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1
المؤلفون: Pier F. Cirillo, Susan Pav, John R. Regan, L. Churchill, Eugene R. Hickey, A. G. Graham, Liang Tong, Gilmore Thomas A, Neil Moss, Peter M. Grob, Christopher Pargellis
المصدر: Nature Structural Biology. 9:268-272
مصطلحات موضوعية: Models, Molecular, Time Factors, Protein Conformation, Amino Acid Motifs, Allosteric regulation, Naphthalenes, Mitogen-activated protein kinase kinase, Crystallography, X-Ray, p38 Mitogen-Activated Protein Kinases, Biochemistry, Cell Line, Substrate Specificity, MAP2K7, Inhibitory Concentration 50, Structural Biology, Genetics, Humans, c-Raf, Enzyme Inhibitors, biology, MAP kinase kinase kinase, Cyclin-dependent kinase 2, Kinetics, Allosteric enzyme, biology.protein, Pyrazoles, Cyclin-dependent kinase 9, Mitogen-Activated Protein Kinases, Allosteric Site, Protein Binding
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2
المؤلفون: Peter M. Grob, Janice R. Brickwood, Cheng-Kon Shih, Maryann Hoermann, Julian Adams, Racheline Schwartz, Daniel Pauletti, Eva David, David A. Erickson, Kevin Barringer, Charles L. Cywin, David Joseph, Susan E. Hattox, Janice M. Klunder, Christopher L. Sorge
المصدر: Journal of Medicinal Chemistry. 41:2960-2971
مصطلحات موضوعية: Nevirapine, Pyridines, Mutant, In Vitro Techniques, Antiviral Agents, Structure-Activity Relationship, Drug Discovery, medicine, Humans, Potency, Cell Line, Transformed, chemistry.chemical_classification, biology, Chemistry, Wild type, Drug Resistance, Microbial, Azepines, Nucleotidyltransferase, Virology, HIV Reverse Transcriptase, Reverse transcriptase, Enzyme, Amino Acid Substitution, Enzyme inhibitor, Mutation, HIV-1, Microsomes, Liver, biology.protein, Reverse Transcriptase Inhibitors, Molecular Medicine, medicine.drug
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3
المؤلفون: David D. Ho, Yunzhen Cao, Joseph W. Pav, Julian Adams, Elizabeth Muchmore, Steve Norris, Peter M. Grob, Cheng-Kon Shih
المصدر: Nature Medicine. 3:665-670
مصطلحات موضوعية: Time Factors, Nevirapine, Pan troglodytes, Anti-HIV Agents, Pyridines, HIV Infections, Viremia, HIV Antibodies, Biology, Peripheral blood mononuclear cell, General Biochemistry, Genetics and Molecular Biology, Tetanus Toxoid, medicine, Animals, Phytohemagglutinins, Dna viral, Seroconversion, General Medicine, medicine.disease, Virology, Reverse transcriptase, Regimen, DNA, Viral, Immunology, HIV-1, Leukocytes, Mononuclear, RNA, Viral, Reverse Transcriptase Inhibitors, Tetradecanoylphorbol Acetate, Nested polymerase chain reaction, medicine.drug
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4
المؤلفون: L. Churchill, Peter M. Grob, D. Pauletti, C-K. Shih, Peter R. Farina, A. G. Graham
المصدر: InflammoPharmacology. 4:125-135
مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Naproxen, Chemistry, Immunology, Sf9, Piroxicam, Meloxicam, Diclofenac, Enzyme, medicine, Microsome, Pharmacology (medical), medicine.drug, Nimesulide
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5
المؤلفون: Eva David, Mcneil Daniel W, Julian Adams, John R. Proudfoot, Mario G. Cardozo, Atul Agarwal, Usha R. Patel, Karl D. Hargrave, Peter M. Grob, Terence A. Kelly
المصدر: Journal of Medicinal Chemistry. 38:4839-4847
مصطلحات موضوعية: Models, Molecular, chemistry.chemical_classification, Nevirapine, biology, Pyridines, Stereochemistry, Mutant, Molecular Conformation, Wild type, Nucleotidyltransferase, Reverse transcriptase, Structure-Activity Relationship, Enzyme, chemistry, Enzyme inhibitor, Drug Discovery, HIV-1, medicine, biology.protein, Humans, Reverse Transcriptase Inhibitors, Molecular Medicine, Nucleoside, medicine.drug
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6
المؤلفون: Thomas C. Warren, Deborah E.H. Palladino, Peter M. Grob, Suresh R. Kapadia, Kenneth A. Cohen, Jerry L. Hopkins, Richard H. Ingraham, James M. Stevenson, Glenn J. Van Moffaert
المصدر: Journal of Chromatography A. 676:99-112
مصطلحات موضوعية: chemistry.chemical_classification, Chromatography, Nevirapine, biology, Chemistry, Protein subunit, Organic Chemistry, Peptide, General Medicine, Biochemistry, Reverse transcriptase, Analytical Chemistry, Amino acid, A-site, biology.protein, medicine, Binding site, Polymerase, medicine.drug
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7
المؤلفون: Mario G. Cardozo, Terence A. Kelly, A. Agarwal, Mcneil Daniel W, K. D. Hargrave, John R. Proudfoot, Usha R. Patel, Peter M. Grob, Julian Adams, Eva David
المصدر: ChemInform. 27
مصطلحات موضوعية: Nevirapine, Chemistry, Stereochemistry, Human immunodeficiency virus (HIV), medicine, General Medicine, medicine.disease_cause, Nucleoside, Virology, Reverse transcriptase, medicine.drug
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8
المؤلفون: Sorcek Ronald J, Simon J. Coutts, L. Churchill, Eva David, Mcneil Daniel W, Gunter Trummlitz, Hin-Chor Wong, Peter M. Grob, Ian Potocki, Hans Meier, Matt Aaron Tschantz, Wolfhard Engel, Lazer Edward S, Miao Clara K, A. G. Graham, Terence A. Kelly, Charles L. Cywin, Maryann Hoermann, Zhaoxing Meng, Roger J. Snow
المصدر: Journal of medicinal chemistry. 40(6)
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, medicine.drug_class, Stereochemistry, Thiazines, Carboxamide, Pharmacology, Piroxicam, Meloxicam, Chemical synthesis, Substrate Specificity, Structure-Activity Relationship, Drug Discovery, medicine, Potency, Structure–activity relationship, Humans, Cyclooxygenase Inhibitors, biology, Cyclooxygenase 2 Inhibitors, Molecular Structure, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Membrane Proteins, Recombinant Proteins, Isoenzymes, Thiazoles, Enzyme inhibitor, Cyclooxygenase 2, Prostaglandin-Endoperoxide Synthases, biology.protein, Cyclooxygenase 1, Molecular Medicine, Selectivity, medicine.drug
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9
المؤلفون: Peter M. Grob, Richard H. Ingraham, Tari L. Mctague, Cheng-Kon Shih, Vincent J. Merluzzi, Joe C. Wu, Karl D. Hargrave, Kenneth A. Cohen
المصدر: AIDS research and human retroviruses. 8(2)
مصطلحات موضوعية: Nevirapine, Pyridines, Immunology, Molecular Sequence Data, Substrate Specificity, Structure-Activity Relationship, Virology, medicine, Animals, Humans, Amino Acid Sequence, Binding site, chemistry.chemical_classification, Binding Sites, biology, Active site, Drug Resistance, Microbial, Azepines, Reverse transcriptase, Infectious Diseases, Enzyme, chemistry, Mechanism of action, Biochemistry, Enzyme inhibitor, biology.protein, HIV-1, Mutagenesis, Site-Directed, Reverse Transcriptase Inhibitors, medicine.symptom, Nucleoside, medicine.drug
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10
المؤلفون: Peter M. Grob, Anthony Shrutkowski, John Miglietta, Mark T. Skoog, Elizabeth B. Kopp, Cheng-Kon Shih
مصطلحات موضوعية: chemistry.chemical_classification, Base Sequence, Stereochemistry, Pyridines, Molecular Sequence Data, Processivity, Templates, Genetic, Biology, Molecular biology, Reverse transcriptase, A-site, Kinetics, chemistry, Genetics, HIV-1, RNA, Viral, Reverse Transcriptase Inhibitors, Nucleotide, Electrophoresis, Polyacrylamide Gel, Enzyme kinetics, Steady state (chemistry), Nevirapine, Binding site, Nucleoside
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11
المؤلفون: Ian Potocki, Jerry W. Skiles, Joe C. Wu, Peter R. Farina, Peter M. Grob, Julian Adams, Palayakotai Raghavan, Clark Perry, John R. Proudfoot, Thomas C. Warren
المصدر: Biochemistry. 30(8)
مصطلحات موضوعية: Stereochemistry, DNA polymerase, Pyridines, Biochemistry, Antiviral Agents, Structure-Activity Relationship, Non-competitive inhibition, medicine, Escherichia coli, Leukocytes, Humans, Nevirapine, Binding site, Polymerase, chemistry.chemical_classification, Binding Sites, biology, Affinity Labels, RNA-Directed DNA Polymerase, Blood Proteins, Reverse transcriptase, Recombinant Proteins, Kinetics, Enzyme, Mechanism of action, chemistry, Enzyme inhibitor, biology.protein, HIV-1, Reverse Transcriptase Inhibitors, medicine.symptom, Protein Binding
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12
المؤلفون: Pier F. Cirillo, Susan Pav, John R. Regan, L. Churchill, Eugene R. Hickey, A. G. Graham, Liang Tong, Gilmore Thomas A, Neil Moss, Peter M. Grob, Christopher Pargellis
المصدر: Acta Crystallographica Section A Foundations of Crystallography. 58:c231-c231
مصطلحات موضوعية: biology, MAP kinase kinase kinase, Structural Biology, Chemistry, p38 mitogen-activated protein kinases, Mitogen-activated protein kinase, Allosteric regulation, biology.protein, Cell biology
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13
المؤلفون: K. D. Hargrave, J. Klunder, Peter M. Grob, M. Cardozo, Cheng-Kon Shih, Julian Adams, L. Tong, J. Proudfoot
المصدر: Antiviral Research. 20:97
مصطلحات موضوعية: Pharmacology, Chemistry, Virology, Human immunodeficiency virus (HIV), medicine, medicine.disease_cause, Reverse transcriptase, Nucleoside binding
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14
المؤلفون: Kailash C. Chadha, Peter M. Grob
المصدر: Cell Biology International Reports. 3:663-669
مصطلحات موضوعية: Poly U, Sodium, Newcastle disease virus, chemistry.chemical_element, Chromatography, Affinity, Sepharose, chemistry.chemical_compound, Interferon, Leukocytes, medicine, Humans, Binding site, Binding Sites, Elution, Polyribonucleotides, Cell Biology, Hydrogen-Ion Concentration, chemistry, Biochemistry, Poly I, Ionic strength, Interferons, Poly A, Ethylene glycol, medicine.drug
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15
المؤلفون: Kailash C. Chadha, Peter M. Grob
المصدر: Biochemistry. 18:5782-5786
مصطلحات موضوعية: Newcastle disease virus, Biochemistry, General Biochemistry, Genetics and Molecular Biology, Chromatography, Affinity, Vesicular stomatitis Indiana virus, Neutralization, Epitopes, chemistry.chemical_compound, History and Philosophy of Science, Species Specificity, Affinity chromatography, Interferon, Concanavalin A, Leukocytes, medicine, Humans, Immunoassay, Gel electrophoresis, Chromatography, biology, General Neuroscience, Lectin, Tunicamycin, Molecular biology, Molecular Weight, chemistry, biology.protein, Agarose, Interferons, medicine.drug
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16
المؤلفون: Peter M. Grob, Kailash C. Chadha
مصطلحات موضوعية: Gel electrophoresis, Interferon inducer, Chromatography, biology, Size-exclusion chromatography, chemistry.chemical_compound, chemistry, Biochemistry, Affinity chromatography, Concanavalin A, Interferon, biology.protein, medicine, Agarose, Sodium dodecyl sulfate, medicine.drug
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17
المؤلفون: Catherine H. Berlot, Mark Bothwell, Peter M. Grob
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 80(22)
مصطلحات موضوعية: Affinity label, Adrenal Gland Neoplasms, Receptors, Cell Surface, Pheochromocytoma, Receptors, Nerve Growth Factor, Biology, Cell Line, chemistry.chemical_compound, Animals, Humans, Nerve Growth Factors, Receptor, Polyacrylamide gel electrophoresis, Melanoma, Gel electrophoresis, Multidisciplinary, Affinity labeling, Affinity Labels, Tunicamycin, Molecular biology, Wheat germ agglutinin, Rats, Molecular Weight, Nerve growth factor, Cross-Linking Reagents, chemistry, Biochemistry, nervous system, biology.protein, Research Article