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1
المؤلفون: Rodolfo J. Chaparro, Paige Ruthardt, Wynona Bautista, R.D. Seidel, John F. Ross, Anish Suri, Zohra Merazga, Dharma Thapa, Emily Spaulding, Peter A. Kiener, Jonathan Soriano, Steven N. Quayle, Ahmet S. Vakkasoglu, Saso Cemerski, Simon Low, Steven C. Almo
المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Scientific Reportsمصطلحات موضوعية: T cell, Recombinant Fusion Proteins, Science, Immunology, Primary Cell Culture, Stimulation, Peptide, Mice, Transgenic, Human leukocyte antigen, CD8-Positive T-Lymphocytes, Lymphocyte Activation, Protein Engineering, Article, Mice, Antigen specific, Neoplasms, medicine, Animals, Humans, Cells, Cultured, chemistry.chemical_classification, Multidisciplinary, HLA-A Antigens, Chemistry, Cancer, medicine.disease, In vitro, medicine.anatomical_structure, Mutation, Cancer research, B7-1 Antigen, Medicine, Immunotherapy, Peptides, CD80, Biotechnology
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المؤلفون: R.D. Seidel, Ross W. Cheloha, Ella L. Zeyang, Stephen C. Kolifrath, Alan B. Packard, Rodolfo J. Chaparro, Mohammad Rashidian, Steven C. Almo, Scott J. Garforth, Jason L. J. Dearling, Stad H. Zeigler, Phaneendra K. Duddempudi, Andrew W. Woodham, Hidde L. Ploegh, Maia Mesyngier
المصدر: Nature methods
مصطلحات موضوعية: CD8-Positive T-Lymphocytes, Biochemistry, Article, Epitopes, Mice, 03 medical and health sciences, Immune system, Orthomyxoviridae Infections, In vivo, Antigen specific, medicine, Animals, Humans, Cytotoxic T cell, Antigens, Cloning, Molecular, Lung, Papillomaviridae, Molecular Biology, 030304 developmental biology, 0303 health sciences, medicine.diagnostic_test, Chemistry, Histocompatibility Antigens Class I, Influenza a, Cell Biology, Mice, Inbred C57BL, Gene Expression Regulation, Influenza A virus, Positron emission tomography, Immunoglobulin G, Positron-Emission Tomography, Cancer research, Female, CD8, Biotechnology, Major histocompatibility
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3
المؤلفون: John F. Ross, Dominic R. Beal, Jonathan Soriano, R.D. Seidel, Rodolfo J. Chaparro, Natasha Girgis, Kenneth J. Pienta, Zohra Merazga, Paige Ruthardt, Fan Zhao, Peter A. Kiener, Miguel Moreta, Sandrine Hulot, Anish Suri, Steven N. Quayle, Luke Witt, Saso Cemerski, Dharma Thapa, Mark Haydock, Alex Histed, Melissa M. Kemp, Steven C. Almo, Lauren D. Kraemer, Jessica Ryabin, Mary Simcox, Emily Spaulding, Alyssa Nelson
المصدر: Clinical Cancer Research. 26:1953-1964
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Papillomavirus E7 Proteins, T cell, Mice, Transgenic, Human leukocyte antigen, CD8-Positive T-Lymphocytes, Epitope, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, Neoplasms, HLA-A2 Antigen, medicine, Animals, Humans, Cytotoxic T cell, Cells, Cultured, Chemistry, Fusion protein, Healthy Volunteers, Tumor antigen, Immunoglobulin Fc Fragments, Tumor Necrosis Factor Receptor Superfamily, Member 7, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Leukocytes, Mononuclear, Cancer research, Interleukin-2, Female, CD8
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المؤلفون: Fulvio Diaz, Jonathan Soriano, Fan Zhao, Natasha Girgis, John F. Ross, Steven N. Quayle, Saso Cemerski, Paige Ruthardt, BS Luke Witt, Alex Histed, Anish Suri, Zohra Merazga, R.D. Seidel, Mary Simcox, Kenneth J. Pienta, Miguel Moreta, Dharma Thapa, Melissa M. Kemp
المصدر: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
مصطلحات موضوعية: Chemistry, medicine.medical_treatment, T cell, T-cell receptor, Human leukocyte antigen, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Tumor antigen, Immune system, Cytokine, medicine.anatomical_structure, Cancer research, medicine, Receptor, CD8
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المؤلفون: John F. Ross, Steve Quayle, Tina Daigneault, R.D. Seidel, Natasha Girgis, Simon Low, Raymond Moniz, Ahmet S. Vakkasoglu, Zohra Merazga, Anish Suri
المصدر: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
مصطلحات موضوعية: Pharmacology, Interleukin 2, Cancer Research, Chemistry, Immunology, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Oncology, Antigen specific, medicine, Cancer research, Molecular Medicine, Immunology and Allergy, RC254-282, medicine.drug
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6
المؤلفون: Lisa Scandiuzzi, B. Hillerich, Elena V. Fedorov, Chandan Guha, Scott J. Garforth, R.D. Seidel, Jeffrey B. Bonanno, J. Love, Steven C. Almo, Aldo Massimi, Sarah C. Garrett-Thomson
المصدر: PLoS ONE
PLoS ONE, Vol 15, Iss 6, p e0233578 (2020)مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Luminescence, Microarrays, Polymers, Mutant, Plasma protein binding, Antigen-Antibody Complex, Lymphocyte Activation, B7-H1 Antigen, Mice, White Blood Cells, Binding Analysis, Animal Cells, hemic and lymphatic diseases, Medicine and Health Sciences, CTLA-4 Antigen, Materials, Multidisciplinary, Chemistry, T Cells, Physics, Electromagnetic Radiation, Ligand (biochemistry), Bioassays and Physiological Analysis, Macromolecules, Antigens, Surface, Physical Sciences, B7-1 Antigen, Medicine, Cell lines, DNA microarray, Cellular Types, Biological cultures, Cell Binding Assay, Protein Binding, Research Article, Cell Binding, Cell Physiology, Science, Immune Cells, Immunology, Materials Science, Computational biology, Transfection, Research and Analysis Methods, Microbeads, CD28 Antigens, Animals, Humans, Binding site, Binding selectivity, Chemical Characterization, Binding Sites, Blood Cells, HEK 293 cells, Biology and Life Sciences, Cell Biology, Polymer Chemistry, Mice, Inbred C57BL, HEK293 Cells, Mutant Proteins, Function (biology)
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المؤلفون: B. Hillerich, John E. Cronan, Steven C. Almo, Jose Solbiati, R.D. Seidel, C. Dale Poulter, Gurusankar Ramamoorthy, Jian-Jung Pan
المصدر: ACS Central Science
ACS Central Science, Vol 1, Iss 2, Pp 77-82 (2015)مصطلحات موضوعية: chemistry.chemical_classification, General Chemical Engineering, General Chemistry, Biology, medicine.disease_cause, biology.organism_classification, Zymomonas mobilis, lcsh:Chemistry, chemistry.chemical_compound, Squalene, Enzyme, lcsh:QD1-999, Biochemistry, Biosynthesis, chemistry, Oxidoreductase, medicine, Rhodopseudomonas palustris, Escherichia coli, Bacteria, Research Article
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المؤلفون: Xinshuai Zhang, Matthew P. Jacobson, John E. Cronan, Jungwook Kim, Dmitry A. Rodionov, Jose Solbiati, Hoan Vu, Nawar Al-Obaidi, James D. Love, Daniel J. Wichelecki, Suwen Zhao, Steven C. Almo, R.D. Seidel, Jason T. Bouvier, Brian San Francisco, John A. Gerlt, Matthew W. Vetting, B. Hillerich, Andrei L. Osterman, Ronald J. Quinn
المصدر: Biochemistry
مصطلحات موضوعية: Carbohydrates, Bacillus, Computational biology, Plasma protein binding, Biology, Crystallography, X-Ray, Ligands, Biochemistry, DNA-binding protein, Article, Metabolomics, Fluorometry, Targeted screening, Cloning, Molecular, Panning (camera), Sequence Homology, Amino Acid, Reproducibility of Results, Molecular Sequence Annotation, Chemical space, Kinetics, Functional annotation, Metabolome, Carrier Proteins, Metabolic Networks and Pathways
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المؤلفون: John A. Gerlt, Subramaniam Eswaramoorthy, Subramanyam Swaminathan, Salehe Ghasempur, R.D. Seidel, B. Hillerich, Steven C. Almo
المصدر: Biochemistry
مصطلحات موضوعية: chemistry.chemical_classification, Enolase superfamily, Molecular Sequence Data, Mandelate racemase, Sugar Acids, Biology, Biochemistry, Protein Structure, Secondary, Article, Sugar acids, In vitro, Enzyme, Bacterial Proteins, chemistry, In vivo, Dehydratase, Pseudomonas aeruginosa, biology.protein, Amino Acid Sequence, Transcriptome, Gene, Signal Transduction
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المؤلفون: John A. Gerlt, Mark B. Stead, Bryan M. Balthazor, R.D. Seidel, Steven C. Almo, Alexander A. Fedorov, Matthew W. Vetting, Daniel J. Wichelecki, Tiit Lukk, Elena V. Fedorov, Yury Patskovsky, Anthony C. Chau, B. Hillerich
المصدر: Biochemistry
مصطلحات موضوعية: Protein Conformation, Molecular Sequence Data, Crystallography, X-Ray, Biochemistry, Gluconates, Homology (biology), DNA sequencing, Sugar acids, Article, Substrate Specificity, 03 medical and health sciences, Structure-Activity Relationship, Protein structure, Protein sequencing, Catalytic Domain, Hydro-Lyases, 030304 developmental biology, chemistry.chemical_classification, Genetics, 0303 health sciences, biology, Enolase superfamily, 030302 biochemistry & molecular biology, Sugar Acids, Mand, Kinetics, chemistry, Dehydratase, Phosphopyruvate Hydratase, Mutation, biology.protein
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المؤلفون: Matthew W. Vetting, Swapnil V. Ghodge, Frank M. Raushel, Jennifer A. Cummings, R.D. Seidel, Steven C. Almo, B. Hillerich, Chengfu Xu
المصدر: Biochemistry
مصطلحات موضوعية: Models, Molecular, Coenzyme A, Molecular Sequence Data, Phosphoadenosine Phosphosulfate, Crystallography, X-Ray, Biochemistry, Histidinol-phosphatase, Article, Amidohydrolases, Substrate Specificity, chemistry.chemical_compound, Bacterial Proteins, Hydrolase, Amino Acid Sequence, Enzyme kinetics, Sulfate assimilation, chemistry.chemical_classification, biology, Amidohydrolase, Chromobacterium, Active site, Phosphoric Monoester Hydrolases, Adenosine Diphosphate, Enzyme, chemistry, biology.protein, Crystallization, Sequence Alignment
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المؤلفون: John E. Cronan, Matthew P. Jacobson, Suwen Zhao, B. Hillerich, Jonathan V. Sweedler, Ayano Sakai, Patricia C. Babbitt, Steven C. Almo, Matthew W. Vetting, Shoshana D. Brown, R.D. Seidel, John A. Gerlt, Jeffery B. Bonanno, Ritesh Kumar, B. Mc Kay Wood
المصدر: Nature
مصطلحات موضوعية: Genetics, 0303 health sciences, Multidisciplinary, In silico, 030302 biochemistry & molecular biology, Genome project, Biology, Genome, Article, Gene expression profiling, 03 medical and health sciences, Metabolic pathway, Docking (molecular), Gene cluster, Gene, 030304 developmental biology
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المؤلفون: Frank M. Raushel, R.D. Seidel, B. Hillerich, Matthew W. Vetting, Brian K. Shoichet, Daniel S. Hitchcock, Steven C. Almo, Hao Fan, Andrej Sali, Jungwook Kim
المصدر: Journal of the American Chemical Society. 135:13927-13933
مصطلحات موضوعية: Models, Molecular, Deamination, Nucleoside Deaminases, Crystallography, X-Ray, Biochemistry, Article, Catalysis, Substrate Specificity, Structure-Activity Relationship, Colloid and Surface Chemistry, Catalytic Domain, medicine, Enzyme Assays, chemistry.chemical_classification, Molecular Structure, biology, Amidohydrolase, SUPERFAMILY, General Chemistry, biology.organism_classification, Adenosine, Enzyme assay, Kinetics, Enzyme, chemistry, Docking (molecular), Thermotoga maritima, biology.protein, medicine.drug
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المؤلفون: Yuh Min Chook, B. Hillerich, Radhika N. Banu, Michael M. Soniat, P. Rajesh Kumar, P. Sampathkumar, Garen Collett, Andras Fiser, A. Gizzi, R. Bhosle, Rafael Toro, James Hammonds, Alan S. Glenn, J. Bonanno, Kamil Khafizov, Steven C. Almo, Sukanya Chowdhury, Swetha Chamala, Bridget Matikainen, J. Love, R.D. Seidel
المصدر: Journal of Structural and Functional Genomics. 14:31-35
مصطلحات موضوعية: Nucleocytoplasmic Transport Proteins, Saccharomyces cerevisiae Proteins, Molecular Sequence Data, Nuclear Localization Signals, RNA-binding protein, Saccharomyces cerevisiae, Importin, Biology, Crystallography, X-Ray, environment and public health, Biochemistry, Article, Structural Biology, Genetics, Humans, Amino Acid Sequence, RNA, Messenger, Nuclear pore, Karyopherin, Cell Nucleus, chemistry.chemical_classification, Binding Sites, RNA-Binding Proteins, General Medicine, beta Karyopherins, Cell biology, chemistry, Beta Karyopherins, Nuclear transport, Hydrophobic and Hydrophilic Interactions, Nuclear localization sequence
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المؤلفون: Elena V. Fedorov, Frank M. Raushel, Alexander A. Fedorov, R.D. Seidel, Steven C. Almo, Swapnil V. Ghodge, B. Hillerich
المصدر: Biochemistry. 52:1101-1112
مصطلحات موضوعية: Models, Molecular, Molecular Sequence Data, Phosphatase, Crystallography, X-Ray, Biochemistry, Histidinol-phosphatase, Catalysis, Article, Catalytic Domain, Hydrolase, Escherichia coli, Histidine, Amino Acid Sequence, chemistry.chemical_classification, Sequence Homology, Amino Acid, Amidohydrolase, biology, Lactococcus lactis, Computational Biology, Active site, Histidinol-Phosphatase, Hydrogen-Ion Concentration, biology.organism_classification, Recombinant Proteins, Enzyme, chemistry, Multigene Family, Mutation, Mutagenesis, Site-Directed, biology.protein, Arsenates
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المؤلفون: Matthew W. Vetting, R.D. Seidel, Tamari Narindoshvili, B. Hillerich, Frank M. Raushel, Devon M. Kebodeaux, Howard J. Williams, Merlin Eric Hobbs, Steven C. Almo
المصدر: Biochemistry. 52:239-253
مصطلحات موضوعية: Models, Molecular, Burkholderia, Protein Conformation, Stereochemistry, Dehydrogenase, Crystallography, X-Ray, Biochemistry, Article, Sugar acids, Amidohydrolases, Substrate Specificity, Divalent, Lactones, Protein structure, Catalytic Domain, Lactonase, Enzyme kinetics, Fucose, chemistry.chemical_classification, Amidohydrolase, biology, Hydrolysis, Burkholderia multivorans, Sugar Acids, biology.organism_classification, chemistry, biology.protein, Carbohydrate Dehydrogenases, NADP
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المؤلفون: Tianshun Hu, David Soriano del Amo, Peng Wu, R.D. Seidel, Sarah Garret, Wei Wang, Brian A. Gerwe, Tianqing Zheng, Patrick A. Frantom
المصدر: Proceedings of the National Academy of Sciences. 106:16096-16101
مصطلحات موضوعية: Glycan, Magnetic Resonance Spectroscopy, Fucosyltransferase, Stereochemistry, Lewis X Antigen, Crystallography, X-Ray, Catalysis, Fucose, Epitope, Substrate Specificity, Bacteroides fragilis, chemistry.chemical_compound, Adenosine Triphosphate, Bacterial Proteins, Polysaccharides, Guanosine Diphosphate Fucose, Humans, Trisaccharide, Guanidine, chemistry.chemical_classification, Multidisciplinary, Molecular Structure, biology, Glycobiology, Nucleotidyltransferases, Kinetics, Phosphotransferases (Alcohol Group Acceptor), chemistry, Biochemistry, Physical Sciences, biology.protein, Electrophoresis, Polyacrylamide Gel, Guanosine Triphosphate
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18
المؤلفون: Boxue Tian, C. Dale Poulter, Jeng Yeong Chow, R.D. Seidel, Matthew P. Jacobson, Steven C. Almo, B. Hillerich, Gurusankar Ramamoorthy
المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol 112, iss 18
مصطلحات موضوعية: Protein Structure, sesquiterpene, Stereochemistry, 1.1 Normal biological development and functioning, Streptomyces clavuligerus, Streptomyces, structure-function, Terpene, Structure-Activity Relationship, Underpinning research, Catalytic Domain, Cations, Cluster Analysis, Computer Simulation, Homology modeling, Pentalenene synthase, Multidisciplinary, Alkyl and Aryl Transferases, biology, Active site, Computational Biology, Biological Sciences, biology.organism_classification, Carbon, Protein Structure, Tertiary, cyclase, annotation, biology.protein, UniProt, Tertiary, Function (biology), Algorithms, Software, Biotechnology
وصف الملف: application/pdf
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المؤلفون: Hua Huang, Scott J. Garforth, Min Wang, Steven C. Almo, J. Love, Patrick S. Mariano, Nawar Al-Obaidi, Brandon Evans, Debra Dunaway-Mariano, Chunliang Liu, Li Zheng, Miyuki Aono, Karen N. Allen, B. Hillerich, Chetanya Pandya, Sarah Toews Keating, R.D. Seidel, Jeremiah D. Farelli
المصدر: Proceedings of the National Academy of Sciences. 112
مصطلحات موضوعية: Genetics, chemistry.chemical_classification, Rossmann fold, Multidisciplinary, Subfamily, Phosphatase, Reproducibility of Results, SUPERFAMILY, Computational biology, Biology, Phosphoric Monoester Hydrolases, High-Throughput Screening Assays, Substrate Specificity, Kinetics, Enzyme, PNAS Plus, chemistry, Multigene Family, Profiling (information science), Taxonomic rank, Dehalogenase
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المؤلفون: B. Hillerich, Matthew W. Vetting, Ritesh Kumar, John A. Gerlt, Shoshana D. Brown, R.D. Seidel, Adam Steves, Steven C. Almo, Alan E. Barber, Suwen Zhao, Ayano Sakai, Eyal Akiva, Jose Solbiati, Brian San Francisco, Matthew P. Jacobson, Xinshuai Zhang, Patricia C. Babbitt
مصطلحات موضوعية: Similarity (network science), Computational biology, Biology, Genome, Sequence (medicine)