نتائج البحث - "Poly(ADP-ribose) glycohydrolase"

1

Academic Journal

Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors

المؤلفون: Brosey, Chris A, Houl, Jerry H, Katsonis, Panagiotis, Balapiti-Modarage, Lakshitha PF, Bommagani, Shobanbabu, Arvai, Andy, Moiani, Davide, Bacolla, Albino, Link, Todd, Warden, Leslie S, Lichtarge, Olivier, Jones, Darin E, Ahmed, Zamal, Tainer, John A

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Emerging Infectious Diseases, Infectious Diseases, Biodefense, Coronaviruses, 5.1 Pharmaceuticals, Infection, Generic health relevance, Good Health and Well Being, Amino Acid Sequence, Antiviral Agents, Catalytic Domain, Coronavirus Papain-Like Proteases, Crystallography, X-Ray, Drug Discovery, Enzyme Inhibitors, Glycoside Hydrolases, Humans, Models, Molecular, Protein Domains, SARS-CoV-2, Small Molecule Libraries, Structure-Activity Relationship, Xanthines, COVID-19 Drug Treatment, SARS-CoV-2 Nsp3 macrodomain, Poly(ADP-Ribose) glycohydrolase, PARG inhibitor, Evolutionary trace, In silico screening, Drug discovery, Biophysics, Biochemistry and cell biology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/97w9b43x
https://escholarship.org/content/qt97w9b43x/qt97w9b43x.pdf

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2

Academic Journal

Intrinsic PARG inhibitor sensitivity is mimicked by TIMELESS haploinsufficiency and rescued by nucleoside supplementation

المؤلفون: Coulson-Gilmer, Camilla, Littler, Samantha, Barnes, Bethany, Brady, Rosie, Anagho, Holda A, Pillay, Nisha, Dey, Malini, Macmorland, William, Bronder, Daniel, Nelson, Louisa, Tighe, Anthony, Lin, Wei-Hsiang, Morgan, Robert, Unwin, Richard, Nielsen, Michael L, Mcgrail, Joanne, Taylor, Stephen

المصدر: Coulson-Gilmer , C , Littler , S , Barnes , B , Brady , R , Anagho , H A , Pillay , N , Dey , M , Macmorland , W , Bronder , D , Nelson , L , Tighe , A , Lin , W-H , Morgan , R , Unwin , R , Nielsen , M L , Mcgrail , J & Taylor , S 2024 , ' Intrinsic PARG inhibitor sensitivity is mimicked by TIMELESS haploinsufficiency and rescued by nucleoside supplementation ' , NAR cancer , vol. 6 , no. 3 , zcae030 . ....

مصطلحات موضوعية: High-grade serous ovarian cancer, DNA replication, Replication stress, ADP-ribosylation, poly(ADP-ribose) glycohydrolase

Relation: https://research.manchester.ac.uk/en/publications/2a1959a3-2026-4a30-af7a-3a677bf7e24a

الاتاحة: https://research.manchester.ac.uk/en/publications/2a1959a3-2026-4a30-af7a-3a677bf7e24a
https://doi.org/10.1093/narcan/zcae030

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3

Academic Journal

PARG suppresses tumorigenesis and downregulates genes controlling angiogenesis, inflammatory response, and immune cell recruitment

المؤلفون: Sarah Johnson, Yaroslava Karpova, Danping Guo, Atreyi Ghatak, Dmitriy A. Markov, Alexei V. Tulin

المصدر: BMC Cancer, Vol 22, Iss 1, Pp 1-17 (2022)

مصطلحات موضوعية: PARP, PARG, Poly(ADP-ribose) glycohydrolase, Poly(ADP-ribose) polymerase, Poly(ADP-ribose), chemokines, Tumorigenesis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1471-2407

URL الوصول: https://doaj.org/article/556c762c69cf449d9c1284bce015a7fb

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4

Academic Journal

Genomic and biological aspects of resistance to selective poly(ADP‐ribose) glycohydrolase inhibitor PDD00017273 in human colorectal cancer cells

المؤلفون: Kaede Tsuda, Chinatsu Kurasaka, Yoko Ogino, Akira Sato

المصدر: Cancer Reports, Vol 6, Iss 2, Pp n/a-n/a (2023)

مصطلحات موضوعية: drug resistance, exome sequencing, PARG inhibitor, PDD00017273, poly(ADP‐ribose) glycohydrolase, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2573-8348

URL الوصول: https://doaj.org/article/e84445096a35457abc37c84e8e9eeab3

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5

Academic Journal

PARPs and ADP-Ribosylation in Chronic Inflammation: A Focus on Macrophages

المؤلفون: Diego V. Santinelli-Pestana, Elena Aikawa, Sasha A. Singh, Masanori Aikawa

المصدر: Pathogens; Volume 12; Issue 7; Pages: 964

مصطلحات موضوعية: immunity, mass spectrometry, proteomics, ADP-ribosylation, poly(ADP-ribose) glycohydrolase, Diphtheria toxin-like ADP-ribosyltransferases, chronic infection, arboviruses, cardiovascular disease, emphysema, alcoholic liver disease, SARS-CoV-2, host–pathogen interactions

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/pathogens12070964

الاتاحة: https://doi.org/10.3390/pathogens12070964

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6

Academic Journal

Analysis of Genome Structure and Its Variations in Potato Cultivars Grown in Russia

المؤلفون: Dmitry I. Karetnikov, Gennady V. Vasiliev, Stepan V. Toshchakov, Nikolay A. Shmakov, Mikhail A. Genaev, Mikhail A. Nesterov, Salmaz M. Ibragimova, Daniil A. Rybakov, Tatjana A. Gavrilenko, Elena A. Salina, Maxim V. Patrushev, Alex V. Kochetov, Dmitry A. Afonnikov

المصدر: International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5713

مصطلحات موضوعية: potato, Solanum tuberosum L., breeding cultivars, genome structural variation, copy number variation, potato diversification, genome annotation, NBS-LRR genes, photoperiod control, phytochrome A, poly(ADP-ribose) glycohydrolase

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Informatics; https://dx.doi.org/10.3390/ijms24065713

الاتاحة: https://doi.org/10.3390/ijms24065713

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7

Academic Journal

Disrupting Poly(ADP-ribosyl)ating Pathway Creates Premalignant Conditions in Mammalian Liver

المؤلفون: Yaroslava Karpova, David J. Orlicky, Edward E. Schmidt, Alexei V. Tulin

المصدر: International Journal of Molecular Sciences, Vol 24, Iss 24, p 17205 (2023)

مصطلحات موضوعية: PARP1, PARG, poly(ADP-ribose) polymerase, poly(ADP-ribose) glycohydrolase, hepatocyte maturation, hepatocellular carcinoma, Biology (General), QH301-705.5, Chemistry, QD1-999

Relation: https://www.mdpi.com/1422-0067/24/24/17205; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/c0cf1cc541cc4787bd1b3886b82905fd

الاتاحة: https://doi.org/10.3390/ijms242417205
https://doaj.org/article/c0cf1cc541cc4787bd1b3886b82905fd

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8

Academic Journal

Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib.

المؤلفون: Gravells, Polly¹, Neale, James¹, Grant, Emma¹, Nathubhai, Amit², Smith, Kate M.³, James, Dominic I.³, Bryant, Helen E.¹ h.bryant@sheffield.ac.uk

المصدر: DNA Repair. Jan2018, Vol. 61, p25-36. 12p.

مصطلحات موضوعية: *POLY(ADP-ribose) glycohydrolase, *RADIATION-sensitizing agents, *IONIZING radiation, *GENETIC recombination, *DNA damage, *OLAPARIB

9

News

Ovarian cancer: Sequencing strategy identifies biomarker that could guide treatment.

المؤلفون: Splete, Heidi

المصدر: Family Practice News; Jun2023, p1-4, 4p

مصطلحات موضوعية: OVARIAN cancer, DNA sequencing, OVARIAN cancer patients, POLY(ADP-ribose) glycohydrolase, POLYMERASE genetics, SINGLE nucleotide polymorphisms

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10

Academic Journal

Inhibition of Poly ADP-Ribose Glycohydrolase Sensitizes Ovarian Cancer Cells to Poly ADP-Ribose Polymerase Inhibitors and Platinum Agents

المؤلفون: Emad Matanes, Vanessa M. López-Ozuna, David Octeau, Tahira Baloch, Florentin Racovitan, Amandeep Kaur Dhillon, Roy Kessous, Oded Raban, Liron Kogan, Shannon Salvador, Susie Lau, Walter H. Gotlieb, Amber Yasmeen

المصدر: Frontiers in Oncology, Vol 11 (2021)

مصطلحات موضوعية: ovarian cancer, targeted therapies, homologous recombination, poly (ADP-ribose) glycohydrolase (PARG), poly (ADP-ribose) polymerase (PARP) inhibitors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.745981/full; https://doaj.org/toc/2234-943X

URL الوصول: https://doaj.org/article/0d9e891b94894a599e68b3cae7e6c7f2

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11

Academic Journal

MLN4924 suppresses the BRCA1 complex and synergizes with PARP inhibition in NSCLC cells.

المؤلفون: Guo, Zong-Pei¹, Hu, Ying-Chun¹, Xie, Yu², Jin, Feng³, Song, Zhi-Quan¹, Liu, Xiao-Dan¹, Ma, Teng¹ mateng82913@163.com, Zhou, Ping-Kun^1,2 zhoupk@bmi.ac.cn

المصدر: Biochemical & Biophysical Research Communications. Jan2017, Vol. 483 Issue 1, p223-229. 7p.

مصطلحات موضوعية: *POLY(ADP-ribose) glycohydrolase, *BRCA genes, *ENZYME inhibitors, *NON-small-cell lung carcinoma, *CANCER cells

12

Academic Journal

Novel N-Substituted 2-(2-(Adamantan-1-yl)-1H-Indol-3-yl)-2-Oxoacetamide Derivatives: Synthesis and Biological Evaluation.

المؤلفون: Hong-Yu Hu¹ huhongyu22@126.com, Xu-Dong Yu¹ yuxudong91@163.com, Fei Wang¹ tjdxwangfei@163.com, Chun-Rong Lin¹ reyiai@163.com, Jin-Zhang Zeng¹ jzzeng@xmu.edu.cn, Ying-Kun Qiu¹ qyk@xmu.edu.cn, Mei-Juan Fang¹ fangmj@xmu.edu.cn, Zhen Wu¹ wuzhen@xmu.edu.cn

المصدر: Molecules. May2016, Vol. 21 Issue 5, p530. 15p. 3 Diagrams, 2 Graphs.

مصطلحات موضوعية: *CHEMICAL derivatives, *POLY(ADP-ribose) glycohydrolase, *POLYMERASES, *CASPASES, *CHEMICAL synthesis

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13

Academic Journal

Unravelling Differences in Candidate Genes for Drought Tolerance in Potato (Solanum tuberosum L.) by Use of New Functional Microsatellite Markers

المؤلفون: Schumacher, Christina, Krannich, Christoph Tim, Maletzki, Lisa, Köhl, Karin, Kopka, Joachim, Sprenger, Heike, Hincha, Dirk Karl, Seddig, Sylvia, Peters, Rolf, Hamera, Sadia, Zuther, Ellen, Haas, Manuela, Horn, Renate

مصطلحات موضوعية: Text, article, ddc:630, potato -- Solanum tuberosum -- drought tolerance -- microsatellite -- candidate gene -- aldehyde dehydrogenase -- protein phosphatase 2C -- 1-aminocyclopropane-1-carboxylate synthase -- ethylene responsive transcription factor -- poly(ADP-ribose) glycohydrolase

Relation: Genes -- 2073-4425 -- 2527218-4 -- http://www.mdpi.com/journal/genes -- https://www.ncbi.nlm.nih.gov/pmc/journals/2104/ -- http://www.bibliothek.uni-regensburg.de/ezeit/?2527218; https://doi.org/10.3390/genes12040494; https://www.openagrar.de/receive/openagrar_mods_00067920; https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00036512/2021_0060.pdf

الاتاحة: https://doi.org/10.3390/genes12040494
https://www.openagrar.de/receive/openagrar_mods_00067920
https://www.openagrar.de/servlets/MCRFileNodeServlet/openagrar_derivate_00036512/2021_0060.pdf

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14

Academic Journal

ADP-Ribosylation as Post-Translational Modification of Proteins: Use of Inhibitors in Cancer Control

المؤلفون: Palmiro Poltronieri, Masanao Miwa, Mitsuko Masutani

المصدر: International Journal of Molecular Sciences; Volume 22; Issue 19; Pages: 10829

مصطلحات موضوعية: ADP-ribosyl transferase (ART), poly ADP-ribose polymerase (PARP), ADP-ribose (ADPR), sirtuin (SIRT), poly ADP-ribose glycohydrolase (PARG), ADP-ribose hydrolase (ARH), macro-domain (MACRO)

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Biophysics; https://dx.doi.org/10.3390/ijms221910829

الاتاحة: https://doi.org/10.3390/ijms221910829

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15

Academic Journal

Down-regulation of poly (ADP-ribose) polymerase 1 leads to change of hydroquinone cytotoxicity in TK6 cells.

المؤلفون: Sha, Yan¹ (AUTHOR) sandyee123@126.com, Zhou, Wei² (AUTHOR), Yang, Zhenyu² (AUTHOR), Zhu, Xiaoling² (AUTHOR), Yang, Xinyue¹ (AUTHOR), Li, Tian-di³ (AUTHOR), Zhu, Dexiang⁴ (AUTHOR)