المؤلفون: Victoria G. Klein (9225489), Adam G. Bond (11571018), Conner Craigon (11571021), R. Scott Lokey (133725), Alessio Ciulli (762789)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Neuroscience, Pharmacology, Evolutionary Biology, Immunology, Developmental Biology, Cancer, Computational Biology, Chemical Sciences not elsewhere classified, “ beyond rule, using model compounds, ternary complex formation, may prove beneficial, cellular activity criteria, beyond ro5 molecules, largely unexplored amide, bearing either amides, based bet degraders, optimizing protac permeability, ester substitution provides, enhance protac permeability, ester substitution, protac components, increase permeability, potent degraders, poor absorption

Relation: https://figshare.com/articles/journal_contribution/Amide-to-Ester_Substitution_as_a_Strategy_for_Optimizing_PROTAC_Permeability_and_Cellular_Activity/17153102

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01496.s001

المؤلفون: Victoria G. Klein (9225489), Walter M. Bray (132474), Hao-Yuan Wang (1490710), Quinn Edmondson (6068012), Joshua Schwochert (1670326), Satoshi Ono (381142), Matthew R. Naylor (2823329), Alexandra C. Turmon (6068015), Justin H. Faris (11113126), Okimasa Okada (6681620), Jack Taunton (67759), R. Scott Lokey (133725)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, side chain, NCI -60 cell line panel, protein synthesis inhibitor, membrane permeability, cordyheptapeptide, Synthetic Derivatives Cordyheptapeptide, intracellular disease targets, backbone amide N, cytotoxicity profile, eukaryotic translation elongation f., lipophilic compounds, Cellular Target, bioactivity, backbone-modified derivatives, eEF 1A, intramolecular hydrogen bond, cancer cell lines, solid-phase synthesis, microscopy-based cytological assay, physicochemical properties, lipophilic cyclic peptide, methylated cyclic heptapeptide, cyclic peptide

Relation: https://figshare.com/articles/journal_contribution/Identifying_the_Cellular_Target_of_a_Cordyheptapeptide_A_and_Synthetic_Derivatives/14959642

الاتاحة: https://doi.org/10.1021/acschembio.1c00094.s001

المؤلفون: Yihui Shi, Walter Bray, Alexander J Smith, Wei Zhou, Joy Calaoagan, Chandraiah Lagisetti, Lidia Sambucetti, Phillip Crews, R Scott Lokey, Thomas R Webb

المصدر: PLoS ONE, Vol 15, Iss 5, p e0233672 (2020)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/aee47b160f21479b987ca0add01dfec1

المؤلفون: R. Scott Lokey, Cameron Pye

المصدر: Science (New York, N.Y.). 378(6624)

مصطلحات موضوعية: Multidisciplinary

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8610295f0c5d929d7ff669ec586aca
https://pubmed.ncbi.nlm.nih.gov/36480613

المؤلفون: Christopher van Hoorebeke, Kevin Yang, Samuel J. Mussetter, Grant Koch, Natalie Rutz, R. Scott Lokey, Phillip Crews, Theodore R. Holman

المصدر: ACS omega. 7(47)

مصطلحات موضوعية: General Chemical Engineering, General Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56c52d714a3fbacfbfdf0659a0baade
https://pubmed.ncbi.nlm.nih.gov/36467910

المؤلفون: Alexandra C Turmon, Matthew R. Naylor, R. Scott Lokey, Okimasa Okada, Hao-Yuan Wang, Walter M. Bray, Joshua Schwochert, Quinn Edmondson, Satoshi Ono, Jack Taunton, Victoria G. Klein, Justin H Faris

المصدر: ACS Chem Biol

مصطلحات موضوعية: Protein Synthesis Inhibitors, chemistry.chemical_classification, Molecular Structure, Membrane permeability, Chemistry, Antineoplastic Agents, General Medicine, Peptides, Cyclic, Biochemistry, Article, Cyclic peptide, Elongation factor, Structure-Activity Relationship, Peptide Elongation Factor 1, Eukaryotic translation, Cell culture, Cell Line, Tumor, Protein Biosynthesis, Side chain, Humans, Molecular Medicine, Cytotoxicity, Solid-Phase Synthesis Techniques, Intracellular

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ef22094d2527c9d53b0e48af95ef1d
https://doi.org/10.1021/acschembio.1c00094

المؤلفون: Alejandro R. Foley, Glenn L. Millhauser, Amanda Smart, Thomas S. Finn, R. Scott Lokey, Ka Chan, Kevin Yang, Jevgenij A. Raskatov, Graham Roseman

المصدر: Proceedings of the National Academy of Sciences. 117:28625-28631

مصطلحات موضوعية: chemistry.chemical_classification, Multidisciplinary, biology, Amyloid beta, media_common.quotation_subject, Peptide, Cell biology, Mediator, chemistry, Docking (molecular), Toxicity, biology.protein, Prion protein, Receptor, Internalization, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::45ff555b8b88082ccb05228fc6402c4f
https://doi.org/10.1073/pnas.2009238117

المؤلفون: R. Scott Lokey, Victoria G. Klein, Daigo Asano, Quinn Edmondson, Cameron R. Pye, Akihiro Furukawa, Joshua Schwochert, Satoshi Ono, Okimasa Okada, Alexandra C Turmon

المصدر: Angew Chem Int Ed Engl

مصطلحات موضوعية: chemistry.chemical_classification, Macrocyclic Compounds, Molecular Structure, Membrane permeability, 010405 organic chemistry, Peptoid, General Medicine, General Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Article, Catalysis, Cyclic peptide, Chemical space, 0104 chemical sciences, Molecular Weight, chemistry.chemical_compound, Rigidity (electromagnetism), chemistry, Lipophilicity, Side chain, Peptides, Hydrophobic and Hydrophilic Interactions, ADME

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1093734f1141e2862b09aace99f0bac8
https://doi.org/10.1002/anie.202004550

المؤلفون: Jaru Taechalertpaisarn, Satoshi Ono, Okimasa Okada, Timothy C. Johnstone, R. Scott Lokey

المصدر: Journal of medicinal chemistry, vol 65, iss 6

مصطلحات موضوعية: Cyclic, Medicinal & Biomolecular Chemistry, Organic Chemistry, Hydrogen Bonding, Pharmacology and Pharmaceutical Sciences, Amides, Peptides, Cyclic, Permeability, Medicinal and Biomolecular Chemistry, Solubility, Drug Discovery, Molecular Medicine, Amino Acids, Peptides

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0b5f42ff11340000b296f29c87ccd5
https://pubmed.ncbi.nlm.nih.gov/35275623

المؤلفون: Laura Kapitzky, Pedro Beltrao, Theresa J Berens, Nadine Gassner, Chunshui Zhou, Arthur Wüster, Julie Wu, M Madan Babu, Stephen J Elledge, David Toczyski, R Scott Lokey, Nevan J Krogan

المصدر: Molecular Systems Biology, Vol 6, Iss 1, Pp 1-13 (2010)

مصطلحات موضوعية: chemogenomics, evolution, modularity, Biology (General), QH301-705.5, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1744-4292

URL الوصول: https://doaj.org/article/2f5a0ad2ef864d9bbc46df89f6b00810

المؤلفون: Matthew R. Naylor, Okimasa Okada, Chad E. Townsend, Chieko Okumura, R. Scott Lokey, Satoshi Ono, Hsiau-Wei Lee

المصدر: J Chem Inf Model

مصطلحات موضوعية: Cyclohexane, Force field (physics), Stereochemistry, Protein Conformation, General Chemical Engineering, Molecular Conformation, Water, General Chemistry, Library and Information Sciences, Molecular Dynamics Simulation, Article, Computer Science Applications, chemistry.chemical_compound, Molecular dynamics, chemistry, Cyclosporin a, Cyclosporine, Solvents, Conformational ensembles, Conformational isomerism, Isomerization, Cis–trans isomerism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7ea54d0a7b0e5c120ff8e74cbdf7ca
https://pubmed.ncbi.nlm.nih.gov/34672629

المؤلفون: Victoria G. Klein, Adam G. Bond, Conner Craigon, Alessio Ciulli, R. Scott Lokey

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: Cell Membrane Permeability, Ubiquitin-Protein Ligases, Cooperativity, Protein degradation, Ligands, 01 natural sciences, Article, Madin Darby Canine Kidney Cells, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Amide, Drug Discovery, Animals, Bifunctional, Ternary complex, 030304 developmental biology, 0303 health sciences, 010405 organic chemistry, Reproducibility of Results, Esters, Hydrogen Bonding, Amides, Combinatorial chemistry, 0104 chemical sciences, chemistry, Permeability (electromagnetism), Proteolysis, Lipophilicity, Lipinski's rule of five, Molecular Medicine, Oligopeptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226920245ada52fb4ef09296381b6379
https://doi.org/10.26434/chemrxiv-2021-47tqn

المؤلفون: Alejandro Cabrera-Cortez, Annalyse Lalljie, Karen Hug, Hanh Lam, Jessica Sherry, Victoria Auerbuch, R. Scott Lokey, Joanne N. Engel, Tannia Lau, Adam Lentz

المصدر: Antimicrobial Agents and Chemotherapy

مصطلحات موضوعية: Gram-negative bacteria, antibiotic resistance, Virulence, Yersinia, Type three secretion system, Microbiology, cyclic peptide, 03 medical and health sciences, Bacterial Proteins, Salmonella, Type III Secretion Systems, Yersinia pseudotuberculosis, Humans, Pharmacology (medical), Secretion, Chlamydia, Mechanisms of Action: Physiological Effects, 030304 developmental biology, Pharmacology, chemistry.chemical_classification, 0303 health sciences, biology, 030306 microbiology, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Cyclic peptide, type III secretion system, inhibitor, Infectious Diseases, chemistry, Pseudomonas aeruginosa, bacteria, Bacteria, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97fd490c263056d6c69b5d0bb523ee7e
https://pubmed.ncbi.nlm.nih.gov/33875435

المؤلفون: Colin N Kelly, Joshua Schwochert, Chad E. Townsend, Cameron R. Pye, R. Scott Lokey, Matthew R. Naylor, Ajay N. Jain

المصدر: J Am Chem Soc

مصطلحات موضوعية: chemistry.chemical_classification, Models, Molecular, Natural product, Cell Membrane Permeability, Membrane permeability, Molecular Structure, Peptide, General Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Catalysis, Cyclic peptide, Didemnin B, Chemical space, Article, 0104 chemical sciences, chemistry.chemical_compound, Colloid and Surface Chemistry, Membrane, chemistry, Biophysics, Side chain, Humans, Peptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ae1cad21157d7a366ef19ab15d0e00
https://pubmed.ncbi.nlm.nih.gov/33381960

المؤلفون: Matthew R. Naylor, Chad E. Townsend, Eva Jason, Quinn Edmondson, R. Scott Lokey, Joshua Schwochert, Cameron R. Pye

مصطلحات موضوعية: Design phase, chemistry.chemical_classification, chemistry.chemical_compound, Passive permeability, chemistry, Membrane permeability, Peptide synthesis, Peptoid, HEXA, Combinatorial chemistry, DNA, Cyclic peptide

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fdaa0e41b0ed9daf3d05c37276a42fe
https://doi.org/10.26434/chemrxiv.13335941

المؤلفون: Govindan Subramanian, Chad E. Townsend, R. Scott Lokey, Sanjay Menon, Marc-Olivier Ebert, Sereina Riniker, Thomas Stadelmann

المصدر: Organic & biomolecular chemistry
Organic & Biomolecular Chemistry, 18 (36)

مصطلحات موضوعية: chemistry.chemical_classification, 010304 chemical physics, Membrane permeability, Ionophores, 010405 organic chemistry, Chemistry, Stereochemistry, Hydrogen bond, Organic Chemistry, 01 natural sciences, Biochemistry, Cyclic peptide, Article, 0104 chemical sciences, chemistry.chemical_compound, Molecular dynamics, Membrane, Intramolecular force, Amide, 0103 physical sciences, Physical and Theoretical Chemistry, Conformational isomerism

وصف الملف: application/application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8bc9eb2f2770c80806ec64fd529ead
https://pubmed.ncbi.nlm.nih.gov/32902550

المؤلفون: Karen Hug, R. Scott Lokey, Jessica Sherry, Hanh Lam, Victoria Auerbuch, Tannia Lau, Alejandro Cabrera-Cortez, Adam Lentz, Joanne N. Engel

مصطلحات موضوعية: biology, Chemistry, Pseudomonas aeruginosa, Virulence, Yersinia, biology.organism_classification, medicine.disease_cause, Type three secretion system, Microbiology, Secretory protein, medicine, Secretion, Pathogen, Bacteria

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6a40829f10f778a500b6acbdb723c725
https://doi.org/10.1101/2020.08.03.235622

المؤلفون: Andrea Testa, Kwok-Ho Chan, R. Scott Lokey, Chad E. Townsend, Victoria G. Klein, Chiara Maniaci, Alessio Ciulli, Michael Zengerle, Scott J. Hughes

المصدر: ACS Medicinal Chemistry Letters

مصطلحات موضوعية: Letter, Membrane permeability, Proteolysis, Selective degradation, Synthetic membrane, 01 natural sciences, Biochemistry, Ubiquitin, Drug Discovery, medicine, biology, medicine.diagnostic_test, 010405 organic chemistry, Chemistry, Organic Chemistry, structure−permeability relationships, Chemical space, 0104 chemical sciences, Ubiquitin ligase, PAMPA, 010404 medicinal & biomolecular chemistry, Proteasome, Permeability (electromagnetism), biology.protein, Biophysics, permeability, LPE

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2bbd70a4a73f831312ab59ea46182b
https://pubmed.ncbi.nlm.nih.gov/32939229

المؤلفون: Colin N Kelly, R. Scott Lokey, Matthew R. Naylor, Yuki Hosono, Chad E. Townsend, Jumpei Morimoto, Shinsuke Sando, Hsiau-Wei Lee

مصطلحات موضوعية: Depsipeptide, chemistry.chemical_classification, chemistry.chemical_compound, Membrane permeability, Chemistry, Permeability (electromagnetism), Amide, Rational design, Biophysics, Peptide bond, Permeation, Cyclic peptide

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::670959e992c9f826d8fe1ad2b138639e
https://doi.org/10.26434/chemrxiv.12272861

المؤلفون: Laura R Serbus, Frederic Landmann, Walter M Bray, Pamela M White, Jordan Ruybal, R Scott Lokey, Alain Debec, William Sullivan

المصدر: PLoS Pathogens, Vol 8, Iss 9, p e1002922 (2012)

مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC3447747?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

URL الوصول: https://doaj.org/article/462c1353791e401ebbfccec1727587c5