المؤلفون: Erhan Aptullahoglu, Sirintra Nakjang, Jonathan P. Wallis, Helen Marr, Scott Marshall, Elaine Willmore, John Lunec

المصدر: Biomedicines, Vol 12, Iss 7, p 1388 (2024)

مصطلحات موضوعية: RNA sequencing (RNA-seq), MDM2–p53 antagonists, idasanutlin (RG7388), DNA damage repair, chronic lymphocytic leukemia (CLL), Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2227-9059/12/7/1388; https://doaj.org/toc/2227-9059

URL الوصول: https://doaj.org/article/d985462f94fb48a19b17942c67dfd921

المؤلفون: Anas Abed, Michelle K. Greene, Alhareth A. Alsa’d, Andrea Lees, Andrew Hindley, Daniel B Longley, Simon S McDade, Christopher J. Scott

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, murine blood leukocytes, investigated whether coencapsulation, could overcome efficacy, systemic toxicity inhibitors, synergistic antitumor effects, hdac inhibitor entinostat, free drugs could, limiting toxicity issues, mdm2 inhibitor rg7388, toxicity limitations, synergistic increases, limiting neutropenia, free drug, entinostat across, vivo <, taken together, study demonstrates, significantly mitigated

Relation: https://figshare.com/articles/journal_contribution/Nanoencapsulation_of_MDM2_Inhibitor_RG7388_and_Class_I_HDAC_Inhibitor_Entinostat_Enhances_their_Therapeutic_Potential_Through_Synergistic_Antitumor_Effects_and_Reduction_of_Systemic_Toxicity/25196728

الاتاحة: https://doi.org/10.1021/acs.molpharmaceut.3c00926.s001
https://figshare.com/articles/journal_contribution/Nanoencapsulation_of_MDM2_Inhibitor_RG7388_and_Class_I_HDAC_Inhibitor_Entinostat_Enhances_their_Therapeutic_Potential_Through_Synergistic_Antitumor_Effects_and_Reduction_of_Systemic_Toxicity/25196728

المؤلفون: Erhan Aptullahoglu, Carmela Ciardullo, Jonathan P. Wallis, Helen Marr, Scott Marshall, Nick Bown, Elaine Willmore, John Lunec

المصدر: International Journal of Molecular Sciences; Volume 24; Issue 3; Pages: 2410

مصطلحات موضوعية: p53 pathway, splicing modulation, MDM2–p53 antagonists, RG7388 (idasanutlin), E7107

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Oncology; https://dx.doi.org/10.3390/ijms24032410

الاتاحة: https://doi.org/10.3390/ijms24032410

المؤلفون: Erhan Aptullahoglu, Jonathan P. Wallis, Helen Marr, Scott Marshall, Nick Bown, Elaine Willmore, John Lunec

المصدر: International Journal of Molecular Sciences, Vol 24, Iss 14, p 11335 (2023)

مصطلحات موضوعية: SF3B1, splicing factor, MDM2-p53 antagonists, RG7388 (idasanutlin), chronic lymphocytic leukemia (CLL), Biology (General), QH301-705.5, Chemistry, QD1-999

Relation: https://www.mdpi.com/1422-0067/24/14/11335; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/996f7e0a42974ae6920e29d3628f2072

الاتاحة: https://doi.org/10.3390/ijms241411335
https://doaj.org/article/996f7e0a42974ae6920e29d3628f2072

المؤلفون: Cheng Xu, Heng Liu, Christopher J. Pirozzi, Lee H. Chen, Paula K. Greer, Bill H. Diplas, Liwei Zhang, Matthew S. Waitkus, Yiping He, Hai Yan

المصدر: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-12 (2021)

مصطلحات موضوعية: Diffuse intrinsic pontine gliomas, RG7388, p53 pathway, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2051-5960

URL الوصول: https://doaj.org/article/e93641f3ec424b8eb9474f91fac10d50

المؤلفون: Qianqian Wang, Jun Li, Jing Zhu, Jiaqi Mao, Chao Duan, Xiao Liang, Lingyun Zhu, Mengyan Zhu, Zhihong Zhang, Fan Lin, Renhua Guo

المصدر: Clinical and Translational Medicine, Vol 12, Iss 6, Pp n/a-n/a (2022)

مصطلحات موضوعية: CRISPR/Cas9 screen, MDM2, NSCLC, RG7388, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2001-1326

URL الوصول: https://doaj.org/article/b7068d62e44540f6a06ab02177bf651c

المؤلفون: Chiao-En Wu, Tsin Shue Koay, Yi-Hsuan Ho, Penny Lovat, John Lunec

المصدر: Cancer Cell International, Vol 19, Iss 1, Pp 1-15 (2019)

مصطلحات موضوعية: Melanoma, p53, MDM2, Nutlin-3, RG7388, HDM201, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s12935-019-0768-3; https://doaj.org/toc/1475-2867

URL الوصول: https://doaj.org/article/d52f6c520f674aa0ad3934c0311b3100

المؤلفون: Italiano, Antoine, Miller, Wilson H, Blay, Jean-Yves, Gietema, Jourik A, Bang, Yung-Jue, Mileshkin, Linda R, Hirte, Hal W, Higgins, Brian, Blotner, Steven, Nichols, Gwen L, Chen, Lin Chi, Petry, Claire, Yang, Qi Joy, Schmitt, Christophe, Jamois, Candice, Siu, Lillian L

المصدر: Italiano , A , Miller , W H , Blay , J-Y , Gietema , J A , Bang , Y-J , Mileshkin , L R , Hirte , H W , Higgins , B , Blotner , S , Nichols , G L , Chen , L C , Petry , C , Yang , Q J , Schmitt , C , Jamois , C & Siu , L L 2021 , ' Phase I study of daily and weekly regimens of the orally administered MDM2 antagonist idasanutlin in patients with advanced tumors ' , Investigational new drugs ....

مصطلحات موضوعية: p53 activation, MDM2 antagonist, Cis-imidazoline analog, Idasanutlin, Nutlin, MIC-1, ANTITUMOR-ACTIVITY, P53 PATHWAY, CANCER, RG7112, COMBINATION, RG7388

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/0143a8fc-ea65-443c-87e6-0e31f1ba08b1
https://research.rug.nl/en/publications/0143a8fc-ea65-443c-87e6-0e31f1ba08b1
https://doi.org/10.1007/s10637-021-01141-2
https://pure.rug.nl/ws/files/175931044/Phase_I_study_of_daily_and_weekly_regimens_of_the_orally_administered_mdm2_antagonist_idasanutlin_in_patients_with_advanced_tumors.pdf

المؤلفون: Zhengyuan Zhou (561059), Michael R. Zalutsky (2944272), Satish K. Chitneni (2461300)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Physiology, Pharmacology, Biotechnology, Cancer, Computational Biology, Space Science, Chemical Sciences not elsewhere classified, two fluorinated analogues, trimethylammonium triflate precursor, showed fast clearance, promising molecular scaffold, positron emission tomography, kg body weight, improve binding affinity, fp assays revealed, binding affinity (<, 80 ± 0, mdm2 expressing wild, 7 , 6 , f ]­ fn, preliminary evaluation rg7388, ), obtain [< sup, intact [< sup

Relation: https://figshare.com/articles/journal_contribution/Fluorine-18_Labeling_of_the_MDM2_Inhibitor_RG7388_for_PET_Imaging_Chemistry_and_Preliminary_Evaluation/16622433

الاتاحة: https://doi.org/10.1021/acs.molpharmaceut.1c00531.s001

المؤلفون: Cheng Xu (352754), Heng Liu (293917), Christopher J. Pirozzi (11645666), Lee H. Chen (11645669), Paula K. Greer (11645672), Bill H. Diplas (11645675), Liwei Zhang (490121), Matthew S. Waitkus (11645678), Yiping He (168012), Hai Yan (11645681)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Pharmacology, Cancer, Biological Sciences not elsewhere classified, Diffuse intrinsic pontine gliomas, RG7388, p53 pathway

Relation: https://figshare.com/articles/journal_contribution/Additional_file_5_of_TP53_wild-type_PPM1D_mutant_diffuse_intrinsic_pontine_gliomas_are_sensitive_to_a_MDM2_antagonist/16928348

الاتاحة: https://doi.org/10.6084/m9.figshare.16928348.v1

المؤلفون: Cheng Xu (352754), Heng Liu (293917), Christopher J. Pirozzi (11645666), Lee H. Chen (11645669), Paula K. Greer (11645672), Bill H. Diplas (11645675), Liwei Zhang (490121), Matthew S. Waitkus (11645678), Yiping He (168012), Hai Yan (11645681)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Pharmacology, Cancer, Biological Sciences not elsewhere classified, Diffuse intrinsic pontine gliomas, RG7388, p53 pathway

Relation: https://figshare.com/articles/journal_contribution/Additional_file_6_of_TP53_wild-type_PPM1D_mutant_diffuse_intrinsic_pontine_gliomas_are_sensitive_to_a_MDM2_antagonist/16928351

الاتاحة: https://doi.org/10.6084/m9.figshare.16928351.v1

المؤلفون: Cheng Xu (352754), Heng Liu (293917), Christopher J. Pirozzi (11645666), Lee H. Chen (11645669), Paula K. Greer (11645672), Bill H. Diplas (11645675), Liwei Zhang (490121), Matthew S. Waitkus (11645678), Yiping He (168012), Hai Yan (11645681)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Pharmacology, Cancer, Biological Sciences not elsewhere classified, Diffuse intrinsic pontine gliomas, RG7388, p53 pathway

Relation: https://figshare.com/articles/journal_contribution/Additional_file_7_of_TP53_wild-type_PPM1D_mutant_diffuse_intrinsic_pontine_gliomas_are_sensitive_to_a_MDM2_antagonist/16928354

الاتاحة: https://doi.org/10.6084/m9.figshare.16928354.v1

المؤلفون: Bérengère Dadone-Montaudié, Audrey Laroche-Clary, Aline Mongis, Emmanuel Chamorey, Ilaria Di Mauro, Vanessa Chaire, Pascal Finetti, Renaud Schiappa, François Le Loarer, Isabelle Birtwisle-Peyrottes, Jean-François Michiels, François Bertucci, Florence Pedeutour, Antoine Italiano, Laurence Bianchini

المصدر: Cancers; Volume 12; Issue 10; Pages: 3058

مصطلحات موضوعية: liposarcoma, FGFR, MDM2, JNJ42756493, RG7388

وصف الملف: application/pdf

Relation: Cancer Therapy; https://dx.doi.org/10.3390/cancers12103058

الاتاحة: https://doi.org/10.3390/cancers12103058

المؤلفون: Justyna Kocik, Monika Machula, Aneta Wisniewska, Ewa Surmiak, Tad A. Holak, Lukasz Skalniak

المصدر: Cancers; Volume 11; Issue 7; Pages: 1014

مصطلحات موضوعية: HDM2 antagonist, MDM2, p53, p21, synergy, combined cancer treatment, targeted therapy, chemotherapy, nutlin, RG7388, idasanutlin

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/cancers11071014

الاتاحة: https://doi.org/10.3390/cancers11071014

المؤلفون: Umamaheswari Natarajan, Thiagarajan Venkatesan, Vijayaraghavan Radhakrishnan, Shila Samuel, Periannan Rasappan, Appu Rathinavelu

المصدر: Medicina; Volume 55; Issue 2; Pages: 30

مصطلحات موضوعية: SAHA, RG7388, MDM2, p53, p21, cell cycle arrest, cell death

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/medicina55020030

الاتاحة: https://doi.org/10.3390/medicina55020030

المؤلفون: Khurana A, Shafer DA

المصدر: OncoTargets and Therapy, Vol Volume 12, Pp 2903-2910 (2019)

مصطلحات موضوعية: AML, myeloid leukemia, nutlins, MDM2, idasanutlin, RG7388, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Relation: https://www.dovepress.com/mdm2-antagonists-as-a-novel-treatment-option-for-acute-myeloid-leukemi-peer-reviewed-article-OTT; https://doaj.org/toc/1178-6930; https://doaj.org/article/235943528c924ba7a81a337974091b61

الاتاحة: https://doaj.org/article/235943528c924ba7a81a337974091b61

المؤلفون: Wu, C-E, Koay, TS, Esfandiari, A, Ho, Y-H, Lovat, P, Lunec, J

المصدر: Cancers , 11 (1) , Article 3. (2018)

مصطلحات موضوعية: ATM, DUSP6, HDM201, MDM2, RG7388, melanoma, nutlin-3, p53, trametinib

وصف الملف: text

Relation: https://discovery.ucl.ac.uk/id/eprint/10064948/1/cancers-11-00003.pdf; https://discovery.ucl.ac.uk/id/eprint/10064948/

الاتاحة: https://discovery.ucl.ac.uk/id/eprint/10064948/1/cancers-11-00003.pdf
https://discovery.ucl.ac.uk/id/eprint/10064948/

المؤلفون: Wu, C-E, Esfandiari, A, Ho, Y-H, Wang, N, Mahdi, AK, Aptullahoglu, E, Lovat, P, Lunec, J

المصدر: British Journal of Cancer , 118 (4) pp. 495-508. (2018)

مصطلحات موضوعية: Oncology, Cutaneous Melanoma, P53, MDM2, WIP1, NUTLIN-3, RG7388, HDM201, ATM-dependent Phosphorylation, DNA damage, Phosphatase, Cancer, Mutations, Pathway, Cells, Acetylation, Inhibition, Activation

وصف الملف: text

Relation: https://discovery.ucl.ac.uk/id/eprint/10046500/23/Esfandiari_OA_bjc2017433.pdf; https://discovery.ucl.ac.uk/id/eprint/10046500/

الاتاحة: https://discovery.ucl.ac.uk/id/eprint/10046500/23/Esfandiari_OA_bjc2017433.pdf
https://discovery.ucl.ac.uk/id/eprint/10046500/

المؤلفون: Umamaheswari Natarajan, Thiagarajan Venkatesan, Vijayaraghavan Radhakrishnan, Shila Samuel, Appu Rathinavelu

المصدر: Cells; Volume 8; Issue 1; Pages: 8

مصطلحات موضوعية: SAHA, RG7388, necroptosis, apoptosis, p21, phospho-RIP3, MLKL, MCF-7

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/cells8010008

الاتاحة: https://doi.org/10.3390/cells8010008

المؤلفون: Chiao-En Wu, Tsin Shue Koay, Arman Esfandiari, Yi-Hsuan Ho, Penny Lovat, John Lunec

المصدر: Cancers; Volume 11; Issue 1; Pages: 3

مصطلحات موضوعية: trametinib, nutlin-3, RG7388, HDM201, p53, DUSP6, melanoma, MDM2, ATM

وصف الملف: application/pdf

Relation: Cancer Drug Development; https://dx.doi.org/10.3390/cancers11010003

الاتاحة: https://doi.org/10.3390/cancers11010003