المؤلفون: Rebecca C. S. Edgar, Tess R. Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A. Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D. Suraweera, Ric N. Price, Sergio Wittlin, Vicky M. Avery, Nyssa Drinkwater, Susan A. Charman, Darren J. Creek, Tania F. de Koning-Ward, Peter J. Scammells, Sheena McGowan

المصدر: mBio, Vol 15, Iss 6 (2024)

مصطلحات موضوعية: malaria, drug resistance, aminopeptidase, Plasmodium falciparum, Plasmodium vivax, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2150-7511

URL الوصول: https://doaj.org/article/2d940180a1bd41efa98e153bebf7c041

المؤلفون: Rebecca CS Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren J Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward

المصدر: eLife, Vol 11 (2022)

مصطلحات موضوعية: P. falciparum, hemoglobin digestion, aminopeptidase, drug target, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://elifesciences.org/articles/80813; https://doaj.org/toc/2050-084X

URL الوصول: https://doaj.org/article/0679868db9304f46bdc0d01432a2d431

المؤلفون: Scott A. Hollingsworth, Brendan Kelly, Celine Valant, Jordan Arthur Michaelis, Olivia Mastromihalis, Geoff Thompson, A. J. Venkatakrishnan, Samuel Hertig, Peter J. Scammells, Patrick M. Sexton, Christian C. Felder, Arthur Christopoulos, Ron O. Dror

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/a0e90ef319f249dd8f9b3fd6b23a0233

المؤلفون: Matthew C. L. Wakeham (11836887), Briana J. Davie (11836890), David K. Chalmers (1455451), Arthur Christopoulos (538751), Ben Capuano (1435147), Celine Valant (1583104), Peter J. Scammells (694050)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Evolutionary Biology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, muscarinic acetylcholine receptors, machr responses compared, restoring nonselective agonism, methoxybenzyl )- 4, ligands possessed noticeable, possible allosteric interaction, machr selective agonists, machr subtypes suggests, 1 -( 4, 4 , efficacy selective agonists, 1 , 5 , selective agonism, machr subtypes, n <, hybrid ligands, allosteric site, allosteric pharmacophore, machr selectivity

Relation: https://figshare.com/articles/journal_contribution/Structural_Features_of_Iperoxo_BQCA_Muscarinic_Acetylcholine_Receptor_Hybrid_Ligands_Determining_Subtype_Selectivity_and_Efficacy/17203743

الاتاحة: https://doi.org/10.1021/acschemneuro.1c00572.s001

المؤلفون: Eleonora Comeo (8270664), Phuc Trinh (10312494), Anh T. Nguyen (7865891), Cameron J. Nowell (735904), Nicholas D. Kindon (2393749), Mark Soave (8270667), Leigh A. Stoddart (1451152), Jonathan M. White (1366602), Stephen J. Hill (481670), Barrie Kellam (1280532), Michelle L. Halls (1372671), Lauren T. May (1684459), Peter J. Scammells (694050)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Inorganic Chemistry, Infectious Diseases, Plant Biology, Computational Biology, Chemical Sciences not elsewhere classified, equilibrium ligand binding parameters, functionalized, series, receptor distribution patterns, 1 AR, understanding, TIRF, 1-yl xanthine scaffolds, 1 AR pharmacology, 1 AR-selective, GPCR

Relation: https://figshare.com/articles/journal_contribution/Development_and_Application_of_Subtype-Selective_Fluorescent_Antagonists_for_the_Study_of_the_Human_Adenosine_A_sub_1_sub_Receptor_in_Living_Cells/14224290

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02067.s001

المؤلفون: Tim J. Fyfe, Peter J. Scammells, J. Robert Lane, Ben Capuano

المصدر: Molecules; Volume 26; Issue 13; Pages: 3799

مصطلحات موضوعية: dopamine D 1 receptor, positive allosteric modulator, PAM, G protein-coupled receptors, synthetic medicinal chemistry, pharmacological evaluation, enantioenriched, chiral auxiliary, cAMP BRET

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Medicinal Chemistry; https://dx.doi.org/10.3390/molecules26133799

الاتاحة: https://doi.org/10.3390/molecules26133799

المؤلفون: Owindeep Deo, Sadia Alvi, Vi Pham, Arthur Christopoulos, David M. Thal, Manuela Jörg, Ben Capuano, Celine Valant, Peter J. Scammells

المصدر: Journal of Medicinal Chemistry. 65:12367-12385

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::364a539930cda1616d78dd8b368e75d7
https://doi.org/10.1021/acs.jmedchem.2c01061

المؤلفون: Jon Kyle Awalt, Anh T.N. Nguyen, Tim J. Fyfe, Bui San Thai, Paul J. White, Arthur Christopoulos, Manuela Jörg, Lauren T. May, Peter J. Scammells

المصدر: Journal of Medicinal Chemistry. 65:9076-9095

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9d8429a945b8d6183a3d736c910f0b02
https://doi.org/10.1021/acs.jmedchem.2c00320

المؤلفون: Erin Tay, Tri-Hung Nguyen, Leigh Ford, Hywel D. Williams, Hassan Benameur, Peter J. Scammells, Christopher J. H. Porter

المصدر: Pharmaceutics; Volume 12; Issue 1; Pages: 17

مصطلحات موضوعية: ionic liquid, lipophilic salt, drug delivery, drug absorption, poorly water-soluble drug, lumefantrine, lipid-based formulation, SEDDS, lipid formulation classification system

وصف الملف: application/pdf

Relation: Physical Pharmacy and Formulation; https://dx.doi.org/10.3390/pharmaceutics12010017

الاتاحة: https://doi.org/10.3390/pharmaceutics12010017

المؤلفون: Carmen Klein Herenbrink, David A. Sykes, Prashant Donthamsetti, Meritxell Canals, Thomas Coudrat, Jeremy Shonberg, Peter J. Scammells, Ben Capuano, Patrick M. Sexton, Steven J. Charlton, Jonathan A. Javitch, Arthur Christopoulos, J. Robert Lane

المصدر: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/0783ff6940594b04b8cd38d7c0762fb1

المؤلفون: Philip E. Thompson, Hywel David Williams, Peter J. Scammells, Shadabul Haque, Mitchell P. McInerney, Peng Li, Hassan Benameur, Vincent Jannin, Christopher J.H. Porter, Colin W. Pouton, Leigh Ford

المصدر: Pharmaceutical Research. 38:1125-1137

مصطلحات موضوعية: Male, genetic structures, Drug Compounding, Synthetic membrane, Administration, Oral, Pharmaceutical Science, Peptide, 02 engineering and technology, Absorption (skin), Octreotide, 030226 pharmacology & pharmacy, Excipients, Rats, Sprague-Dawley, 03 medical and health sciences, Drug Delivery Systems, 0302 clinical medicine, Gastrointestinal Agents, In vivo, Animals, Humans, Pharmacology (medical), Pharmacology, chemistry.chemical_classification, Chromatography, Organic Chemistry, 021001 nanoscience & nanotechnology, eye diseases, In vitro, Rats, chemistry, Gastrointestinal Absorption, Permeability (electromagnetism), Drug delivery, Lipophilicity, Molecular Medicine, Salts, sense organs, Caco-2 Cells, 0210 nano-technology, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b12d9de7c2a9f94d3ad127d5c492292
https://doi.org/10.1007/s11095-021-03063-3

المؤلفون: Anh Nguyen, Stephen J. Hill, Eleonora Comeo, Peter J. Scammells, Leigh A. Stoddart, Michelle L. Halls, Nicholas D Kindon, Mark Soave, Cameron J. Nowell, Barrie Kellam, Jonathan M. White, Phuc N. H. Trinh, Lauren T. May

المصدر: Journal of Medicinal Chemistry. 64:6670-6695

مصطلحات موضوعية: 0303 health sciences, Total internal reflection fluorescence microscope, Chemistry, HEK 293 cells, Allosteric regulation, Molecular Pharmacology, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Adenosine A1 receptor, Förster resonance energy transfer, Drug Discovery, Biophysics, Molecular Medicine, Receptor, 030304 developmental biology, G protein-coupled receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::943d2ba5ca01da830c950a86cefcf592
https://doi.org/10.1021/acs.jmedchem.0c02067

المؤلفون: Rebecca CS Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren J Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::64837c0876829a0b9019d72507ac5aa8
https://doi.org/10.7554/elife.80813.sa2

المؤلفون: Roselyn B. Rose'Meyer, Shane M. Devine, Peter J. Scammells, Paul J. White, Anna Butcher

المصدر: Pharmaceuticals, Vol 6, Iss 4, Pp 546-556 (2013)

مصطلحات موضوعية: allosteric modulator, adenosine A1 receptor, cardioprotection, heart, Medicine, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1424-8247/6/4/546; https://doaj.org/toc/1424-8247

URL الوصول: https://doaj.org/article/58b5bddb17704ae48ab4bbc72a4471df

المؤلفون: Celine Valant, Peter J. Scammells, Arthur Christopoulos, Ben Capuano, Manuela Jörg, Patrick M. Sexton, Elham Khajehali, David M. Shackleford, Kwok Ho Christopher Choy, Andrew B. Tobin, Emma T van der Westhuizen

المصدر: ChemMedChem. 16:216-233

مصطلحات موضوعية: Pharmacology, 010405 organic chemistry, Chemistry, Organic Chemistry, Allosteric regulation, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Radioligand binding, Drug Discovery, Muscarinic acetylcholine receptor, Biophysics, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4c2a8709f5b47591f003a0e2e8c6a516
https://doi.org/10.1002/cmdc.202000540

المؤلفون: O.V. Ilyichova, Begoña Heras, M.R. Bentley, Gaurav Sharma, Martin J. Scanlon, Jennifer L. Martin, Martin Williams, Biswaranjan Mohanty, Peter J. Scammells, Geqing Wang, Makrina Totsika, Ben Capuano, Rebecca L. Whitehouse, Bradley C. Doak, Wesam S. Alwan

المصدر: Journal of Medicinal Chemistry. 63:6863-6875

مصطلحات موضوعية: Models, Molecular, 0303 health sciences, Chemistry, Drug Evaluation, Preclinical, Molecular Conformation, Crystallography, X-Ray, 01 natural sciences, Molecular conformation, 0104 chemical sciences, Small Molecule Libraries, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Crystallography, Low affinity, Solubility, Fragment (logic), Drug Discovery, Molecular Medicine, Elaboration, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e77ff44eab3bb42776e903568b483e4
https://doi.org/10.1021/acs.jmedchem.0c00111

المؤلفون: Anthony Lai, Nathania Leong, Dan Zheng, Leigh Ford, Tri-Hung Nguyen, Hywel D. Williams, Hassan Benameur, Peter J. Scammells, Christopher J. H. Porter

المصدر: Pharmaceutical research. 39(10)

مصطلحات موضوعية: Pharmacology, Organic Chemistry, Pharmaceutical Science, Administration, Oral, Ionic Liquids, Lipids, Pharmaceutical Preparations, Solubility, Cations, Molecular Medicine, Pharmacology (medical), Amino Acids, Fatty Alcohols, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ae245050bd09dece5c257e8b4eb275
https://pubmed.ncbi.nlm.nih.gov/35661084

المؤلفون: Matthew C. L. Wakeham, Briana J. Davie, David K. Chalmers, Arthur Christopoulos, Ben Capuano, Celine Valant, Peter J. Scammells

المصدر: ACS chemical neuroscience. 13(1)

مصطلحات موضوعية: 0303 health sciences, Physiology, Cognitive Neuroscience, Receptor, Muscarinic M1, Cell Biology, General Medicine, CHO Cells, Isoxazoles, Ligands, Biochemistry, Quaternary Ammonium Compounds, 03 medical and health sciences, 0302 clinical medicine, Allosteric Regulation, Cricetinae, Animals, Humans, 030217 neurology & neurosurgery, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0150aaa3a3dbca484647cc0bd7fc9d51
https://pubmed.ncbi.nlm.nih.gov/34905693

المؤلفون: Petar P.S. Calic, Natalie B. Vinh, Chaille T. Webb, Tess R. Malcolm, Anna Ngo, Kym Lowes, Nyssa Drinkwater, Sheena McGowan, Peter J. Scammells

المصدر: European Journal of Medicinal Chemistry. 248:115051

مصطلحات موضوعية: Pharmacology, Organic Chemistry, Drug Discovery, General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7b8e81b37acfeefd0bf2e8efe87ad93b
https://doi.org/10.1016/j.ejmech.2022.115051

المؤلفون: Samantha Cooper, Stephen J. Hill, Jeanette Woolard, Andrea R. Sabbatini, Peter J. Scammells, Manuela Jörg, Julie E. March

المصدر: British Journal of Pharmacology

مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, Adenosine, Adenosine A2 Receptor Agonists, Consciousness, Receptor, Adenosine A2A, medicine.drug_class, Aminopyridines, Thiophenes, Pharmacology, Ligands, Receptor, Adenosine A2B, Partial agonist, Cardiovascular System, Rats, Sprague-Dawley, 03 medical and health sciences, Adenosine A1 receptor, chemistry.chemical_compound, 0302 clinical medicine, Heart Rate, medicine, Animals, Mesenteric arteries, Caudal artery, Receptor, Adenosine A1, Hemodynamics, Adenosine receptor, Research Papers, Adenosine A1 Receptor Agonists, Drug Partial Agonism, Thiazoles, 030104 developmental biology, medicine.anatomical_structure, chemistry, Regional Blood Flow, CCPA, 030217 neurology & neurosurgery, medicine.drug, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cd4aed4c491c99e68ab8236d88d334
http://europepmc.org/articles/PMC6989947