المؤلفون: Ponnienselvan, Karthikeyan, Liu, Pengpeng, Nyalile, Thomas, Oikemus, Sarah, Maitland, Stacy A, Lawson, Nathan D, Luban, Jeremy, Wolfe, Scot A

المساهمون: National Institutes of Health, Rett Syndrome Research Trust

المصدر: Nucleic Acids Research ; volume 51, issue 13, page 6966-6980 ; ISSN 0305-1048 1362-4962

الاتاحة: http://dx.doi.org/10.1093/nar/gkad456
https://academic.oup.com/nar/article-pdf/51/13/6966/50902892/gkad456.pdf

المؤلفون: Liang, Shun-Qing, Zheng, Chunwei, Mintzer, Esther, Zhao, Yan G., Ponnienselvan, Karthikeyan, Mir, Aamir, Sontheimer, Erik J., Gao, Guangping, Flotte, Terence R., Wolfe, Scot A., Xue, Wen

المساهمون: Graduate School of Biomedical Sciences, Department of Pediatrics, Horae Gene Therapy Center, Li Weibo Institute for Rare Diseases Research, Program in Molecular Medicine, RNA Therapeutics Institute, Department of Molecular, Cell and Cancer Biology

المصدر: Nature communications ; 12 ; 1 ; 2121

مصطلحات موضوعية: Gene therapy, Cancer genetics, CRISPR-Cas9 genome editing, Cancer Biology, Disease Modeling, Genetics and Genomics, Neoplasms, Therapeutics

Relation: Link to Article in PubMed; Liu P, Liang SQ, Zheng C, Mintzer E, Zhao YG, Ponnienselvan K, Mir A, Sontheimer EJ, Gao G, Flotte TR, Wolfe SA, Xue W. Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice. Nat Commun. 2021 Apr 9;12(1):2121. doi:10.1038/s41467-021-22295-w. PMID: 33837189; PMCID: PMC8035190. Link to article on publisher's site; 2041-1723 (Linking); http://hdl.handle.net/20.500.14038/41891; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5732&context=oapubs&unstamped=1; https://escholarship.umassmed.edu/oapubs/4699; oapubs/4699

الاتاحة: https://doi.org/10.1038/s41467-021-22295-w
https://hdl.handle.net/20.500.14038/41891
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5732&context=oapubs&unstamped=1
https://escholarship.umassmed.edu/oapubs/4699

المؤلفون: Luk, Kevin, Shin, Masahiro, Idrizi, Feston, Kwok, Samantha F., Roscoe, Benjamin P., Mintzer, Esther, Suresh, Sneha, Morrison, Kyle, Frazao, Josias B., Bolukbasi, Mehmet Fatih, Ponnienselvan, Karthikeyan, Luban, Jeremy, Zhu, Lihua Julie, Lawson, Nathan D., Wolfe, Scot A.

المساهمون: Li Weibo Institute for Rare Diseases Research, Program in Molecular Medicine, Department of Biochemistry and Molecular Pharmacology, Department of Molecular, Cell and Cancer Biology

المصدر: Nucleic acids research ; 47 ; 8 ; 4169–4180

مصطلحات موضوعية: Biochemistry, Biophysics, and Structural Biology, Cell and Developmental Biology, Embryonic Structures, Genetic Phenomena, Genetics and Genomics, Nucleic Acids, Nucleotides, and Nucleosides

Relation: Link to Article in PubMed; Nucleic Acids Res. 2019 May 7; 47(8): 4169–4180. Published online 2019 Mar 20. doi:10.1093/nar/gkz184. Link to article on publisher's site; 0305-1048 (Linking); http://hdl.handle.net/20.500.14038/41012; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4822&context=oapubs&unstamped=1; https://escholarship.umassmed.edu/oapubs/3808; oapubs/3808

الاتاحة: https://doi.org/10.1093/nar/gkz184
https://hdl.handle.net/20.500.14038/41012
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4822&context=oapubs&unstamped=1
https://escholarship.umassmed.edu/oapubs/3808

المؤلفون: Liu, Pengpeng, Ponnienselvan, Karthikeyan, Nyalile, Thomas, Oikemus, Sarah, Joynt, Anya T, Iyer, Sukanya, Kelly, Karen, Guo, Dongsheng, Kyawe, Pyae P, Vanderleeden, Emma, Redick, Sambra D, Huang, Lei, Chen, Zexiang, Lee, Jeong Min, Schiffer, Celia A, Harlan, David M, Wang, Jennifer P, Emerson, Charles P. Jr., Lawson, Nathan D, Watts, Jonathan K, Sontheimer, Erik J, Luban, Jeremy, Wolfe, Scot A

المساهمون: Biochemistry and Molecular Biotechnology, Medicine, Molecular, Cell and Cancer Biology, Neurology, Program in Molecular Medicine, RNA Therapeutics Institute, Wellstone Center for FSHD

المصدر: Nature biotechnology ; United States

Relation: Nature biotechnology; https://doi.org/10.1038/s41587-024-02405-x; http://hdl.handle.net/20.500.14038/53920

الاتاحة: https://doi.org/10.1038/s41587-024-02405-x
https://hdl.handle.net/20.500.14038/53920

المؤلفون: Liang, Shun-Qing, Zheng, Chunwei, Mintzer, Esther, Zhao, Yan G., Ponnienselvan, Karthikeyan, Mir, Aamir, Sontheimer, Erik J., Gao, Guangping, Flotte, Terence R., Wolfe, Scot A., Xue, Wen

المساهمون: Graduate School of Biomedical Sciences, Li Weibo Institute for Rare Diseases Research, Program in Molecular Medicine, Department of Microbiology and Physiological Systems, Department of Pediatrics, Horae Gene Therapy Center, RNA Therapeutics Institute, Department of Molecular, Cell and Cancer Biology

المصدر: bioRxiv

مصطلحات موضوعية: Bioengineering, Prime editors, genome editing, Cancer Biology, Disease Modeling, Genetics and Genomics, Molecular Biology, Molecular, Cellular, and Tissue Engineering, Nucleic Acids, Nucleotides, and Nucleosides

Relation: Now published in Nature Communications doi:10.1038/s41467-021-22295-w; bioRxiv 2020.12.15.422970; doi: https://doi.org/10.1101/2020.12.15.422970. Link to preprint on bioRxiv.; http://hdl.handle.net/20.500.14038/29657; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2891&context=faculty_pubs&unstamped=1; https://escholarship.umassmed.edu/faculty_pubs/1872; faculty_pubs/1872

الاتاحة: https://doi.org/10.1101/2020.12.15.422970
https://hdl.handle.net/20.500.14038/29657
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2891&context=faculty_pubs&unstamped=1
https://escholarship.umassmed.edu/faculty_pubs/1872

المؤلفون: Liang, Shun-Qing, Liu, Pengpeng, Ponnienselvan, Karthikeyan, Suresh, Sneha, Chen, Zexiang, Kramme, Christian, Chatterjee, Pranam, Zhu, Lihua Julie, Sontheimer, Erik J., Xue, Wen, Wolfe, Scot A.

المساهمون: Foundation for the National Institutes of Health, National Institutes of Health

المصدر: Nature Methods ; volume 20, issue 6, page 898-907 ; ISSN 1548-7091 1548-7105

الاتاحة: http://dx.doi.org/10.1038/s41592-023-01859-2
https://www.nature.com/articles/s41592-023-01859-2.pdf
https://www.nature.com/articles/s41592-023-01859-2

المؤلفون: Ponnienselvan, Karthikeyan

المساهمون: Scot Wolfe, Molecular, Cell and Cancer Biology

مصطلحات موضوعية: Prime editor, pegRNA, auto-inhibition, dNTP concentration, PEmax

Relation: http://hdl.handle.net/20.500.14038/52801; orcid:0000-0002-8016-9433

الاتاحة: https://doi.org/10.13028/mn4v-0r72
https://hdl.handle.net/20.500.14038/52801

المؤلفون: Lim, Kah Suan, Li, Heng, Roberts, Emma A., Gaudiano, Emily F., Clairmont, Connor, Sambel, Larissa Alina, Ponnienselvan, Karthikeyan, Liu, Jessica C., Yang, Chunyu, Kozono, David, Parmar, Kalindi, Yusufzai, Timur, Zheng, Ning, D’Andrea, Alan D.

المساهمون: Stand Up To Cancer, Ovarian Cancer Research Fund Alliance, National Ovarian Cancer Coalition, American Association for Cancer Research, NIH, US Department of Defense, Breast Cancer Research Foundation, Fanconi Anemia Research Fund, A∗STAR

المصدر: Molecular Cell ; volume 72, issue 6, page 925-941.e4 ; ISSN 1097-2765

الاتاحة: http://dx.doi.org/10.1016/j.molcel.2018.10.045
https://api.elsevier.com/content/article/PII:S1097276518309390?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1097276518309390?httpAccept=text/plain

المؤلفون: Ponnienselvan, Karthikeyan, Liu, Pengpeng, Nyalile, Thomas, Oikemus, Sarah, Joynt, Anya T, Kelly, Karen, Guo, Dongsheng, Chen, Zexiang, Lee, Jeong Min, Schiffer, Celia A, Emerson, Charles P. Jr., Lawson, Nathan D, Watts, Jonathan K, Sontheimer, Erik J, Luban, Jeremy, Wolfe, Scot A

المساهمون: Biochemistry and Molecular Biotechnology, Li Weibo Institute for Rare Diseases Research, Molecular, Cell and Cancer Biology, Morningside Graduate School of Biomedical Sciences, Program in Molecular Medicine, RNA Therapeutics Institute, Wellstone Center for FSHD, Schiffer Lab, Thomas Nyalile

المصدر: bioRxiv : the preprint server for biology ; United States

مصطلحات موضوعية: Biochemistry, prime editing efficiency, mutations

Relation: bioRxiv; https://doi.org/10.1101/2023.10.21.563443; Ponnienselvan K, Liu P, Nyalile T, Oikemus S, Joynt AT, Kelly K, Guo D, Chen Z, Lee JM, Schiffer CA, Emerson CP, Lawson ND, Watts JK, Sontheimer EJ, Luban J, Wolfe SA. Addressing the dNTP bottleneck restricting prime editing activity. bioRxiv [Preprint]. 2023 Oct 29:2023.10.21.563443. doi:10.1101/2023.10.21.563443. PMID: 37904991; PMCID: PMC10614944.; http://hdl.handle.net/20.500.14038/52857; bioRxiv : the preprint server for biology

الاتاحة: https://doi.org/10.1101/2023.10.21.563443
https://hdl.handle.net/20.500.14038/52857

المؤلفون: Luk, Kevin, Liu, Pengpeng, Zeng, Jing, Wang, Yetao, Maitland, Stacy A., Idrizi, Feston, Ponnienselvan, Karthikeyan, Zhu, Lihua Julie, Luban, Jeremy, Bauer, Daniel E., Wolfe, Scot A.

المصدر: GEN Biotechnology ; volume 1, issue 3, page 271-284 ; ISSN 2768-1572 2768-1556

الاتاحة: http://dx.doi.org/10.1089/genbio.2022.0003
https://www.liebertpub.com/doi/full-xml/10.1089/genbio.2022.0003
https://www.liebertpub.com/doi/pdf/10.1089/genbio.2022.0003

المؤلفون: Clairmont, Connor S., Sarangi, Prabha, Ponnienselvan, Karthikeyan, Galli, Lucas D., Csete, Isabelle, Moreau, Lisa, Adelmant, Guillaume, Chowdhury, Dipanjan, Marto, Jarrod A., D’Andrea, Alan D.

المصدر: Nature Cell Biology ; volume 22, issue 1, page 87-96 ; ISSN 1465-7392 1476-4679

الاتاحة: http://dx.doi.org/10.1038/s41556-019-0442-y
http://www.nature.com/articles/s41556-019-0442-y.pdf
http://www.nature.com/articles/s41556-019-0442-y

المؤلفون: Liu, Pengpeng, Liang, Shun-Qing, Zheng, Chunwei, Mintzer, Esther, Zhao, Yan G., Ponnienselvan, Karthikeyan, Mir, Aamir, Sontheimer, Erik J., Gao, Guangping, Flotte, Terence R., Wolfe, Scot A., Xue, Wen

المصدر: Nature Communications; 4/9/2021, Vol. 12 Issue 1, p1-13, 13p

مصطلحات موضوعية: DOUBLE-strand DNA breaks, GENOME editing, RNA editing, CANCER patients, ADENO-associated virus, ALLELES

المؤلفون: Liu, Pengpeng, Luk, Kevin, Shin, Masahiro, Idrizi, Feston, Kwok, Samantha, Roscoe, Benjamin, Mintzer, Esther, Suresh, Sneha, Morrison, Kyle, Frazão, Josias B, Bolukbasi, Mehmet Fatih, Ponnienselvan, Karthikeyan, Luban, Jeremy, Zhu, Lihua Julie, Lawson, Nathan D, Wolfe, Scot A

المصدر: Nucleic Acids Research; 5/7/2019, Vol. 47 Issue 8, p4169-4180, 12p