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1Academic Journal
المؤلفون: Prekovic, Stefan, Schuurman, Karianne, Mayayo-Peralta, Isabel, Manjón, Anna G., Buijs, Mark, Yavuz, Selçuk, Wellenstein, Max D., Barrera, Alejandro, Monkhorst, Kim, Huber, Anne, Morris, Ben, Lieftink, Cor, Chalkiadakis, Theofilos, Alkan, Ferhat, Silva, Joana, Győrffy, Balázs, Hoekman, Liesbeth, van den Broek, Bram, Teunissen, Hans, Debets, Donna O., Severson, Tesa, Jonkers, Jos, Reddy, Timothy, de Visser, Karin E., Faller, William, Beijersbergen, Roderick, Altelaar, Maarten, de Wit, Elzo, Medema, Rene, Zwart, Wilbert
المصدر: Prekovic , S , Schuurman , K , Mayayo-Peralta , I , Manjón , A G , Buijs , M , Yavuz , S , Wellenstein , M D , Barrera , A , Monkhorst , K , Huber , A , Morris , B , Lieftink , C , Chalkiadakis , T , Alkan , F , Silva , J , Győrffy , B , Hoekman , L , van den Broek , B , Teunissen , H , Debets , D O , Severson , T , Jonkers , J , Reddy , T , de Visser ....
مصطلحات موضوعية: Animals, Antineoplastic Agents/pharmacology, Cell Cycle/genetics, Cell Line, Tumor, Cell Proliferation/drug effects, Cell Survival/drug effects, Chromatin/genetics, Chromatin Immunoprecipitation Sequencing, Chromosomal Proteins, Non-Histone/genetics, Cyclin-Dependent Kinase Inhibitor p57/genetics, Enhancer Elements, Genetic, Gene Expression Regulation, Neoplastic/drug effects, Glucocorticoids/pharmacology, Humans, Imidazoles/pharmacology, Immunohistochemistry, Lung Neoplasms/genetics, Mice, Proteomics, Pyrazines/pharmacology, RNA, Small Interfering, RNA-Seq, Receptor, IGF Type 1/metabolism, Receptors
وصف الملف: application/pdf
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2Academic Journal
المؤلفون: Silva, LP, Magalhães, CM, Núñez-Montenegro, A, Ferreira, PJO, Duarte, D, Rodríguez-Borges, JE, Vale, N, Silva, JCGE
المساهمون: Instituto de Investigação e Inovação em Saúde
مصطلحات موضوعية: Anticancer drug, Breast cancer, Chemiluminescence, Chemotherapy, Multidrug combinations, Photodynamic therapy, Photosensitizer, Prostate cancer, Antineoplastic Agents / chemical synthesis, Antineoplastic Agents / chemistry, Antineoplastic Agents / pharmacology, Cell Proliferation / drug effects, Cell Survival / drug effects, Drug Screening Assays, Antitumor, Humans, Imidazoles / chemical synthesis, Imidazoles / chemistry, Imidazoles / pharmacology, MCF-7 Cells, Molecular Structure, PC-3 Cells, Photochemotherapy, Photosensitizing Agents / chemical synthesis, Photosensitizing Agents / chemistry, Photosensitizing Agents / pharmacology, Pyrazines / chemical synthesis, Pyrazines / chemistry, Pyrazines / pharmacology, Tumor Cells
وصف الملف: application/pdf
Relation: info:eu-repo/grantAgreement/FCT/5876/147218/PT; Biomolecules, vol.9(8):384; https://www.mdpi.com/2218-273X/9/8/384; https://hdl.handle.net/10216/136251
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3Academic Journal
المؤلفون: Picco, Gabriele, Petti, Consalvo, Centonze, Alessia, Torchiaro, Erica, Crisafulli, Giovanni, Novara, Luca, Acquaviva, Andrea, Bardelli, Alberto, Medico, Enzo
المصدر: EMBO molecular medicine, 9 (3
مصطلحات موضوعية: Sciences bio-médicales et agricoles, Axin Protein -- deficiency, Cell Line, Tumor, Cell Proliferation, Colorectal Neoplasms -- pathology, Drug Resistance, Enzyme Inhibitors -- pharmacology, Gene Fusion, Humans, Pyrazines -- pharmacology, Pyridines -- pharmacology, Thrombospondins -- genetics, Wnt Proteins -- metabolism, Wnt Signaling Pathway, R‐spondin, WNT pathway, colorectal cancer, targeted therapy
وصف الملف: 1 full-text file(s): application/pdf
Relation: uri/info:doi/10.15252/emmm.201606773; uri/info:pii/emmm.201606773; uri/info:pmid/28100566; uri/info:pmcid/PMC5331210; https://dipot.ulb.ac.be/dspace/bitstream/2013/266082/4/doi_249709.pdf; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/266082
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4Academic Journal
المساهمون: Qian, Chenyu (author.), Zuo, Zhong (thesis advisor.), Chinese University of Hong Kong Graduate School. Division of Pharmacy. (degree granting institution.)
مصطلحات موضوعية: Pyrazines, Aspirin, Clopidogrel, Coronary heart disease, Transient ischemic attack, Pyrazines--pharmacokinetics, Pyrazines--pharmacology, Aspirin--therapeutic use, Clopidogrel--therapeutic use, Acute Coronary Syndrome--drug therapy, Ischemic Attack, Transient--drug therapy
وصف الملف: electronic resource; remote; 1 online resource (xvi, 159 leaves) : illustrations (some color); computer; online resource
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5Academic Journal
المساهمون: Sang Hoon Han, Jin Seok Kim, Jun Hee Woo, Su Jin Jeong, Jeon-Soo Shin, Young Soo Ahn, June Myung Kim, Shin, Jeon Soo, Ahn, Young Soo, Jeong, Su Jin, Han, Sang Hoon, Kim, June Myung, Kim, Jin Seok
المصدر: T201500271.pdf
مصطلحات موضوعية: Animals, Boronic Acids/administration & dosage, Boronic Acids/pharmacology, Boronic Acids/therapeutic use, Bortezomib, Cecum/pathology, Cell Adhesion Molecules/metabolism, Cell Line, Cell Proliferation/drug effects, Cell Survival/drug effects, Chymotrypsin/metabolism, Cytokines/metabolism, Disease Models, Animal, Inflammation Mediators/metabolism, Ligation, Lipopolysaccharides/pharmacology, Lung/drug effects, Lung/metabolism, Lung/pathology, Male, Mice, Inbred C57BL, Nitric Oxide/metabolism, Proteasome Inhibitors/pharmacology, Punctures, Pyrazines/administration & dosage, Pyrazines/pharmacology, Pyrazines/therapeutic use, Sepsis/drug therapy
وصف الملف: 112~123
Relation: YONSEI MEDICAL JOURNAL; J02813; OAK-2015-00180; https://ir.ymlib.yonsei.ac.kr/handle/22282913/139340; T201500271; YONSEI MEDICAL JOURNAL, Vol.56(1) : 112-123, 2015
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6Academic Journal
المؤلفون: van de Weijer, Tineke, Phielix, Esther, Bilet, Lena, WILLIAMS, Evan, Ropelle, Eduardo R., Bierwagen, Alessandra, Livingstone, Roshan, Nowotny, Peter, Sparks, Lauren M., Paglialunga, Sabina, Szendroedi, Julia, Havekes, Bas, Moullan, Norman, Pirinen, Eija, Hwang, Jong-Hee, Schrauwen-Hinderling, Vera B., Hesselink, Matthijs K. C., Auwerx, Johan, Roden, Michael, Schrauwen, Patrick
المصدر: Diabetes, 64 (4), 1193-201 (2015)
مصطلحات موضوعية: Cross-Over Studies, Diabetes Mellitus, Type 2/metabolism, Female, Humans, Hypolipidemic Agents/pharmacology, Insulin Resistance/physiology, Male, Middle Aged, Mitochondria, Muscle/drug effects/metabolism, Muscle, Skeletal/drug effects/metabolism, Pyrazines/pharmacology, Life sciences, Genetics & genetic processes, Sciences du vivant, Génétique & processus génétiques
Relation: urn:issn:0012-1797; urn:issn:1939-327X; https://orbilu.uni.lu/handle/10993/43158; info:hdl:10993/43158; https://orbilu.uni.lu/bitstream/10993/43158/1/00_Final%20Pub.pdf; info:pmid:25352640; wos:000351619300016
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7Academic Journal
المساهمون: Kihyun Kim, Seok Jin Kim, Verena Voelter, Cheolwon Suh, Sung-Soo Yoon, Je-Jung Lee, Jae-Yong Kwak, Hun-Mo Ryoo, Yang Soo Kim, Joon Ho Moon, Seong Kyu Park, Sung-Hyun Kim, Yeung-Chul Mun, Jin Seok Kim, Hyeon-Seok Eom, Deog-Yeon Jo, Hyun Jung Jun, Ki-Hwan Kim, Jeong-Ok Lee, Jae Hoon Lee, Chang-Ki Min, Kim, Jin Seok
مصطلحات موضوعية: Adult, Aged, Antineoplastic Combined Chemotherapy Protocols/adverse effects, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Boronic Acids/pharmacology, Bortezomib, Chromosome Aberrations, Combined Modality Therapy, Dexamethasone/administration & dosage, Dexamethasone/adverse effects, Disease-Free Survival, Drug Evaluation, Drug Resistance, Neoplasm, Fatigue/chemically induced, Female, Follow-Up Studies, Gastrointestinal Diseases/chemically induced, Hematologic Diseases/chemically induced, Hematopoietic Stem Cell Transplantation, Humans, Kaplan-Meier Estimate, Korea, Male, Middle Aged, Multiple Myeloma/drug therapy, Multiple Myeloma/genetics, Multiple Myeloma/surgery, Pyrazines/pharmacology, Retrospective Studies
وصف الملف: 113~121
Relation: ANNALS OF HEMATOLOGY; J00161; OAK-2014-03061; https://ir.ymlib.yonsei.ac.kr/handle/22282913/138794; http://link.springer.com/article/10.1007%2Fs00277-013-1893-z; T201405622; ANNALS OF HEMATOLOGY, Vol.93(1) : 113-121, 2014
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8Academic Journal
المساهمون: S. Lee, B. Kim, Kim, Beom Seok, Lee, Sang Won
مصطلحات موضوعية: Animals, Boronic Acids/pharmacology, Bortezomib, Cell Division, Disease Models, Animal, Drug Therapy, Combination, Female, Glucocorticoids/pharmacology, Immunoglobulin G/metabolism, Immunosuppressive Agents/pharmacology, Kidney Glomerulus/immunology, Kidney Glomerulus/pathology, Lupus Nephritis/drug therapy, Lupus Nephritis/immunology, Lupus Nephritis/pathology, Mice, Inbred NZB, Mycophenolic Acid/analogs & derivatives, Mycophenolic Acid/pharmacology, Prednisolone/pharmacology, Protease Inhibitors/pharmacology, Proteinuria/drug therapy, Proteinuria/immunology, Proteinuria/pathology, Pyrazines/pharmacology, lupus nephritis, NZB/WF1 mice
وصف الملف: 393~396
Relation: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY; J00555; OAK-2010-01438; https://ir.ymlib.yonsei.ac.kr/handle/22282913/101838; http://www.clinexprheumatol.org/abstract.asp?a=595; T201002883; CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol.28(3) : 393-396, 2010
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9Academic Journal
المؤلفون: Park, Juwon, Ayyappan, Vasudevan, Bae, Eun-Kyung, Lee, Chansu, Kim, Byung-Su, Kim, Byoung Kook, Lee, Young-Yiul, Ahn, Kwang-Sung, Yoon, Sung-Soo
المساهمون: 박주원, 배은경, 이찬수, 김병수, 김병국, 이영열, 안광성, 윤성수
مصطلحات موضوعية: Antineoplastic Combined Chemotherapy Protocols/pharmacology, Apoptosis/*drug effects, Boronic Acids/*pharmacology, Cell Line, Tumor, Cell Proliferation/drug effects, Coculture Techniques, Curcumin/*pharmacology, Cytokines/antagonists &, inhibitors, Drug Synergism, Humans, Inflammation Mediators/antagonists &, Multiple Myeloma/*drug therapy, Pyrazines/*pharmacology, Stromal Cells/cytology
Relation: Mol Oncol. 2008 Dec;2(4):317-26.; 1878-0261 (Electronic); http://hdl.handle.net/10371/62180
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10Academic Journal
المؤلفون: Shin, Dong Hoon, Chun, Yang-Sook, Lee, Dong Soon, Huang, L Eric, Park, Jong-Wan
المساهمون: 신동훈, 전양숙, 이동순, 박종완
مصطلحات موضوعية: Adaptation, Biological/*drug effects, Boronic Acids/*pharmacology, Cell Hypoxia/drug effects, Cell Line, DNA-Binding Proteins/metabolism, Humans, Hypoxia-Inducible Factor 1/antagonists &, inhibitors/genetics/*metabolism, Neoplasms/*metabolism, Pyrazines/*pharmacology, Repressor Proteins/genetics/*metabolism, Trans-Activators/metabolism, Transcription Factors/genetics/*metabolism, Transcription, Genetic/drug effects/genetics, p300-CBP Transcription Factors/metabolism
Relation: Blood. 2008;111(6):3131-3136; 0006-4971 (Print); http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18174379; http://bloodjournal.hematologylibrary.org/cgi/reprint/111/6/3131.pdf; http://hdl.handle.net/10371/68181
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11Academic Journal
المؤلفون: Bae, Eun Ju, Yang, Yoon Mee, Kim, Sang Geon
المساهمون: 배은주, 양윤미, 김상건
مصطلحات موضوعية: Adaptor Proteins, Signal Transducing, Adipocytes/drug effects/metabolism, Animals, Cell Line, Enzyme Activation/drug effects, Glucose/metabolism, Glycogen Synthase Kinase 3/metabolism, Humans, Insulin/*metabolism, Insulin Receptor Substrate Proteins, Mice, Muscle Fibers, Skeletal/drug effects/metabolism, Mutant Proteins/metabolism, Osmotic Pressure/drug effects, Phosphorylation/drug effects, Phosphoserine/metabolism, Pyrazines/pharmacology, Ribosomal Protein S6 Kinases/antagonists &, inhibitors/*metabolism, Signal Transduction/*drug effects, Thiones/chemistry/*pharmacology, Tumor Necrosis Factor-alpha/pharmacology
Relation: Mol Pharmacol 73:1502-1512; 1521-0111 (Electronic); http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18252807; http://hdl.handle.net/10371/21296
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12Academic Journal
المؤلفون: Bae, Eun Ju, Yang, Yoon Mee, Kim, Jin Wan, Kim, Sang Geon
المساهمون: 배은주, 양윤미, 김진완, 김상건
مصطلحات موضوعية: AMP-Activated Protein Kinases, Animals, Cell Line, Glucose/metabolism, Hypoglycemia/chemically induced, Insulin/pharmacology, Leptin/genetics, Liver/*drug effects/enzymology, Mice, Mutant Strains, Multienzyme Complexes/genetics/metabolism, Phosphorylation, Protein-Serine-Threonine Kinases/genetics/metabolism, Pyrazines/*pharmacology, Ribosomal Protein S6 Kinases, 70-kDa/*antagonists & inhibitors, Thiones/*isolation & purification/*pharmacology, Transfection, Transforming Growth Factor alpha/*antagonists & inhibitors, Insulin Resistance
Relation: Hepatology 2007;46:730-739; 0270-9139 (Print); http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17668885; https://hdl.handle.net/10371/21303
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13Academic Journal
المؤلفون: Sinn, Dong-In, Lee, Soon-Tae, Chu, Kon, Jung, Keun-Hwa, Kim, Eun-Hee, Kim, Jeong-Min, Park, Dong-Kyu, Song, Eun-Cheol, Kim, Byung-Su, Yoon, Sung-Soo, Kim, Manho, Roh, Jae-Kyu
المساهمون: 신동인, 이순태, 주건, 정근화, 김은희, 김정민, 박동규, 송은철, 김병수, 윤성수, 김만호, 노재규
مصطلحات موضوعية: Animals, Anti-Inflammatory Agents/pharmacology, Biological Markers/analysis/metabolism, Boronic Acids/*pharmacology, Brain Edema/drug therapy/etiology/physiopathology, Cerebral Cortex/blood supply/*drug effects/physiopathology, Cerebral Hemorrhage/complications/*drug therapy/physiopathology, Cytokines/antagonists &, inhibitors/genetics, Disease Models, Animal, Dose-Response Relationship, Drug, Encephalitis/*drug therapy/etiology/physiopathology, Gliosis/drug therapy/etiology/physiopathology, Inflammation Mediators/antagonists &, inhibitors/metabolism, Male, Microglia/drug effects/immunology/metabolism, Neuroprotective Agents/pharmacology, Neutrophils/drug effects/immunology/metabolism, Protease Inhibitors/*pharmacology, Proteasome Endopeptidase Complex/*drug effects/metabolism, Pyrazines/*pharmacology, RNA, Messenger/drug effects/metabolism, Rats, Sprague-Dawley, Treatment Outcome
Relation: Neurosci. Res. 58, 12-18; 0168-0102 (Print); http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17328981; http://hdl.handle.net/10371/25597
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14
المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research, Graduate School, Pathology, CCA - Cancer biology and immunology
المصدر: Gastroenterology, 157(4), 1153-1155.e1. W.B. Saunders Ltd
مصطلحات موضوعية: Neoplastic Stem Cells/drug effects, Colorectal cancer, Drug Resistance, Drug resistance, Drug Resistance, Neoplasm/drug effects, medicine.disease_cause, Proto-Oncogene Proteins c-met/antagonists & inhibitors, Cell Proliferation/drug effects, Neoplasm/drug effects, ErbB Receptors/antagonists & inhibitors, Epidermal growth factor receptor, Intestinal Mucosa, Mutation, Tumor, biology, Triazines, Gastroenterology, Gefitinib, Colorectal Neoplasms/drug therapy, Proto-Oncogene Proteins c-met, ErbB Receptors, Gefitinib/pharmacology, Pyrazines, Neoplastic Stem Cells, Pyrazines/pharmacology, Signal transduction, Stem cell, Colorectal Neoplasms, Antineoplastic Agents/pharmacology, Signal Transduction, Genes, APC, Intestinal Mucosa/drug effects, Antineoplastic Agents, Cell Line, Cell Line, Tumor, medicine, Humans, Protein Kinase Inhibitors, Gene, Cell Proliferation, Hepatology, medicine.disease, APC, Triazines/pharmacology, Genes, Drug Resistance, Neoplasm, Cell culture, Protein Kinase Inhibitors/pharmacology, Cancer research, biology.protein
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15Academic Journal
المؤلفون: Joosten, Sander P J, Mizutani, Tomohiro, Spaargaren, Marcel, Clevers, Hans, Pals, Steven T
المصدر: Joosten , S P J , Mizutani , T , Spaargaren , M , Clevers , H & Pals , S T 2019 , ' MET Signaling Overcomes Epidermal Growth Factor Receptor Inhibition in Normal and Colorectal Cancer Stem Cells Causing Drug Resistance ' , Gastroenterology , vol. 157 , no. 4 , pp. 1153-1155.e1 . https://doi.org/10.1053/j.gastro.2019.06.029
مصطلحات موضوعية: Antineoplastic Agents/pharmacology, Cell Line, Tumor, Cell Proliferation/drug effects, Colorectal Neoplasms/drug therapy, Drug Resistance, Neoplasm/drug effects, ErbB Receptors/antagonists & inhibitors, Gefitinib/pharmacology, Genes, APC, Humans, Intestinal Mucosa/drug effects, Mutation, Neoplastic Stem Cells/drug effects, Protein Kinase Inhibitors/pharmacology, Proto-Oncogene Proteins c-met/antagonists & inhibitors, Pyrazines/pharmacology, Signal Transduction, Triazines/pharmacology
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16Academic Journal
المساهمون: E J Lee, S Y Nam, K R Kim, H C Lee, J H Cho, M S Nam, Y D Song, S K Lim, K B Huh, Lee, Hyun Chul
مصطلحات موضوعية: Adult, Cohort Studies, Drug Synergism, Fatty Acids, Nonesterified / blood, Growth Hormone / blood, Growth Hormone / metabolism, Growth Hormone-Releasing Hormone / pharmacology, Humans, Hypolipidemic Agents / pharmacology, Kinetics, Male, Obesity / blood, Obesity / physiopathology, Pyrazines / pharmacology, Reference Values, Time Factors
Relation: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM; J01318; OAK-1995-00081; https://ir.ymlib.yonsei.ac.kr/handle/22282913/186092; 7629249; https://academic.oup.com/jcem/article-abstract/80/8/2495/2655613; T199500633; JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol.80(8) : 2495-2498, 1995-08
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17Academic Journal
المساهمون: Eun Jig Lee, Kyung Rae Kim, Hyun Chul Lee, Jae Hwa Cho, Moon Suk Nam, Su Youn Nam, Young Duk Song, Sung Kil Lim, Kap Bum Huh, Lee, Hyun Chul
مصطلحات موضوعية: Administration, Oral, Adult, Fatty Acids, Nonesterified / blood, Growth Hormone / blood, Growth Hormone / physiology, Growth Hormone-Releasing Hormone / pharmacology, Humans, Hyperthyroidism / blood, Hyperthyroidism / drug therapy, Hyperthyroidism / metabolism, Hypolipidemic Agents / administration & dosage, Hypolipidemic Agents / pharmacology, Hypolipidemic Agents / therapeutic use, Male, Pyrazines / administration & dosage, Pyrazines / pharmacology, Pyrazines / therapeutic use
Relation: METABOLISM-CLINICAL AND EXPERIMENTAL; J02223; OAK-1995-00083; https://ir.ymlib.yonsei.ac.kr/handle/22282913/186093; 7476342; http://www.sciencedirect.com/science/article/pii/002604959590154X; T199500634; METABOLISM-CLINICAL AND EXPERIMENTAL, Vol.44(11) : 1509-1512, 1995-11
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18
المؤلفون: Paulo J.O. Ferreira, Ara Núñez-Montenegro, Luís Pinto da Silva, Joaquim C.G. Esteves da Silva, Carla M. Magalhães, Diana Duarte, José E. Rodríguez-Borges, Nuno Vale
المساهمون: Instituto de Investigação e Inovação em Saúde
المصدر: Biomolecules
Biomolecules, Vol 9, Iss 8, p 384 (2019)
Volume 9
Issue 8مصطلحات موضوعية: Photosensitizing Agents / pharmacology, Chemiluminescence, Cell Survival / drug effects, Pyrazines / pharmacology, photosensitizer, medicine.medical_treatment, lcsh:QR1-502, Antineoplastic Agents / pharmacology, Photodynamic therapy, 02 engineering and technology, chemotherapy, 01 natural sciences, Biochemistry, lcsh:Microbiology, Prostate cancer, Breast cancer, Prostate, Tumor Cells, Cultured, anticancer drug, Photosensitizer, Antineoplastic Agents / chemical synthesis, Pyrazines / chemical synthesis, health care economics and organizations, Photosensitizing Agents, Molecular Structure, Multidrug combinations, Imidazoles, prostate cancer, 021001 nanoscience & nanotechnology, 3. Good health, medicine.anatomical_structure, photodynamic therapy, Pyrazines, PC-3 Cells, MCF-7 Cells, 0210 nano-technology, medicine.drug, Antineoplastic Agents / chemistry, Imidazoles / pharmacology, Combination therapy, Cell Survival, Antineoplastic Agents, 010402 general chemistry, Article, breast cancer, Photosensitizing Agents / chemical synthesis, medicine, Chemotherapy, Humans, Photosensitizing Agents / chemistry, Molecular Biology, multidrug combinations, Cell Proliferation, business.industry, Cancer, Imidazoles / chemical synthesis, Anticancer drug, medicine.disease, Imidazoles / chemistry, chemiluminescence, 0104 chemical sciences, Photochemotherapy, Cancer research, Pyrazines / chemistry, Cell Proliferation / drug effects, Drug Screening Assays, Antitumor, business, Tamoxifen
وصف الملف: application/pdf
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19
المؤلفون: Odile Burlet-Schiltz, Bernard Monsarrat, Stéphane Manenti, Marie-Pierre Bousquet-Dubouch, Mariette Matondo, Christian Recher, Sandrine Uttenweiler-Joseph, Bernard Payrastre, Nathalie Gallay
المساهمون: Institut de pharmacologie et de biologie structurale (IPBS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Centre de Physiopathologie de Toulouse-Purpan (INSERM U563 - CNRS UMR1037), Centre National de la Recherche Scientifique (CNRS)-Centre de lutte contre le cancer (CLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse]-Institut Claudius Regaud, This work was supported by the CNRS, by grants from the Fonds Sociaux Européens and the Ligue contre le Cancer (MM), and in part by grants from the Région Midi-Pyrénées and the Génopole Toulouse Midi-Pyrénées., The authors would like to thank Millennium Pharmaceuticals for their generous gift of bortezomib and are very grateful to Dr. C. Demur for helpful assistance in managing the patient samples used in this study.
المصدر: Leukemia Research
Leukemia Research, Elsevier, 2010, 34 (4), pp.498-506. ⟨10.1016/j.leukres.2009.09.020⟩مصطلحات موضوعية: Proteomics, Male, Cancer Research, Leupeptins, MESH: Drug Resistance, Neoplasm / drug effects, MESH: Leukemia, Myeloid, Acute / metabolism, Apoptosis, MESH: Proteasome Endopeptidase Complex / metabolism, Proteasome regulators, Bortezomib, MESH: Aged, 80 and over, 0302 clinical medicine, Tumor Cells, Cultured, MESH: Bortezomib, MESH: Aged, Aged, 80 and over, MESH: Proteasome Endopeptidase Complex / analysis, 0303 health sciences, MESH: Middle Aged, MESH: Leukemia, Myeloid, Acute / pathology, U937 cell, Myeloid leukemia, U937 Cells, Hematology, Middle Aged, Cell cycle, Prognosis, Boronic Acids, 3. Good health, Leukemia, Myeloid, Acute, Oncology, Pyrazines, 030220 oncology & carcinogenesis, MESH: Pyrazines / pharmacology, Female, MESH: Daunorubicin / pharmacology, Proteasome Inhibitors, medicine.drug, Adult, Proteasome Endopeptidase Complex, MESH: Protease Inhibitors / pharmacology, Daunorubicin, Antineoplastic Agents, HL-60 Cells, MESH: U937 Cells, Biology, MESH: Prognosis, 03 medical and health sciences, MESH: Leukemia, Myeloid, Acute / diagnosis, MESH: Proteasome Inhibitors, MESH: Apoptosis / drug effects, MESH: HL-60 Cells, medicine, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Protease Inhibitors, MESH: Tumor Cells, Cultured, Aged, 030304 developmental biology, MESH: Humans, Mass spectrometry, MESH: Drug Resistance, Neoplasm / physiology, MESH: Leupeptins / pharmacology, MESH: Adult, MESH: Boronic Acids / pharmacology, 2D gel electrophoresis, MESH: Antineoplastic Agents / pharmacology, MESH: Male, 20S proteasome, Proteasome, Drug Resistance, Neoplasm, Proteasome inhibitor, Cancer research, MESH: Female
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20
المؤلفون: Rosa Barreira da Silva, Melissa E Laird, Nader Yatim, Laurence Fiette, Molly A Ingersoll, Matthew L Albert
المساهمون: Immunobiologie des Cellules Dendritiques, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Histopathologie humaine et Modèles animaux, Institut Pasteur [Paris] (IP), Funding was provided by the Institut Pasteur (Pasteur-Roux post-doctoral fellowship to R.B.d.S.), the Pasteur Foundation (fellowship to M.E.L.), the Ligue Contre le Cancer (M.L.A.), the Fondation ARC pour la recherche sur le cancer (M.L.A.) and the French government's Invest in the Future Program, managed by the Agence Nationale de la Recherche (LabEx Immuno-Onco (R.B.d.S., M.E.L., N.Y., M.A.I. and M.L.A.))., ANR-11-IDEX-0005,USPC,Université Sorbonne Paris Cité(2011), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris]
المصدر: Nature Immunology
Nature Immunology, 2015, 16 (8), pp.850-858. ⟨10.1038/ni.3201⟩
Nature Immunology, Nature Publishing Group, 2015, 16 (8), pp.850-858. ⟨10.1038/ni.3201⟩مصطلحات موضوعية: Male, Adoptive cell transfer, Lymphocyte, medicine.medical_treatment, Cancer immunotherapy, MESH: Flow Cytometry, CXCR3, MESH: Mice, Knockout, MESH: Cell Movement/drug effects, 0302 clinical medicine, Cell Movement, MESH: Triazoles/pharmacology, Immunology and Allergy, MESH: Animals, MESH: Chemokines/metabolism, Lymphocytes, Mice, Knockout, Mice, Inbred BALB C, 0303 health sciences, Chemistry, Flow Cytometry, Adoptive Transfer, 3. Good health, MESH: Dipeptidyl Peptidase 4/immunology, medicine.anatomical_structure, MESH: Neoplasms, Experimental/genetics, MESH: Dipeptidyl Peptidase 4/genetics, MESH: Pyrazines/pharmacology, Pyrazines, 030220 oncology & carcinogenesis, MESH: Neoplasms, Experimental/immunology, MESH: Chemokine CXCL10/metabolism, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Immunotherapy, Chemokines, MESH: Chemokine CXCL10/immunology, Receptors, CXCR3, MESH: Cell Line, Tumor, MESH: Mice, Transgenic, Dipeptidyl Peptidase 4, T cell, Immunology, MESH: Mice, Inbred BALB C, MESH: Immunotherapy/methods, MESH: Cell Movement/immunology, Mice, Transgenic, MESH: Receptors, CXCR3/immunology, 03 medical and health sciences, Immune system, MESH: Mice, Inbred C57BL, Cell Line, Tumor, MESH: Lymphocytes/metabolism, medicine, Animals, CXCL10, MESH: Sitagliptin Phosphate, 030304 developmental biology, MESH: Neoplasms, Experimental/therapy, Dipeptidyl-Peptidase IV Inhibitors, Protein transport, MESH: Dipeptidyl-Peptidase IV Inhibitors/pharmacology, Sitagliptin Phosphate, Neoplasms, Experimental, Triazoles, MESH: Male, Chemokine CXCL10, Mice, Inbred C57BL, MESH: Adoptive Transfer, MESH: Receptors, CXCR3/metabolism, MESH: Dipeptidyl Peptidase 4/metabolism, MESH: Lymphocytes/immunology, MESH: Female, MESH: Chemokines/immunology