المؤلفون: Bogacheva, MS, Kuivanen, S, Potdar, S, Hassinen, A, Huuskonen, S, Pohner, I, Luck, TJ, Turunen, L, Feodoroff, M, Szirovicza, L, Savijoki, K, Saarela, J, Tammela, P, Paavolainen, L, Poso, A, Varjosalo, M, Kallioniemi, O, Pietiainen, V, Vapalahti, O

المصدر: Antiviral research. 223:105813

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:155111605

المؤلفون: Santos, Lucianna H, Kronenberger, Thales, Almeida, Renata G, Silva, Elany B, Rocha, Rafael EO, Oliveira, Joyce C, Barreto, Luiza V, Skinner, Danielle, Fajtová, Pavla, Giardini, Miriam A, Woodworth, Brendon, Bardine, Conner, Lourenço, André L, Craik, Charles S, Poso, Antti, Podust, Larissa M, McKerrow, James H, Siqueira-Neto, Jair L, O’Donoghue, Anthony J, da Silva Júnior, Eufrânio N, Ferreira, Rafaela S

المصدر: Journal of Chemical Information and Modeling. 62(24)

مصطلحات موضوعية: Medicinal and Biomolecular Chemistry, Chemical Sciences, Emerging Infectious Diseases, Infectious Diseases, Coronaviruses, Infection, Humans, Antiviral Agents, COVID-19, Molecular Docking Simulation, Naphthoquinones, Papain, Protease Inhibitors, SARS-CoV-2, Coronavirus 3C Proteases, Coronavirus Papain-Like Proteases, Theoretical and Computational Chemistry, Computation Theory and Mathematics, Medicinal & Biomolecular Chemistry, Medicinal and biomolecular chemistry, Theoretical and computational chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3722p8m4
https://escholarship.org/content/qt3722p8m4/qt3722p8m4.pdf

المؤلفون: Florian Wittlinger, Blessing C. Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D. Pham, Ilse K. Schaeffner, Brandon T. Oligny, Surbhi P. Chitnis, Tyler S. Beyett, Alexander Rasch, Brian Buckley, Daniel A. Urul, Tatiana Shaurova, Earl W. May, Erik M. Schaefer, Michael J. Eck, Pamela A. Hershberger, Antti Poso, Stefan A. Laufer, David E. Heppner

المصدر: Communications Chemistry, Vol 7, Iss 1, Pp 1-14 (2024)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2399-3669

URL الوصول: https://doaj.org/article/4d98b317db4743c79540cdb1697614f4

المؤلفون: Stephan Spahn, Fabian Kleinhenz, Ekaterina Shevchenko, Aaron Stahl, Yvonne Rasen, Christine Geisler, Kristina Ruhm, Marion Klaumuenzer, Thales Kronenberger, Stefan A. Laufer, Holly Sundberg-Malek, Khac Cuong Bui, Marius Horger, Saskia Biskup, Klaus Schulze-Osthoff, Markus Templin, Nisar P. Malek, Antti Poso, Michael Bitzer

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/4e23905b41b4488d8d1d8c66053fe10f

المؤلفون: Maurício T. Tavares, Arne Krüger, Sun L. Rei Yan, Karoline B. Waitman, Vinícius M. Gomes, Daffiny Sumam de Oliveira, Franciarli Paz, Sebastian Hilscher, Mike Schutkowski, Wolfgang Sippl, Claudia Ruiz, Mônica F. Z. J. Toledo, Neuza M. A. Hassimotto, João A. Machado-Neto, Antti Poso, Michael D. Cameron, Thomas D. Bannister, Giuseppe Palmisano, Carsten Wrenger, Thales Kronenberger, Roberto Parise-Filho

المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/661e63afc62b4a918f5086fa3323ea43

المؤلفون: Julia de Paula Dutra, Gustavo Scheiffer, Thales Kronenberger, Lucas Julian Cruz Gomes, Isadora Zanzarini, Kelly Karoline dos Santos, Arun K. Tonduru, Antti Poso, Fabiane Gomes de Moraes Rego, Geraldo Picheth, Glaucio Valdameri, Vivian Rotuno Moure

المصدر: EXCLI Journal : Experimental and Clinical Sciences, Vol 22, Pp 1155-1172 (2023)

مصطلحات موضوعية: abcg2, drug repositioning, lopinavir, ivermectin, molecular modelling, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.excli.de/index.php/excli/article/view/6427; https://doaj.org/toc/1611-2156

URL الوصول: https://doaj.org/article/89c372996acc4eafb0e43f13022f3e07

المؤلفون: Khan Suleiman A, Faisal Ali, Mpindi John, Parkkinen Juuso A, Kalliokoski Tuomo, Poso Antti, Kallioniemi Olli P, Wennerberg Krister, Kaski Samuel

المصدر: BMC Bioinformatics, Vol 13, Iss 1, p 112 (2012)

مصطلحات موضوعية: Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.biomedcentral.com/1471-2105/13/112; https://doaj.org/toc/1471-2105

URL الوصول: https://doaj.org/article/d81f8d059528452f9250afdee83c732d

المؤلفون: Ashik Jawahar Deen, Simone Adinolfi, Jouni Härkönen, Tommi Patinen, Xiaonan Liu, Tuomo Laitinen, Piia Takabe, Kirsi Kainulainen, Sanna Pasonen-Seppänen, Lisa M. Gawriyski, Uma Thanigai Arasu, Ilakya Selvarajan, Petri Mäkinen, Hanna Laitinen, Emilia Kansanen, Minna U. Kaikkonen, Antti Poso, Markku Varjosalo, Anna-Liisa Levonen

المصدر: Redox Biology, Vol 69, Iss , Pp 103031- (2024)

مصطلحات موضوعية: KEAP1, Apoptosis, TRAF2, NFκB, TNFα, Lung cancer, Medicine (General), R5-920, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231724000077; https://doaj.org/toc/2213-2317

URL الوصول: https://doaj.org/article/6424cb4692934e1e8076ab053da688af

المؤلفون: Kurki, Milla, Nesterenko, Alexey M., Alsaker, Nicolai E., M. Ferreira, Tiago, Kyllönen, Sami, Poso, Antti, Bartos, Piia, Miettinen, Markus S.

المساهمون: Emil Aaltosen S??ti, Suomen Farmaseuttinen Yhdistys, Trond Mohn stiftelse, Norges Forskningsr?d, Suomen Kulttuurirahasto

المصدر: The Journal of Physical Chemistry B ; volume 128, issue 50, page 12483-12492 ; ISSN 1520-6106 1520-5207

الاتاحة: https://doi.org/10.1021/acs.jpcb.4c04719
https://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.4c04719

المؤلفون: Jenifer Lizeth Herrera Vilca, Cristian Fernando Benavides Salazar, Julio Cesar Benavides Salazar, Esteven Antonio Poso Vélez

Relation: https://doi.org/10.5281/zenodo.13988298; https://doi.org/10.5281/zenodo.13988299; oai:zenodo.org:13988299

الاتاحة: https://doi.org/10.5281/zenodo.13988299

المؤلفون: Pylkkö, Tuomas, Tomašič, Tihomir, Poso, Antti, Tammela, Päivi

المساهمون: Division of Pharmaceutical Biosciences, Bioactivity Screening Group, Drug Research Program, Divisions of Faculty of Pharmacy

مصطلحات موضوعية: Epec, High-content imaging, Intimin, Translocated intimin receptor, Pharmacy

وصف الملف: application/pdf

Relation: The authors wish to acknowledge CSC - IT Center for Science, Finland, for computational resources and OpenEye Scientific Software (Santa Fe, NM, USA) for free academic licenses for the use of their software. The facilities and expertise of the FIMM High Throughput Biomedicine Unit and the DDCB unit at the Faculty of Pharmacy, supported by HiLIFE and Biocenter Finland, are gratefully acknowledged. Figure 1A and Table of Contents image created with BioRender.com.; Pylkkö , T , Tomašič , T , Poso , A & Tammela , P 2024 , ' Virtual Screening Assisted Search for Inhibitors of the Translocated Intimin Receptor of Enteropathogenic Escherichia coli ' , ChemBioChem : a European journal of chemical biology , vol. 25 , no. 2 , e202300638 . https://doi.org/10.1002/cbic.202300638; http://hdl.handle.net/10138/585215; 85178135157; 001109840700001

الاتاحة: http://hdl.handle.net/10138/585215

المؤلفون: Álvarez Fernández, María Inés, Diaz Poso, A., Lorenzo González, María de las Nieves, Roye, D.

مصطلحات موضوعية: 2509.06 Meteorología Marina, 2502 Climatología

Relation: info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-125060OB-I00/ES; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/TED2021-129152B-C43/ES; info:eu-repo/grantAgreement/EC/HE/101103978; Atmospheric Research, 308, 107512 (2024); http://hdl.handle.net/11093/7170; https://linkinghub.elsevier.com/retrieve/pii/S0169809524002941

الاتاحة: http://hdl.handle.net/11093/7170
https://doi.org/10.1016/j.atmosres.2024.107512
https://linkinghub.elsevier.com/retrieve/pii/S0169809524002941

المؤلفون: Philipp Flury, Julian Breidenbach, Nadine Krüger, Rabea Voget, Laura Schäkel, Yaoyao Si, Vesa Krasniqi, Sara Calistri, Matthias Olfert, Katharina Sylvester, Cheila Rocha, Raphael Ditzinger, Alexander Rasch, Stefan Pöhlmann, Thales Kronenberger, Antti Poso, Katharina Rox, Stefan A. Laufer, Christa E. Müller, Michael Gütschow, Thanigaimalai Pillaiyar

مصطلحات موضوعية: Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Cancer, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, terminal warhead functions, terminal capping groups, human cathepsins l, high metabolic stability, biological activity cathepsins, 9b , 9a , 11e , promising cathepsin l, 50 , k <, , (< b, inhibitory activity, antiviral activity, tailored series, successful entry, subnanomolar range, structural diversity, several compounds, preclinical development

Relation: https://figshare.com/articles/journal_contribution/Cathepsin-Targeting_SARS-CoV_2_Inhibitors_Design_Synthesis_and_Biological_Activity/25033849

الاتاحة: https://doi.org/10.1021/acsptsci.3c00313.s001
https://figshare.com/articles/journal_contribution/Cathepsin-Targeting_SARS-CoV_2_Inhibitors_Design_Synthesis_and_Biological_Activity/25033849

المؤلفون: Bogacheva, Mariia, Kuivanen, Suvi, Potdar, Swapnil, Hassinen, Antti, Huuskonen, Sini, Pöhner, Ina, Luck, Tamara J., Turunen, Laura, Feodoroff, Michaela, Szirovicza, Leonóra, Savijoki, Kirsi, Saarela, Jani, Tammela, Päivi, Paavolainen, Lassi, Poso, Antti, Varjosalo, Markku, Kallioniemi, Olli, Pietiäinen, Vilja, Vapalahti, Olli

المساهمون: Department of Virology, Medicum, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Viral Zoonosis Research Unit, Institute of Biotechnology, Molecular Systems Biology, Division of Pharmaceutical Biosciences, Drug Research Program, Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, Bioactivity Screening Group, Bioimage Profiling, Precision Systems Medicine, Helsinki One Health (HOH), HUSLAB, Veterinary Microbiology and Epidemiology, Veterinary Biosciences, Olli Pekka Vapalahti / Principal Investigator, HUS Diagnostic Center

مصطلحات موضوعية: 11832 Microbiology and virology, General medicine, internal medicine and other clinical medicine, Pharmacy

وصف الملف: application/pdf

Relation: The authors thank Minerva Institute (Helsinki, Finland) for providing utilities for the project; the FIMM High Throughput Biomedicine Unit for providing access to HT robotics, the FIMM High Content Imaging and Analysis Unit for HC imaging and analysis, and FIMM Genomics unit for genotyping services (HiLIFE, University of Helsinki and Biocenter Finland) . The authors acknowledge the CSC-IT Center for Science Ltd. for computational resources. The grants awarded by the Academy of Finland [grant numbers iCOIN-336496: OK, VP, OV; FIRI 2020-337036: FIMM-HCA, AH, VP] , the EU H2020 VEO project (OV) , Juho Vainio foundation, anonymous donors through Helsinki University Research funds (OV) and Minerva Foundation for the COVID19 research project grant (VP) are also greatly acknowledged. The authors thank Katja Rosti, University of Helsinki, Dr. Petri Saviranta, and Sirpa Jylha , VTT, Finland for the supply of 7A12 antibodies against SARS-CoV-2 S protein. The authors thank Prof. Kari Alitalo for providing a fluorescence reader at BSL-3 and Alyce Whipp for checking the English language grammar in the manuscript.; Bogacheva , M , Kuivanen , S , Potdar , S , Hassinen , A , Huuskonen , S , Pöhner , I , Luck , T J , Turunen , L , Feodoroff , M , Szirovicza , L , Savijoki , K , Saarela , J , Tammela , P , Paavolainen , L , Poso , A , Varjosalo , M , Kallioniemi , O , Pietiäinen , V & Vapalahti , O 2024 , ' Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome ' , Antiviral Research , vol. 223 , 105813 . https://doi.org/10.1016/j.antiviral.2024.105813; ORCID: /0000-0001-7306-7175/work/152924410; ORCID: /0000-0003-2270-6824/work/152925170; ORCID: /0000-0003-3125-2406/work/152926687; ORCID: /0000-0003-4697-8066/work/152926723; ORCID: /0000-0003-1528-044X/work/152927229; ORCID: /0000-0002-1340-9732/work/152927567; ORCID: /0000-0002-6094-9838/work/152928335; ORCID: /0000-0003-3857-1805/work/152931879; ORCID: /0000-0001-9491-2868/work/152932584; ORCID: /0000-0002-9859-1261/work/152932735; ORCID: /0000-0003-1508-2718/work/152933216; ORCID: /0000-0002-2778-6918/work/152933252; ORCID: /0000-0001-6608-1120/work/152933672; ORCID: /0000-0003-0274-4794/work/155648905; http://hdl.handle.net/10138/571055; 05032077-daad-4120-a874-3c60fa96febb; 001177707500001

الاتاحة: http://hdl.handle.net/10138/571055

المؤلفون: Deen, Ashik Jawahar, Adinolfi, Simone, Harkonen, Jouni, Patinen, Tommi, Liu, Xiaonan, Laitinen, Tuomo, Takabe, Piia, Kainulainen, Kirsi, Pasonen-Seppanen, Sanna, Gawriyski, Lisa M., Arasu, Uma Thanigai, Selvarajan, Ilakya, Makinen, Petri, Laitinen, Hanna, Kansanen, Emilia, Kaikkonen, Minna U., Poso, Antti, Varjosalo, Markku, Levonen, Anna-Liisa

المساهمون: Institute of Biotechnology, Molecular Systems Biology, Helsinki Institute of Life Science HiLIFE

مصطلحات موضوعية: Apoptosis, Keap1, Lung cancer, NF kappa B, TNF alpha, Traf2, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: We thank Anne Karppinen, Joanna Lempiainen and Emilia Kontio for technical assistance. Technical support from UEF cell and tissue imaging unit is also acknowledged. This study was funded by the Academy of Finland (A -LL) , Sigrid Juselius Foundation (A -LL) , Finnish Cancer Society (A -LL) , the Finnish Cultural Foundation (AJD) , Kuopio University Foundation (AJD, SA) , Horizon 2020 Framework Programme (SA, Marie Sklodowska Curie grant agreement No 740264) and Ida Montin Foundation (SA) . We thank Biocenter Finland/DDCB and Biocenter Kuopio for financial support and the CSC -IT Center for Science Ltd. (Finland) for allocation of computational resources.; Deen , A J , Adinolfi , S , Harkonen , J , Patinen , T , Liu , X , Laitinen , T , Takabe , P , Kainulainen , K , Pasonen-Seppanen , S , Gawriyski , L M , Arasu , U T , Selvarajan , I , Makinen , P , Laitinen , H , Kansanen , E , Kaikkonen , M U , Poso , A , Varjosalo , M & Levonen , A-L 2024 , ' Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells ' , Redox biology , vol. 69 , 103031 . https://doi.org/10.1016/j.redox.2024.103031; ORCID: /0000-0002-1340-9732/work/155091082; ORCID: /0000-0002-1950-4749/work/155095054; http://hdl.handle.net/10138/572797; 9a048fee-a009-4bd0-a59b-af13c61c2d1c; 001155774800001

الاتاحة: http://hdl.handle.net/10138/572797

المؤلفون: Eloranta, Jari, Ojala, Jari, Valtonen, Heli, Poso, Eetu

المساهمون: Economic and Social History

مصطلحات موضوعية: 5202 Economic and Social History

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

Relation: Eloranta , J , Ojala , J , Valtonen , H & Poso , E 2023 , ' Between the Number and the Word : Quantitative Methods in Business History Revisited ' , Revista de Historia Industrial , vol. 32 , no. 88 , pp. 19-48 . https://doi.org/10.1344/rhiihr.40896; 4104c2e0-2f8f-4962-8e58-40efc67bc087; http://hdl.handle.net/10138/570761

الاتاحة: http://hdl.handle.net/10138/570761

المؤلفون: Germán Fabricio Acurio Hidalgo, José Luis Maldonado Cando, Esteven Antonio Poso Vélez, Génesis Ariana Loayza Zambrano

Relation: https://doi.org/10.5281/zenodo.13970782; https://doi.org/10.5281/zenodo.13970783; oai:zenodo.org:13970783

الاتاحة: https://doi.org/10.5281/zenodo.13970783

المؤلفون: Asquith, Christopher R.M., East, Michael P., Laitinen, Tuomo, Alamillo-Ferrer, Carla, Hartikainen, Erkka, Wells, Carrow I., Axtman, Alison D., Drewry, David H., Tizzard, Graham J., Poso, Antti, Willson, Timothy M., Johnson, Gary L.

وصف الملف: text

Relation: https://eprints.soton.ac.uk/491136/1/1-s2.0-S022352342400237X-main.pdf; Asquith, Christopher R.M., East, Michael P., Laitinen, Tuomo, Alamillo-Ferrer, Carla, Hartikainen, Erkka, Wells, Carrow I., Axtman, Alison D., Drewry, David H., Tizzard, Graham J., Poso, Antti, Willson, Timothy M. and Johnson, Gary L. (2024) Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships. European Journal of Medicinal Chemistry, 271, [116357]. (doi:10.1016/j.ejmech.2024.116357 ).

الاتاحة: https://eprints.soton.ac.uk/491136/
https://eprints.soton.ac.uk/491136/1/1-s2.0-S022352342400237X-main.pdf

المؤلفون: Tambunan, Batara Poso

المصدر: Jurnal Pendidikan Tambusai; Vol. 8 No. 1 (2024): April 2024; 13970-13986 ; 2614-3097 ; 2614-6754

مصطلحات موضوعية: Harga, Promosi, Keputusan Pembelian

وصف الملف: application/pdf

Relation: https://jptam.org/index.php/jptam/article/view/14367/11024; https://jptam.org/index.php/jptam/article/view/14367

الاتاحة: https://jptam.org/index.php/jptam/article/view/14367

المؤلفون: Zwirner, Stefan, Abu Rmilah, Anan A., Klotz, Sabrina, Pfaffenroth, Bent, Kloevekorn, Philip, Moschopoulou, Athina A., Schuette, Svenja, Haag, Mathias, Selig, Roland, Li, Kewei, Zhou, Wei, Nelson, Erek, Poso, Antti, Chen, Harvey, Amiot, Bruce, Jia, Yao, Minshew, Anna, Michalak, Gregory, Cui, Wei, Rist, Elke, Longerich, Thomas, Jung, Birgit, Felgendreff, Philipp, Trompak, Omelyan, Premsrirut, Prem K., Gries, Katharina, Muerdter, Thomas E., Heinkele, Georg, Wuestefeld, Torsten, Shapiro, David, Weissbach, Markus, Koenigsrainer, Alfred, Sipos, Bence, AB, Eiso, Zacarias, Magdalena Ortiz, Theisgen, Stephan, Gruenheit, Nicole, Biskup, Saskia, Schwab, Matthias, Albrecht, Wolfgang, Laufer, Stefan, Nyberg, Scott, Zender, Lars

المساهمون: Robert-Bosch Foundation GmbH, German Research Foundation, German Cancer Consortium

المصدر: Cell ; volume 187, issue 7, page 1666-1684.e26 ; ISSN 0092-8674

الاتاحة: http://dx.doi.org/10.1016/j.cell.2024.02.023
https://api.elsevier.com/content/article/PII:S0092867424002253?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0092867424002253?httpAccept=text/plain