المؤلفون: Michon, Maya, Müller-Schiffmann, Andreas, Lingappa, Anuradha, Yu, Shao, Du, Li, Deiter, Fred, Broce, Sean, Mallesh, Suguna, Crabtree, Jackelyn, Lingappa, Usha, Macieik, Amanda, Müller, Lisa, Ostermann, Philipp, Andrée, Marcel, Adams, Ortwin, Schaal, Heiner, Hogan, Robert, Tripp, Ralph, Appaiah, Umesh, Anand, Sanjeev, Campi, Thomas, Ford, Michael, Reed, Jonathan, Lin, Jim, Akintunde, Olayemi, Copeland, Kiel, Nichols, Christine, Petrouski, Emma, Moreira, Ana, Jiang, I-Ting, DeYarman, Nicholas, Brown, Ian, Lau, Sharon, Segal, Ilana, Goldsmith, Danielle, Hong, Shi, Asundi, Vinod, Briggs, Erica, Phyo, Ngwe, Froehlich, Markus, Onisko, Bruce, Matlack, Kent, Dey, Debendranath, Lingappa, Jaisri, Prasad, Dharma, Kitaygorodskyy, Anatoliy, Solas, Dennis, Boushey, Homer, Greenland, John, Pillai, Satish, Lo, Michael, Montgomery, Joel, Spiropoulou, Christina, Korth, Carsten, Selvarajah, Suganya, Paulvannan, Kumar, Lingappa, Vishwanath

المصدر: Open Biology. 14(6)

مصطلحات موضوعية: allosteric modulator, drug discovery, host–viral interface, pan-respiratory antiviral therapeutics, phenotypic screen, viral capsid assembly, Antiviral Agents, Humans, Animals, 14-3-3 Proteins, Multiprotein Complexes, Host-Pathogen Interactions, Cell Line

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4kp6g8gs
https://escholarship.org/content/qt4kp6g8gs/qt4kp6g8gs.pdf

المؤلفون: Maya Michon, Andreas Müller-Schiffmann, Anuradha F. Lingappa, Shao Feng Yu, Li Du, Fred Deiter, Sean Broce, Suguna Mallesh, Jackelyn Crabtree, Usha F. Lingappa, Amanda Macieik, Lisa Müller, Philipp Niklas Ostermann, Marcel Andrée, Ortwin Adams, Heiner Schaal, Robert J. Hogan, Ralph A. Tripp, Umesh Appaiah, Sanjeev K. Anand, Thomas W. Campi, Michael J. Ford, Jonathan C. Reed, Jim Lin, Olayemi Akintunde, Kiel Copeland, Christine Nichols, Emma Petrouski, Ana R. Moreira, I-ting Jiang, Nicholas DeYarman, Ian Brown, Sharon Lau, Ilana Segal, Danielle Goldsmith, Shi Hong, Vinod Asundi, Erica M. Briggs, Ngwe Sin Phyo, Markus Froehlich, Bruce Onisko, Kent Matlack, Debendranath Dey, Jaisri R. Lingappa, Dharma M. Prasad, Anatoliy Kitaygorodskyy, Dennis Solas, Homer Boushey, John Greenland, Satish Pillai, Michael K. Lo, Joel M. Montgomery, Christina F. Spiropoulou, Carsten Korth, Suganya Selvarajah, Kumar Paulvannan, Vishwanath R. Lingappa

المصدر: Open Biology, Vol 14, Iss 6 (2024)

مصطلحات موضوعية: drug discovery, host–viral interface, phenotypic screen, pan-respiratory antiviral therapeutics, allosteric modulator, viral capsid assembly, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2046-2441

URL الوصول: https://doaj.org/article/ab895c6ab92c405ab16479c74bcf64ea

المؤلفون: Martin Cottet, Yuniel Fernandez Marrero, Simon Mathien, Karine Audette, Raphaelle Lambert, Eric Bonneil, Kenneth Chng, Alex Campos, David W. Andrews

المصدر: SLAS Discovery, Vol 29, Iss 3, Pp 100121- (2024)

مصطلحات موضوعية: Live cell painting, High content screening, ChromaLive, Live cell imaging, Phenotypic screen, Automation, Medicine (General), R5-920, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2472555223000758; https://doaj.org/toc/2472-5552

URL الوصول: https://doaj.org/article/5564449d6c78415e9c5915e263f7b2df

المؤلفون: Maya Michon, Andreas Müller-Schiffmann, Anuradha F. Lingappa, Shao Feng Yu, Li Du, Fred Deiter, Sean Broce, Suguna Mallesh, Jackelyn Crabtree, Usha F. Lingappa, Amanda Macieik, Lisa Müller, Philipp Niklas Ostermann, Marcel Andrée, Ortwin Adams, Heiner Schaal, Robert J. Hogan, Ralph A. Tripp, Umesh Appaiah, Sanjeev K. Anand, Thomas W. Campi, Michael J. Ford, Jonathan C. Reed, Jim Lin, Olayemi Akintunde, Kiel Copeland, Christine Nichols, Emma Petrouski, Ana R. Moreira, I-ting Jiang, Nicholas DeYarman, Ian Brown, Sharon Lau, Ilana Segal, Danielle Goldsmith, Shi Hong, Vinod Asundi, Erica M. Briggs, Ngwe Sin Phyo, Markus Froehlich, Bruce Onisko, Kent Matlack, Debendranath Dey, Jaisri R. Lingappa, Dharma M. Prasad, Anatoliy Kitaygorodskyy, Dennis Solas, Homer Boushey, John Greenland, Satish Pillai, Michael K. Lo, Joel M. Montgomery, Christina F. Spiropoulou, Carsten Korth, Suganya Selvarajah, Kumar Paulvannan, Vishwanath R. Lingappa

مصطلحات موضوعية: Biochemistry and cell biology not elsewhere classified, Medical biotechnology not elsewhere classified, drug discovery, host–viral interface, phenotypic screen, pan-respiratory antiviral therapeutics, allosteric modulator, viral capsid assembly

Relation: https://figshare.com/articles/journal_contribution/Electronic_supplementary_material_for_Open_Biology_article_230363_from_A_pan-respiratory_antiviral_chemotype_targeting_a_transient_host_multi-protein_complex/25934182

الاتاحة: https://doi.org/10.6084/m9.figshare.25934182.v1
https://figshare.com/articles/journal_contribution/Electronic_supplementary_material_for_Open_Biology_article_230363_from_A_pan-respiratory_antiviral_chemotype_targeting_a_transient_host_multi-protein_complex/25934182

المؤلفون: George M. Ramzy, Maxim Norkin, Thibaud Koessler, Lionel Voirol, Mathieu Tihy, Dina Hany, Thomas McKee, Frédéric Ris, Nicolas Buchs, Mylène Docquier, Christian Toso, Laura Rubbia-Brandt, Gaetan Bakalli, Stéphane Guerrier, Joerg Huelsken, Patrycja Nowak-Sliwinska

المصدر: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-17 (2023)

مصطلحات موضوعية: Drug-drug interaction, Drug resistance, Multidrug combination, Organoid, Phenotypic screen, Synergy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1756-9966

URL الوصول: https://doaj.org/article/60bf5c4478c549e8812684c5f9a09d4e

المؤلفون: Changtong Liu, Yingchao Wang, Yixin Zeng, Zirong Kang, Hong Zhao, Kun Qi, Hongzhi Wu, Lu Zhao, Yi Wang

المصدر: Advanced Science, Vol 10, Iss 30, Pp n/a-n/a (2023)

مصطلحات موضوعية: cyanidin chloride, deep learning, doxorubicin, Keap1‐Nrf2 interaction, zebrafish phenotypic screen, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2198-3844

URL الوصول: https://doaj.org/article/19c401b617da45ebbc4ab5d719e7f50d

المؤلفون: Maccesi, Martina, Aguiar, Pedro HN, Pasche, Valérian, Padilla, Melody, Suzuki, Brian M, Montefusco, Sandro, Abagyan, Ruben, Keiser, Jennifer, Mourão, Marina M, Caffrey, Conor R

المصدر: Parasites & Vectors. 12(1)

مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Vector-Borne Diseases, Infectious Diseases, Rare Diseases, Orphan Drug, Infection, Good Health and Well Being, Animals, Biomphalaria, Cricetinae, Drug Discovery, Female, Larva, Life Cycle Stages, Mesocricetus, Parasitic Sensitivity Tests, Phenotype, Schistosoma mansoni, Schistosomiasis mansoni, Schistosomicides, Schistosoma, Schistosomiasis, Drug discovery, Phenotypic screen, Pathogen Box, MMV, Public Health and Health Services, Mycology & Parasitology, Tropical Medicine, Microbiology, Medical microbiology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3937v5z0
https://escholarship.org/content/qt3937v5z0/qt3937v5z0.pdf

المؤلفون: Koen J. Dechering, Martijn Timmerman, Kim Rensen, Karin M.J. Koolen, Saman Honarnejad, Martijn W. Vos, Tonnie Huijs, Rob W.M. Henderson, Elodie Chenu, Benoît Laleu, Bailey C. Montefiore, Matthew D. Segall, James E.J. Mills, Eric M. Guantai, James Duffy, Maëlle Duffey

المصدر: SLAS Discovery, Vol 27, Iss 6, Pp 337-348 (2022)

مصطلحات موضوعية: Malaria, High throughput screening, Phenotypic screen, Drug discovery, Nanoluciferase, Screening cascade, Medicine (General), R5-920, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2472555222136841; https://doaj.org/toc/2472-5552

URL الوصول: https://doaj.org/article/5462a223647e4fcf83104fa393c505f1

المؤلفون: Maximillian Fischer, Moritz Jakab, Marc N. Hirt, Tessa R. Werner, Stefan Engelhardt, Antonio Sarikas

المصدر: Frontiers in Physiology, Vol 14 (2023)

مصطلحات موضوعية: cardiomyocyte, hypertrophy, phenotypic screen, Cullin-RING E3 ligase (CRL), F-box protein, Fbxo25, Physiology, QP1-981

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2023.1134339/full; https://doaj.org/toc/1664-042X

URL الوصول: https://doaj.org/article/9ab662ddb713488bb5c37af7395bd7e5

المؤلفون: Lee, Sun-Young, Bissell, Mina J

المصدر: Bio-protocol. 8(22)

مصطلحات موضوعية: 3D Culture, Drug resistance, EGFR-TKI, Extracellular matrix, HMT3522, Phenotypic screen, cDNA overexpression library

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/16c70699

المؤلفون: Ramzy, George Mourad, Norkin, Maxim, Kossler, Thibaud, Voirol, Lionel, Tihy, Matthieu, Hany, Dina, Mckee, Thomas Alexander, Ris, Frédéric, Buchs, Nicolas, Docquier, Mylene, Toso, Christian, Rubbia-Brandt, Laura, Bakalli, Gaetan, Guerrier, Stéphane, Huelsken, Joerg, Nowak-Sliwinska, Patrycja

المصدر: ISSN: 1756-9966 ; Journal of experimental & clinical cancer research, vol. 42, no. 1 (2023) 79.

مصطلحات موضوعية: info:eu-repo/classification/ddc/310, info:eu-repo/classification/ddc/615, info:eu-repo/classification/ddc/616.07, info:eu-repo/classification/ddc/616, info:eu-repo/classification/ddc/617, info:eu-repo/classification/ddc/590, Drug‑drug interaction, Drug resistance, Multidrug combination, Organoid, Phenotypic screen, Synergy, Targeted RNAseq

Relation: info:eu-repo/semantics/altIdentifier/pmid/37013646; info:eu-repo/grantAgreement/EC/H2020/680209/EU/Optimized drug combinations for effective cancer treatment: a personalised approach./OPTIM; https://archive-ouverte.unige.ch/unige:168618; unige:168618

الاتاحة: https://archive-ouverte.unige.ch/unige:168618

المؤلفون: Julia Beveridge (6693530), Eric Tran (234607), Girdhar Singh Deora (1676818), Fei Huang (9205), Yuzhi Wang (690944), Kieran Stockton (14375508), Ignacio Cotillo (685738), Maria Santos Martinez Martinez (14375511), Silvia Gonzalez (1322532), Pablo Castañeda (1662799), Julian Sherman (7372811), Ana Rodriguez (266842), Albane Kessler (2148916), Jonathan B. Baell (115410)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Immunology, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, promising new chemotype, observed excellent activity, novel diarylthioether compounds, diarylthioether compounds represent, cell phenotypic screen, chagas disease herein, chagas disease, vivo <, vitro <, several analogues, parasite responsible, mice infected, investigations led, hit optimization, hit compound, efficacy studies, chemical class

Relation: https://figshare.com/articles/journal_contribution/Novel_Diarylthioether_Compounds_as_Agents_for_the_Treatment_of_Chagas_Disease/21861573

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01725.s001

المؤلفون: Adam McDermott‐Rouse, Eleni Minga, Ida Barlow, Luigi Feriani, Philippa H Harlow, Anthony J Flemming, André E X Brown

المصدر: Molecular Systems Biology, Vol 17, Iss 5, Pp 1-14 (2021)

مصطلحات موضوعية: anthelmintics, C.elegans, computational ethology, pesticide, phenotypic screen, Biology (General), QH301-705.5, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1744-4292

URL الوصول: https://doaj.org/article/7f6f11a769624a6cac0239709f443cfd

المؤلفون: Jaqueline A. Picache, Wei Zheng, Catherine Z. Chen

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: drug development, enzymatic assay, phenotypic screen, high throughput screen (HTS), mass spectrometry, tay-sachs disease (TSD), Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.906647/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/3635182fa85b4adfa256c46abccea0e5

المؤلفون: Pan Wang, Ying Lin, Chengjuan Zou, Fengguang Zhao, Shuli Liang, Suiping Zheng, Shuangyan Han

المصدر: BMC Microbiology, Vol 20, Iss 1, Pp 1-12 (2020)

مصطلحات موضوعية: GPI protein, Deletion, Phenotypic screen, Pichia pastoris, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s12866-020-01928-y; https://doaj.org/toc/1471-2180

URL الوصول: https://doaj.org/article/2e20c35265e44b67ab057472d6775a9f

المؤلفون: Alexander T. Bakker (14312845), Ioli Kotsogianni (9930187), Liza Mirenda (14312848), Verena M. Straub (6713687), Mariana Avalos (14312851), Richard J. B. H. N. van den Berg (14312854), Bogdan I. Florea (1330800), Gilles P. van Wezel (7838948), Antonius P. A. Janssen (7449809), Nathaniel I. Martin (847378), Mario van der Stelt (222751)

مصطلحات موضوعية: Biochemistry, Pharmacology, Sociology, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, target interaction landscape, revealed several cysteine, resistant staphylococcus aureus, novel antibacterial chemotype, identify novel antibiotics, high antibacterial potency, comparative chemical proteomics, mrsa phenotypic screening, data showcase oxadiazolones, phenotypic screen, targets responsible, situ competitive, serine hydrolases, resistance studies, relevant targets, powerful approach, polypharmacological mode, ones identified, often challenging, central role, based probe, adhe play

Relation: https://figshare.com/articles/journal_contribution/Chemical_Proteomics_Reveals_Antibiotic_Targets_of_Oxadiazolones_in_MRSA/21799438

الاتاحة: https://doi.org/10.1021/jacs.2c10819.s001

المؤلفون: Kwon, Hye Kyeong, Choi, Hyunwoo, Park, Sung-Gyoo, Park, Woo Jin, Kim, Do Han, Park, Zee-Yong

المساهمون: Park, Sung-Gyoo

مصطلحات موضوعية: BINDING-PROTEIN-C, RYANODINE RECEPTOR PHOSPHORYLATION, HEART-FAILURE, ATRIAL-FIBRILLATION, DEPENDENT PHOSPHORYLATION, DILATED CARDIOMYOPATHY, RYR2 PHOSPHORYLATION, SIGNALING PATHWAYS, PHENOTYPIC SCREEN, PDZ DOMAINS, Cardiac hypertrophy, Cell-based functional screening, Neonatal rat ventricle cardiomyocytes, Phosphorylation sites, Quantitative phosphoproteomics, Transgenic mice

Relation: Molecules and Cells, Vol.44 No.7, pp.500-516; https://hdl.handle.net/10371/190322; 000687756100008; 2-s2.0-85112369509; 165368; ART002741644

الاتاحة: https://hdl.handle.net/10371/190322
https://doi.org/10.14348/molcells.2021.4002

المؤلفون: Suzawa, Miyuki, Miranda, Diego A, Ramos, Karmela A, Ang, Kenny K-H, Faivre, Emily J, Wilson, Christopher G, Caboni, Laura, Arkin, Michelle R, Kim, Yeong-Sang, Fletterick, Robert J, Diaz, Aaron, Schneekloth, John S, Ingraham, Holly A

المصدر: eLife. 4(DECEMBER2015)

مصطلحات موضوعية: Cells, Cultured, Hepatocytes, Animals, Humans, Mice, Mice, SCID, Tannins, Receptors, Cytoplasmic and Nuclear, Enzyme Inhibitors, Drug Evaluation, Preclinical, Gene Expression Profiling, Inhibitory Concentration 50, Sumoylation, NASH, NR5As, cell biology, human, human biology, medicine, mouse, phenotypic screen, primary hepatocytes, sumoylation, tannic acid, Cells, Cultured, SCID, Receptors, Cytoplasmic and Nuclear, Drug Evaluation, Preclinical, Biotechnology, Genetics, Digestive Diseases, Liver Disease, 5.1 Pharmaceuticals, Biochemistry and Cell Biology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/24g913vn

المؤلفون: Wanni Chia (11525311), Maria G. Gomez-Lorenzo (7832105), Isabel Castellote (2148934), Jie Xin Tong (8151210), Rajesh Chandramohanadas (217006), Trang Thi Thu Chu (11525314), Wanxiang Shen (11525317), Mei Lin Go (2855729), Cristina de Cozar (4354270), Benigno Crespo (181336), Maria J. Almela (7494524), Fernando Neria-Serrano (11525320), Virginia Franco (326417), Francisco-Javier Gamo (181360), Kevin S. W. Tan (8151216)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tres cantos anti, throughput phenotypic screen, possible inhibitory effects, mitochondrial membrane potential, initiated lead inevitably, content phenotypic screen, computational methods identified, cause minimal toxicity, best fit assigned, low micromolar range, like features characterized, inducing calcium redistribution, tightly synchronized artemisinin, programmed cell death, parasite calcium distribution, action recently characterized, 50 , target specific mechanisms, identified three compounds, new antimalarial drugs, unexplored mechanisms

Relation: https://figshare.com/articles/journal_contribution/High-Content_Phenotypic_Screen_of_a_Focused_TCAMS_Drug_Library_Identifies_Novel_Disruptors_of_the_Malaria_Parasite_Calcium_Dynamics/16746145

الاتاحة: https://doi.org/10.1021/acschembio.1c00512.s001

المؤلفون: Ndeye Khady Thiombane, Nicolas Coutin, Daniel Berard, Radin Tahvildari, Sabrina Leslie, Corey Nislow

المصدر: BioTechniques, Vol 67, Iss 5, Pp 210-217 (2019)

مصطلحات موضوعية: CLiC, dose-response, methotrexate, phenotypic screen, single cell, yeast, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/0736-6205; https://doaj.org/toc/1940-9818

URL الوصول: https://doaj.org/article/a690e384a868473e8c02b84e8d524bf6