المؤلفون: Joey L. Methot (1822573), Hua Zhou (50017), Meredeth A. McGowan (1995799), Neville John Anthony (10522303), Matthew Christopher (9661265), Yudith Garcia (6618500), Abdelghani Achab (2177274), Kathryn Lipford (10522306), Benjamin Wesley Trotter (6618527), Michael D. Altman (1302795), Xavier Fradera (2585029), Charles A. Lesburg (1834624), Chaomin Li (1976134), Stephen Alves (10522309), Craig P. Chappell (3863689), Renu Jain (10522312), Ruban Mangado (10522315), Elaine Pinheiro (9470096), Sybill M. G. Williams (10522318), Peter Goldenblatt (4640101), Armetta Hill (6618512), Lynsey Shaffer (4640083), Dapeng Chen (528941), Vincent Tong (1570804), Robbie L. McLeod (2351071), Hyun-Hee Lee (4255930), Hongshi Yu (1730716), Sanjiv Shah (1412503), Jason D. Katz (2188990)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Physiology, Pharmacology, Immunology, Cancer, Chemical Sciences not elsewhere classified, dose, Treg cell proliferation, C 57BL reporter mice, ovalbumin-challenged Brown Norway rats, bronchoalveolar lavage inflammation., heterocycloalkyl purine inhibitors, Hydroxypyrrolidine Purine PI 3K Imm., 3 c, PI 3K pathway, mg, MSD, PI 3K inhibitors

Relation: https://figshare.com/articles/journal_contribution/Projected_Dose_Optimization_of_Amino-_and_Hydroxypyrrolidine_Purine_PI3K_Immunomodulators/14368261

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00237.s001

المؤلفون: Prasanthi Geda, Mark A. McCoy, Liping Yang, Chaomin Li, Armetta D. Hill, Xavier Fradera, Marianne L. Spatz, Matthew Ernst Voss, Carolyn Michele Cammarano, Pierre Daublain, Xiao Wang, Christopher F. Thompson, B. Wesley Trotter, C. Gary Marshall, Michael H. Reutershan, Peter Goldenblatt, Latha G. Nair, Manami Shizuka, Tammie C. Yeh, John G. Cryan, Isabelle Dussault, Michelle Martinez, Mingmei Cai, Raymond A. Kemper, Binyuan Sun, Michelle R. Machacek, Dietrich Steinhuebel, Giovanna Scapin, Michael D. Altman, Stephane L. Bogen, Matthew Christopher, Dapeng Chen, Victoria Kutilek, Weidong Pan

المصدر: Journal of Medicinal Chemistry. 64:16213-16241

مصطلحات موضوعية: Chemistry, Clinical investigation, Drug Discovery, P53 protein, Molecular Medicine, Computational biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a9f003ba884dc7f950fc132b2a33cadf
https://doi.org/10.1021/acs.jmedchem.1c01524

المؤلفون: Michael H, Reutershan, Michelle R, Machacek, Michael D, Altman, Stephane, Bogen, Mingmei, Cai, Carolyn, Cammarano, Dapeng, Chen, Matthew, Christopher, John, Cryan, Pierre, Daublain, Xavier, Fradera, Prasanthi, Geda, Peter, Goldenblatt, Armetta D, Hill, Raymond A, Kemper, Victoria, Kutilek, Chaomin, Li, Michelle, Martinez, Mark, McCoy, Latha, Nair, Weidong, Pan, Christopher F, Thompson, Giovanna, Scapin, Manami, Shizuka, Marianne L, Spatz, Dietrich, Steinhuebel, Binyuan, Sun, Matthew E, Voss, Xiao, Wang, Liping, Yang, Tammie C, Yeh, Isabelle, Dussault, C Gary, Marshall, B Wesley, Trotter

المصدر: Journal of medicinal chemistry. 64(21)

مصطلحات موضوعية: Structure-Activity Relationship, Pyridines, Imidazoles, Humans, Proto-Oncogene Proteins c-mdm2, Tumor Suppressor Protein p53, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::7c70be0458a74b9595c42b9269bd0b63
https://pubmed.ncbi.nlm.nih.gov/34714078

المؤلفون: Sam Kattar, Jason D. Katz, Peter Goldenblatt, Kenneth E. Wilson, Augustin, Matthew Christopher, Abdelghani Achab, Charles A. Lesburg, H. Zhou, Shrenik K. Shah, Xavier Fradera, Yudith Garcia, Joey L. Methot, Altman, McGowan

المصدر: Bioorganic & Medicinal Chemistry Letters. 29:2575-2580

مصطلحات موضوعية: Gene isoform, Scaffold, Clinical Biochemistry, Pharmaceutical Science, Computational biology, Scaffold hopping, 01 natural sciences, Biochemistry, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Oxindole, Molecular Biology, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Binding Sites, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Oxindoles, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Workflow, Drug Design, Molecular Medicine, Cell signaling pathways

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b939d5f9d279a3d02ee126d137ba8e4
https://doi.org/10.1016/j.bmcl.2019.08.004

المؤلفون: Joey L. Methot, Hua Zhou, Sam D. Kattar, Meredeth A. McGowan, Kevin Wilson, Yudith Garcia, Yongi Deng, Michael Altman, Xavier Fradera, Charles Lesburg, Thierry Fischmann, Chaomin Li, Steve Alves, Sanjiv Shah, Rafael Fernandez, Peter Goldenblatt, Armetta Hill, Lynsey Shaffer, Dapeng Chen, Vince Tong, Robbie L. McLeod, Hongshi Yu, Alan Bass, Ray Kemper, Nicholas T. Gatto, Lisa LaFranco-Scheuch, Benjamin Wesley Trotter, Timothy Guzi, Jason D. Katz

المصدر: Journal of Medicinal Chemistry. 62:4370-4382

مصطلحات موضوعية: Class Ia Phosphatidylinositol 3-Kinase, Male, Dogs, Pyrrolidines, Purines, Drug Design, Drug Discovery, Animals, Humans, Molecular Medicine, Rats, Wistar, Protein Kinase Inhibitors, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22455e06a228a36e7b0e36ea97794591
https://doi.org/10.1021/acs.jmedchem.8b01818

المؤلفون: Abbas Walji, Sonia DelRizzo, Elisabetta Bianchi, Jonathan D. Mortison, Vladimir Simov, Yingzi Yue, Thomas J. Tucker, Peter Goldenblatt, Alexander Stoeck, Raffaele Ingenito, Edward DiNunzio, Christopher Sondey, Hui Wan, Erin F. DiMauro, Venkat Sriraman, Victor Serebrov, My Sam Mansueto, Scott A. Johnson, Todd Mayhood, Guo Feng, Michael D. Altman

المصدر: European journal of medicinal chemistry. 224

مصطلحات موضوعية: MafG Transcription Factor, NF-E2-Related Factor 2, Peptide, Electrophoretic Mobility Shift Assay, Pembrolizumab, chemistry.chemical_compound, Structure-Activity Relationship, Drug Stability, Transcription (biology), Neoplasms, Drug Discovery, medicine, Humans, Homology modeling, Ternary complex, Transcription factor, Pharmacology, chemistry.chemical_classification, Chemistry, Organic Chemistry, Cancer, General Medicine, DNA, respiratory system, medicine.disease, Antioxidant Response Elements, Drug Design, Cancer research, Peptides, Half-Life, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b0d49161744ae4b7f2ebe6b8374f07
https://pubmed.ncbi.nlm.nih.gov/34303079

المؤلفون: Benjamin Wesley Trotter, Xavier Fradera, Stephen E. Alves, Meredeth A. McGowan, Peter Goldenblatt, Jason D. Katz, Yudith Garcia, Lynsey Shaffer, Michael D. Altman, Matthew Christopher, Kathryn Lipford, Charles A. Lesburg, Hyun-Hee Lee, Chaomin Li, Craig P. Chappell, Vincent Tong, Elaine M. Pinheiro, Armetta D. Hill, Ruban Mangado, Renu Jain, Robbie L. McLeod, Sanjiv J. Shah, Hongshi Yu, Abdelghani Achab, Dapeng Chen, Joey L. Methot, Sybill M G Williams, Hua Zhou, Neville J. Anthony

المصدر: Journal of medicinal chemistry. 64(8)

مصطلحات موضوعية: Purine, Antigens, Differentiation, T-Lymphocyte, Pyrrolidines, Class I Phosphatidylinositol 3-Kinases, Pharmacology, Molecular Dynamics Simulation, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Dogs, Antigens, CD, Drug Discovery, medicine, Bioluminescence imaging, Potency, Animals, Humans, Immunologic Factors, Lectins, C-Type, Rats, Wistar, Protein kinase B, PI3K/AKT/mTOR pathway, B-Lymphocytes, Binding Sites, Eosinophil, Duvelisib, Rhinitis, Allergic, Rats, Mice, Inbred C57BL, Disease Models, Animal, medicine.anatomical_structure, chemistry, Molecular Medicine, Idelalisib, Proto-Oncogene Proteins c-akt, Half-Life, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a62dfaa61d20ec22ebc7d156d70d73
https://pubmed.ncbi.nlm.nih.gov/33797901

المؤلفون: Michael D. Altman, Jason D. Katz, Hua Zhou, Joey L. Methot, Vincent Tong, Kevin J. Wilson, Yudith Garcia, Peter Goldenblatt, Abdelganhi Achab, Martin Augustin, Charles A. Lesburg, Qiaolin Deng, Solomon Kattar, Lynsey Shaffer, Xavier Fradera, Meredeth A. McGowan, Sanjiv J. Shah

المصدر: Bioorganicmedicinal chemistry letters. 42

مصطلحات موضوعية: Class I Phosphatidylinositol 3-Kinases, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Phthalimides, Computational biology, 01 natural sciences, Biochemistry, Structure-Activity Relationship, Drug Discovery, Potency, Humans, Molecular Biology, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Virtual screening, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Ligand (biochemistry), 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Cell signaling pathways

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9bff15a42c345e0eae2a3ff5da3cf0
https://pubmed.ncbi.nlm.nih.gov/33865969

المؤلفون: Xavier Fradera, Meredeth A. McGowan, Jason D. Katz, Dapeng Chen, Matthew Christopher, B. Wesley Trotter, Armetta D. Hill, Joey L. Methot, Karin M. Otte, Charles A. Lesburg, Sanjiv J. Shah, Hua Zhou, Abdelghani Achab, Martin Augustin, Peter Goldenblatt

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: 010404 medicinal & biomolecular chemistry, Scaffold, chemistry.chemical_compound, 010405 organic chemistry, Chemistry, Organic Chemistry, Drug Discovery, Moiety, Oxindole, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19931c570ed0a5cf798e83465396efb
https://pubmed.ncbi.nlm.nih.gov/33335668

المؤلفون: Kevin W. Johnson, Peter Fuller, Sujal V. Deshmukh, Fang He, Peter Goldenblatt, Lauren Dorosh, Hongbo Zeng, Jason D. Brubaker, Luis E. Torres, Tony Siu, Fiona Elwood, Charles A. Lesburg, Sangita B. Patel, Duan Liu, Elma Kadic, Christopher J. Dinsmore, Xavier Fradera, Lynsey Shaffer, Jonathan R. Young, Lily Y. Moy, Feng Shi, Carla Alpert, Joel A. Klappenbach, Joshua Close, Rafael Fernandez, Hongshi Yu, Nathan Bays, Dawn M. Mampreian

المصدر: Journal of Medicinal Chemistry. 60:9676-9690

مصطلحات موضوعية: 0301 basic medicine, Halogenation, Stereochemistry, medicine.drug_class, Carboxamide, Pyrazole, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, Ligand efficiency, Chemistry, Drug discovery, Janus Kinase 1, Ligand (biochemistry), Rats, Bioavailability, Molecular Docking Simulation, 030104 developmental biology, Pyran, Pyrazoles, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6959a9f84f358dff1679660f1f0b87e
https://doi.org/10.1021/acs.jmedchem.7b01135

المؤلفون: Peter Goldenblatt, Martin Augustin, Abdelghani Achab, Sanjiv J. Shah, Xavier Fradera, Meredeth A. McGowan, Sam Kattar, Joey L. Methot, Charles A. Lesburg, Kevin J. Wilson, Jason D. Katz, Matthew Christopher, Michael D. Altman, Yudith Garcia, Hua Zhou

المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127363

مصطلحات موضوعية: Workflow, Chemistry, Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Scaffold hopping, Molecular Biology, Biochemistry, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b688147f08acd826d047491884662e91
https://doi.org/10.1016/j.bmcl.2020.127363

المؤلفون: Chaomin Li, Charles A. Lesburg, Jason D. Katz, Xavier Fradera, Robbie L. McLeod, Ruban Mangado, Elaine M. Pinheiro, Sybil M. G. Williams, Benjamin Wesley Trotter, Craig P. Chappell, Stephen E. Alves, Armetta D. Hill, Sanjiv J. Shah, Lynsey Shaffer, Michael D. Altman, Joey L. Methot, Hua Zhou, Renu Jain, Dapeng Chen, Hyun-Hee Lee, Meredith A. McGowan, Peter Goldenblatt

المصدر: Cancer Research. 79:2254-2254

مصطلحات موضوعية: Cancer Research, Tumor microenvironment, business.industry, Chronic lymphocytic leukemia, FOXP3, Cancer, medicine.disease, Lymphoma, Oncology, Cancer research, Medicine, Potency, Kinome, business, CD8

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::01203c857b786686ef70cf3c512ad5f8
https://doi.org/10.1158/1538-7445.am2019-2254

المؤلفون: Peter J. Dandliker, Hao Tang, Christopher J. Dinsmore, Chi-Sung Chiu, Fiona Elwood, Deborah Slipetz, Jennifer Piesvaux, Sujal V. Deshmukh, Ilona Kariv, Bo-Sheng Pan, Carla Alpert, Nathan Bays, Alan Byford, Alexey Rivkin, Peter Goldenblatt, Irena Ivanovska, Mark E. Scott, Joel A. Klappenbach, Hyun-Hee Lee, David J. Witter, Kalyan Chakravarthy, Lauren Dorosh, Yujie Qu, Brian Kraybill, Mark Zielstorff

المصدر: The Journal of pharmacology and experimental therapeutics. 361(2)

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Pharmacology, Biology, Isozyme, Autoimmune Diseases, 03 medical and health sciences, Piperidines, In vivo, Monitoring, Immunologic, medicine, Animals, Humans, Kinome, Pyrroles, Protein Kinase Inhibitors, Dose-Response Relationship, Drug, Kinase, Janus Kinase 3, Janus Kinase 1, Arthritis, Experimental, In vitro, Rats, Isoenzymes, Haematopoiesis, 030104 developmental biology, Cytokine, Pyrimidines, STAT protein, Molecular Medicine, Drug Monitoring

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30dcce0e8183db5060a7c6ebeec57fe3
https://pubmed.ncbi.nlm.nih.gov/28193636

المؤلفون: W. Hardy Hendren, Martin Kaefer, Alan B. Retik, Anthony Atala, Stuart B. Bauer, Craig A. Peters, Peter Goldenblatt

المصدر: The Journal of Urology. :2187-2190

مصطلحات موضوعية: medicine.medical_specialty, Urinary bladder, business.industry, Stomach, Urinary system, medicine.medical_treatment, Urology, Urinary diversion, Retrospective cohort study, Bacteriuria, Urine, urologic and male genital diseases, medicine.disease, Gastroenterology, Surgery, medicine.anatomical_structure, Internal medicine, medicine, Complication, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3543aef89f12810f5004e4e27ce076
https://doi.org/10.1097/00005392-199812010-00080

المؤلفون: Michael H. Reutershan (2470597), Michelle R. Machacek (2639716), Michael D. Altman (1302795), Stephane Bogen (2519965), Mingmei Cai (9470078), Carolyn Cammarano (11624110), Dapeng Chen (528941), Matthew Christopher (9661265), John Cryan (3485639), Pierre Daublain (1625986), Xavier Fradera (2585029), Prasanthi Geda (1412485), Peter Goldenblatt (4640101), Armetta D. Hill (11624113), Raymond A. Kemper (2317396), Victoria Kutilek (5741171), Chaomin Li (1976134), Michelle Martinez (642014), Mark McCoy (2600125), Latha Nair (2299723), Weidong Pan (1427614), Christopher F. Thompson (1706539), Giovanna Scapin (1427611), Manami Shizuka (2650621), Marianne L. Spatz (11624116), Dietrich Steinhuebel (1586218), Binyuan Sun (1648267), Matthew E. Voss (2354965), Xiao Wang (19312), Liping Yang (156318), Tammie C. Yeh (2653399), Isabelle Dussault (1638010), C. Gary Marshall (163727), B. Wesley Trotter (2517580)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Pharmacology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, overall favorable pharmacokinetic, efficiency metrics led, conformationally constrained analogs, 4688 , projected dose inhibitors, weight inhibitor suitable, like inhibitors, efficient inhibitor, derived inhibitor, therapeutic potential, strategy focused, recent success, ppi inhibition, physical properties, highly potent, describe herein, clinical investigation, biostructural information

Relation: https://figshare.com/articles/dataset/Discovery_of_b_MK-4688_b_an_Efficient_Inhibitor_of_the_HDM2_p53_Protein_Protein_Interaction/16903996

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01524.s002