المؤلفون: Loesche, Christian, Picard, Damien, Van Hoorick, Benjamin, Schuhmann, Imelda, Jäger, Petra, Klein, Kai, Schuhler, Carole, Thoma, Gebhard, Markert, Christian, Poller, Birk, Zamurovic, Natasa, Weiss, H. Markus, Otto, Heike, Fink, Martin, Röhn, Till A.

المصدر: Clinical and Translational Science ; volume 17, issue 2 ; ISSN 1752-8054 1752-8062

الاتاحة: http://dx.doi.org/10.1111/cts.13724
https://ascpt.onlinelibrary.wiley.com/doi/pdf/10.1111/cts.13724

المؤلفون: Kastrinou-Lampou, Vlasia, Rodríguez-Pérez, Raquel, Poller, Birk, Huth, Felix, Schadt, Heiko S, Kullak-Ublick, Gerd A, Arand, Michael, Camenisch, Gian

المصدر: Kastrinou-Lampou, Vlasia; Rodríguez-Pérez, Raquel; Poller, Birk; Huth, Felix; Schadt, Heiko S; Kullak-Ublick, Gerd A; Arand, Michael; Camenisch, Gian (2025). Drug-induced cholestasis (DIC) predictions based on in vitro inhibition of major bile acid clearance mechanisms. Archives of Toxicology, 99(1):377-391.

مصطلحات موضوعية: Institute of Pharmacology and Toxicology, Clinic for Clinical Pharmacology and Toxicology, 570 Life sciences, biology, 610 Medicine & health

Time: 142-005

وصف الملف: application/pdf

Relation: https://www.zora.uzh.ch/id/eprint/265399/1/Drug_induced_cholestasis.pdf; info:pmid/39542928; urn:issn:0340-5761

الاتاحة: https://www.zora.uzh.ch/id/eprint/265399/
https://www.zora.uzh.ch/id/eprint/265399/1/Drug_induced_cholestasis.pdf

المؤلفون: Keuper-Navis, Marit, Eslami Amirabadi, Hossein, Donkers, Joanne, Walles, Markus, Poller, Birk, Heming, Bo, Pieters, Lisanne, de Wagenaar, Bjorn, Myszczyszyn, Adam, Sinnige, Theo, Spee, Bart, Masereeuw, Rosalinde, van de Steeg, Evita

المصدر: Micromachines; Dec2024, Vol. 15 Issue 12, p1464, 18p

مصطلحات موضوعية: INTESTINAL barrier function, LAMINAR flow, INTESTINAL absorption, PERMEABILITY, MONOMOLECULAR films

المؤلفون: Keuper-Navis, Marit, Walles, Markus, Poller, Birk, Myszczyszyn, Adam, van der Made, Thomas K, Donkers, Joanne, Amirabadi, Hossein Eslami, Wilmer, Martijn J, Aan, Saskia, Spee, Bart, Masereeuw, Rosalinde, van de Steeg, Evita

المساهمون: Afd Pharmacology, Interne geneeskunde GD, CS_STEM, Pharmacology

مصطلحات موضوعية: Organ-on-chip, Drug development, Pharmacokinetics, ADME

وصف الملف: application/pdf

Relation: https://dspace.library.uu.nl/handle/1874/430857

الاتاحة: https://dspace.library.uu.nl/handle/1874/430857

المؤلفون: Kastrinou-Lampou, Vlasia, Rodríguez-Pérez, Raquel, Poller, Birk, Huth, Felix, Gáborik, Zsuzsanna, Mártonné-Tóth, Beáta, Temesszentandrási-Ambrus, Csilla, Schadt, Heiko S., Kullak-Ublick, Gerd A., Arand, Michael, Camenisch, Gian

المصدر: Archives of Toxicology; Oct2024, Vol. 98 Issue 10, p3409-3424, 16p

مصطلحات موضوعية: BILE acids, CYTOCHROME P-450, CYTOCHROME P-450 CYP3A, DRUG side effects, CHOLESTASIS

المؤلفون: Trunzer, Markus, Teigao, Joana, Huth, Felix, Poller, Birk, Rodriguez Perez, Raquel, Desrayaud, Sandrine, Faller, Bernard

Relation: Trunzer, Markus, Teigao, Joana, Huth, Felix, Poller, Birk, Rodriguez Perez, Raquel, Desrayaud, Sandrine and Faller, Bernard (2024) Improving In Vitro-In Vivo Extrapolation of Clearance Using Rat Liver Microsomes for Highly Plasma Protein-Bound Molecules. Drug metabolism and disposition: the biological fate of chemicals, 52 (5). pp. 345-354. ISSN 1521-009X

الاتاحة: https://oak.novartis.com/52137/
https://dmd.aspetjournals.org/content/52/5/345
https://doi.org/10.1124/dmd.123.001597

المؤلفون: Poller, Birk, Walles, Markus

Relation: Poller, Birk and Walles, Markus (2024) Intestinal Cells-on-Chip for Permeability Studies. Intestinal Cells-on-Chip for Permeability Studies, 15 (12). pp. 1464-1469.; https://www.mdpi.com/2072-666X/15/12/1464

الاتاحة: https://oak.novartis.com/55627/
https://doi.org/10.3390/mi15121464
https://www.mdpi.com/2072-666X/15/12/1464

المؤلفون: Huth, Felix, Schiller, Hilmar, Jin, Yi, Poller, Birk, Schuhler, Carole, Weis, Wendy, Woessner, Ralph, Drollmann, Anton, End, Peter

المصدر: Clinical and Translational Science ; volume 15, issue 1, page 118-129 ; ISSN 1752-8054 1752-8062

الاتاحة: http://dx.doi.org/10.1111/cts.13126
https://onlinelibrary.wiley.com/doi/pdf/10.1111/cts.13126
https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cts.13126
https://ascpt.onlinelibrary.wiley.com/doi/pdf/10.1111/cts.13126

المؤلفون: Afd Pharmacology, Interne geneeskunde GD, CS_STEAM, Pharmacology, STEAM, Keuper-Navis, Marit, Walles, Markus, Poller, Birk, Myszczyszyn, Adam, van der Made, Thomas K, Donkers, Joanne, Amirabadi, Hossein Eslami, Wilmer, Martijn J, Aan, Saskia, Spee, Bart, Masereeuw, Rosalinde, van de Steeg, Evita

URL: https://doi.org/10.1016/j.phrs.2023.106853
http://hdl.handle.net/1874/430857
http://www.scopus.com/inward/record.url?scp=85169597892&partnerID=8YFLogxK
1043-6618
Pharmacological Research
195
106853

المؤلفون: Kastrinou Lampou, Vlasia, Poller, Birk, Huth, Felix, Fischer, Audrey, Kullak-Ublick, Gerd A, Arand, Michael, Schadt, Heiko S, Camenisch, Gian

المصدر: Kastrinou Lampou, Vlasia; Poller, Birk; Huth, Felix; Fischer, Audrey; Kullak-Ublick, Gerd A; Arand, Michael; Schadt, Heiko S; Camenisch, Gian (2023). Novel insights into bile acid detoxification via CYP, UGT and SULT enzymes. Toxicology in Vitro, 87:105533.

مصطلحات موضوعية: Institute of Pharmacology and Toxicology, Clinic for Clinical Pharmacology and Toxicology, 610 Medicine & health, Toxicology, General Medicine

وصف الملف: application/pdf

Relation: https://www.zora.uzh.ch/id/eprint/231847/1/1_s2.0_S0887233322002314_main.pdf; info:pmid/36473578; urn:issn:0887-2333

الاتاحة: https://www.zora.uzh.ch/id/eprint/231847/
https://www.zora.uzh.ch/id/eprint/231847/1/1_s2.0_S0887233322002314_main.pdf
https://doi.org/10.1016/j.tiv.2022.105533

المؤلفون: James, Alexander David, Kulmatycki, Ken, Poller, Birk, Romeo, Andrea, Van Lier, Jan Jaap, Klein, Kai, Pearson, David

Relation: James, Alexander David, Kulmatycki, Ken, Poller, Birk, Romeo, Andrea, Van Lier, Jan Jaap, Klein, Kai and Pearson, David (2023) Absorption, Distribution, Metabolism, and Excretion of [14C]iptacopan in Healthy Male Volunteers and in In Vivo and In Vitro Studies. Drug metabolism and disposition: the biological fate of chemicals, 51 (7). pp. 873-883. ISSN 1521-009X

الاتاحة: https://oak.novartis.com/49443/
https://dmd.aspetjournals.org/content/51/7/873
https://doi.org/10.1124/dmd.123.001290

المؤلفون: Patel, Mitesh, Riede, Julia, Bednarczyk, Dallas, Poller, Birk, Deshmukh, Sujal

Relation: Patel, Mitesh, Riede, Julia, Bednarczyk, Dallas, Poller, Birk and Deshmukh, Sujal (2023) Simplifying the Extended Clearance Concept Classification System (EC3S) to Guide Clearance Prediction in Drug Discovery. Pharmaceutical research. ISSN 1573-904X

الاتاحة: https://oak.novartis.com/48170/
https://link.springer.com/article/10.1007/s11095-023-03482-4
https://doi.org/10.1007/s11095-023-03482-4

المؤلفون: Poller, Birk, Werner, Sophie, Domange, Norbert, Bednarczyk, Dallas, Mettler, Lina, Stein, Richard, Loretan, Jacqueline, Wartmann, Markus, Faller, Bernard, Huth, Felix

Relation: Poller, Birk, Werner, Sophie, Domange, Norbert, Bednarczyk, Dallas, Mettler, Lina, Stein, Richard, Loretan, Jacqueline, Wartmann, Markus, Faller, Bernard and Huth, Felix (2022) Time matters – In vitro cellular disposition kinetics help identifying disconnects in cell-based potency assays. Xenobiotica, 52 (8). pp. 878-889. ISSN https://doi.org/10.1080/00498254.2022.2130837

الاتاحة: https://oak.novartis.com/47952/
https://www.tandfonline.com/doi/full/10.1080/00498254.2022.2130837

المؤلفون: Kulkarni, Swarupa, Poller, Birk, Drollmann, Anton, Shah, Bharti, Gray, Cathy, Greco, Erin, Rahmanzadeh, Gholamreza, Hanna, Imad, Weiss, H Markus

المصدر: Pulmonary Pharmacology & Therapeutics ; volume 72, page 102097 ; ISSN 1094-5539

الاتاحة: http://dx.doi.org/10.1016/j.pupt.2021.102097
https://api.elsevier.com/content/article/PII:S1094553921001097?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1094553921001097?httpAccept=text/plain

المؤلفون: Birk Poller, Felix Huth, Gáborik Zsuzsanna, Hanna Imad, Huth Felix, Imad Hanna, Imola Juhász, Juhász Imola, Patrick Schweigler, Poller Birk, Péter Tátrai, Sakata Takeshi, Schweigler Patrick, Takeshi Sakata, Tátrai Péter, Zsuzsanna Gáborik

المصدر: Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2019, :1-112

المؤلفون: Poller, Birk, Huth, Felix, Kastrinou‐Lampou, Vlasia, Kullak‐Ublick, Gerd A, Arand, Michael, Camenisch, Gian

المساهمون: Li, Albert P, Li, A P ( Albert P )

المصدر: Poller, Birk; Huth, Felix; Kastrinou‐Lampou, Vlasia; Kullak‐Ublick, Gerd A; Arand, Michael; Camenisch, Gian (2021). The Extended Clearance Model. In: Li, Albert P. Transporters and Drug-Metabolizing Enzymes in Drug Toxicity. Hoboken, New Jersey: John Wiley & Sons, 455-479.

مصطلحات موضوعية: Institute of Pharmacology and Toxicology, Clinic for Clinical Pharmacology and Toxicology, 570 Life sciences, biology, 610 Medicine & health

Relation: https://www.zora.uzh.ch/223030; urn:isbn:978-1-119-17084-6

الاتاحة: https://www.zora.uzh.ch/id/eprint/223030/
https://www.zora.uzh.ch/223030
https://doi.org/10.1002/9781119171003.ch15

المؤلفون: Huth, Felix, Domange, Norbert, Poller, Birk, Vapurcuyan, Natasha, Durrwell, Alexandre, Hanna, Imad, Faller, Bernard

Relation: Huth, Felix, Domange, Norbert, Poller, Birk, Vapurcuyan, Natasha, Durrwell, Alexandre, Hanna, Imad and Faller, Bernard (2021) Predicting Oral Absorption for Compounds Outside the Rule of Five Property Space. Journal of pharmaceutical sciences, 110 (6). pp. 2562-2569. ISSN 00223549

الاتاحة: https://oak.novartis.com/43819/
https://www.sciencedirect.com/science/article/pii/S002235492100071X?via%3Dihub
https://doi.org/10.1016/j.xphs.2021.01.029

المؤلفون: Weiss, Markus, Cain, Meredith, Langenickel, Thomas, Kulkarni, Swarupa, Shah, Bharti, Rahmanzadeh, Gholamreza, Poller, Birk, Vemula, Janardhana Rao

Relation: Weiss, Markus, Cain, Meredith, Langenickel, Thomas, Kulkarni, Swarupa, Shah, Bharti, Rahmanzadeh, Gholamreza, Poller, Birk and Vemula, Janardhana Rao (2021) Clinical investigation of metabolic and renal clearance pathways contributing to the elimination of fevipiprant using probenecid as perpetrator. Drug metabolism and disposition, 49 (5). pp. 389-394. ISSN 1521-009X

الاتاحة: https://oak.novartis.com/43600/
https://doi.org/10.1124/dmd.120.000273

المؤلفون: Li, Albert P, Li, A P ( Albert P ), Poller, Birk, Huth, Felix, Kastrinou‐Lampou, Vlasia, Kullak‐Ublick, Gerd A, Arand, Michael, Camenisch, Gian

المصدر: Poller, Birk; Huth, Felix; Kastrinou‐Lampou, Vlasia; Kullak‐Ublick, Gerd A; Arand, Michael; Camenisch, Gian (2021). The Extended Clearance Model. In: Li, Albert P. Transporters and Drug-Metabolizing Enzymes in Drug Toxicity. Hoboken, New Jersey: John Wiley & Sons, 455-479.

مصطلحات الفهرس: Institute of Pharmacology and Toxicology, Clinic for Clinical Pharmacology and Toxicology, 570 Life sciences; biology, 610 Medicine & health, Book Section, PeerReviewed, info:eu-repo/semantics/bookPart

URL: https://www.zora.uzh.ch/223030
https://www.zora.uzh.ch/id/eprint/223030/
https://www.zora.uzh.ch/id/eprint/223030
Online ISBN:9781119171003
10.1002/9781119171003.ch15

المؤلفون: Poller, Birk, Gutmann, Heike, Krähenbühl, Stephan, Weksler, Babette, Romero, Ignacio, Couraud, Pierre‐Olivier, Tuffin, Gerald, Drewe, Jürgen, Huwyler, Jörg

المصدر: Journal of Neurochemistry ; volume 107, issue 5, page 1358-1368 ; ISSN 0022-3042 1471-4159

الاتاحة: http://dx.doi.org/10.1111/j.1471-4159.2008.05730.x
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1471-4159.2008.05730.x
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-4159.2008.05730.x