المؤلفون: Zhou, J., Quah, J.Y., Ng, Y., Chooi, J.-Y., Toh, S.H.-M., Lin, B., Tan, T.Z., Hosoi, H., Osato, M., Seet, Q., Lisa Ooi, A.G., Lindmark, B., McHale, M., Chng, W.-J.

المساهمون: CANCER SCIENCE INSTITUTE OF SINGAPORE, DEAN'S OFFICE (MEDICINE), DEPT OF MEDICINE, DEPT OF PAEDIATRICS, DEPT OF PHYSIOLOGY, NATIONAL UNIVERSITY MEDICAL INSTITUTES

المصدر: Scopus OA2020

Relation: Zhou, J., Quah, J.Y., Ng, Y., Chooi, J.-Y., Toh, S.H.-M., Lin, B., Tan, T.Z., Hosoi, H., Osato, M., Seet, Q., Lisa Ooi, A.G., Lindmark, B., McHale, M., Chng, W.-J. (2020). ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia. Haematologica 105 (9) : 2286-2297. ScholarBank@NUS Repository. https://doi.org/10.3324/haematol.2019.230482; https://scholarbank.nus.edu.sg/handle/10635/198181

الاتاحة: https://scholarbank.nus.edu.sg/handle/10635/198181

المؤلفون: Zhou, J, Toh, S.H.-M, Chan, Z.-L, Quah, J.Y, Chooi, J.-Y, Tan, T.Z, Chong, P.S.Y, Zeng, Q, Chng, W.-J

المساهمون: CANCER SCIENCE INSTITUTE OF SINGAPORE, BIOCHEMISTRY, MEDICINE

المصدر: Unpaywall 20201031

مصطلحات موضوعية: beta catenin, mammalian target of rapamycin, oncoprotein, PRL 3 phosphatase, protein kinase B, short hairpin RNA, unclassified drug, Wnt protein, MTOR protein, human, protein tyrosine phosphatase, PTP4A3 protein, target of rapamycin kinase, tumor protein, acute myeloid leukemia, acute myeloid leukemia cell line, Akt/mTOR signaling, animal experiment, animal model, Article, bone marrow cell, cancer prognosis, cancer survival, cell assay, controlled study, enzyme inhibition, gene library, genetic screening, human cell, in vitro study

Relation: Zhou, J, Toh, S.H.-M, Chan, Z.-L, Quah, J.Y, Chooi, J.-Y, Tan, T.Z, Chong, P.S.Y, Zeng, Q, Chng, W.-J (2018). A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase. Journal of Hematology and Oncology 11 (1) : 36. ScholarBank@NUS Repository. https://doi.org/10.1186/s13045-018-0581-9; https://scholarbank.nus.edu.sg/handle/10635/178101

الاتاحة: https://scholarbank.nus.edu.sg/handle/10635/178101

المؤلفون: Zhou, J, Bi, C, Ching, Y.Q, Chooi, J.-Y, Lu, X, Quah, J.Y, Toh, S.H.-M, Chan, Z.-L, Tan, T.Z, Chong, P.S, Chng, W.-J

المساهمون: CANCER SCIENCE INSTITUTE OF SINGAPORE, MEDICINE

المصدر: Unpaywall 20200831

مصطلحات موضوعية: let 7a, LIN28B protein, microRNA, stem cell factor, unclassified drug, human, mirnlet7 microRNA, RNA binding protein, small interfering RNA, acute myeloid leukemia, animal experiment, animal model, animal tissue, Article, bioinformatics, cancer inhibition, carcinogenicity, cell cycle arrest, cell metabolism, cell proliferation, colony formation, controlled study, female, G2 phase cell cycle checkpoint, gene, gene function, gene overexpression, gene silencing, gene targeting, genetic association

Relation: Zhou, J, Bi, C, Ching, Y.Q, Chooi, J.-Y, Lu, X, Quah, J.Y, Toh, S.H.-M, Chan, Z.-L, Tan, T.Z, Chong, P.S, Chng, W.-J (2017). Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia. Journal of Hematology and Oncology 10 (1) : 138. ScholarBank@NUS Repository. https://doi.org/10.1186/s13045-017-0507-y; https://scholarbank.nus.edu.sg/handle/10635/173782

الاتاحة: https://scholarbank.nus.edu.sg/handle/10635/173782