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1
المؤلفون: Judith L. Treadway, David W. Piotrowski, R. Kirk McPherson, Jana Polivkova, Anne M. Brodeur, Shenping Liu, Bernard Hulin, David D. Boyer, Stephen J. Orena, Xiayang Qiu, Maria A. Vanvolkenburg, Dennis E. Danley, Donald C. Wilder, Janice C. Parker, Shawn D. Doran, Carolyn B. Soglia, Mark Ammirati, Kim M. Andrews
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:1991-1995
مصطلحات موضوعية: Pyrrolidines, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Carboxamide, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Dipeptidyl peptidase, Rats, Sprague-Dawley, Structure-Activity Relationship, Dogs, Oral administration, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Molecular Biology, Dipeptidyl peptidase-4, ADME, Dipeptidyl-Peptidase IV Inhibitors, biology, Chemistry, Organic Chemistry, Rats, Bioavailability, Pyrimidines, Diabetes Mellitus, Type 2, Enzyme inhibitor, biology.protein, Molecular Medicine
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2
المؤلفون: Hong Wang, Judith L. Treadway, Maria A. Vanvolkenburg, Anne M. Brodeur, L. D. Mcclure, Shawn D. Doran, Jay S. Lillquist, Kim M. Andrews, Stephen J. Orena, Stephen W. Wright, Donald C. Wilder, Jana Polivkova, R. Kirk McPherson, Mark Ammirati, Janice C. Parker, Thanh V. Olson, Walter C. Soeller, Xiayang Qiu, Carolyn B. Soglia, Dennis E. Danley
المصدر: Journal of Medicinal Chemistry. 49:3068-3076
مصطلحات موضوعية: Male, Models, Molecular, Proteases, Pyrrolidines, Adenosine Deaminase, medicine.drug_class, Stereochemistry, Dipeptidyl Peptidase 4, Administration, Oral, Biological Availability, Carboxamide, Crystallography, X-Ray, Dipeptidyl peptidase, Rats, Sprague-Dawley, Serine, Mice, Structure-Activity Relationship, Dogs, In vivo, Nitriles, Drug Discovery, Adenosine Deaminase Inhibitors, medicine, Animals, Humans, Hypoglycemic Agents, Structure–activity relationship, Glycoproteins, chemistry.chemical_classification, biology, Chemistry, Rats, Crystallography, Enzyme, Diabetes Mellitus, Type 2, Biochemistry, Enzyme inhibitor, Injections, Intravenous, biology.protein, Molecular Medicine
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3
المؤلفون: Tara B. Manion, Michael Patrick Pence, Jennifer L. LaPerle, David W. Piotrowski, Susan Tapley, Paul DaSilva-Jardine, R. Kirk McPherson, Robert L. Dow, Angel Guzman-Perez, William J. Zavadoski, Gregory S. Walker, E. Michael Gibbs, Jian-Cheng Li, John Litchfield, Eliot Sugarman, Michael John Munchhof
المصدر: ACS medicinal chemistry letters. 2(5)
مصطلحات موضوعية: Triglyceride, business.industry, Organic Chemistry, Pharmacology, medicine.disease, Biochemistry, chemistry.chemical_compound, Biosynthesis, chemistry, Pharmacokinetics, In vivo, Diabetes mellitus, Drug Discovery, Knockout mouse, medicine, business, IC50, Diacylglycerol kinase
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4
المؤلفون: R. Kirk McPherson, Peter F. Blackmore, R W Stevenson
المصدر: Metabolism. 42:1583-1587
مصطلحات موضوعية: Male, medicine.medical_specialty, Glycogenolysis, Vasopressins, Endocrinology, Diabetes and Metabolism, Biology, Glucagon, Rats, Sprague-Dawley, chemistry.chemical_compound, Glycogen phosphorylase, Adenosine Triphosphate, Endocrinology, Internal medicine, Cyclic AMP, medicine, Animals, Hypoglycemic Agents, Benzopyrans, Phosphorylase a, Cyclic adenosine monophosphate, Cells, Cultured, Dose-Response Relationship, Drug, Gluconeogenesis, Phosphodiesterase, Englitazone, Rats, Kinetics, Thiazoles, Liver, chemistry, Mechanism of action, Calcium, Thiazolidinediones, medicine.symptom
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5
المؤلفون: H. James Harwood, R. Kirk McPherson, Susan Tapley, Leanne M. Buzon, Kevin Daniel Freeman-Cook, Steven B. Coffey, Richard L. Elliott, Darcy Kohls, Liang Tong, Felix Vajdos, Meihua Tu, Eliot Sugarman, Shawn D. Doran, Francis Rajamohan, Eric S. Marr, Hailong Zhang, Wei Song, Kenneth J. DiRico, Jeffrey W. Corbett, Janet A. Houser, Sharad B. Murdande, William P. Esler, Martha L. Minich, Christopher J. Jones
المصدر: Bioorganicmedicinal chemistry letters. 20(7)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Isozyme, Small Molecule Libraries, Structure-Activity Relationship, Drug Discovery, Transferase, Animals, Humans, Enzyme Inhibitors, Molecular Biology, biology, Drug discovery, Chemistry, Organic Chemistry, Acetyl-CoA carboxylase, Acetyl-CoA Carboxylase 1, Small molecule, Pyruvate carboxylase, Rats, Isoenzymes, Enzyme inhibitor, biology.protein, Molecular Medicine, Acetyl-CoA Carboxylase
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6
المؤلفون: Maria A. Vanvolkenburg, L. D. Mcclure, Stephen J. Orena, Kim M. Andrews, Benjamin N. Rocke, Jay S. Lillquist, Judith L. Treadway, Stephen W. Wright, Zhengrong Zhao, Thanh V. Olson, Janice C. Parker, Shawn D. Doran, Walter C. Soeller, R. Kirk McPherson, Anne M. Brodeur, Cox Eric David, Carolyn B. Soglia, Shenping Liu, Mark Ammirati, Dennis E. Danley
المصدر: Bioorganicmedicinal chemistry letters. 17(20)
مصطلحات موضوعية: Models, Molecular, Pyrrolidines, Stereochemistry, Dipeptidyl Peptidase 4, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Pyrrolidine, Dipeptidyl peptidase, chemistry.chemical_compound, Dogs, In vivo, Drug Discovery, Animals, Humans, Protease Inhibitors, Molecular Biology, chemistry.chemical_classification, Dipeptidyl-Peptidase IV Inhibitors, biology, Molecular Structure, Organic Chemistry, Stereoisomerism, Fluorine, In vitro, Rats, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Selectivity
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7
المؤلفون: Yue Chen, Li J. Yu, R. Kirk McPherson, E. Michael Gibbs, Dennis J. Hoover, Judith L. Treadway, Scott C. McCoid
المصدر: The Journal of pharmacology and experimental therapeutics. 317(3)
مصطلحات موضوعية: Pharmacology, Blood Glucose, Drug discovery, Biological activity, Endogeny, Mice, Inbred Strains, Blood Proteins, Biology, Models, Biological, In vitro, Glycogen Phosphorylase, Liver Form, Diabetes Mellitus, Experimental, Enzyme binding, Glycogen phosphorylase, Mice, Biochemistry, Liver, In vivo, Molecular Medicine, Potency, Animals, Humans, Enzyme Inhibitors, Protein Binding
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8
المؤلفون: Scott C. McCoid, L. D. Mcclure, E. Michael Gibbs, Paul E. Genereux, Donald E. Wilder, William J. Zavadoski, Teresa M. Schelhorn, Carolyn B. Levy, Judith L. Treadway, Stephen W. Wright, David L. Hageman, Virginia L. Rath, R. Kirk McPherson
المصدر: Bioorganicmedicinal chemistry letters. 15(2)
مصطلحات موضوعية: Indoles, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Allosteric regulation, Glycine, Pharmaceutical Science, Carboxamide, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Glycogen phosphorylase, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Aminocaproates, Glycogen, Organic Chemistry, Glycogen Phosphorylase, Amides, Crystallography, Enzyme, chemistry, Liver, Molecular Medicine, Allosteric Site
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9
المؤلفون: R. Kirk McPherson, Donald E. Wilder, Ravi Mysore Shanker, Yue Chen, Alison K. Mutchler, Andrew H. Smith, Judith L. Treadway, Jill C. Sutt, David M. Flynn, Delvin R. Knight, W. Ross Tracey, Carolyn B. Levy, Li J. Yu, William P. Magee
المصدر: American journal of physiology. Heart and circulatory physiology. 286(3)
مصطلحات موضوعية: Male, medicine.medical_specialty, Cardiotonic Agents, Indoles, Pyrrolidines, Physiology, Ischemia, Myocardial Infarction, Myocardial Reperfusion Injury, In Vitro Techniques, Glycogen phosphorylase, Physiology (medical), Internal medicine, Glycosyltransferase, medicine, Animals, Enzyme Inhibitors, chemistry.chemical_classification, Lagomorpha, biology, Dose-Response Relationship, Drug, Glycogen Phosphorylase, biology.organism_classification, medicine.disease, Enzyme, Endocrinology, chemistry, Enzyme inhibitor, Anaerobic glycolysis, Circulatory system, biology.protein, Rabbits, Cardiology and Cardiovascular Medicine, Glycogen
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10
المؤلفون: R. Kirk McPherson, E. Michael Gibbs, Judith L. Treadway, Alan M. Mathiowetz, Jennifer L Ekstrom, Mark Ammirati, Thanh V. Olson, Dennis E. Danley, Dennis J. Hoover, Virginia L. Rath, Thomas R Hynes
المصدر: Chemistrybiology. 7(9)
مصطلحات موضوعية: Models, Molecular, Indoles, Phosphorylases, Protein Conformation, Allosteric regulation, Clinical Biochemistry, Biology, Crystallography, X-Ray, Biochemistry, Drug design, Protein Structure, Secondary, X-ray, chemistry.chemical_compound, Glycogen phosphorylase, Drug Discovery, Humans, Hypoglycemic Agents, Glycolysis, Phosphorylation, Binding site, Enzyme Inhibitors, Phosphorylase kinase, Glycogen synthase, Molecular Biology, Pharmacology, Binding Sites, Glycogen, Crystal structure, Incidence, Diabetes, General Medicine, United States, chemistry, Diabetes Mellitus, Type 2, Liver, biology.protein, Molecular Medicine, Allosteric Site
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11Academic Journal
المؤلفون: Janice C. Parker, R. Kirk Mcpherson, Kim M. Andrews, Carolyn B. Levy, Jeffrey S. Dubins, Janice E. Chin, Pia V. Perry, Bernard Hulin, David A. Perry, Taisuke Inagaki, Koen A. Dekker, Kiyoshi Tachikawa, Yutaka Sugie, Judith L. Treadway
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.615.9780; http://diabetes.diabetesjournals.org/content/49/12/2079.full.pdf
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12
المؤلفون: Ralph W Stevenson, Nancy J Hutson, Michael N Krupp, Robert A Volkmann, Gerald F Holland, James F Eggler, David A Clark, R Kirk McPherson, Karla L Hall, Bernice H Danbury, E Michael Gibbs, David K Kreutter
المصدر: Diabetes. 39(10)
مصطلحات موضوعية: Blood Glucose, Glycerol, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Hydroxybutyrates, Mice, Obese, Hypoglycemia, Fatty Acids, Nonesterified, chemistry.chemical_compound, Mice, Reference Values, Internal medicine, Adipocyte, Hyperinsulinism, Internal Medicine, Hyperinsulinemia, Medicine, Animals, Hypoglycemic Agents, Insulin, Benzopyrans, Triglycerides, Triglyceride, 3-Hydroxybutyric Acid, business.industry, Englitazone, medicine.disease, Glucagon, Mice, Inbred C57BL, Kinetics, Thiazoles, Endocrinology, Cholesterol, chemistry, Glycogenesis, Hyperglycemia, Lipogenesis, Thiazolidinediones, business
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13
المصدر: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 928:98-106
مصطلحات موضوعية: Biology, Dephosphorylation, Protein Phosphatase 1, Cyclic AMP, Phosphoprotein Phosphatases, medicine, Animals, Phosphorylation, Glycogen synthase, Protein kinase A, Molecular Biology, ATP synthase, Kinase, Myocardium, Protein phosphatase 1, Cell Biology, Phosphoproteins, Trypsin, Molecular biology, Peptide Fragments, Rats, Glycogen Synthase, Biochemistry, Immunologic Techniques, biology.protein, Protein Kinases, medicine.drug