المؤلفون: Prema S. Karunanithi, Puja Dhanota, J. Bennett Addison, Shen Tong, Oliver Fiehn, Philipp Zerbe

المصدر: BMC Plant Biology, Vol 19, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: Diterpene synthase, Cytochrome P450 monooxygenase, Diterpenoid biosynthesis, Marrubiin, Plant natural products, Marrubium vulgare, Botany, QK1-989

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s12870-019-1702-5; https://doaj.org/toc/1471-2229

URL الوصول: https://doaj.org/article/bdc260edd6b14d91aa4f16e3cec0ba1b

المؤلفون: Guillaume Mata (1685596), Dillon H. Miles (8962160), Samuel L. Drew (8682102), Jeremy Fournier (3594275), Kenneth V. Lawson (2391673), Artur K. Mailyan (1588903), Ehesan U. Sharif (6847676), Xuelei Yan (1698157), Joel W. Beatty (1328199), Jesus Banuelos (4036886), Jie Chen (5892), Elaine Ginn (2124058), Ada Chen (1698127), Kimberline Y. Gerrick (6061382), Amber T. Pham (8682105), Kent Wong (2160739), Divyank Soni (9383865), Puja Dhanota (6506090), Stefan G. Shaqfeh (9383868), Cesar Meleza (6899225), Nell Narasappa (11592941), Hema Singh (11592944), Xiaoning Zhao (184301), Lixia Jin (1570120), Ulrike Schindler (9383871), Matthew J. Walters (296691), Stephen W. Young (7022015), Nigel P. Walker (8682108), Manmohan Reddy Leleti (8682111), Jay P. Powers (1721107), Jenna L. Jeffrey (2029015)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Immunology, Developmental Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, early lead series, tumor immune microenvironment, significant immune response, molecular docking studies, selective pi3kγ inhibitors, pyrazolopyrimidine amide inhibitors, 56 , immune cells, vitro <, studies indicate, pyrazolopyrimidine isoindolinones, optimal amide, metabolic stability, m1 macrophages, like properties, kinase γ, isoindolinone substituents, inflammatory phenotype, inflammatory mediators, increasing pro, highly potent, highly expressed, favorable drug

Relation: https://figshare.com/articles/journal_contribution/Design_Synthesis_and_Structure_Activity_Relationship_Optimization_of_Pyrazolopyrimidine_Amide_Inhibitors_of_Phosphoinositide_3_Kinase_PI3K_/16850249

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01153.s001

المؤلفون: Dillon H. Miles, Ada Chen, Manmohan Reddy Leleti, Divyank Soni, Stephen W Young, Artur K. Mailyan, Kenneth V. Lawson, Stefan G Shaqfeh, Ehesan U. Sharif, Jenna L. Jeffrey, Jesus Banuelos, Xuelei Yan, Samuel L Drew, Kimberline Gerrick, Nigel Walker, Puja Dhanota, Lixia Jin, Jay P. Powers, Elaine Ginn, Guillaume Mata, Kent Wong, Hema Singh, Jeremy Fournier, Joel W. Beatty, Ulrike Schindler, Amber Pham, Matthew J. Walters, Jie Chen, Cesar Meleza, Xiaoning Zhao, Nell Narasappa

المصدر: Journal of Medicinal Chemistry. 65:1418-1444

مصطلحات موضوعية: Male, Pyrazolopyrimidine, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Immune system, Amide, Drug Discovery, Animals, Class Ib Phosphatidylinositol 3-Kinase, Humans, Structure–activity relationship, Potency, Phosphoinositide-3 Kinase Inhibitors, Phosphoinositide 3-kinase, biology, Amides, Phenotype, In vitro, Rats, Molecular Docking Simulation, Pyrimidines, chemistry, Biochemistry, Drug Design, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37aec4464f4375ff8b99d31a40b9e89
https://doi.org/10.1021/acs.jmedchem.1c01153

المؤلفون: Dillon H. Miles, Ada Chen, Manmohan Reddy Leleti, Divyank Soni, Stephen W Young, Artur K. Mailyan, Kenneth V. Lawson, Stefan G Shaqfeh, Ehesan U. Sharif, Pei-Yu Chen, Jenna L. Jeffrey, Jesus Banuelos, Xuelei Yan, Samuel L Drew, Nigel Walker, Puja Dhanota, Lixia Jin, Jay P. Powers, Elaine Ginn, Guillaume Mata, Kent Wong, Jeremy Fournier, Joel W. Beatty, Rhiannon Thomas-Tran, Ulrike Schindler, Amber Pham, Matthew J. Walters, Jie Chen, Cesar Meleza, Xiaoning Zhao

المصدر: Journal of Medicinal Chemistry. 63:11235-11257

مصطلحات موضوعية: Gene isoform, Stereochemistry, Crystallography, X-Ray, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Animals, Class Ib Phosphatidylinositol 3-Kinase, Humans, Binding site, Phosphoinositide-3 Kinase Inhibitors, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Trifluoromethyl, Bicyclic molecule, Lipid signaling, Rats, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, Drug Design, Molecular Medicine, Selectivity, Adenosine triphosphate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237c477c3969b94ce636dfc76aca3e4f
https://doi.org/10.1021/acs.jmedchem.0c01203

المؤلفون: Prema Karunanithi, Puja Dhanota, J. Addison, Tong, Shen, Fiehn, Oliver, Zerbe, Philipp

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05920e09441eb5ebdc1b86787d51b2a4

المؤلفون: Prema Karunanithi, Puja Dhanota, J. Addison, Tong, Shen, Fiehn, Oliver, Zerbe, Philipp

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5bf8ff6e1a8e47f5f2a77f76de76ce

المؤلفون: Prema Karunanithi, Puja Dhanota, J. Addison, Tong, Shen, Fiehn, Oliver, Zerbe, Philipp

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bae338f7d3b240187f75688a660772

المؤلفون: Prema Karunanithi, Puja Dhanota, J. Addison, Tong, Shen, Fiehn, Oliver, Zerbe, Philipp

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5561f12fb81f104e384c08ac432b40c

المؤلفون: Prema Karunanithi, Puja Dhanota, J. Addison, Tong, Shen, Fiehn, Oliver, Zerbe, Philipp

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ededa04336acb77796af2c28242e249

المؤلفون: Prema Karunanithi, Puja Dhanota, J. Addison, Tong, Shen, Fiehn, Oliver, Zerbe, Philipp

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0359ba7d31eb171cbcfe9c75a15256

المؤلفون: Prema Karunanithi, Puja Dhanota, J. Addison, Tong, Shen, Fiehn, Oliver, Zerbe, Philipp

مصطلحات موضوعية: 3. Good health

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::48f4059b0561c4b4ec15027b51aa6f07

المؤلفون: Prema Karunanithi, Puja Dhanota, J. Addison, Tong, Shen, Fiehn, Oliver, Zerbe, Philipp

مصطلحات موضوعية: 6. Clean water

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6305bb051e4c8cf065dc2a4a41d95c6d

المؤلفون: Prema Karunanithi, Puja Dhanota, J. Addison, Tong, Shen, Fiehn, Oliver, Zerbe, Philipp

مصطلحات موضوعية: 3. Good health

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8206eb74dc2a494d9f7cf410e364f396