المؤلفون: Kevin D. Dykstra (1738981), Eric Streckfuss (1367958), Min Liu (45756), Jian Liu (33711), Younong Yu (1398901), Ming Wang (172316), Joseph A. Kozlowski (1398850), Robert W. Myers (3010719), Alexei V. Buevich (1433287), Milana M. Maletic (9514661), Petr Vachal (1445962), Shane W. Krska (1339053)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Pharmacology, Inorganic Chemistry, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, histone deacetylase, testing, microgram scale, CAD, aerosol detection, material requirements, Microscale Workflow, HPLC, approach, workflow, library synthesis, chemistry techniques, HDAC Inhibitor Libraries, high-throughput experimentation, compound libraries

Relation: https://figshare.com/articles/journal_contribution/Synthesis_of_HDAC_Inhibitor_Libraries_via_Microscale_Workflow/13770448

الاتاحة: https://doi.org/10.1021/acsmedchemlett.0c00596.s001

المؤلفون: Chi “Chip” Le, Michael K. Wismer, Zhi-Cai Shi, Rui Zhang, Donald V. Conway, Guoqing Li, Petr Vachal, Ian W. Davies, David W. C. MacMillan

المصدر: ACS Central Science, Vol 3, Iss 6, Pp 647-653 (2017)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2374-7943; https://doaj.org/toc/2374-7951

URL الوصول: https://doaj.org/article/355e301843374f69939e53056a9ec5f8

المؤلفون: Shane W. Krska, Sriram Tyagarajan, Deodial Guiadeen, Eric Streckfuss, Xiaolei Gao, Alexei V. Buevich, George Doss, Jian Liu, Petr Vachal

المصدر: Synlett. 33:1259-1265

مصطلحات موضوعية: Organic Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::93fa372b4b2a7b9f22bfd3c4fdcca4e7
https://doi.org/10.1055/s-0040-1719923

المؤلفون: Douglas G. Johns, Louis-Charles Campeau, Puja Banka, An Bautmans, Tjerk Bueters, Elisabetta Bianchi, Danila Branca, Paul G. Bulger, Inne Crevecoeur, Fa-Xiang Ding, Robert M. Garbaccio, Erik D. Guetschow, Yan Guo, Sookhee N. Ha, Jennifer M. Johnston, Hubert Josien, Eunkyung A. Kauh, Kenneth A. Koeplinger, Jeffrey T. Kuethe, Eseng Lai, Christine L. Lanning, Anita Y.H. Lee, Li Li, Anilkumar G. Nair, Edward A. O’Neill, S. Aubrey Stoch, David A. Thaisrivongs, Thomas J. Tucker, Petr Vachal, Kristien van Dyck, Frederic P. Vanhoutte, Bram Volckaert, Dennis G. Wolford, Andy Xu, Tian Zhao, Dan Zhou, Susan Zhou, Xiaohong Zhu, Hratch J. Zokian, Abbas Walji, Harold B. Wood

المصدر: Circulation.

مصطلحات موضوعية: Physiology (medical), Cardiology and Cardiovascular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6f19bd0c61c330917293f0ae4cf3d908
https://doi.org/10.1161/circulationaha.122.063372

المؤلفون: Robert O. Blaustein, Georgy Hartmann, Guiquan Liu, Dennis Leung, Beth Ann Murphy, Sriram Tyagarajan, Yingju Xu, Zhijian Lu, Jian Liu, Louis-Charles Campeau, Sheng-Ping Wang, Daniel Metzger, Joseph L. Duffy, Qinghao Chen, Josee Cote, Rupesh P. Amin, Debra Ondeyka, Jianming Bao, Wanying Sun, Yi-Heng Chen, Peter J. Sinclair, Concetta Lipardi, Feng Ye, Douglas G. Johns, Katipally Revathi Reddy, Petr Vachal, Kaushik Mitra, Gordon K. Wollenberg, Shao Pengcheng Patrick, Kake Zhao, Lushi Tan

المصدر: Journal of Medicinal Chemistry. 64:13215-13258

مصطلحات موضوعية: Statin, medicine.drug_class, Coronary Disease, Pharmacology, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Anacetrapib, In vivo, Drug Discovery, Cholesterylester transfer protein, medicine, Animals, Humans, Rats, Wistar, Adverse effect, CETP inhibitor, Oxazolidinones, Molecular Structure, biology, Chemistry, Drug discovery, Anticholesteremic Agents, Macaca mulatta, Cholesterol Ester Transfer Proteins, Mice, Inbred C57BL, biology.protein, Molecular Medicine, lipids (amino acids, peptides, and proteins), Lipoprotein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::573c5ff3dfab385ab49a4f550abe8129
https://doi.org/10.1021/acs.jmedchem.1c00959

المؤلفون: Alexei V. Buevich, Ming Wang, Shane W. Krska, Milana Maletic, Min Liu, Eric Streckfuss, Younong Yu, Robert W. Myers, Jian Liu, Petr Vachal, Kevin D. Dykstra, Joseph A. Kozlowski

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Biological data, Preparative hplc, 010405 organic chemistry, Computer science, Organic Chemistry, Computational biology, Material requirements, 01 natural sciences, Biochemistry, Biological Testing, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Workflow, Drug Discovery, HDAC inhibitor, Microscale chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e258e2554547baddad36c5f86e745eda
https://doi.org/10.1021/acsmedchemlett.0c00596

المؤلفون: Kaushik Mitra, Anne-Marie Cumiskey, Beth Ann Murphy, Qiaolin Deng, Deodial Guiadeen, Douglas G. Johns, Wanying Sun, Joseph L. Duffy, Arto D. Krikorian, Ruth A. Duffy, Patrick P. Shao, Petr Vachal, Jian Liu

المصدر: Bioorganicmedicinal chemistry letters. 32

مصطلحات موضوعية: Very low-density lipoprotein, Apolipoprotein B, Clinical Biochemistry, Pharmaceutical Science, Mice, Transgenic, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Bridged Bicyclo Compounds, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, Cholesterylester transfer protein, Animals, Humans, Urea, Molecular Biology, Sulfamide, Dyslipidemias, Sulfonamides, Bicyclic molecule, biology, 010405 organic chemistry, Anticholesteremic Agents, Organic Chemistry, Cholesterol, HDL, 0104 chemical sciences, Cholesterol Ester Transfer Proteins, carbohydrates (lipids), 010404 medicinal & biomolecular chemistry, chemistry, Cyclization, biology.protein, Molecular Medicine, lipids (amino acids, peptides, and proteins), Lipoprotein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da9a02fbe73b1ba256c4a4723c4306f
https://pubmed.ncbi.nlm.nih.gov/33161125

المؤلفون: Li-Kang Zhang, Younong Yu, Steven L. Colletti, Alexei V. Buevich, Haiqun Tang, Guoqing Li, Zhi-Cai Shi, Petr Vachal

المصدر: Journal of the American Chemical Society. 140:6797-6800

مصطلحات موضوعية: chemistry.chemical_classification, Peptide modification, Bioconjugation, 010405 organic chemistry, Chemistry, Molecular Conformation, Tryptophan, Proteins, Peptide, General Chemistry, Conjugated system, Photochemical Processes, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, Colloid and Surface Chemistry, Amide, Michael reaction, Chemoselectivity, Peptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d3349ea2021360c4907ac2ceef7a75
https://doi.org/10.1021/jacs.8b03973

المؤلفون: Michael K. Wismer, Steven L. Colletti, Zhi-Cai Shi, Petr Vachal, Guoqing Li, Rui Zhang

المصدر: ACS Medicinal Chemistry Letters. 9:773-777

مصطلحات موضوعية: chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Aryl, Organic Chemistry, Photoredox catalysis, Halide, 010402 general chemistry, 01 natural sciences, Biochemistry, Medicinal chemistry, 0104 chemical sciences, Catalysis, Reaction rate, chemistry.chemical_compound, Drug Discovery, Photocatalysis, Alkyl

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8d924b6750b29ed8086fab7098f70eb0
https://doi.org/10.1021/acsmedchemlett.8b00183

المؤلفون: Petr Vachal (1445962), Joseph L. Duffy (1601548), Louis-Charles Campeau (1392772), Rupesh P. Amin (11256557), Kaushik Mitra (1445974), Beth Ann Murphy (1445965), Pengcheng P. Shao (1884841), Peter J. Sinclair (2193679), Feng Ye (173489), Revathi Katipally (11256560), Zhijian Lu (2193661), Debra Ondeyka (11256563), Yi-Heng Chen (2952183), Kake Zhao (1445980), Wanying Sun (1927315), Sriram Tyagarajan (1580329), Jianming Bao (2125180), Sheng-Ping Wang (1463758), Josee Cote (11256566), Concetta Lipardi (7905071), Daniel Metzger (363813), Dennis Leung (5987798), Georgy Hartmann (11256569), Gordon K. Wollenberg (11256572), Jian Liu (33711), Lushi Tan (1433473), Yingju Xu (1923742), Qinghao Chen (1367955), Guiquan Liu (2812297), Robert O. Blaustein (11256575), Douglas G. Johns (1445989)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, guide optimization informed, coronary heart disease, clinical outcomes trial, reduced chd risk, risk reduction, clinical evidence, vivo paradigms, statin ), represents one, present preclinical, key regulators, inhibitor backup, including high, density lipoprotein, critical understanding, class molecule

Relation: https://figshare.com/articles/dataset/Invention_of_MK-8262_a_Cholesteryl_Ester_Transfer_Protein_CETP_Inhibitor_Backup_to_Anacetrapib_with_Best-in-Class_Properties/15144548

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00959.s001

المؤلفون: Michael K. Wismer, Guoqing Li, Zhi-Cai Shi, Rui Zhang, David W. C. MacMillan, Donald V. Conway, Petr Vachal, Chi Chip Le, Ian W. Davies

المصدر: ACS Central Science, Vol 3, Iss 6, Pp 647-653 (2017)
ACS Central Science

مصطلحات موضوعية: Protocol (science), Standardization, 010405 organic chemistry, business.industry, Chemistry, General Chemical Engineering, Scale (chemistry), Nanotechnology, General Chemistry, 010402 general chemistry, 7. Clean energy, 01 natural sciences, 0104 chemical sciences, lcsh:Chemistry, Chemical energy, Acceleration, chemistry.chemical_compound, lcsh:QD1-999, Photocatalysis, Photon capture, Organic synthesis, Process engineering, business, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199e8ac83a8b0946f30782e79f682bf2
https://doaj.org/article/355e301843374f69939e53056a9ec5f8

المؤلفون: Robert J. De Vita, Zhi-Cai Shi, Bindhu V. Karanam, Beth Ann Murphy, Shuwen He, Tianying Jian, Christine C. Chung, Maria Madeira, Qingmei Hong, Tim Cernak, Ravi P. Nargund, James M. Balkovec, Donald M. Sperbeck, Min Liu, Andreas Verras, Judyann Wiltsie, Jian Liu, Lisa M. Sonatore, Sharon Tong, Shirly Pinto, Deodial Guiadeen, Michael Wolff, Zhicai Wu, Dong-Ming Shen, Arto D. Krikorian, Yang Yu, Judith N. Gorski, Petr Vachal, Jianying Xiao, Jinqi Liu, Zhong Lai

المصدر: Bioorganicmedicinal chemistry letters. 29(11)

مصطلحات موضوعية: Library design, Benzimidazole, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Chemistry, Pharmaceutical, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, Medicinal chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Molecular Medicine, Humans, Benzimidazoles, Diacylglycerol O-Acyltransferase, Enzyme Inhibitors, Molecular Biology, Diacylglycerol kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0380ff27cfdf10ca6e079a9a149965
https://pubmed.ncbi.nlm.nih.gov/30952592

المؤلفون: Jinchu Liu, Maarten Hoek, Qiang Tan, Andreas Verras, Don Gauthier, Tim Cernak, Kevin D. Dykstra, Anthony Ogawa, Yun-Fang Yang, Shane W. Krska, Robert J. DeVita, Dong-Ming Shen, Beata Zamlynny, Thomas Bateman, Ravi Kurukulasuriya, Yili Chen, Lisa DiMichelle, Kun Liu, Alejandro Crespo, Petr Vachal, Jeffrey Madwed, Kendall N. Houk

المصدر: Bioorganicmedicinal chemistry letters. 29(14)

مصطلحات موضوعية: Indazole, Indazoles, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Clinical Biochemistry, Late stage, Pharmaceutical Science, Metabolic stability, 01 natural sciences, Biochemistry, Borylation, Combinatorial chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Mineralocorticoid receptor, Drug Development, Drug Discovery, Molecular Medicine, Surface modification, Molecular Biology, Mineralocorticoid Receptor Antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9397cb2536275f111ddd3b473f58897d
https://pubmed.ncbi.nlm.nih.gov/31104995

المؤلفون: Rui, Zhang, Guoqing, Li, Michael, Wismer, Petr, Vachal, Steven L, Colletti, Zhi-Cai, Shi

المصدر: ACS medicinal chemistry letters. 9(7)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::cead554b7f9b9a62d49f8780d4653e5f
https://pubmed.ncbi.nlm.nih.gov/30034617

المؤلفون: Daniel A. DiRocco, Bing Li, Spencer D. Dreher, Shane W. Krska, Tim Cernak, Eric Streckfuss, Peter S. Kutchukian, Ian W. Davies, Petr Vachal, James F. Dropinski, Louis-Charles Campeau, Kevin D. Dykstra

المصدر: Chem. Sci.. 7:2604-2613

مصطلحات موضوعية: 010405 organic chemistry, Chemistry, business.industry, Nanotechnology, General Chemistry, 010402 general chemistry, Machine learning, computer.software_genre, 01 natural sciences, 0104 chemical sciences, Visualization, Cheminformatics, Artificial intelligence, Chemistry (relationship), business, computer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3bcd64675da33d4e536cbac82c269c4b
https://doi.org/10.1039/c5sc04751j

المؤلفون: Kevin P. Bateman, Spencer D. Dreher, Yong Liu, Ian W. Davies, Zhi-Cai Shi, Tim Cernak, Christopher J. Welch, Erik L. Regalado, Tony Pereira, Roy Helmy, Jonathan Schneeweis, Louis-Charles Campeau, Simon Berritt, Alexander Buitrago Santanilla, Petr Vachal, Michael Shevlin, Philippe G. Nantermet

المصدر: Science. 347:49-53

مصطلحات موضوعية: High throughput chemistry, chemistry.chemical_compound, Multidisciplinary, Natural product, Chemistry, Drug discovery, Scale (chemistry), Molecule, Nanotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c2fc5f0c9b37a015f4ea6f9a68db07fd
https://doi.org/10.1126/science.1259203

المؤلفون: James M. Balkovec, Kevin D. Dykstra, Beth Ann Murphy, Edward C. Sherer, Donald M. Sperbeck, Claire Lee, Tim Cernak, James Cuff, Jeffrey T. Kuethe, Ravi P. Nargund, Andreas Verras, Zhi-Cai Shi, Spencer D. Dreher, Shuwen He, Maud Reiter, Petr Vachal, Stephen D. Goble, Dong-Ming Shen, Zhicai Wu, Yang Yu, Robert J. DeVita, Nicholas Perrotto, Steven Williams, Lisa M. Sonatore, Shirly Pinto, Nathan J. Gesmundo, Maria Madeira

المصدر: Journal of medicinal chemistry. 60(9)

مصطلحات موضوعية: Benzimidazole, 010405 organic chemistry, Drug discovery, Proton Magnetic Resonance Spectroscopy, Nanotechnology, 010402 general chemistry, 01 natural sciences, Mass Spectrometry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Drug Discovery, Molecular Medicine, Diacylglycerol Acyltransferase, Diacylglycerol O-Acyltransferase, Enzyme Inhibitors, Microscale chemistry, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572283ae6d3dcf65fa072d0c3033562b
https://pubmed.ncbi.nlm.nih.gov/28252959

المؤلفون: Karen O. Akinsanya, Daphne Szeto, David G. McLaren, Andrew Gewain, Stephen F. Previs, Keiana Dunn, Kelly Albanese, Alison A. Kulick, Gail Forrest, Petr Vachal, Xi Ai, Douglas G. Johns, M. Donnelly, Dan Xie, Michele A. Cleary, Ying Chen, Hayes M. Dansky, Harmony Lederman, Thomas P. Roddy, Kristian K. Jensen, Cesaire Gai

المصدر: European Journal of Pharmacology. 740:410-416

مصطلحات موضوعية: Male, medicine.medical_specialty, Statin, medicine.drug_class, Coronary artery disease, chemistry.chemical_compound, Anacetrapib, Internal medicine, Cholesterylester transfer protein, medicine, Animals, CETP inhibitor, Oxazolidinones, Triglycerides, Pharmacology, biology, Cholesterol, business.industry, Anticholesteremic Agents, PCSK9, Cholesterol, HDL, Serine Endopeptidases, Cholesterol, LDL, medicine.disease, Macaca mulatta, Cholesterol Ester Transfer Proteins, Apolipoproteins, Endocrinology, chemistry, biology.protein, lipids (amino acids, peptides, and proteins), Proprotein Convertases, business, Chylomicron

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc0878eb8dfc3254f78bd45da66f2846
https://doi.org/10.1016/j.ejphar.2014.04.015

المؤلفون: Ian W. Davies, Spencer D. Dreher, Ana Bellomo, Sophia M. Manolikakes, Keith P. Moore, Ray T. McClain, Cheol K. Chung, Peter S. Kutchukian, Petr Vachal, Philippe G. Nantermet, Thomas J. Greshock, Mario Ellwart, Zhengwei Peng, Paul Knochel

المصدر: Angewandte Chemie (International ed. in English). 55(44)

مصطلحات موضوعية: Principal Component Analysis, Molecular Structure, Chemistry, Negishi coupling, 010405 organic chemistry, Pyridines, Hochdurchsatz screening, General Chemistry, General Medicine, 010402 general chemistry, 01 natural sciences, Catalysis, 0104 chemical sciences, High-Throughput Screening Assays, Zinc, Reagent, Electrophile, Organometallic Compounds, Organic chemistry, Molecule, Reactivity (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f46dda6b7a8a8e4f11d35aff39e0c7
https://pubmed.ncbi.nlm.nih.gov/27690172

المؤلفون: Petr Vachal, Tim Cernak, Shane W. Krska, Kevin D. Dykstra, Sriram Tyagarajan

المصدر: ChemInform. 47

مصطلحات موضوعية: Chemistry, Drug discovery, Chemical biology, Late stage, Molecule, Surface modification, Nanotechnology, General Medicine, Toolbox

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::92c60f836534a2508bf67e1805023965
https://doi.org/10.1002/chin.201613254