المساهمون: College of Medicine, Dept. of Microbiology, Chang Mo Yang, Joo Chun Yoon, Jeon Han Park, Jae Myun Lee, Park, Jeon Han, Lee, Jae Myun

مصطلحات موضوعية: Carbamates/chemistry, Carbamates/pharmacology, Cell Line, Cell Survival/drug effects, Coculture Techniques, Down-Regulation/drug effects, Hepacivirus/enzymology, Hepatitis C/immunology, Hepatitis C/pathology, Hepatitis C/virology, Humans, Interferon-gamma/analysis, Interferon-gamma/metabolism, Interleukin-12/genetics, Interleukin-12/metabolism, Interleukin-12/pharmacology, K562 Cells, Killer Cells, Natural/drug effects, Natural/immunology, Natural/metabolism, Macrocyclic Compounds/chemistry, Macrocyclic Compounds/pharmacology, Microscopy, Confocal, Natural Cytotoxicity Triggering Receptor 1/genetics, Natural Cytotoxicity Triggering Receptor 1/metabolism, Natural Cytotoxicity Triggering Receptor 3/genetics, Natural Cytotoxicity Triggering Receptor 3/metabolism, Quinolines/chemistry

Relation: PLOS ONE; J02540; OAK-2017-01787; https://ir.ymlib.yonsei.ac.kr/handle/22282913/154572; T201701200; PLOS ONE, Vol.12(4) : e0175793, 2017

الاتاحة: https://ir.ymlib.yonsei.ac.kr/handle/22282913/154572
https://doi.org/10.1371/journal.pone.0175793

المؤلفون: Nakasone, Mark A., Lewis, Timothy A., Walker, Olivier, Thakur, Anita, Mansour, Wissam, Castañeda, Carlos A., Goeckeler-Fried, Jennifer L., Parlati, Frank, Chou, Tsui-Fen, Hayat, Ortal, Zhang, Daoning, Camara, Christina M., Bonn, Steven M., Nowicka, Urszula K., Krueger, Susan, Glickman, Michael H., Brodsky, Jeffrey L., Deshaies, Raymond J., Fushman, David

المصدر: Nakasone , M A , Lewis , T A , Walker , O , Thakur , A , Mansour , W , Castañeda , C A , Goeckeler-Fried , J L , Parlati , F , Chou , T-F , Hayat , O , Zhang , D , Camara , C M , Bonn , S M , Nowicka , U K , Krueger , S , Glickman , M H , Brodsky , J L , Deshaies , R J & Fushman , D 2017 , ' Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome ....

مصطلحات موضوعية: Binding Sites, Cell Line, HeLa Cells, Humans, Molecular Docking Simulation, Proteasome Endopeptidase Complex/chemistry, Protein Binding, Quinolines/chemistry, Saccharomyces cerevisiae/enzymology, Sulfanilic Acids/chemistry, Ubiquitins/antagonists & inhibitors

Relation: https://discovery.dundee.ac.uk/en/publications/60bb8211-e5e1-40d6-8e4d-2b9f9043e384

الاتاحة: https://discovery.dundee.ac.uk/en/publications/60bb8211-e5e1-40d6-8e4d-2b9f9043e384
https://doi.org/10.1016/j.str.2017.10.007

المؤلفون: González-Vera, Juan, Fueyo-González, Francisco, Alkorta, Ibon, Peyressatre, Marion, Morris, May, Herranz, Rosario

المساهمون: Consejo Superior de Investigaciones Cientificas España = Spanish National Research Council Spain (CSIC), Institut des Biomolécules Max Mousseron Pôle Chimie Balard (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Instituto de Quimica Médica (CSIC)

المصدر: ISSN: 1359-7345.

مصطلحات موضوعية: MESH: Cyclin-Dependent Kinase 5 / chemistry, MESH: Fluorescent Dyes / chemistry, MESH: Humans, MESH: Molecular Structure, MESH: Quinolines / chemistry, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology

Relation: hal-03032093; https://hal.umontpellier.fr/hal-03032093; https://hal.umontpellier.fr/hal-03032093/document; https://hal.umontpellier.fr/hal-03032093/file/C6CC04566A.pdf

الاتاحة: https://hal.umontpellier.fr/hal-03032093
https://hal.umontpellier.fr/hal-03032093/document
https://hal.umontpellier.fr/hal-03032093/file/C6CC04566A.pdf
https://doi.org/10.1039/c6cc04566a

المؤلفون: Pelleau, Stéphane, Moss, Eli L, Dhingra, Satish K, Volney, Béatrice, Casteras, Jessica, Gabryszewski, Stanislaw J, Volkman, Sarah K, Wirth, Dyann F, Legrand, Eric, Fidock, David A, Neafsey, Daniel E, Musset, Lise

المساهمون: Centre National de Référence du Paludisme Cayenne, Guyane française (CNR - laboratoire associé), Institut Pasteur de la Guyane, Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur), Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School Boston (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital Boston, Columbia University College of Physicians and Surgeons, Harvard School of Public Health, This work was supported by European Commission Grant REGPOT-CT-2011-285837-430 STRonGer (to S.P.), AgenceNationale de la Recherche Investissements d’Avenir Grant ANR-10-LABX-25-01(to S.P. and L.M.), NIH Grants R01AI50234 (to D.A.F.) and R01AI109023 (to D.A.F.),and the Institut de Veille Sanitaire. Sequencing was supported, in part, byNational Institute of Allergy and Infectious Diseases, NIH, Department ofHealth and Human Services Contract HHSN272200900018C., ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), European Project: 285837,EC:FP7:REGPOT,FP7-REGPOT-2011-1,STRONGER(2011)

المصدر: ISSN: 0027-8424.

مصطلحات موضوعية: evolution, drug resistance, malaria, PfCRT, Plasmodium falciparum, MESH: Alleles, MESH: Chloroquine/therapeutic use, MESH: Principal Component Analysis, MESH: Protozoan Proteins/genetics, MESH: Drug Resistance/genetics, MESH: Quinolines/chemistry, MESH: Retrospective Studies, MESH: Evolution, Molecular, MESH: French Guiana, MESH: Genetic Markers, MESH: Genome, MESH: Genotype, MESH: Inhibitory Concentration 50, MESH: Haplotypes, MESH: Humans, MESH: Malaria/drug therapy, MESH: Membrane Transport Proteins/genetics, MESH: Mutation, MESH: Phenotype, MESH: Plasmodium falciparum/drug effects, MESH: Plasmodium falciparum/genetics, MESH: Prevalence, [SDV]Life Sciences [q-bio], [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology

Relation: info:eu-repo/semantics/altIdentifier/pmid/26261345; info:eu-repo/grantAgreement/EC/FP7/285837/EU/Strengthening transdisciplinary research on infectious and emerging diseases in French Guiana: linking fieldwork, benchside and bedside/STRONGER; PUBMED: 26261345; PUBMEDCENTRAL: PMC4577156

الاتاحة: https://hal.science/hal-01229321
https://hal.science/hal-01229321v1/document
https://hal.science/hal-01229321v1/file/PNAS-2015-Pelleau-11672-7.pdf
https://doi.org/10.1073/pnas.1507142112

المؤلفون: Gloria Rubiales, Cinzia Tesauro, María Fuertes, Endika Martin-Encinas, Asier Selas, Concepción Alonso, Francisco Palacios, Birgitta K. Knudssen

المصدر: Alonso, C, Fuertes, M, Martín-Encinas, E, Selas, A, Rubiales, G, Tesauro, C, Knudssen, B K & Palacios, F 2018, ' Novel topoisomerase I inhibitors. Syntheses and biological evaluation of phosphorus substituted quinoline derivates with antiproliferative activity ', European Journal of Medicinal Chemistry, vol. 149, pp. 225-237 . https://doi.org/10.1016/j.ejmech.2018.02.058

مصطلحات موضوعية: Phosphines, Phosphorus/chemistry, Antineoplastic Agents, 010402 general chemistry, 01 natural sciences, Stereocenter, Cell Proliferation/drug effects, Structure-Activity Relationship, chemistry.chemical_compound, DESIGN, Cell Line, Tumor, Drug Discovery, Humans, Structure–activity relationship, Dehydrogenation, MEDICINAL CHEMISTRY, DNA TOPOISOMERASES, Quinolines/chemistry, Cell Proliferation, Antiproliferative effect, Pharmacology, A549 cell, biology, 010405 organic chemistry, Chemistry, Topoisomerase, Topoisomerase I Inhibitors/chemical synthesis, Organic Chemistry, Quinoline, Phosphorated quinolines, Phosphorus, General Medicine, CANCER, Combinatorial chemistry, 0104 chemical sciences, Topoisomerase I, Enzyme inhibition, MULTICOMPONENT REACTIONS, DISCOVERY, Quinolines, biology.protein, COMPLEXES, Hydrogenation, Topoisomerase I Inhibitors, Drug Screening Assays, Antitumor, Selectivity, Phosphine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6015f40e306409f613037ba63637fa
https://doi.org/10.1016/j.ejmech.2018.02.058

المؤلفون: Lemaire, Sandrine, Tulkens, Paul M., Van Bambeke, Françoise

المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute

المصدر: Antimicrobial Agents and Chemotherapy, Vol. 55, no. 2, p. 649-658 (2011)

مصطلحات موضوعية: Animals, Anti-Infective Agents - chemistry, pharmacokinetics, pharmacology, Microbial Sensitivity Tests, Models, Biological, Monocytes - metabolism, microbiology, Quinolines - chemistry, Staphylococcal Infections - microbiology, Staphylococcus aureus - drug effects, metabolism, Aza Compounds - chemistry, Cell Line, Culture Media - chemistry, Fluoroquinolones - chemistry, Humans, Hydrogen-Ion Concentration, Macrophages - metabolism, Mice

Relation: boreal:105976; http://hdl.handle.net/2078.1/105976; info:pmid/21135179; urn:ISSN:0066-4804; urn:EISSN:1098-6596

الاتاحة: http://hdl.handle.net/2078.1/105976
https://doi.org/10.1128/AAC.01201-10

المؤلفون: Bensikaddour, Hayet, Fa, Nathalie, Burton, Ingrid, Deleu, Magali, Lins, Laurence, Schanck, Andre, Brasseur, Robert, Dufrene, Yves F, Goormaghtigh, Erik, Mingeot-Leclercq, Marie*-Paule

المصدر: Biophysical Journal, 94 (8), 3035-46 (2008)

مصطلحات موضوعية: Anti-Bacterial Agents/chemistry, Aza Compounds/chemistry, Ciprofloxacin/chemistry, Complex Mixtures/chemistry, Fluoroquinolones/chemistry, Membrane Lipids/chemistry, Membrane Microdomains/chemistry, Microscopy, Atomic Force/methods, Molecular Conformation, Phase Transition, Phospholipids/chemistry, Quinolines/chemistry, Spectroscopy, Fourier Transform Infrared/methods, Surface Properties, Life sciences, Biochemistry, biophysics & molecular biology, Sciences du vivant, Biochimie, biophysique & biologie moléculaire

Relation: urn:issn:0006-3495; urn:issn:1542-0086; https://orbi.uliege.be/handle/2268/63309; info:hdl:2268/63309; info:pmid:18178657

الاتاحة: https://orbi.uliege.be/handle/2268/63309
https://orbi.uliege.be/bitstream/2268/63309/1/261-cv.pdf
https://doi.org/10.1529/biophysj.107.114843

المساهمون: Eui-Nam Lee, Sun-Young Lee, Seung R. Paik, Jongsun Kim, Daekyun Lee, Kim, Jong Sun

مصطلحات موضوعية: Catalysis, Copper/chemistry, Cross-Linking Reagents/chemistry, Electrophoresis, Polyacrylamide Gel, Hydrogen Peroxide/chemistry, Lipids/chemistry, Macromolecular Substances, Nerve Tissue Proteins/chemistry, Oxidation-Reduction, Phosphatidylinositols/chemistry, Protein Binding/physiology, Quinolines/chemistry, Recombinant Proteins/chemistry, Spectrometry, Fluorescence, Synucleins, alpha-Synuclein, beta-Synuclein, copper, lipid interaction, metal-catalyzed oxida-tion, Parkinson�셲 disease, self-oligomerization, a-synuclein. J. Neurochem

وصف الملف: 1128~1142

Relation: JOURNAL OF NEUROCHEMISTRY; J01620; OAK-2003-00399; https://ir.ymlib.yonsei.ac.kr/handle/22282913/113559; T200303428; JOURNAL OF NEUROCHEMISTRY, Vol.84(5) : 1128-1142, 2003

الاتاحة: https://ir.ymlib.yonsei.ac.kr/handle/22282913/113559
https://doi.org/10.1046/j.1471-4159.2003.01612.x
http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.2003.01612.x/abstract

المؤلفون: Roberta Mazzone, Piero Picci, Katia Scotlandi, Michela Pasello, Patrizia Nanni, Giordano Nicoletti, Maria Cristina Manara, Antonello Mai, Clara Guerzoni, Camilla Cristalli, Pier Luigi Lollini, Lorena Landuzzi, Sergio Valente, Giulia Stazi, Paola B. Arimondo, Clemens Zwergel

المساهمون: Istituto Ortopedico Rizzoli [Bologna, Italy], Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Centre National de la Recherche Scientifique (CNRS), Department of Medicinal Chemistry and Technologies, Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], This work was funded by AIRC (IG 18451 to K. Scotlandi, IG 19162 to A. Mai), the Italian Ministry of Health (TRANSCAN_ project TORPEDO_ER-2015-23604059 to K. Scotlandi), Progetto Ateneo Sapienza (to A. Mai), PRIN 2016 (prot 20152TE5PK to A. Mai), and the NIH (R01GM114306 to A. Mai)., The authors thank Cristina Ghinelli for editing the manuscript., Manara, Maria Cristina, Valente, Sergio, Cristalli, Camilla, Nicoletti, Giordano, Landuzzi, Lorena, Zwergel, Clemen, Mazzone, Roberta, Stazi, Giulia, Arimondo, Paola B, Pasello, Michela, Guerzoni, Clara, Picci, Piero, Nanni, Patrizia, Lollini, Pier-Luigi, Mai, Antonello, Scotlandi, Katia

المصدر: Molecular Cancer Therapeutics
Molecular Cancer Therapeutics, American Association for Cancer Research, 2018, 17 (9), pp.1881-1892. ⟨10.1158/1535-7163.MCT-17-0818⟩

مصطلحات موضوعية: 0301 basic medicine, Male, patient-derived xenograft (PDX), MESH: Osteosarcoma/genetics, MESH: Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Cellular differentiation, DNA Methyltransferase Inhibitor, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, chemotherapy, MESH: Mice, Knockout, 0302 clinical medicine, MESH: Osteosarcoma/drug therapy, Antineoplastic Combined Chemotherapy Protocols, MESH: Aminoquinolines/administration & dosage, MESH: Animals, MESH: Quinolines/chemistry, Enzyme Inhibitors, MESH: DNA (Cytosine-5-)-Methyltransferase 1/metabolism, Mice, Knockout, DNA methylation, Chemistry, 3. Good health, Tumor Burden, MESH: Benzamides/pharmacology, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Benzamides, oncology, Aminoquinolines, Quinolines, MESH: Cisplatin/administration & dosage, MESH: Bone Neoplasms/metabolism, Osteosarcoma, MESH: Doxorubicin/administration & dosage, epigenetic, MESH: Bone Neoplasms/genetics, medicine.drug, DNA (Cytosine-5-)-Methyltransferase 1, musculoskeletal diseases, MESH: Aminoquinolines/pharmacology, MESH: Cell Line, Tumor, DNA damage, MESH: Gene Expression Regulation, Neoplastic/drug effects, MESH: Tumor Burden/genetics, MESH: Xenograft Model Antitumor Assays, Bone Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, 03 medical and health sciences, Cell Line, Tumor, osteosarcoma, medicine, Animals, Humans, Doxorubicin, MESH: DNA (Cytosine-5-)-Methyltransferase 1/antagonists & inhibitors, MESH: Enzyme Inhibitors/chemistry, Cisplatin, MESH: Humans, Nucleoside inhibitor, medicine.disease, MESH: Enzyme Inhibitors/pharmacology, Xenograft Model Antitumor Assays, MESH: Male, MESH: Enzyme Inhibitors/administration & dosage, MESH: Bone Neoplasms/drug therapy, 030104 developmental biology, MESH: Osteosarcoma/metabolism, Cancer research, cancer research, MESH: DNA (Cytosine-5-)-Methyltransferase 1/genetics, MESH: Benzamides/administration & dosage, MESH: Tumor Burden/drug effects

وصف الملف: STAMPA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55d5482d55dc2ed43ad6818ec4cbf60
https://hal.archives-ouvertes.fr/hal-02383680

المؤلفون: Manara, Maria Cristina, Valente, Sergio, Cristalli, Camilla, Nicoletti, Giordano, Landuzzi, Lorena, Zwergel, Clemens, Mazzone, Roberta, Stazi, Giulia, Arimondo, Paola, Pasello, Michela, Guerzoni, Clara, Picci, Piero, Nanni, Patrizia, Lollini, Pier-Luigi, Mai, Antonello, Scotlandi, Katia

المساهمون: Istituto Ortopedico Rizzoli Bologna, Italy, Università degli Studi di Roma "La Sapienza" = Sapienza University Rome (UNIROMA), Centre National de la Recherche Scientifique (CNRS), Department of Medicinal Chemistry and Technologies, Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Università degli Studi di Roma "La Sapienza" = Sapienza University Rome (UNIROMA), This work was funded by AIRC (IG 18451 to K. Scotlandi, IG 19162 to A. Mai), the Italian Ministry of Health (TRANSCAN_ project TORPEDO_ER-2015-23604059 to K. Scotlandi), Progetto Ateneo Sapienza (to A. Mai), PRIN 2016 (prot 20152TE5PK to A. Mai), and the NIH (R01GM114306 to A. Mai)., The authors thank Cristina Ghinelli for editing the manuscript.

المصدر: ISSN: 1535-7163.

مصطلحات موضوعية: MESH: Aminoquinolines/administration & dosage, MESH: Aminoquinolines/pharmacology, MESH: Cisplatin/administration & dosage, MESH: DNA (Cytosine-5-)-Methyltransferase 1/antagonists & inhibitors, MESH: DNA (Cytosine-5-)-Methyltransferase 1/genetics, MESH: DNA (Cytosine-5-)-Methyltransferase 1/metabolism, MESH: Doxorubicin/administration & dosage, MESH: Enzyme Inhibitors/administration & dosage, MESH: Enzyme Inhibitors/chemistry, MESH: Enzyme Inhibitors/pharmacology, MESH: Gene Expression Regulation, Neoplastic/drug effects, MESH: Humans, MESH: Animals, MESH: Male, MESH: Mice, Knockout, MESH: Osteosarcoma/drug therapy, MESH: Osteosarcoma/genetics, MESH: Osteosarcoma/metabolism, MESH: Quinolines/chemistry, MESH: Tumor Burden/drug effects, MESH: Tumor Burden/genetics, MESH: Xenograft Model Antitumor Assays, MESH: Antineoplastic Combined Chemotherapy Protocols/therapeutic use, MESH: Benzamides/administration & dosage, MESH: Benzamides/pharmacology, MESH: Bone Neoplasms/drug therapy, MESH: Bone Neoplasms/genetics, MESH: Bone Neoplasms/metabolism

Relation: info:eu-repo/semantics/altIdentifier/pmid/2995920; PUBMED: 2995920

الاتاحة: https://hal.science/hal-02383680
https://doi.org/10.1158/1535-7163.MCT-17-0818

المؤلفون: May C. Morris, Juan A. González-Vera, Ibon Alkorta, Francisco Fueyo-González, Marion Peyressatre, Rosario Herranz

المساهمون: Ministerio de Economía y Competitividad (España), Consejo Superior de Investigaciones Científicas (España), European Commission, Spanish National Research Council [Madrid] (CSIC), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Instituto de Quimica Médica (CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)

المصدر: Chemical Communications
Chemical Communications, Royal Society of Chemistry, 2016, 52 (62), pp.9652-9655. ⟨10.1039/c6cc04566a⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: Scaffold, Stereochemistry, MESH: Molecular Structure, Peptide, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, 010402 general chemistry, 01 natural sciences, Catalysis, Materials Chemistry, medicine, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, MESH: Fluorescent Dyes / chemistry, MESH: Quinolines / chemistry, Fluorescent Dyes, chemistry.chemical_classification, MESH: Humans, Molecular Structure, 010405 organic chemistry, Cyclin-dependent kinase 5, Solvatochromism, Metals and Alloys, Cyclin-Dependent Kinase 5, General Chemistry, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, medicine.disease, female genital diseases and pregnancy complications, eye diseases, 3. Good health, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry, Ceramics and Composites, Biophysics, MESH: Cyclin-Dependent Kinase 5 / chemistry, Quinolines, Solvents, Glioblastoma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6da4b43671d415341ed577718974dd
https://pubmed.ncbi.nlm.nih.gov/27383006

المؤلفون: Françoise Van Bambeke, Paul M. Tulkens, Sandrine Lemaire

المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute

المصدر: Antimicrobial Agents and Chemotherapy, Vol. 55, no. 2, p. 649-658 (2011)

مصطلحات موضوعية: Staphylococcus aureus, Moxifloxacin, Staphylococcal Infections - microbiology, Microbial Sensitivity Tests, medicine.disease_cause, Staphylococcal infections, Models, Biological, Monocytes, Cell Line, Microbiology, Mice, chemistry.chemical_compound, Anti-Infective Agents, Staphylococcus aureus - drug effects, metabolism, Aza Compounds - chemistry, pharmacokinetics, pharmacology, medicine, Extracellular, Animals, Humans, Pharmacology (medical), Pharmacology, Aza Compounds, Monocytes - metabolism, microbiology, biology, Macrophages, Anti-Infective Agents - chemistry, pharmacokinetics, pharmacology, Quinolines - chemistry, pharmacokinetics, pharmacology, Hydrogen-Ion Concentration, Staphylococcal Infections, biology.organism_classification, medicine.disease, Culture Media, Infectious Diseases, chemistry, Susceptibility, Cell culture, Fluoroquinolones - chemistry, pharmacokinetics, pharmacology, Macrophages - metabolism, Quinolines, Delafloxacin, Culture Media - chemistry, Bacteria, Intracellular, Fluoroquinolones, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8112214dcc534fc3e5621bbe7cab9e
https://doi.org/10.1128/aac.01201-10

المؤلفون: Brendel, Matthias, Jaworska, Anna, Haass, Christian, Van Leuven, Fred, Okamura, Nobuyuki, Herms, Jochen, Rominger, Axel, Probst, Federico, Overhoff, Felix, Korzhova, Viktoriia, Lindner, Simon, Carlsen, Janette, Bartenstein, Peter, Harada, Ryuichi, Kudo, Yukitsuka

المصدر: Journal of nuclear medicine 57(5), 792-798 (2016). doi:10.2967/jnumed.115.163493

مصطلحات موضوعية: info:eu-repo/classification/ddc/610, Aniline Compounds: chemistry, Animals, Autoradiography, Immunohistochemistry, Mice, Transgenic, Phosphorylation, Positron-Emission Tomography: methods, Quinolines: chemistry, Radiochemistry, tau Proteins: genetics, tau Proteins: metabolism, 6-((3-fluoro-2-hydroxy)propoxy)-2-(4-methylaminophenyl)quinoline, Aniline Compounds, Quinolines, tau Proteins

جغرافية الموضوع: DE

Relation: info:eu-repo/semantics/altIdentifier/issn/2159-662X; info:eu-repo/semantics/altIdentifier/issn/1535-5667; info:eu-repo/semantics/altIdentifier/issn/0097-9058; info:eu-repo/semantics/altIdentifier/pmid/pmid:26912432; info:eu-repo/semantics/altIdentifier/issn/0161-5505; info:eu-repo/semantics/altIdentifier/issn/0022-3123; https://pub.dzne.de/record/138548; https://pub.dzne.de/search?p=id:%22DZNE-2020-04870%22

الاتاحة: https://pub.dzne.de/record/138548
https://pub.dzne.de/search?p=id:%22DZNE-2020-04870%22

المؤلفون: Sarah K. Volkman, Lise Musset, Eric Legrand, Stanislaw J. Gabryszewski, Dyann F. Wirth, Béatrice Volney, Eli L. Moss, Stéphane Pelleau, Satish K. Dhingra, Daniel E. Neafsey, David A. Fidock, Jessica Casteras

المساهمون: Laboratoire de Parasitologie, Centre National de Référence du Paludisme - Région Antilles-Guyane, Institut Pasteur de la Guyane - Réseau International des Instituts Pasteur - WHO Collaborating Center for Surveillance of Antimalarial Drug Resistance, Broad Institute of MIT and Harvard (BROAD INSTITUTE), Broad Institute of MIT and Harvard, Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, Harvard School of Public Health, This work was supported by European Commission Grant REGPOT-CT-2011-285837-430 STRonGer (to S.P.), AgenceNationale de la Recherche Investissements d’Avenir Grant ANR-10-LABX-25-01(to S.P. and L.M.), NIH Grants R01AI50234 (to D.A.F.) and R01AI109023 (to D.A.F.),and the Institut de Veille Sanitaire. Sequencing was supported, in part, byNational Institute of Allergy and Infectious Diseases, NIH, Department ofHealth and Human Services Contract HHSN272200900018C., ANR-10-LABX-25-01/10-LABX-0025, CEBA, CEnter of the study of Biodiversity in Amazonia(2010), European Project : 285837, EC:FP7:REGPOT, FP7-REGPOT-2011-1, STRONGER(2011), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Columbia University College of Physicians and Surgeons, ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), European Project: 285837,EC:FP7:REGPOT,FP7-REGPOT-2011-1,STRONGER(2011), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR), Centre National de Référence du Paludisme - Laboratoire de parasitologie [Cayenne, Guyane française] (CNR)

المصدر: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (37), pp.11672-7
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (37), pp.11672-11677. ⟨10.1073/pnas.1507142112⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (37), pp.11672-11677. ⟨10.1073/pnas.1507142112⟩

مصطلحات موضوعية: [SDV]Life Sciences [q-bio], Protozoan Proteins, Drug resistance, MESH: Genetic Markers, MESH: Genotype, Chloroquine, Genotype, [SDV.SPEE] Life Sciences [q-bio]/Public Health and Epidemiology, MESH: Quinolines/chemistry, MESH: Inhibitory Concentration 50, Genetics, education.field_of_study, Multidisciplinary, biology, MESH: Chloroquine/therapeutic use, Biological Sciences, MESH: Malaria/drug therapy, 3. Good health, [SDV] Life Sciences [q-bio], [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, medicine.drug, PfCRT, MESH: Plasmodium falciparum/drug effects, Population, Plasmodium falciparum, MESH: Plasmodium falciparum/genetics, malaria, MESH: Membrane Transport Proteins/genetics, MESH: Phenotype, Evolution, Molecular, Piperaquine, evolution, MESH: Evolution, Molecular, MESH: French Guiana, parasitic diseases, medicine, Humans, MESH: Genome, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Allele, education, MESH: Prevalence, MESH: Principal Component Analysis, drug resistance, MESH: Humans, MESH: Alleles, Membrane Transport Proteins, MESH: Retrospective Studies, MESH: Haplotypes, biology.organism_classification, medicine.disease, MESH: Protozoan Proteins/genetics, Mutation, MESH: Mutation, MESH: Drug Resistance/genetics, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Malaria

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f1f82c8002d2b8ac21235f6b72c4a9
https://hal-pasteur.archives-ouvertes.fr/pasteur-01229321/document

المؤلفون: Dahal, Upendra P, Joswig-Jones, Carolyn, Jones, Jeffrey P

مصطلحات موضوعية: Catalytic Domain, Hydroxylation, Amides - chemical synthesis, Pyridines - chemistry, Pyrimidines - chemical synthesis, Dealkylation, Quinolines - chemistry, Pyridines - chemical synthesis, Substrate Specificity, Structure-Activity Relationship, Pyrazines - chemical synthesis, Pyrimidines - chemistry, Quinolines - chemical synthesis, Pyrazines - chemistry, Cytochrome P-450 CYP3A Inhibitors, Small Molecule Libraries, Cytochrome P-450 CYP3A - chemistry, Amides - chemistry, Protein Binding

Relation: ispartof: Journal of medicinal chemistry spage 280 epage 290 issue 1 vol 55; PMC3257383; WOS:000298978800021; 2376/101949; https://doi.org/10.1021/jm201207h; 99900546504701842; alma:01ALLIANCE_WSU/bibs/99900546504701842

الاتاحة: https://doi.org/10.1021/jm201207h
https://rex.libraries.wsu.edu/esploro/outputs/journalArticle/Comparative-study-of-the-affinity-and/99900546504701842

المؤلفون: Petit, Morgane, Tran, Christine, Roger, Thomas, Gallavardin, Thibault, Dhimane, Hamid, Palma-Cerda, Francisco, Blanchard-Desce, Mireille, Acher, Francine, C., Ogden, David, Dalko, Peter

المساهمون: Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (LCBPT - UMR 8601), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physiologie cérébrale (LPC - UMR 8118), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Chimie et Photonique Moléculaires (CPM), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 1523-7060.

مصطلحات موضوعية: Glutamates/chemistry, Molecular Structure, Photolysis, Photons, Quinolines/chemistry, Structure-Activity Relationship, Glutamates, Quinolines, [CHIM]Chemical Sciences, [CHIM.ORGA]Chemical Sciences/Organic chemistry

Relation: hal-02383436; https://normandie-univ.hal.science/hal-02383436

الاتاحة: https://normandie-univ.hal.science/hal-02383436
https://doi.org/10.1021/ol3031704

المؤلفون: Dejaegher, Bieke, Dhooghe, L., Goodarzi, M, Apers, Sandra, Pieters, Luc, Vander Heyden, Yvan

المصدر: Analytica chimica acta, 705 (1-2

مصطلحات موضوعية: Sciences bio-médicales et agricoles, Alkaloids -- chemistry -- pharmacology, Antimalarials -- chemistry -- pharmacology, Discriminant Analysis, Hemeproteins -- antagonists & inhibitors -- metabolism, Humans, Least-Squares Analysis, Malaria -- drug therapy, Models, Biological, Plasmodium falciparum -- drug effects, Quantitative Structure-Activity Relationship, Quinolines -- chemistry -- pharmacology, Support Vector Machines

وصف الملف: 1 full-text file(s): application/pdf

Relation: uri/info:doi/10.1016/j.aca.2011.04.019; uri/info:pii/S0003-2670(11)00541-1; uri/info:pmid/21962353; https://dipot.ulb.ac.be/dspace/bitstream/2013/191703/1/Elsevier_175330.pdf; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/191703

الاتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/191703
https://dipot.ulb.ac.be/dspace/bitstream/2013/191703/1/Elsevier_175330.pdf

المؤلفون: Francisco Palma-Cerda, Francine Acher, Christine Tran, Morgane Petit, Hamid Dhimane, Peter I. Dalko, Mireille Blanchard-Desce, Thibault Gallavardin, Thomas Roger, David Ogden

المساهمون: Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques (LCBPT - UMR 8601), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physiologie cérébrale (LPC - UMR 8118), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Chimie et Photonique Moléculaires (CPM), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Gallavardin, Thibault, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Organic Letters
Organic Letters, 2012, 14 (24), pp.6366-6369. ⟨10.1021/ol3031704⟩
Organic Letters, American Chemical Society, 2012, 14 (24), pp.6366-6369. ⟨10.1021/ol3031704⟩

مصطلحات موضوعية: Stereochemistry, Quinolines/chemistry, Glutamates/chemistry, 010402 general chemistry, Photochemistry, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Two-photon excitation microscopy, Glutamates, [CHIM] Chemical Sciences, Structure–activity relationship, Molecule, [CHIM]Chemical Sciences, Substitution effect, Physical and Theoretical Chemistry, Photons, Photolysis, Molecular Structure, 010405 organic chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Organic Chemistry, Quinoline, Photodissociation, Glutamate receptor, [CHIM.ORGA] Chemical Sciences/Organic chemistry, 3. Good health, 0104 chemical sciences, chemistry, Quinolines, Derivative (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e8138397f55f8fe897e91594a2237e
https://hal-normandie-univ.archives-ouvertes.fr/hal-02383436

المؤلفون: Peng, Chi-Chi, Cape, Jonathan L, Rushmore, Tom, Crouch, Gregory J, Jones, Jeffrey P

مصطلحات موضوعية: Cytochrome P-450 CYP2C9, Catalytic Domain, Chemistry, Pharmaceutical - methods, Humans, Iron - chemistry, Molecular Conformation, Quinolines - chemistry, Imidazoles - chemistry, Models, Molecular, Substrate Specificity, Structure-Activity Relationship, Arginine - chemistry, Aryl Hydrocarbon Hydroxylases - metabolism, Heme - chemistry, Drug Design, Protein Binding, Aryl Hydrocarbon Hydroxylases - chemistry

Relation: ispartof: Journal of medicinal chemistry spage 8000 epage 8011 issue 24 vol 51; PMC2630467; WOS:000261876400036; 2376/113069; https://doi.org/10.1021/jm8011257; 99900547915101842; alma:01ALLIANCE_WSU/bibs/99900547915101842

الاتاحة: https://doi.org/10.1021/jm8011257
https://rex.libraries.wsu.edu/esploro/outputs/journalArticle/Cytochrome-P450-2C9-type-II-binding/99900547915101842

المؤلفون: Benjamin D. Bax, Pan F. Chan, Michael M. Hann, Michael N. Gwynn, Daniel R. Gentry, Ceri J. Lewis, Jo J. Jones, Claus Spitzfaden, Andrew P. Fosberry, Martin Hibbs, Earl May, Kristin K. Brown, Alexandre Wohlkonig, Drake S. Eggleston, Onkar M. P. Singh, Alan Joseph Hennessy, Andrew J. Theobald, Fabrice Gorrec, Martin R. Saunders, Anthony Shillings, Emma J. Jones, Carol Shen, Neil D. Pearson, Jianzhong Huang, Ilaria Giordano

المساهمون: Department of Bio-engineering Sciences, Structural Biology Brussels

مصطلحات موضوعية: Models, Molecular, Gepotidacin, Staphylococcus aureus, Stereochemistry, Protein Conformation, Drug Resistance, Anti-Bacterial Agents/chemistry, Quinolones, Manganese/metabolism, Arginine, Crystallography, X-Ray, DNA gyrase, Apoenzymes, Arginine/metabolism, Ciprofloxacin, Catalytic Domain, Escherichia coli, Topoisomerase II Inhibitors, Ciprofloxacin/chemistry, DNA Gyrase/chemistry, DNA, Superhelical/chemistry, Escherichia coli/enzymology, DNA Cleavage, DNA/chemistry, Quinolines/chemistry, Antibacterial agent, Aspartic Acid, Manganese, Multidisciplinary, Binding Sites, biology, Apoenzymes/chemistry, Drug discovery, DNA, Superhelical, Topoisomerase, DNA, Staphylococcus aureus/enzymology, Structure-activity relationship, Quinolones/chemistry, Anti-Bacterial Agents, Biochemistry, DNA Gyrase, Drug Design, biology.protein, Quinolines, Primase, Topoisomerase-II Inhibitor, Type II topoisomerase, Aspartic Acid/metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea159ed95a9dbead771494c8d86bdb2
https://doi.org/10.1038/nature09197