يعرض 1 - 20 نتائج من 119,630 نتيجة بحث عن '"Precursor"', وقت الاستعلام: 0.87s تنقيح النتائج
  1. 1
    Academic Journal
    NRF2 activation by 6-MSITC increases the generation of neuroprotective, soluble α amyloid precursor protein by inducing the metalloprotease gene ADAM17.

    المؤلفون: Carnicero-Senabre, Daniel1,2,3 (AUTHOR), Jiménez-Villegas, José1,2,3 (AUTHOR), Álvarez-Garrote, Sofía1 (AUTHOR), Escoll, Maribel1,2,3 (AUTHOR), Cuadrado, Antonio1,2,3 (AUTHOR), Rojo, Ana I.1,2,3 (AUTHOR) ana.rojo@uam.es

    المصدر: Free Radical Biology & Medicine. Feb2025, Vol. 227, p94-102. 9p.

    مصطلحات موضوعية: *TRANSCRIPTION factors, *AMYLOID beta-protein precursor, *PEPTIDES, *ALZHEIMER'S disease, *BINDING sites


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  2. 2
    Academic Journal
    Diverse Interactions of Sterols with Amyloid Precursor Protein Transmembrane Domain Can Shift Distribution Between Alternative Amyloid-β Production Cascades in Manner Dependent on Local Lipid Environment.

    المؤلفون: Volynsky, Pavel E.1 (AUTHOR) volynski@yandex.ru, Urban, Anatoly S.1 (AUTHOR) anatoly.urban@gmail.com, Pavlov, Konstantin V.2 (AUTHOR) qpavlov@mail.ru, Bershatsky, Yaroslav V.1 (AUTHOR) bershackyjaroslav@gmail.com, Bocharova, Olga V.1 (AUTHOR) o.bocharova@gmail.com, Kryuchkova, Anastasia K.2 (AUTHOR) anastasiakruckova44@gmail.com, Zlobina, Veronika V.1,2 (AUTHOR) t-amir@bk.ru, Gavrilenkova, Alina A.1,2 (AUTHOR) alycat1008@gmail.com, Dolotova, Sofya M.1,2 (AUTHOR) sm.dolotova@gmail.com, Kamynina, Anna V.1,2 (AUTHOR) aneskaminina@mail.ru, Zangieva, Olga T.3 (AUTHOR) zolgat@yandex.ru, Taldaev, Amir2,4 (AUTHOR), Batishchev, Oleg V.5 (AUTHOR) olegbati@gmail.com, Okhrimenko, Ivan S.2 (AUTHOR), Rakitina, Tatiana V.1 (AUTHOR) r-efremov@yandex.ru, Efremov, Roman G.1,6 (AUTHOR), Bocharov, Eduard V.1,2 (AUTHOR) taniarakitina@yahoo.com

    المصدر: International Journal of Molecular Sciences. Jan2025, Vol. 26 Issue 2, p553. 18p.

    مصطلحات موضوعية: *AMYLOID beta-protein precursor, *TRANSMEMBRANE domains, *MEMBRANE lipids, *ALZHEIMER'S disease, *MEMBRANE proteins, *PRESENILINS

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  3. 3
    Academic Journal
    Molecular Mechanisms of Alzheimer's Disease Induced by Amyloid-β and Tau Phosphorylation Along with RhoA Activity: Perspective of RhoA/Rho-Associated Protein Kinase Inhibitors for Neuronal Therapy.

    المؤلفون: Ahn, Eun Hee1,2 (AUTHOR) eunhee.ahn@hallym.ac.kr, Park, Jae-Bong3,4,5 (AUTHOR) jbpark@hallym.ac.kr

    المصدر: Cells (2073-4409). Jan2025, Vol. 14 Issue 2, p89. 46p.

    مصطلحات موضوعية: *TAU proteins, *AMYLOID beta-protein precursor, *CELL morphology, *ALZHEIMER'S disease, *RHO GTPases

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  4. 4
    Academic Journal
    Association between gene polymorphisms and glaucoma susceptibility among Africans: a systematic review and meta-analysis.

    المؤلفون: Asiamah, Randy1 (AUTHOR), Kyei, Samuel1 (AUTHOR) skyei@ucc.edu.gh, Owusu, Paul1 (AUTHOR), Koomson, Keren1 (AUTHOR), Arthur, Prince1 (AUTHOR)

    المصدر: Ophthalmic Genetics. Jan2025, p1-12. 12p. 3 Illustrations.

    مصطلحات موضوعية: *AMYLOID beta-protein precursor, *LYSYL oxidase, *GENETIC polymorphisms, *GENETIC mutation, *PROTEIN binding, *BIBLIOGRAPHIC databases


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  5. 5
    Academic Journal
    Evaluation of the Anti-Amyloid and Anti-Inflammatory Properties of a Novel Vanadium(IV)–Curcumin Complex in Lipopolysaccharides-Stimulated Primary Rat Neuron-Microglia Mixed Cultures.

    المؤلفون: Katsipis, Georgios1,2 (AUTHOR) gerom@chem.auth.gr, Lavrentiadou, Sophia N.2,3 (AUTHOR) mtsant@vet.auth.gr, Geromichalos, George D.2,4 (AUTHOR), Tsantarliotou, Maria P.3 (AUTHOR), Halevas, Eleftherios1,5 (AUTHOR) lefterishalevas@gmail.com, Litsardakis, George6 (AUTHOR) lits@eng.auth.gr, Pantazaki, Anastasia A.1,2 (AUTHOR) slavrent@vet.auth.gr

    المصدر: International Journal of Molecular Sciences. Jan2025, Vol. 26 Issue 1, p282. 27p.

    مصطلحات موضوعية: *AMYLOID beta-protein precursor, *NITRIC-oxide synthases, *ALZHEIMER'S disease, *PATHOLOGY, *CURCUMIN

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  6. 6
    Academic Journal
    Beclin 1-Mediated Autophagy Is Potentiated by an Interaction with the Neuronal Adaptor FE65.

    المؤلفون: Chan, Wai Wa Ray1 (AUTHOR), Chow, Jessica1 (AUTHOR), Chau, Dennis Dik-Long1 (AUTHOR) waiwachan1114@gmail.com, Zhai, Yuqi1 (AUTHOR), Lau, Kwok-Fai1 (AUTHOR) kflau@cuhk.edu.hk

    المصدر: Biology (2079-7737). Jan2025, Vol. 14 Issue 1, p97. 20p.

    مصطلحات موضوعية: *AMYLOID beta-protein precursor, *PHOSPHATIDYLINOSITOL 3-kinases, *ALZHEIMER'S disease, *ADAPTOR proteins, *EUKARYOTIC cells

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  7. 7
    Academic Journal
    Transmembrane and coiled‐coil 2 associates with Alzheimer's disease pathology in the human brain.

    المؤلفون: Hopkins, Paul C. R.1 (AUTHOR) hopkins.dementin@gmail.com, Troakes, Claire2 (AUTHOR), King, Andrew2 (AUTHOR), Tear, Guy1 (AUTHOR)

    المصدر: Brain Pathology. Jan2025, Vol. 35 Issue 1, p1-14. 14p.

    مصطلحات موضوعية: *AMYLOID beta-protein precursor, *ALZHEIMER'S disease, *TEMPORAL lobe, *AMYLOID plaque, *APOLIPOPROTEIN E

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  8. 8
    Academic Journal
    APP lysine 612 lactylation ameliorates amyloid pathology and memory decline in Alzheimer's disease.

    المؤلفون: Qiuyun Tian1, Junjie Li1, Bin Wu1, Yayan Pang1, Wenting He1, Qian Xiao1, Jiaojiao Wang1, Lilin Yi1, Na Tian1, Xiuyu Shi1, Lei Xia1, Xin Tian2,3, Mulan Chen1, Yepeng Fan1, Boqing Xu1, Yuhan Tao1, Weihong Song1,4,5, Yehong Du1 dudu0000807@126.com, Zhifang Dong1 zfdong@cqmu.edu.cn

    المصدر: Journal of Clinical Investigation. 1/2/2025, Vol. 135 Issue 1, p1-18. 19p.

    مصطلحات موضوعية: *AMYLOID beta-protein precursor, *POST-translational modification, *ALZHEIMER'S disease, *SPATIAL memory, *MEMORY disorders


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  9. 9
    Academic Journal
    Applying low levels of strain to model nascent phenomenon of retinal pathologies.

    المؤلفون: Paterson, Chase1 (AUTHOR), Vargis, Elizabeth1 (AUTHOR) vargis@usu.edu

    المصدر: Lab on a Chip. 12/21/2024, Vol. 24 Issue 24, p5338-5346. 9p.

    مصطلحات موضوعية: *MACULAR degeneration, *AMYLOID beta-protein precursor, *RHODOPSIN, *GENE expression, *CELL physiology


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  10. 10
    Academic Journal
    Unveiling Cathepsin B inhibition with repurposed drugs for anticancer and anti-Alzheimer's drug discovery.

    المؤلفون: Alrouji, Mohammed1 (AUTHOR), Yasmin, Sabina2 (AUTHOR), Alshammari, Mohammed S.3 (AUTHOR), Alhumaydhi, Fahad A.4 (AUTHOR), Sharaf, Sharaf E.5 (AUTHOR), Shahwan, Moyad6 (AUTHOR), Shamsi, Anas6 (AUTHOR) anas.shamsi18@gmail.com

    المصدر: PLoS ONE. 12/19/2024, Vol. 19 Issue 12, p1-19. 19p.

    مصطلحات موضوعية: *AMYLOID beta-protein precursor, *CATHEPSIN B, *DRUG discovery, *PROTEOLYSIS, *VIRTUAL high-throughput screening (Drug development)

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  11. 11
    Academic Journal
    Effect of diffusivity of amyloid beta monomers on the formation of senile plaques.

    المؤلفون: Kuznetsov, Andrey V1 (AUTHOR)

    المصدر: Mathematical Medicine & Biology: A Journal of the IMA. Dec2024, Vol. 41 Issue 4, p346-362. 17p.

    مصطلحات موضوعية: *AMYLOID beta-protein precursor, *AMYLOID plaque, *ALZHEIMER'S disease, *POLYMERIZATION kinetics, *PARTIAL differential equations


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  12. 12
    Academic Journal
    Catalpol alleviates amyloid-B generation and neuronal oxidative stress injury via activating the Keap1-N rf2/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer's disease and SKNMC cells co-culture model.

    المؤلفون: Caixia Xiang1,2, Yunwei Lu1,3, Renjuan Hao1, Yuyan Wei1, Yingchao Hu1, Guran Yu1 yushengzh@126.com

    المصدر: Iranian Journal of Basic Medical Sciences. Dec2024, Vol. 27 Issue 12, p1547-1557. 11p.

    مصطلحات موضوعية: *AMYLOID beta-protein precursor, *LYMPHOBLASTOID cell lines, *ALZHEIMER'S patients, *ALZHEIMER'S disease, *OXIDANT status

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  13. 13
    Academic Journal
    Vesicular Transport and Amyloids: The Growing Relationship.

    المؤلفون: Upadhyay, Arun1 (AUTHOR) arun@iitbhilai.ac.in

    المصدر: Biologics. Dec2024, Vol. 4 Issue 4, p376-389. 14p.

    مصطلحات موضوعية: *AMYLOID beta-protein precursor, *CARRIER proteins, *ADAPTOR proteins, *ALZHEIMER'S disease, *AMYLOID


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  14. 14
    Academic Journal
    Targeting Iron Responsive Elements (IREs) of APP mRNA into Novel Therapeutics to Control the Translation of Amyloid-β Precursor Protein in Alzheimer's Disease.

    المؤلفون: Khan, Mateen A.1 (AUTHOR) matkhan@alfaisal.edu

    المصدر: Pharmaceuticals (14248247). Dec2024, Vol. 17 Issue 12, p1669. 24p.

    مصطلحات موضوعية: *AMYLOID beta-protein precursor, *ALZHEIMER'S disease, *PROTEIN precursors, *IRON proteins, *GENE expression

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  15. 15
    Academic Journal
    Zinc and copper effect mechanical cell adhesion properties of the amyloid precursor protein.

    المؤلفون: August, Alexander1 (AUTHOR), Hartmann, Sabrina2 (AUTHOR), Schilling, Sandra1 (AUTHOR), Müller-Renno, Christine2 (AUTHOR), Begic, Tarik3 (AUTHOR), Pierik, Antonio J.3 (AUTHOR), Ziegler, Christiane2 (AUTHOR), Kins, Stefan1 (AUTHOR) kins@rptu.de

    المصدر: Biological Chemistry. Dec2024, Vol. 405 Issue 11/12, p701-710. 10p.

    مصطلحات موضوعية: *AMYLOID beta-protein precursor, *COPPER, *ION bombardment, *CELLULAR mechanics, *ALZHEIMER'S disease


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  16. 16
    Academic Journal
    The AICD interactome: implications in neurodevelopment and neurodegeneration.

    المؤلفون: Lok-Haang Ng, Laura, Chow, Jessica, Kwok-Fai Lau kflau@cuhk.edu.hk

    المصدر: Biochemical Society Transactions. Dec2024, Vol. 52 Issue 6, p2539-2556. 18p.

    مصطلحات موضوعية: *AMYLOID beta-protein precursor, *ALZHEIMER'S disease, *CENTRAL nervous system, *AMYLOID plaque, *NEURAL circuitry


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  17. 17
    Academic Journal
    Biochemical changes precede affective and cognitive anomalies in aging adult C57BL/6J mice with a prior history of adolescent alcohol binge-drinking.

    المؤلفون: Chavez, C, Scheldrup, Gavin, Madory, Lauren, Denning, Christopher, Lee, Edward, Nguyen, Dylan, Castro, Marian, Garcia, Andrew, Torres-Gonzales, Jose, Herbert, Jessica, Kotlyar, Daniel, Riazat, Neda, Pakter, William, Le, William, Van Doren, Eliyanna, Ter Galstian, Marianna, Szumlinski, Karen

    المصدر: Addiction Biology. 29(12)

    مصطلحات موضوعية: Alzheimers disease, Morris water maze, glutamate receptors, negative affect, radial arm maze, Animals, Binge Drinking, Female, Mice, Mice, Inbred C57BL, Male, Aging, Cognitive Dysfunction, tau Proteins, Amyloid Precursor Protein Secretases, Entorhinal Cortex, Brain, Underage Drinking, Sensory Gating, Amyloid beta-Protein Precursor, Cognition, Amyloid beta-Peptides, Prefrontal Cortex, Aspartic Acid Endopeptidases

    وصف الملف: application/pdf

    URL الوصول: https://escholarship.org/uc/item/407159q1
    https://escholarship.org/content/qt407159q1/qt407159q1.pdf

    View record in eScholarship

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  18. 18
    Report
    Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma

    المصدر: A Randomized Trial of Levocarnitine Prophylaxis to Prevent Asparaginase-Associated Hepatotoxicity in Adolescents and Young Adults Receiving Acute Lymphoblastic Leukemia Therapy

    View record in ClinicalTrials.gov

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  19. 19
    Report
    Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)

    المؤلفون: AbbVie

    المصدر: SJALL23T: Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)

    View record in ClinicalTrials.gov

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  20. 20
    Report
    A Study Evaluating the Safety and Efficacy of BEAM-201 in Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LL)

    المصدر: A Phase 1/2, Dose-Exploration and Dose-Expansion Study Evaluating the Safety and Efficacy of Multiplex Base-Edited, Allogeneic Anti-CD7 CAR-T Cells (BEAM-201) in Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LL)

    View record in ClinicalTrials.gov

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