المؤلفون: Zhangping Xiao (5855825), Angelina Osipyan (5666825), Shanshan Song (500562), Deng Chen (4047067), Reinder A. Schut (11966038), Ronald van Merkerk (3138039), Petra E. van der Wouden (6615692), Robbert H. Cool (2386171), Wim J. Quax (1881640), Barbro N. Melgert (7951046), Gerrit J. Poelarends (1264938), Frank J. Dekker (1514791)

مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Immunology, Developmental Biology, Cancer, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, play key roles, cellular models systems, activated protein kinase, improved antiproliferative activity, 5d , 50 , mif2 tautomerase activity, biological activity, dopachrome tautomerase, h <, targeting mif2, molecules binding, high selectivity, drug target, cell cultures, cancer treatment, >] pyrimidine, >

Time: 3

Relation: https://figshare.com/articles/journal_contribution/Thieno_2_3_i_d_i_pyrimidine-2_4_1_i_H_i_3_i_H_i_dione_Derivative_Inhibits_d_Dopachrome_Tautomerase_Activity_and_Suppresses_the_Proliferation_of_Non-Small_Cell_Lung_Cancer_Cells/18665515

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01598.s001

المؤلفون: Martijn R. H. Zwinderman, Peter M. Lansdorp, Marcel A. T. M. van Vugt, Petra E van der Wouden, Frank J. Dekker, Victor Guryev, Diana C.J. Spierings, Thamar Jessurun Lobo

المساهمون: Chemical and Pharmaceutical Biology, Stem Cell Aging Leukemia and Lymphoma (SALL), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Groningen Research Institute for Asthma and COPD (GRIAC), Medicinal Chemistry and Bioanalysis (MCB), Biopharmaceuticals, Discovery, Design and Delivery (BDDD)

المصدر: ACS Chemical Biology
ACS chemical biology, 16(11), 2193-2201. AMER CHEMICAL SOC

مصطلحات موضوعية: DNA Replication, Cell Cycle Proteins, Ataxia Telangiectasia Mutated Proteins, Biochemistry, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Stress, Physiological, BINDING, Humans, Hydroxyurea, Sister chromatids, HELICASE, Replication protein A, Polymerase, 030304 developmental biology, DAMAGE, 0303 health sciences, biology, Chemistry, DNA replication, Articles, General Medicine, Processivity, Chromatin, Cell biology, ATR, Gene Expression Regulation, Replication Initiation, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Tumor Suppressor Protein p53, DNA

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d071ef73e3164387cd275fe1c1a53f0e
https://doi.org/10.1021/acschembio.1c00321

المؤلفون: Petra E van der Wouden, Zhangping Xiao, Frank J. Dekker, Deng Chen, Dea Gogishvili, Rita Setroikromo, Hao Guo

المساهمون: Chemical and Pharmaceutical Biology, Chemical and Pharmaceutical Biology (GRIP), Medicinal Chemistry and Bioanalysis (MCB), Biopharmaceuticals, Discovery, Design and Delivery (BDDD)

المصدر: Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International ed. in English), 60(40), 21875-21883. WILEY-V C H VERLAG GMBH

مصطلحات موضوعية: musculoskeletal diseases, endocrine system diseases, activity-based probes, Molecular Conformation, Context (language use), Activity‐Based Probes | Hot Paper, Catalysis, Lipoxygenase, inhibitors, bromodomains, Arachidonate 15-Lipoxygenase, Humans, Enzyme Inhibitors, Research Articles, biology, integumentary system, Chemistry, Chromatin binding, food and beverages, Lipid metabolism, General Medicine, General Chemistry, lipoxygenases, Bromodomain, Chromatin, oxidoreductases, Histone, Biochemistry, biology.protein, lipids (amino acids, peptides, and proteins), Nuclear localization sequence, Research Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcaf1ff2001ab82da878efb2ea45452
https://doi.org/10.1002/anie.202106968

المؤلفون: Zhangping Xiao, Gerrit J. Poelarends, Wim J. Quax, Shanshan Song, Barbro N. Melgert, Frank J. Dekker, Robbert H. Cool, Deng Chen, Ronald van Merkerk, Petra E van der Wouden

المساهمون: Chemical and Pharmaceutical Biology, Molecular Pharmacology, Chemical and Pharmaceutical Biology (GRIP), Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Nanotechnology and Biophysics in Medicine (NANOBIOMED), Medicinal Chemistry and Bioanalysis (MCB)

المصدر: Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International ed. in English), 60(32), 17514-17521. WILEY-V C H VERLAG GMBH

مصطلحات موضوعية: MAPK/ERK pathway, Cell cycle checkpoint, Macrophage migration inhibitory factor (MIF), 01 natural sciences, proteolysis targeting chimera (PROTACs), ACTIVATION, BINDING, A549 cells, Research Articles, Chemistry, General Medicine, respiratory system, Small molecule, Cell biology, G2 Phase Cell Cycle Checkpoints, Intramolecular Oxidoreductases, cell cycle arrest, Cancer Therapy | Hot Paper, medicine.symptom, Research Article, MAP Kinase Signaling System, PROTEINS, Ubiquitin-Protein Ligases, Inflammation, Antineoplastic Agents, Phthalimides, chemical and pharmacologic phenomena, TAUTOMERASE INHIBITORS, 010402 general chemistry, Mitogen-activated protein kinase (MAPK) pathway, Catalysis, PROBES, Spheroids, Cellular, medicine, otorhinolaryngologic diseases, Humans, CYCLE, Macrophage Migration-Inhibitory Factors, Adaptor Proteins, Signal Transducing, Cell Proliferation, A549 cell, COMPLEX, 010405 organic chemistry, POTENT, Proteolysis targeting chimera, Cancer, General Chemistry, medicine.disease, 0104 chemical sciences, Benzoxazines, DISCOVERY, Proteolysis, Macrophage migration inhibitory factor, Drug Screening Assays, Antitumor

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d51164a0c04702db2c8059a858ded3
https://doi.org/10.1002/anie.202101864

المؤلفون: Zhangping, Xiao, Angelina, Osipyan, Shanshan, Song, Deng, Chen, Reinder A, Schut, Ronald, van Merkerk, Petra E, van der Wouden, Robbert H, Cool, Wim J, Quax, Barbro N, Melgert, Gerrit J, Poelarends, Frank J, Dekker

المصدر: Journal of medicinal chemistry. 65(3)

مصطلحات موضوعية: Binding Sites, Lung Neoplasms, Cell Culture Techniques, Antineoplastic Agents, Cell Cycle Checkpoints, Pyrimidinones, Molecular Dynamics Simulation, Intramolecular Oxidoreductases, Kinetics, Structure-Activity Relationship, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Drug Design, Humans, Phosphorylation, Extracellular Signal-Regulated MAP Kinases, Macrophage Migration-Inhibitory Factors, Cell Proliferation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::3f4a2932dbe26ff7dda594b028812747
https://pubmed.ncbi.nlm.nih.gov/35041425

المؤلفون: Zhangping Xiao, Frank J. Dekker, Shanshan Song, Robbert H. Cool, Fabian Mulder, Deng Chen, Barbro N. Melgert, Petra E van der Wouden, Gerrit J. Poelarends

المساهمون: Chemical and Pharmaceutical Biology (GRIP), Chemical and Pharmaceutical Biology, Molecular Pharmacology, Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Groningen Research Institute for Asthma and COPD (GRIAC), Medicinal Chemistry and Bioanalysis (MCB)

المصدر: Chemistry, 28(1):e202103030. Wiley-VCH Verlag GmbH & Co. KGaA

مصطلحات موضوعية: Nuclease, biology, Chemistry, Organic Chemistry, chemical and pharmacologic phenomena, Chromosomal translocation, General Chemistry, biology.organism_classification, Catalysis, Cell biology, Intramolecular Oxidoreductases, HeLa, genomic DNA, medicine.anatomical_structure, Immune system, Cytoplasm, otorhinolaryngologic diseases, medicine, biology.protein, Humans, Macrophage migration inhibitory factor, Macrophage Migration-Inhibitory Factors, Nucleus, HeLa Cells

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c23129d373dc0f1773f9f19268eb5a
https://research.rug.nl/en/publications/4380903a-9d91-4662-8ef1-9828d3a7c6bd

المؤلفون: Maria E. Ourailidou, Frank J. Dekker, Wiktor Szymanski, Petra E van der Wouden, Piermichele Kobauri, Christian Peifer, Malte Kriegs, Theo Rodat, Ben L. Feringa, Mark W. H. Hoorens

المساهمون: Synthetic Organic Chemistry, Chemical and Pharmaceutical Biology, Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Medicinal Chemistry and Bioanalysis (MCB), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE)

المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 179, 133-146. ELSEVIER MASSON, CORPORATION OFFICE

مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Drug, Light, Metastatic melanoma, Cell Survival, media_common.quotation_subject, Mutant, Antineoplastic Agents, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, Cell Line, Tumor, Drug Discovery, medicine, Humans, Melanoma, Protein Kinase Inhibitors, Cell Proliferation, 030304 developmental biology, media_common, Pharmacology, 0303 health sciences, Binding Sites, Dose-Response Relationship, Drug, Molecular Structure, Photoswitch, 010405 organic chemistry, Kinase, Chemistry, Effector, Organic Chemistry, Cancer, General Medicine, medicine.disease, Small molecule, 0104 chemical sciences, 3. Good health, Cancer research, Drug Screening Assays, Antitumor

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ae706f1cde91e345acb958ea0045e6
https://doi.org/10.1016/j.ejmech.2019.06.042

المؤلفون: Lennart Johansson, Petra E van der Wouden, Eddy N. de Boer, Cleo C. van Diemen, Hidde J. Haisma

المساهمون: Chemical and Pharmaceutical Biology, Biopharmaceuticals, Discovery, Design and Delivery (BDDD)

المصدر: Gene Therapy
Gene Therapy, 26(7-8), 338-346. Nature Publishing Group

مصطلحات موضوعية: 0301 basic medicine, Sequence analysis, Computational biology, Biology, Sensitivity and Specificity, Genome, Article, DNA sequencing, law.invention, 03 medical and health sciences, gene doping, 0302 clinical medicine, Plasmid, law, Gene doping, Genetics, Humans, Genetic Testing, Transgenes, Erythropoietin, Molecular Biology, Gene, Polymerase chain reaction, Doping in Sports, next generation sequencing, Genome, Human, High-Throughput Nucleotide Sequencing, Reproducibility of Results, Exons, Sequence Analysis, DNA, Genetic vectors, genomic DNA, 030104 developmental biology, 030220 oncology & carcinogenesis, Intercellular Signaling Peptides and Proteins, Molecular Medicine, Genetic techniques, Plasmids

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f0c72eb9bfc332c8a543db35b8ea0c
https://doi.org/10.1038/s41434-019-0091-6

المؤلفون: Frank J. Dekker, Gerrit J. Poelarends, Zhangping Xiao, Shanshan Song, Barbro N. Melgert, Robbert H. Cool, Wim J. Quax, Ronald van Merkerk, Petra E van der Wouden, Deng Chen, Anna K. H. Hirsch, Ramon van der Vlag

المساهمون: Chemical and Pharmaceutical Biology, Molecular Pharmacology, Chemical Biology 2, Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Nanotechnology and Biophysics in Medicine (NANOBIOMED), Medicinal Chemistry and Bioanalysis (MCB)

المصدر: Journal of medicinal chemistry
United States
Journal of Medicinal Chemistry, 63(20), 11920-11933. AMER CHEMICAL SOC
Journal of Medicinal Chemistry

مصطلحات موضوعية: Models, Molecular, medicine.medical_treatment, animal diseases, INVASION, 01 natural sciences, Assays, Drug Discovery, Imaging probes, Enzyme Inhibitors, chemistry.chemical_classification, 0303 health sciences, Molecular Structure, biology, DERIVATIVES, Chemistry, Biological activity, respiratory system, CANCER, Intramolecular Oxidoreductases, COUMARIN, TARGET, Cytokine, Biochemistry, Molecular Medicine, MIF ENZYMATIC-ACTIVITY, chemical and pharmacologic phenomena, TAUTOMERASE INHIBITORS, Peptides and proteins, Binding, Competitive, Article, Fluorescence, Structure-Activity Relationship, 03 medical and health sciences, medicine, otorhinolaryngologic diseases, Humans, Structure–activity relationship, STRUCTURAL FEATURES, Umbelliferones, Macrophage Migration-Inhibitory Factors, Fluorescent Dyes, 030304 developmental biology, A549 cell, Dose-Response Relationship, Drug, Inhibitors, Active site, Enzyme assay, biological factors, 0104 chemical sciences, CYTOKINE, 010404 medicinal & biomolecular chemistry, Enzyme, DISCOVERY, biology.protein, Macrophage migration inhibitory factor

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1eb77fe69b2442150e2afb9f15b7fd
https://hdl.handle.net/10033/623224

المؤلفون: Floris Bosveld, Anil Rana, Petra E. Van Der Wouden, Willy Lemstra, Martha Ritsema, Harm H. Kampinga, Ody C. M. Sibon

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://hmg.oxfordjournals.org/content/17/13/2058.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.538.164; http://hmg.oxfordjournals.org/content/17/13/2058.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.538.164
http://hmg.oxfordjournals.org/content/17/13/2058.full.pdf

المؤلفون: Frank J. Dekker, Niek G. J. Leus, Alexander Dömling, Gebremedhin Solomon Hailu, Dante Rotili, Jos Hermans, Antonello Mai, Nikolaos Eleftheriadis, Rainer Bischoff, Thea van den Bosch, Hidde J. Haisma, Hannah Wapenaar, Petra E van der Wouden

المساهمون: Chemical and Pharmaceutical Biology, Molecular Biophysics, Analytical Biochemistry, Drug Design, Medicinal Chemistry and Bioanalysis (MCB), Biopharmaceuticals, Discovery, Design and Delivery (BDDD)

المصدر: European Journal of Medicinal Chemistry, 136, 480-486. ELSEVIER MASSON, CORPORATION OFFICE

مصطلحات موضوعية: 0301 basic medicine, Inhibitor, ACETYLATION, Fragment screening, Lysine, DISTINCT, MECHANISMS, 03 medical and health sciences, 0302 clinical medicine, MSL COMPLEX, MSL complex, parasitic diseases, Drug Discovery, Enzyme kinetics, histone acetyltransferases, KAT8, fragment screening, histone acetylation, inhibitor, enzyme kinetics, MOF, PAINS, Pharmacology, chemistry.chemical_classification, Histone Acetyltransferases, ASSAY INTERFERENCE COMPOUNDS, biology, Chemistry, Organic Chemistry, General Medicine, 030104 developmental biology, Enzyme, Histone, Histone acetyltransferases, Histone acetylation, Biochemistry, Acetylation, 030220 oncology & carcinogenesis, Acetyltransferase, biology.protein

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea803c05c55d7729d59d923ca6caa5f2
https://doi.org/10.1016/j.ejmech.2017.05.015

المؤلفون: Hidde J. Haisma, Loes E. M. Kistemaker, Frank J. Dekker, Reinoud Gosens, Wouter T R Hooghiemstra, Petra E van der Wouden, Rainer Bischoff, Thea van den Bosch, Maria E. Ourailidou, Niek G. J. Leus

المساهمون: Chemical and Pharmaceutical Biology, Molecular Pharmacology, Analytical Biochemistry, Medicinal Chemistry and Bioanalysis (MCB), Groningen Research Institute for Asthma and COPD (GRIAC), Biopharmaceuticals, Discovery, Design and Delivery (BDDD)

المصدر: Biochemical Pharmacology
Biochemical Pharmacology, 58-74. PERGAMON-ELSEVIER SCIENCE LTD
STARTPAGE=58;ENDPAGE=74;ISSN=0006-2952;TITLE=Biochemical Pharmacology

مصطلحات موضوعية: Male, 0301 basic medicine, Transcription, Genetic, Myocytes, Smooth Muscle, Anti-Inflammatory Agents, Histone Deacetylase 2, Histone Deacetylase 1, Inflammation, Respiratory Mucosa, Phenylenediamines, Pharmacology, Biochemistry, Histone Deacetylases, Article, Cell Line, Histones, Histone H4, 03 medical and health sciences, Histone H3, HDAC inhibitors, medicine, Animals, Humans, NF-κB p65, Lung, ComputingMethodologies_COMPUTERGRAPHICS, Regulation of gene expression, Acrylamides, biology, Histone deacetylase 2, Macrophages, Transcription Factor RelA, HDACs, Acetylation, Pneumonia, HDAC1, 3. Good health, Histone Deacetylase Inhibitors, Mice, Inbred C57BL, 030104 developmental biology, Histone, Gene Expression Regulation, Lung disease, biology.protein, Lysine acetylation, medicine.symptom

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5f96e9781204ae17f66551574ee6de

المؤلفون: Deng Chen, Petra E van der Wouden, Fangyuan Cao, Sander de Weerd, Martijn R. H. Zwinderman, Frank J. Dekker

المساهمون: Chemical and Pharmaceutical Biology, Medicinal Chemistry and Bioanalysis (MCB), Biopharmaceuticals, Discovery, Design and Delivery (BDDD)

المصدر: European Journal of Medicinal Chemistry, 208:112800. ELSEVIER MASSON, CORPORATION OFFICE

مصطلحات موضوعية: Ubiquitin-Protein Ligases, Proteolysis, Phenylenediamines, Protein degradation, 01 natural sciences, Histone Deacetylases, Mice, 03 medical and health sciences, Downregulation and upregulation, Drug Discovery, medicine, Animals, Humans, Anilides, Adaptor Proteins, Signal Transducing, 030304 developmental biology, Pharmacology, 0303 health sciences, biology, medicine.diagnostic_test, 010405 organic chemistry, Chemistry, Cereblon, Organic Chemistry, Proteolysis targeting chimera, General Medicine, HDAC3, Pomalidomide, Thalidomide, 0104 chemical sciences, Cell biology, Histone Deacetylase Inhibitors, RAW 264.7 Cells, Histone, A549 Cells, biology.protein, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702ec2ed7be7e04c300befdb2fc5567c
https://doi.org/10.1016/j.ejmech.2020.112800

المؤلفون: Niek G. J. Leus, Alexander Dömling, Petra E van der Wouden, Constantinos G. Neochoritis, Nikolaos Eleftheriadis, Frank J. Dekker

المساهمون: Drug Design, Groningen Research Institute of Pharmacy, Medicinal Chemistry and Bioanalysis (MCB), Biopharmaceuticals, Discovery, Design and Delivery (BDDD)

المصدر: Journal of Medicinal Chemistry, 58(19), 7850-7862. AMER CHEMICAL SOC

مصطلحات موضوعية: Male, EXPRESSION, Chronic bronchitis, MAMMALIAN 15-LIPOXYGENASE, Molecular model, medicine.drug_class, Drug Evaluation, Preclinical, SELECTIVE INHIBITORS, MACROPHAGE HETEROGENEITY, In Vitro Techniques, Pharmacology, OBSTRUCTIVE PULMONARY-DISEASE, 01 natural sciences, Article, Anti-inflammatory, Structure-Activity Relationship, 03 medical and health sciences, Lipoxygenase, Drug Discovery, medicine, Animals, Arachidonate 15-Lipoxygenase, Humans, Lipoxygenase Inhibitors, 12/15-LIPOXYGENASE, Lung, 030304 developmental biology, Inflammation, chemistry.chemical_classification, 0303 health sciences, biology, 010405 organic chemistry, Drug discovery, Anti-Inflammatory Agents, Non-Steroidal, LIGAND EFFICIENCY INDEXES, In vitro, 0104 chemical sciences, Mice, Inbred C57BL, Molecular Docking Simulation, Enzyme, Gene Expression Regulation, Biochemistry, chemistry, LIPOXYGENASES, biology.protein, Molecular Medicine, AIRWAY EPITHELIAL INJURY, Ex vivo

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910d53d1d1cbc71845c601bffc8a26f3
https://doi.org/10.1021/acs.jmedchem.5b01121

المؤلفون: Johan te Biesebeek, Frank J. Dekker, Stephanie Thee, Nikolaos Eleftheriadis, Bert-Jan Baas, Petra E van der Wouden

المساهمون: Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Medicinal Chemistry and Bioanalysis (MCB)

المصدر: European Journal of Medicinal Chemistry, 94, 265-275. ELSEVIER MASSON, CORPORATION OFFICE

مصطلحات موضوعية: Models, Molecular, Chronic bronchitis, Kinetic analysis, Pharmacology, Lipoxygenase, Structure-Activity Relationship, Non-competitive inhibition, Drug Discovery, Arachidonate 15-Lipoxygenase, Humans, Enzyme kinetics, Lipoxygenase Inhibitors, chemistry.chemical_classification, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Drug discovery, Organic Chemistry, food and beverages, General Medicine, Salicylates, Kinetics, Enzyme, Biochemistry, biology.protein, Polyunsaturated fatty acid

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5795680e040feb218329921d0320b3
https://hdl.handle.net/11370/b2c5a254-1979-4eb4-829d-9b35baa1aa33

المؤلفون: Frank J. Dekker, Sophie Bos, Reinoud Gosens, Nikolaos Eleftheriadis, Rainer Bischoff, Niek G. J. Leus, Rutger A. F. Gjaltema, Hidde J. Haisma, Kim Krist, Petra E van der Wouden, Thea van den Bosch, Solomon A Mekonnen, Loes E. M. Kistemaker, Maria E. Ourailidou

المساهمون: Chemical and Pharmaceutical Biology, Molecular Biophysics, Molecular Pharmacology, Analytical Biochemistry, Medicinal Chemistry and Bioanalysis (MCB), Groningen Research Institute for Asthma and COPD (GRIAC), Biopharmaceuticals, Discovery, Design and Delivery (BDDD)

المصدر: Scientific Reports
Scientific Reports, 7:45047. Nature Publishing Group

مصطلحات موضوعية: Male, 0301 basic medicine, Pyridines, NF-KAPPA-B, Anti-Inflammatory Agents, INHALED CORTICOSTEROIDS, ANTIINFLAMMATORY PROPERTIES, OBSTRUCTIVE PULMONARY-DISEASE, Article, Cell Line, Mice, Pulmonary Disease, Chronic Obstructive, 03 medical and health sciences, Downregulation and upregulation, Gene expression, Animals, CUT LUNG SLICES, Transcription factor, GENE-EXPRESSION, Multidisciplinary, biology, Macrophages, NF-kappa B, IN-VITRO, NFKB1, HDAC1, Interleukin-10, 3. Good health, MEDIATED INFLAMMATION, Histone Deacetylase Inhibitors, Mice, Inbred C57BL, EX-VIVO, Interleukin 10, 030104 developmental biology, Histone, Acetylation, Benzamides, Immunology, biology.protein, Cancer research, Tobacco Smoke Pollution

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12da130bc37bd50bb0b22427e5e20ef3
https://doi.org/10.1038/srep45047

المؤلفون: Hannah, Wapenaar, Thea, van den Bosch, Niek G J, Leus, Petra E, van der Wouden, Nikolaos, Eleftheriadis, Jos, Hermans, Gebremedhin Solomon, Hailu, Dante, Rotili, Antonello, Mai, Alexander, Dömling, Rainer, Bischoff, Hidde J, Haisma, Frank J, Dekker

المصدر: European journal of medicinal chemistry. 136

مصطلحات موضوعية: Kinetics, Structure-Activity Relationship, Dose-Response Relationship, Drug, Molecular Structure, parasitic diseases, Humans, Naphthols, Enzyme Inhibitors, Article, Histone Acetyltransferases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::fe8b223bf4da7fa8fd0680c1374cdb3d
https://pubmed.ncbi.nlm.nih.gov/28527406

المؤلفون: Antonello Mai, Frank J. Dekker, Petra E van der Wouden, Hannah Wapenaar, Dante Rotili, Matthew Groves

المساهمون: Drug Design, Medicinal Chemistry and Bioanalysis (MCB), Biopharmaceuticals, Discovery, Design and Delivery (BDDD)

المصدر: Wapenaar, H, van der Wouden, P E, Groves, M R, Rotili, D, Mai, A & Dekker, F J 2015, ' Enzyme kinetics and inhibition of histone acetyltransferase KAT8 ', European Journal of Medicinal Chemistry, vol. 105, pp. 289-96 . https://doi.org/10.1016/j.ejmech.2015.10.016
European Journal of Medicinal Chemistry, 105, 289-296. ELSEVIER MASSON, CORPORATION OFFICE

مصطلحات موضوعية: Models, Molecular, enzyme inhibitors, molecular structure, catalytic mechanism, Histones, chemistry.chemical_compound, 0302 clinical medicine, models in science, enzyme kinetics, Drug Discovery, Histone Acetyltransferase KAT8, Enzyme Inhibitors, humans, anacardic acids, Histone Acetyltransferases, 0303 health sciences, biology, Molecular Structure, structure-activity relationship, histone acetylation, drug, General Medicine, Biochemistry, 030220 oncology & carcinogenesis, KAT8, acetyl coenzyme A, biocatalysis, Stereochemistry, dose-response relationship, Article, epigenetics, dose-response relationship, drug, histone acetyltransferases, histones, kinetics, models, molecular, Histone H4, models, 03 medical and health sciences, Structure-Activity Relationship, Acetyl Coenzyme A, Humans, molecular, Enzyme kinetics, 030304 developmental biology, Pharmacology, Dose-Response Relationship, Drug, Organic Chemistry, Isothermal titration calorimetry, Histone acetyltransferase, Anacardic acids, Anacardic Acids, Kinetics, antagonists & inhibitors, chemistry, Acetylation, drug effects, biology.protein, Biocatalysis, metabolism, chemical synthesis

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1471a075b84484ae3cce594dc299b1
https://pubmed.ncbi.nlm.nih.gov/26505788

المؤلفون: Willy Lemstra, Martha Ritsema, Ody C. M. Sibon, Harm H. Kampinga, Anil Rana, Petra E van der Wouden, Floris Bosveld

المساهمون: Depatment of Developmental Biology and Genetics, CNRS UMR 3215/INSERM U934, Institut Curie, PSL Research University, Paris 75248, France, Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

المصدر: Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2008, 17 (13), pp.2058-2069. ⟨10.1093/hmg/ddn105⟩
Human Molecular Genetics, 17(13), 2058-2069. Oxford University Press

مصطلحات موضوعية: Central Nervous System, Male, [SDV]Life Sciences [q-bio], medicine.disease_cause, DOUBLE-STRAND BREAKS, KINASE-ASSOCIATED NEURODEGENERATION, chemistry.chemical_compound, COENZYME-A BIOSYNTHESIS, 0302 clinical medicine, Drosophila Proteins, PANTOTHENATE KINASE, Peptide Synthases, Genetics (clinical), ComputingMilieux_MISCELLANEOUS, LIFE-SPAN, 0303 health sciences, Mutation, biology, Neurodegeneration, General Medicine, Catalase, HALLERVORDEN-SPATZ-SYNDROME, Phosphotransferases (Alcohol Group Acceptor), Drosophila melanogaster, Biochemistry, Pantothenate kinase, Female, COMPARATIVE GENOMICS, Thioredoxin-Disulfide Reductase, MITOCHONDRIAL DYSFUNCTION, Cell Survival, Coenzyme A, Motor Activity, Evolution, Molecular, 03 medical and health sciences, BRAIN IRON ACCUMULATION, Drosophilidae, Genetics, medicine, Animals, Molecular Biology, 030304 developmental biology, Superoxide Dismutase, STRESS RESISTANCE, DNA, medicine.disease, biology.organism_classification, PANK2, Cyclic AMP-Dependent Protein Kinases, Biosynthetic Pathways, Rats, chemistry, Reactive Oxygen Species, 030217 neurology & neurosurgery, Genetic screen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b585263830f5435780936ff2df65e00
https://hal.archives-ouvertes.fr/hal-02989092

المؤلفون: Martijn R. H. Zwinderman (11510961), Thamar Jessurun Lobo (11510964), Petra E. van der Wouden (6615692), Diana C. J. Spierings (11510967), Marcel A. T. M. van Vugt (8938931), Peter M. Lansdorp (8164044), Victor Guryev (9901), Frank J. Dekker (1514791)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Cancer, Inorganic Chemistry, Mental Health, Biological Sciences not elsewhere classified, previously reported effects, p53 inactivation inverted, molecular mechanisms balancing, lagging strand synthesis, lagging strand machinery, replication stress induced, parental chromatin proteins, chromatin proteins inverts, leading strand polymerase, new chromatin proteins, chromatin proteins, strand replicated, replication protein, wide distribution, sister chromatids, related protein, preferentially found, equal amounts, dna replicated, curaxin treatment, control conditions

Relation: https://figshare.com/articles/journal_contribution/Deposition_Bias_of_Chromatin_Proteins_Inverts_under_DNA_Replication_Stress_Conditions/16715370

الاتاحة: https://doi.org/10.1021/acschembio.1c00321.s001