المؤلفون: Paukner, Susanne, Moran, Gregory J, Sandrock, Christian, File, Thomas M, Vidal, Jorge E, Waites, Ken B, Gelone, Steven P, Yu, Kalvin

المصدر: Future Microbiology. 17(6)

مصطلحات موضوعية: Microbiology, Biological Sciences, Emerging Infectious Diseases, Pneumonia & Influenza, Lung, Pneumonia, Antimicrobial Resistance, Infectious Diseases, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Infection, Anti-Bacterial Agents, Bacteria, Community-Acquired Infections, Diterpenes, Hospitals, Humans, Language, Pneumonia, Bacterial, Polycyclic Compounds, Thioglycolates, Antibiotic, antibiotic resistance, bacterial pneumonia, infection, lay summary, lefamulin, plain language summary, pleuromutilin, pneumonia, Medical Microbiology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/12r90519

المؤلفون: Kerrin Hainsworth, Melissa M. Cadelis, Florent Rouvier, Jean Michel Brunel, Brent R. Copp

المصدر: Antibiotics, Vol 13, Iss 11, p 1018 (2024)

مصطلحات موضوعية: pleuromutilin, potentiation, adjuvant, antimicrobial, antibiotics, antifungal agents, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2079-6382/13/11/1018; https://doaj.org/toc/2079-6382

URL الوصول: https://doaj.org/article/ec6ac71094104f4ea113dede3e50ace4

المؤلفون: File, Thomas M, Alexander, Elizabeth, Goldberg, Lisa, Das, Anita F, Sandrock, Christian, Paukner, Susanne, Moran, Gregory J

المصدر: BMC Pulmonary Medicine. 21(1)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Lung, Clinical Trials and Supportive Activities, Cardiovascular, Prevention, Infectious Diseases, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, Respiratory, Good Health and Well Being, Administration, Intravenous, Administration, Oral, Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Comorbidity, Diterpenes, Double-Blind Method, Female, Fluoroquinolones, Humans, Male, Microbial Sensitivity Tests, Middle Aged, Moxifloxacin, Pneumonia, Bacterial, Polycyclic Compounds, Thioglycolates, United States, Young Adult, Antibiotic, Clinical response, Lefamulin, Pleuromutilin, Pneumonia, Cardiorespiratory Medicine and Haematology, Respiratory System, Cardiovascular medicine and haematology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/45x156cc
https://escholarship.org/content/qt45x156cc/qt45x156cc.pdf

المؤلفون: Wenxiang Wang, Jiao Yu, Xuan Ji, Xirui Xia, Huanzhong Ding

المصدر: Microbiology Spectrum, Vol 12, Iss 2 (2024)

مصطلحات موضوعية: Mycoplasma gallisepticum, pleuromutilin, pharmacokinetics, pharmacodynamics, in vitro dynamic model, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2165-0497

URL الوصول: https://doaj.org/article/6582affc7f344afb82a2dba0483a496f

المؤلفون: Christoffer V. Heidtmann, Andreas R. Fejer, Kristian Stærk, Maria Pedersen, Marco G. Asmussen, Frederik B. Hertz, Bala K. Prabhala, Niels Frimodt-Møller, Janne K. Klitgaard, Thomas E. Andersen, Carsten U. Nielsen, Poul Nielsen

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Pharmacology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Chemical Sciences not elsewhere classified, showed rapid reduction, positive bacterial infections, positive antibacterial activity, plasma protein binding, limited likely due, evaluation included caco, 2 cell permeability, safe antibiotic candidate, triaromatic hit reported, like pleuromutilin conjugate, 16 , clear candidate, vivo <, vitro <, systemically infected, staphylococcus aureus, resistance induction, proved satisfactory, oral bioavailability, optimization campaign

Relation: https://figshare.com/articles/journal_contribution/Hit-to-Lead_Identification_and_Validation_of_a_Triaromatic_Pleuromutilin_Antibiotic_Candidate/25262978

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c02153.s001
https://figshare.com/articles/journal_contribution/Hit-to-Lead_Identification_and_Validation_of_a_Triaromatic_Pleuromutilin_Antibiotic_Candidate/25262978

المؤلفون: Sue, Kenneth, Cadelis, Melissa M, Hainsworth, Kerrin, Rouvier, Florent, Bourguet-Kondracki, Marie-Lise, Brunel, Jean Michel, Copp, Brent R

مصطلحات موضوعية: antibiotic enhancement, antimicrobial, membrane disruption, pleuromutilin, polyamine, 31 Biological Sciences, 32 Biomedical and Clinical Sciences, 3107 Microbiology, 3202 Clinical Sciences, 3211 Oncology and Carcinogenesis, Infectious Diseases, Prevention, Biodefense, Vaccine Related, Antimicrobial Resistance, Emerging Infectious Diseases, Infection, Science & Technology, Life Sciences & Biomedicine, Microbiology, ANTIBIOTICS, DERIVATIVES, 3207 Medical microbiology

جغرافية الموضوع: Switzerland

وصف الملف: Electronic; application/pdf

Relation: Microorganisms; (2023). Microorganisms, 11(11), 2791-.; https://hdl.handle.net/2292/67727; 38004802 (pubmed); microorganisms11112791

الاتاحة: https://hdl.handle.net/2292/67727
https://doi.org/10.3390/microorganisms11112791

المؤلفون: Jiaming Zhang, Qinqin Liu, Haoxia Zhao, Guiyu Li, Yunpeng Yi, Ruofeng Shang

المصدر: International Journal of Molecular Sciences, Vol 25, Iss 4, p 2256 (2024)

مصطلحات موضوعية: pleuromutilin, QSAR, synthesis, antimicrobial activity, molecular docking, Biology (General), QH301-705.5, Chemistry, QD1-999

Relation: https://www.mdpi.com/1422-0067/25/4/2256; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/cb809d773494461b97a27f54b8369716

الاتاحة: https://doi.org/10.3390/ijms25042256
https://doaj.org/article/cb809d773494461b97a27f54b8369716

المؤلفون: Jie Ren, Qi-Wen Zhang, Xian-Jin He, Xiao-Ying Chen, Zi-Dan Zhou, Zhen-Ling Zeng, Zhen Jin, You-Zhi Tang

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

مصطلحات موضوعية: Pleuromutilin, Antibiotic, MRSA, Benzoxazole, molecular docking, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/9d562e0180f543379eaa805f6e92a762

المؤلفون: Qi Wang, Jie Liu, Zi-Dan Zhou, Ke-Xin Zhou, Fei Li, Qi-Wen Zhang, Shou-Kai Wang, Wei Wang, Zhen Jin, You-Zhi Tang

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2078-2091 (2022)

مصطلحات موضوعية: Pleuromutilin, alkylamine, nitrogen heterocycles, molecular docking, MRSA, antibacterial activity, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/14538933bf36415fa90253b9bdb1bc2d

المؤلفون: Leila Abod, Natalia Ilnicka, Daria Matyja, Maria Sadlik, Patrycja Zuziak

المصدر: Journal of Education, Health and Sport, Vol 15, Iss 1 (2023)

مصطلحات موضوعية: lefamulin, BC3781, pleuromutilin, CABP, pneumonia, community acquired pneumonia, Education, Sports, GV557-1198.995, Medicine

وصف الملف: electronic resource

Relation: https://apcz.umk.pl/JEHS/article/view/45573; https://doaj.org/toc/2391-8306

URL الوصول: https://doaj.org/article/f7e93dc13adb4d65ac3b7cf19b14c075

المؤلفون: Abod, Leila, Ilnicka, Natalia, Matyja, Daria, Sadlik, Maria, Zuziak, Patrycja

المصدر: Journal of Education, Health and Sport; Tom 15 Nr 1 (2023); 186-196 ; Journal of Education, Health and Sport; Vol. 15 No. 1 (2023); 186-196 ; 2391-8306

مصطلحات موضوعية: lefamulin, BC3781, pleuromutilin, CABP, pneumonia, community acquired pneumonia

وصف الملف: application/pdf

Relation: https://apcz.umk.pl/JEHS/article/view/45573/36429; https://apcz.umk.pl/JEHS/article/view/45573

الاتاحة: https://apcz.umk.pl/JEHS/article/view/45573

المؤلفون: Dechêne-Tempier, Manon, Jouy, Eric, Bayon-Auboyer, Marie-Hélène, Bougeard, Stéphanie, Chauvin, Claire, Libante, Virginie, Payot, Sophie, Marois-Créhan, Corinne

المساهمون: Dynamique des Génomes et Adaptation Microbienne (DynAMic), Université de Lorraine (UL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Mycoplasmologie, Bactériologie et Antibiorésistance (MBA), Laboratoire de Ploufragan-Plouzané-Niort ANSES, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), LABOCEA Laboratoire Plouzané, France, Epidémiologie, Santé et Bien-être (EPISABE), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)

المصدر: ISSN: 0095-1137 ; Journal of Clinical Microbiology ; https://anses.hal.science/anses-04228454 ; Journal of Clinical Microbiology, 2023, 61 (9), pp.e0016423. ⟨10.1128/jcm.00164-23⟩ ; https://journals.asm.org/doi/10.1128/jcm.00164-23.

مصطلحات موضوعية: antimicrobial resistance, CLSI, disc diffusion method, pathogen, Streptococcus suis, Animals, Anti-Bacterial Agents, Drug Resistance, Bacterial, France, Humans, Lincosamides, Macrolides, Penicillins, Sus scrofa, Swine, antiinfective agent, lincosamide, macrolide, penicillin derivative, pleuromutilin, animal, antibiotic resistance, epidemiology, human, pig, MESH: Anti-Bacterial Agents, MESH: Drug Resistance, MESH: France, MESH: Lincosamides

Relation: info:eu-repo/semantics/altIdentifier/pmid/37655935; anses-04228454; https://anses.hal.science/anses-04228454; https://anses.hal.science/anses-04228454/document; https://anses.hal.science/anses-04228454/file/Dechene_Tempier_2023_JCM_postprint.pdf; PUBMED: 37655935; PUBMEDCENTRAL: PMC10512786

الاتاحة: https://anses.hal.science/anses-04228454
https://anses.hal.science/anses-04228454/document
https://anses.hal.science/anses-04228454/file/Dechene_Tempier_2023_JCM_postprint.pdf
https://doi.org/10.1128/jcm.00164-23

المؤلفون: Jun Wang, Yu-Han Hu, Ke-Xin Zhou, Wei Wang, Fei Li, Ke Li, Guang-Yu Zhang, You-Zhi Tang

المصدر: Molecules; Volume 28; Issue 9; Pages: 3975

مصطلحات موضوعية: antibacterial activity, MRSA, pleuromutilin, 1 H -pyrazolo[3,4- d ]pyrimidine

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Bioorganic Chemistry; https://dx.doi.org/10.3390/molecules28093975

الاتاحة: https://doi.org/10.3390/molecules28093975

المؤلفون: Zhenfeng Shi, Jie Zhang, Lei Tian, Liang Xin, Chengyuan Liang, Xiaodong Ren, Min Li

المصدر: Molecules; Volume 28; Issue 4; Pages: 1762

مصطلحات موضوعية: antibacterial resistance, superbugs, aminoglycosides, oxazolidinedione, pleuromutilin, structure–activity relationships (SARs)

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/molecules28041762

الاتاحة: https://doi.org/10.3390/molecules28041762

المؤلفون: Logan M. Breiner, Anthony J. Briganti, Jennifer P. McCord, Moriah E. Heifetz, Sophia Y. Philbrook, Carla Slebodnick, Anne M. Brown, Andrew N. Lowell

المصدر: Tetrahedron Chem, Vol 4, Iss , Pp 100034- (2022)

مصطلحات موضوعية: Ribosome, Antibiotics, Pleuromutilin, Click-chemistry, In silico modeling, Molecular docking, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666951X22000304; https://doaj.org/toc/2666-951X

URL الوصول: https://doaj.org/article/7651b2cc772c4e9b8b5387abcee697df

المؤلفون: Ruscoe, Rebecca

المساهمون: Flitsch, Sabine, Procter, David

مصطلحات موضوعية: 547, Cyanation, Antibacterials, Borylation, Allenes, Samarium, Pleuromutilin, Conjugate addition, Copper-catalysis, Imines

URL الوصول: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.822934

المؤلفون: Thomas M. File, Elizabeth Alexander, Lisa Goldberg, Anita F. Das, Christian Sandrock, Susanne Paukner, Gregory J. Moran

المصدر: BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-10 (2021)

مصطلحات موضوعية: Antibiotic, Clinical response, Lefamulin, Pleuromutilin, Pneumonia, Diseases of the respiratory system, RC705-779

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1471-2466

URL الوصول: https://doaj.org/article/d2fe5de928d243b0b81964df410f04c8

المؤلفون: Zhe Zhang, Zhao-Sheng Zhang, Xiao Wang, Gao-Lei Xi, Zhen Jin, You-Zhi Tang

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 2087-2103 (2021)

مصطلحات موضوعية: pleuromutilin, 1,2,3-triazole, mrsa, spr, molecular docking, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/46f6b03a12434a56889250592988a7ab

المؤلفون: Yuanyuan Zhang, Chuan Xie, Yang Liu, Feng Shang, Rushiya Shao, Jing Yu, Chunxia Wu, Xinghui Yao, Dongfang Liu, Zhouyu Wang

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 764-775 (2021)

مصطلحات موضوعية: pleuromutilin, piperazinyl urea, synthesis, biological activities, mrsa, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/755e9cc87a8f4e9caa02445977d73ab6

المؤلفون: Thomas Schafhauser, Daniel Wibberg, Antonia Binder, Christian Rückert, Tobias Busche, Wolfgang Wohlleben, Jörn Kalinowski

المصدر: Journal of Fungi; Volume 8; Issue 8; Pages: 862

مصطلحات موضوعية: genome assembly, Nanopore sequencing, Illumina sequencing, Clitopilus, Agaricales, mitochondrial genome, heteroplasmic mycelium, pleuromutilin, terpene synthase, biosynthetic gene cluster

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Fungal Genomics, Genetics and Molecular Biology; https://dx.doi.org/10.3390/jof8080862

الاتاحة: https://doi.org/10.3390/jof8080862