المؤلفون: Deng, Feng, Tuomi, Suvi-Kukka, Neuvonen, Mikko, Hirvensalo, Päivi, Kulju, Sami, Wenzel, Christoph, Oswald, Stefan, Filppula, Anne M., Niemi, Mikko

المساهمون: INDIVIDRUG - Individualized Drug Therapy, Department of Clinical Pharmacology, HUSLAB, Medicum, Research Programs Unit

مصطلحات موضوعية: RESISTANCE-ASSOCIATED PROTEIN-3, DRUG-DRUG INTERACTION, BASOLATERAL EFFLUX, BILIARY-EXCRETION, ABCB1 HAPLOTYPES, PHARMACOKINETICS, PRAVASTATIN, PITAVASTATIN, DISPOSITION, ABCG2, Pharmacy, Biomedicine

وصف الملف: application/pdf

Relation: This work was supported by the ERC Consolidator Grant (Grant Agreement number 725249).; Deng , F , Tuomi , S-K , Neuvonen , M , Hirvensalo , P , Kulju , S , Wenzel , C , Oswald , S , Filppula , A M & Niemi , M 2021 , ' Comparative Hepatic and Intestinal Efflux Transport of Statins ' , Drug Metabolism and Disposition , vol. 49 , no. 9 , pp. 750-759 . https://doi.org/10.1124/dmd.121.000430; ORCID: /0000-0002-9173-6923/work/108868026; http://hdl.handle.net/10138/340980; 9833fb4f-7ed9-4206-8607-13aa1537b310; 000692704600005

الاتاحة: http://hdl.handle.net/10138/340980

المؤلفون: Deng, Feng, Tuomi, Suvi-Kukka, Neuvonen, Mikko, Hirvensalo, Päivi, Kulju, Sami, Wenzel, Christoph, Oswald, Stefan, Filppula, Anne M., Niemi, Mikko

المساهمون: INDIVIDRUG - Individualized Drug Therapy, Department of Clinical Pharmacology, HUSLAB, Medicum, Research Programs Unit

مصطلحات موضوعية: DRUG-DRUG INTERACTION, PHARMACOKINETICS, DISPOSITION, BILIARY-EXCRETION, ABCB1 HAPLOTYPES, ABCG2, nutritional and metabolic diseases, RESISTANCE-ASSOCIATED PROTEIN-3, BASOLATERAL EFFLUX, PITAVASTATIN, 317 Pharmacy, PRAVASTATIN, lipids (amino acids, peptides, and proteins), cardiovascular diseases, 3111 Biomedicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4b81d52b0b0e3361b826eccdde90e567
http://hdl.handle.net/10138/340980

المؤلفون: Peter L.M. Jansen, Klaas Nico Faber, Michael Müller

المساهمون: Faculteit Medische Wetenschappen/UMCG, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Center for Liver, Digestive and Metabolic Diseases (CLDM)

المصدر: Advanced Drug Delivery Reviews, 55(1):PII S0169-409X(02)00173-4, 107-124. ELSEVIER SCIENCE BV
Advanced Drug Delivery Reviews 55 (2003)
Advanced Drug Delivery Reviews, 55, 107-124

مصطلحات موضوعية: Organic anion transporter 1, organic anion transporter, resistance-associated protein-3, nuclear hormone receptors, Pharmaceutical Science, Organic Anion Transporters, RESISTANCE-ASSOCIATED PROTEIN-3, Voeding, Metabolisme en Genomica, P-glycoproteins, Drug Interactions, hepatocyte nuclear factor-1-alpha, P-glycoprotein, Organic cation transport proteins, biology, Membrane transport protein, Metabolism and Genomics, ATP-DEPENDENT TRANSPORT, S-CONJUGATE TRANSPORT, Biochemistry, Liver, Pharmaceutical Preparations, Metabolisme en Genomica, Nutrition, Metabolism and Genomics, Efflux, B OATP-B, multidrug resistance proteins, P-GLYCOPROTEIN EXPRESSION, solute carriers, drug efflux pumps, PLASMA-MEMBRANE VESICLES, Organic Cation Transport Proteins, RAT-LIVER, Biological Transport, Active, b oatp-b, rat-liver, atp-dependent transport, HEPATOCYTE NUCLEAR FACTOR-1-ALPHA, Voeding, Animals, Humans, Pharmacokinetics, organic anion transporting proteins, salt export pump, plasma-membrane vesicles, VLAG, Nutrition, PROSTAGLANDIN TRANSPORTER, Membrane Transport Proteins, Transporter, ATP-binding cassette transporters, ORGANIC ANION TRANSPORTER, prostaglandin transporter, SALT EXPORT PUMP, Gene Expression Regulation, s-conjugate transport, organic cation transporting protein, biology.protein, p-glycoprotein expression, Drug metabolism

وصف الملف: application/pdf; application/octet-stream

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092e79a077700e734564680a61d3835f
https://doi.org/10.1016/s0169-409x(02)00173-4

المؤلفون: M Geuken, Peter L.M. Jansen, Louis Libbrecht, Tania Roskams, J.E. Ros

المساهمون: Groningen University Institute for Drug Exploration (GUIDE), Gastroenterology and Hepatology

المصدر: JOURNAL OF PATHOLOGY, 200(5), 553-560. Wiley
Journal of pathology, 200(5), 553-560. John Wiley and Sons Ltd

مصطلحات موضوعية: Pathology, medicine.medical_specialty, RAT-LIVER, CHOLESTASIS, Biology, UP-REGULATION, digestive system, Pathology and Forensic Medicine, Immunoenzyme Techniques, RESISTANCE-ASSOCIATED PROTEIN-3, Necrosis, Liver disease, Primary biliary cirrhosis, DUCTULAR REACTION, Cholestasis, medicine, Humans, chronic hepatitis C, ATP Binding Cassette Transporter, Subfamily B, Member 1, RNA, Messenger, P-glycoprotein, human progenitor cells, Fibrous capsule of Glisson, Liver Cirrhosis, Biliary, Reverse Transcriptase Polymerase Chain Reaction, Bile duct, Liver Diseases, Stem Cells, P-GLYCOPROTEIN, Hepatitis C, Hepatitis C, Chronic, medicine.disease, Liver regeneration, submassive necrosis, TRANSPORT, Liver Regeneration, primary biliary cirrhosis, medicine.anatomical_structure, Liver, ABC transporters, immunohistochemistry, Hepatocytes, biology.protein, ATP-Binding Cassette Transporters, Multidrug Resistance-Associated Proteins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c7eb52cc5f504b258ed048e91debe7
https://doi.org/10.1002/path.1379

المصدر: Gut. 52(7):1060-1067

مصطلحات موضوعية: RESISTANCE-ASSOCIATED PROTEIN-3, LEUKEMIA-CELLS, P-GLYCOPROTEIN, OVAL CELLS, BILE, MULTIDRUG-RESISTANCE, UP-REGULATION, STEM-CELLS, HEPATOCYTES, IN-VIVO

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dris___01423::319738c697cb1db71719c940058620a8
https://research.rug.nl/en/publications/84a5122f-2e1e-411f-8465-c6c0580916ad

المصدر: Advanced Drug Delivery Reviews. 55(1):107-124

مصطلحات موضوعية: solute carriers, drug efflux pumps, PLASMA-MEMBRANE VESICLES, nuclear hormone receptors, RAT-LIVER, ATP-binding cassette transporters, ORGANIC ANION TRANSPORTER, HEPATOCYTE NUCLEAR FACTOR-1-ALPHA, prostaglandin transporter, ATP-DEPENDENT TRANSPORT, S-CONJUGATE TRANSPORT, RESISTANCE-ASSOCIATED PROTEIN-3, SALT EXPORT PUMP, P-glycoproteins, organic cation transporting protein, B OATP-B, organic anion transporting proteins, multidrug resistance proteins, P-GLYCOPROTEIN EXPRESSION

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dris___00893::e3dc6fc97afc3fa4b3a3d5a855384b66
https://hdl.handle.net/11370/2d04514c-0519-45ff-9955-5b78ca9d71ac

المؤلفون: Bryon E. Petersen, Folkert Kuipers, D.M. van der Kolk, Michael Müller, Tania Roskams, Rick Havinga, Klaas Nico Faber, Plm Jansen, J.E. Ros, P.L. Splinter, Nicholas F. LaRusso, M Geuken

المساهمون: Groningen University Institute for Drug Exploration (GUIDE), Center for Liver, Digestive and Metabolic Diseases (CLDM), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Gastroenterology and Hepatology

المصدر: Gut, 52(7), 1060-1067. BMJ PUBLISHING GROUP
University of Groningen
Gut, 52(7), 1060-1067. BMJ Publishing Group
Gut 52 (2003) 7
Gut, 52(7), 1060-1067

مصطلحات موضوعية: Male, oval cells, Cellular differentiation, resistance-associated protein-3, Gene Expression, ATP-binding cassette transporter, UP-REGULATION, in-vivo, Polymerase Chain Reaction, HEPATOCYTES, stem-cells, RESISTANCE-ASSOCIATED PROTEIN-3, Voeding, Metabolisme en Genomica, p-glycoprotein, MULTIDRUG-RESISTANCE, IN-VIVO, P-glycoprotein, leukemia-cells, LEUKEMIA-CELLS, biology, Reverse Transcriptase Polymerase Chain Reaction, Stem Cells, Multidrug resistance-associated protein 2, Gastroenterology, P-GLYCOPROTEIN, multidrug-resistance, Flow Cytometry, Immunohistochemistry, Metabolism and Genomics, Liver regeneration, Specific Pathogen-Free Organisms, medicine.anatomical_structure, Liver, Metabolisme en Genomica, Hepatocyte, embryonic structures, OVAL CELLS, Nutrition, Metabolism and Genomics, hepatocytes, Multidrug Resistance-Associated Proteins, STEM-CELLS, Cell Division, ATP Binding Cassette Transporter, Subfamily B, bile, Cell Line, Voeding, Acetylaminofluorene, medicine, up-regulation, Animals, RNA, Messenger, Rats, Wistar, Progenitor cell, VLAG, Nutrition, Molecular biology, Rats, Inbred F344, Rats, biology.protein, BILE, ATP-Binding Cassette Transporters, Genes, MDR

وصف الملف: application/pdf; application/octet-stream

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8acac06f7b0974cddd1f923174b12504
https://research.rug.nl/en/publications/84a5122f-2e1e-411f-8465-c6c0580916ad

المؤلفون: Ros, J.E., Roskams, T.A.D., Geuken, M., Havinga, R., Splinter, P.L., Petersen, B.E., LaRusso, N.F., van der Kolk, D.M., Kuipers, F., Faber, K.N., Müller, M.R., Jansen, P.L.M.

المصدر: Gut 52 (2003) 7 ; ISSN: 0017-5749

مصطلحات موضوعية: bile, hepatocytes, in-vivo, leukemia-cells, multidrug-resistance, oval cells, p-glycoprotein, resistance-associated protein-3, stem-cells, up-regulation

وصف الملف: application/pdf

Relation: https://edepot.wur.nl/189726

الاتاحة: https://research.wur.nl/en/publications/atp-binding-cassette-transporter-gene-expression-in-rat-liver-pro
https://doi.org/10.1136/gut.52.7.1060

المؤلفون: Faber, K.N., Müller, M.R., Jansen, P.L.M.

المصدر: Advanced Drug Delivery Reviews 55 (2003) ; ISSN: 0169-409X

مصطلحات موضوعية: atp-dependent transport, b oatp-b, hepatocyte nuclear factor-1-alpha, organic anion transporter, p-glycoprotein expression, plasma-membrane vesicles, rat-liver, resistance-associated protein-3, s-conjugate transport, salt export pump

وصف الملف: application/pdf

Relation: https://edepot.wur.nl/374311

الاتاحة: https://research.wur.nl/en/publications/drug-transport-proteins-in-the-liver
https://doi.org/10.1016/S0169-409X(02)00173-4

المؤلفون: Faber, Klaas Nico, Muller, M., Jansen, P.LM

المصدر: Faber , K N , Muller , M & Jansen , P LM 2003 , ' Drug transport proteins in the liver ' , Advanced Drug Delivery Reviews , vol. 55 , no. 1 , PII S0169-409X(02)00173-4 , pp. 107-124 .

مصطلحات موضوعية: solute carriers, ATP-binding cassette transporters, organic anion transporting proteins, organic cation transporting protein, prostaglandin transporter, drug efflux pumps, P-glycoproteins, multidrug resistance proteins, nuclear hormone receptors, ORGANIC ANION TRANSPORTER, SALT EXPORT PUMP, RESISTANCE-ASSOCIATED PROTEIN-3, HEPATOCYTE NUCLEAR FACTOR-1-ALPHA, P-GLYCOPROTEIN EXPRESSION, PLASMA-MEMBRANE VESICLES, ATP-DEPENDENT TRANSPORT, S-CONJUGATE TRANSPORT, B OATP-B, RAT-LIVER

الاتاحة: https://hdl.handle.net/11370/2d04514c-0519-45ff-9955-5b78ca9d71ac
https://research.rug.nl/en/publications/2d04514c-0519-45ff-9955-5b78ca9d71ac

المؤلفون: Barbier, O, Pineda Torra, I., Sirvent, A, Claudel, T, Blanquart, C, Duran-Sandoval, D, Kuipers, F, Kosykh, V, Fruchart, JC, Staels, B

المصدر: Barbier , O , Pineda Torra , I , Sirvent , A , Claudel , T , Blanquart , C , Duran-Sandoval , D , Kuipers , F , Kosykh , V , Fruchart , JC & Staels , B 2003 , ' FXR induces the UGT2B4 enzyme in hepatocytes : A potential mechanism of negative feedback control of FXR activity ' , Gastroenterology , vol. 124 , no. 7 , pp. 1926-1940 . https://doi.org/10.1016/S0016-5085(03)00388-3

مصطلحات موضوعية: ORPHAN NUCLEAR RECEPTOR, RESISTANCE-ASSOCIATED PROTEIN-3, ACID-RESPONSIVE ELEMENT, BILE-ACID, UDP-GLUCURONOSYLTRANSFERASE, RAT-LIVER, ACTIVATED RECEPTOR, TISSUE DISTRIBUTION, BILIARY-SECRETION, POLYMORPHIC GENE

Relation: https://research.rug.nl/en/publications/dca8add8-4a0c-44fc-8f48-f2777de91cae

الاتاحة: https://hdl.handle.net/11370/dca8add8-4a0c-44fc-8f48-f2777de91cae
https://research.rug.nl/en/publications/dca8add8-4a0c-44fc-8f48-f2777de91cae
https://doi.org/10.1016/S0016-5085(03)00388-3

المؤلفون: V. A. Kosykh, Olivier Barbier, Audrey Sirvent, Bart Staels, Daniel Duran-Sandoval, Jean-Charles Fruchart, Thierry Claudel, Folkert Kuipers, Inés Pineda Torra, Christophe Blanquart

المساهمون: Center for Liver, Digestive and Metabolic Diseases (CLDM)

المصدر: Gastroenterology, 124(7), 1926-1940. W B SAUNDERS CO-ELSEVIER INC

مصطلحات موضوعية: ORPHAN NUCLEAR RECEPTOR, Lithocholic acid, medicine.drug_class, Glucuronidation, RAT-LIVER, Receptors, Cytoplasmic and Nuclear, BILIARY-SECRETION, Retinoid X receptor, Biology, Chenodeoxycholic Acid, Response Elements, Feedback, RESISTANCE-ASSOCIATED PROTEIN-3, Bile Acids and Salts, chemistry.chemical_compound, Chenodeoxycholic acid, medicine, Humans, Glucuronosyltransferase, Promoter Regions, Genetic, ACID-RESPONSIVE ELEMENT, TISSUE DISTRIBUTION, Cells, Cultured, UGT2B4, Hepatology, Bile acid, Gastroenterology, UDP-GLUCURONOSYLTRANSFERASE, G protein-coupled bile acid receptor, POLYMORPHIC GENE, DNA-Binding Proteins, chemistry, Biochemistry, Enzyme Induction, ACTIVATED RECEPTOR, Hepatocytes, Farnesoid X receptor, BILE-ACID, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4139f63e049658d847d2376dd35af0d5
https://pubmed.ncbi.nlm.nih.gov/12806625