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1
المؤلفون: John P. Overington, Lourdes Cucurull-Sanchez, Peter J. Eddershaw, George Papadatos, Samiul Hasan, Mark Davies, Phil Jeffrey, Anne Hersey, Matthew D. Hall, Nathan Dedman
المصدر: Bioinformatics
مصطلحات موضوعية: Statistics and Probability, Drug, media_common.quotation_subject, In silico, Databases and Ontologies, Genomics, Computational biology, Biology, Bioinformatics, 030226 pharmacology & pharmacy, Biochemistry, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Dogs, Animals, Humans, Computer Simulation, Pharmacokinetics, Tissue Distribution, Tissue distribution, Molecular Biology, 030304 developmental biology, ADME, media_common, Comparative genomics, 0303 health sciences, Internet, Proteins, Small molecule, Applications Notes, Computer Science Applications, Computational Mathematics, Computational Theory and Mathematics, Pharmacogenetics, Drug metabolism, Software
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2
المؤلفون: F. Peter Guengerich, Stephen G. George, Brian G. Lake, Alan P Beresford, David F.V. Lewis, Maurice Dickins, Peter J Eddershaw, Michael H Tarbit, Peter S. Goldfarb
المصدر: Toxicology. 139:53-79
مصطلحات موضوعية: Models, Molecular, Cytochrome P-450 CYP1A2 Inhibitors, Toxicology, Homology (biology), Mixed Function Oxygenases, Xenobiotics, Mice, Structure-Activity Relationship, Bacterial Proteins, Cytochrome P-450 Enzyme System, Species Specificity, Cytochrome P-450 CYP1A2, Molecular evolution, Cricetinae, Cytochrome P-450 CYP1A1, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Enzyme Inhibitors, Gene, NADPH-Ferrihemoprotein Reductase, chemistry.chemical_classification, Sequence Homology, Amino Acid, biology, Nucleic acid sequence, Active site, Cytochrome P450, Hydrogen Bonding, Rats, Amino acid, Enzyme, chemistry, Biochemistry, Cytochrome P-450 CYP1B1, Flatfishes, Mutagenesis, Site-Directed, biology.protein, Aryl Hydrocarbon Hydroxylases, Rabbits, Oxidation-Reduction
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3
المؤلفون: Michael H Tarbit, Maurice Dickins, David F.V. Lewis, Brian G. Lake, Peter S. Goldfarb, Peter J Eddershaw
المصدر: Toxicology. 133:1-33
مصطلحات موضوعية: Models, Molecular, Quantitative structure–activity relationship, Stereochemistry, Molecular Sequence Data, Toxicology, Isozyme, Mixed Function Oxygenases, Substrate Specificity, Cytochrome P-450 CYP2A6, Mice, Structure-Activity Relationship, Cytochrome P-450 Enzyme System, Coumarins, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Amino Acid Sequence, Homology modeling, Cytochrome P450 Family 2, Furans, CYP2A6, Fadrozole, biology, Mutagenesis, Active site, Cytochrome P450, Biochemistry, biology.protein, Aryl Hydrocarbon Hydroxylases, Pharmacophore
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4
المؤلفون: Maurice Dickins, Peter J Eddershaw
المصدر: Pharmaceutical Science & Technology Today. 2:13-19
مصطلحات موضوعية: Drug, Drug metabolizing enzymes, Drug discovery, media_common.quotation_subject, High-throughput screening, Pharmaceutical Science, Computational biology, Pharmacology, Biology, Metabolic stability, In vitro, Drug metabolism, media_common
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5
المصدر: Chemico-Biological Interactions. 115:175-199
مصطلحات موضوعية: Models, Molecular, Binding Sites, Molecular Structure, biology, Chemistry, Stereochemistry, Binding energy, Substrate (chemistry), Cytochrome P450, General Medicine, Crystal structure, Toxicology, Isozyme, Catalysis, Substrate Specificity, Isoenzymes, Reaction rate, Structure-Activity Relationship, Cytochrome P-450 Enzyme System, Molecular descriptor, biology.protein, Animals, Humans
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6
المؤلفون: Soraya Y. Hughes, Gary R. Manchee, D. E. Games, Peter J Eddershaw, Janet Oxford, Gary D. Bowers
المصدر: Rapid Communications in Mass Spectrometry. 8:217-221
مصطلحات موضوعية: Male, Magnetic Resonance Spectroscopy, Tetrazoles, Thermospray, Glucuronates, Mass spectrometry, High-performance liquid chromatography, Mass Spectrometry, Analytical Chemistry, Matrix (chemical analysis), Angiotensin Receptor Antagonists, chemistry.chemical_compound, Dogs, Chromatography detector, Animals, Bile, Chromatography, High Pressure Liquid, Spectroscopy, Chromatography, Chemistry, Organic Chemistry, Nicotinic Acids, Glucuronic acid, Rats, Biochemistry, Injections, Intravenous, Indicators and Reagents, Spectrophotometry, Ultraviolet, Drug metabolism, Conjugate
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7
المصدر: ResearcherID
مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Stereochemistry, Iron, Clinical Biochemistry, Pharmaceutical Science, Plasma protein binding, Heme, digestive system, chemistry.chemical_compound, Cytochrome P-450 CYP3A, Humans, Pharmacology (medical), skin and connective tissue diseases, chemistry.chemical_classification, CYP3A4, Biochemistry (medical), Nuclear magnetic resonance spectroscopy, Ondansetron, Enzyme, chemistry, Cytochrome P-450 CYP2D6, Docking (molecular), Protein Binding
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8
المؤلفون: Maurice Dickins, Peter J Eddershaw
المصدر: A Handbook of Bioanalysis and Drug Metabolism
مصطلحات موضوعية: Biochemistry, Chemistry, Drug metabolism
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9
المؤلفون: David R, Thomas, Sergio, Melotto, Mario, Massagrande, Andrew D, Gribble, Phillip, Jeffrey, Alexander J, Stevens, Nigel J, Deeks, Peter J, Eddershaw, Susan H, Fenwick, Graham, Riley, Tania, Stean, Claire M, Scott, Matthew J, Hill, Derek N, Middlemiss, Jim J, Hagan, Gary W, Price, Ian T, Forbes
المصدر: British journal of pharmacology. 139(4)
مصطلحات موضوعية: Serotonin, Pyrrolidines, Drug Administration Routes, Cell Membrane, Guinea Pigs, Sleep, REM, CHO Cells, Hypothermia, Tritium, Cell Line, Rats, Rats, Sprague-Dawley, Radioligand Assay, Gene Expression Regulation, Phenols, Guanosine 5'-O-(3-Thiotriphosphate), Cricetinae, Receptors, Serotonin, Papers, Cyclic AMP, Animals, Humans, Serotonin Antagonists
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10
المؤلفون: Martin K Bayliss, Alan P Beresford, Peter J Eddershaw
المصدر: Drug discovery today. 5(9)
مصطلحات موضوعية: Pharmacology, Drug, Drug discovery, In silico, media_common.quotation_subject, Computational biology, Biology, Drug development, Pharmacokinetics, Drug Discovery, Distribution (pharmacology), Drug metabolism, ADME, media_common
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11
المصدر: Drug metabolism and drug interactions. 15(1)
مصطلحات موضوعية: Stereochemistry, Context (language use), Isozyme, Substrate Specificity, Mice, Cytochrome P-450 Enzyme System, Cytochrome P-450 CYP1A2, Animals, Humans, Pharmacology (medical), Binding site, chemistry.chemical_classification, Binding Sites, biology, Molecular Structure, Active site, Substrate (chemistry), Cytochrome P450, Cytochrome P-450 CYP2E1, Rats, Enzyme, Template, chemistry, Cytochrome P-450 CYP2D6, biology.protein, Rabbits
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12Academic Journal
المؤلفون: Dr Gary A Manchee, Gary R Manchee, Peter J Eddershaw, Lisa E Ranshaw, Deborah Herriott, Gilbert A Park, AND Martin K Bayliss, Michael H Tarbit
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1083.8746; http://dmd.aspetjournals.org/content/dmd/24/5/555.full.pdf
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13
المؤلفون: Darko Butina, Ian Cooper, Chris N. Luscombe, Yuan H. Zhao, Joelle Le, Brad Sherborne, Gordon Beck, James Alexis Platts, Anne Hersey, Peter J. Eddershaw, Michael H. Abraham
المصدر: Journal of Pharmaceutical Sciences. 91:605
مصطلحات موضوعية: Quantitative structure–activity relationship, Chemistry, Stereochemistry, Human intestinal absorption, Pharmaceutical Science
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14Academic Journal
المؤلفون: Simon E. Ward, Peter J. Eddershaw, Claire M. Scott, Laurie J. Gordon, Peter J. Lovell, Susan H. Moore, Paul W. Smith, Kathryn R. Starr, Kevin M. Thewlis, Jeannette M. Watson
المصدر: Journal of Medicinal Chemistry. Apr2008, Vol. 51 Issue 10, p2887-2890. 4p.
مصطلحات موضوعية: *LIGANDS (Biochemistry), *MOLECULES, *MENTAL depression, *DRUGS