciences, biology, Alphacoronavirus, NF-kappa B, virus diseases, MERS-CoV, Middle East respiratory syndrome coronavirus, SADS-CoV, swine acute diarrhea syndrome coronavirus, respiratory system, Interferon beta, mRNA, messenger RNA, Sendai virus, IFN-β, interferon beta, Infectious Diseases, CPE, cytopathic effect, Host-Pathogen Interactions, DEAD Box Protein 58, Signal transduction, Coronavirus Infections, TLR3, toll-like receptor 3, IPEC-J2, porcine small intestinal epithelial cells, Signal Transduction, MDA5, melanoma differentiation-associated gene 5, TGEV, transmissible gastroenteritis virus, SARS-CoV, severe acute respiratory syndrome coronavirus, Active Transport, Cell Nucleus, behavioral disciplines and activities, Article, Cell Line, 03 medical and health sciences, NF-κB, nuclear factor-kappaB, RT-PCR, reverse transcription polymerase chain reaction, IKKε, inhibitor of κB kinase-ε, PBS, phosphate buffered saline, PAMPs, pathogen-associated molecular patterns, Virology, mental disorders, medicine, Animals, poly(I:C), polyinosinic-polycytidylic acid, 030304 developmental biology, Cell Nucleus, IFA, indirect immunofluorescence assay, qRT-PCR, quantitative real time RT-PCR, Innate immune system, p.i., post-infection, 030306 microbiology, Interferon-beta, biochemical phenomena, metabolism, and nutrition, NFKB1, biology.organism_classification, Immunity, Innate, SeV, Sendai virus, TBK1, TANK-binding kinase 1, IPS-1, mitochondria antiviral-signaling protein, dsRNA, double-stranded RNA, Interferon Regulatory Factor-3, IRF3, Swine acute diarrhea syndrome coronavirus
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