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المؤلفون: Christine P. Petersen, Kevin A. Bockerstett, Richard J. DiPaolo, Christine N. Noto, Ryan M. Teague, Lindsey M. Kuehm, Eric L. Ford, Jason C. Mills, James R. Goldenring, Chun Fung Wong
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 561-579 (2020)مصطلحات موضوعية: 0301 basic medicine, CD4-Positive T-Lymphocytes, Male, Pathology, Chronic gastritis, Severity of Illness Index, Immune Regulation, Mice, 0302 clinical medicine, Metaplasia, Parietal cell, Original Research, Mice, Knockout, SPEM, spasmolytic polypeptide-expressing metaplasia, Stomach, Gastroenterology, CD44v9, CD44 variant 9, Recombinant Proteins, medicine.anatomical_structure, EpCAM, epithelial cell adhesion molecule, Gastritis, 030211 gastroenterology & hepatology, Lymphocyte, Female, medicine.symptom, rIL27, recombinant interleukin 27, Transcription, GS-II, griffonia simplicifolia, medicine.medical_specialty, Autoimmune Gastritis, PBS, phosphate-buffered saline, Th, helper T cell, Autoimmune Diseases, Minor Histocompatibility Antigens, 03 medical and health sciences, cDNA, complementary DNA, Immune system, EBI, Epstein-Barr Virus-Induced Gene, medicine, Gastric mucosa, MHC, major histocompatibility complex, Animals, Humans, IFN, interferon, lcsh:RC799-869, Receptors, Cytokine, Mouse Model, Hepatology, business.industry, Interleukins, scRNA, single-cell RNA, PDX1, pancreatic and duodenal homeobox 1, medicine.disease, qRT-PCR, quantitative reverse-transcription polymerase chain reaction, HDT, high-dose tamoxifen, IL, interleukin, Treg, regulatory T cells, Disease Models, Animal, 030104 developmental biology, APC, antigen-presenting cell, IF, immunofluorescent, Gastric Mucosa, Chronic Disease, lcsh:Diseases of the digestive system. Gastroenterology, GIF, gastric intrinsic factor, Atrophy, business, Precancerous Conditions
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2Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity
المؤلفون: Amie K. Boal, Scott A. Showalter, Nafiseh Sabri, Roman Rohac, Emery T. Usher, Tanja Mittag
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, endocrine system diseases, SBM1, SB motif 1, Amino Acid Motifs, SPOP, Biochemistry, IDRs, intrinsically disordered regions, PBST, Triton X-100 in PBS, Ubiquitin, Pdx1, biology, diabetes, FA, fluorescence anisotropy, Nuclear Proteins, Editors' Pick, multivalency, MATH, meprin and tumor necrosis factor receptor-associated factor homology, Ubiquitin ligase, Cell biology, LLPS, liquid–liquid phase separation, Protein Transport, Ni-NTA, nickel-nitrilotriacetic acid, PDX1, SBM2, SB motif 2, Protein Binding, Research Article, DAXX, death domain-associated protein 6, SPOP, speckle-type POZ protein, endocrine system, ubiquitination, digestive system, 03 medical and health sciences, Death-associated protein 6, Humans, structure, Molecular Biology, Transcription factor, Puc, puckered protein, Homeodomain Proteins, Nucleoplasm, 030102 biochemistry & molecular biology, Cell Biology, Repressor Proteins, 030104 developmental biology, SB, SPOP-binding, biology.protein, Trans-Activators, Homeobox, AR, androgen receptor, Pdx1, pancreatic and duodenal homeobox 1, DAPI, 4′,6-diamidino-2-phenylindole
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المؤلفون: Maureen Gannon, Peter A. Kropp, Xiaodong Zhu
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 841-856 (2019)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, PDAC, pancreatic ductal adenocarcinoma, Acinar Cells, Epithelium, Nr5a2, nuclear receptor subfamily 5, group A, member 2, Transcriptome, Mice, 0302 clinical medicine, Transcriptional regulation, Morphogenesis, MPC, multipotent pancreatic progenitor cell, Ptf1a, Pancreas transcription factor, 1a, Original Research, Gastroenterology, Gene Expression Regulation, Developmental, Cell Differentiation, Pancreas, Exocrine, Pancreas Development, Cell biology, Hepatocyte Nuclear Factor 6, medicine.anatomical_structure, Cym, Chymosin, 030211 gastroenterology & hepatology, Pancreas, Inhba, Inhibin, Beta A, Sox9, SRY-related HMG-box 9, ChIP-Seq, chromatin immunoprecipitation followed by high-throughput sequencing, RNA-Seq, RNA-sequencing, Hnf6, hepatocyte nuclear factor 6, Biology, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, ADM, acinar-to-ductal metaplasia, 03 medical and health sciences, CK19, Cytokeratin 19, medicine, Acinar cell, Animals, Ihh, Indian hedgehog, Mist1, muscle, intestine, stomach transcription factor 1, lcsh:RC799-869, Transcription factor, Hnf1β, hepatocyte nuclear factor 1β, Cell Proliferation, Pancreatic duct, Oc1, Onecut1, Hepatology, Base Sequence, Ptch2, Patched 2, Smo, Smoothened, HH, Hedgehog, Embryo, Mammalian, Spink 1, serine protease inhibitor Kazal type 1, 030104 developmental biology, Animals, Newborn, lcsh:Diseases of the digestive system. Gastroenterology, FOXA2, Pdx1, pancreatic and duodenal homeobox 1, Exocrine
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المؤلفون: Daniel K. Bricker, Kyle S. McCommis, Wesley T. Hodges, Vincent Compan, Carl S. Thummel, Dona R. Wisidagama, Brian N. Finck, Maria S. Remedi
المساهمون: Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Molecular Metabolism
Molecular metabolism
Molecular metabolism, Elsevier, 2016, 5 (8), pp.602--614. ⟨10.1016/j.molmet.2016.06.016⟩
Molecular Metabolism, Vol 5, Iss 8, Pp 602-614 (2016)مصطلحات موضوعية: 0301 basic medicine, insulin tolerance test, ITT, [SDV]Life Sciences [q-bio], Stimulus-coupled secretion, Pyruvate dehydrogenase phosphatase, immune system diseases, Insulin, Insulin-producing Cells, Inner mitochondrial membrane, ComputingMilieux_MISCELLANEOUS, glucose-stimulated insulin secretion, Pdx1, IMM, Diabetes, MPC1 and MPC2, Pyruvate dehydrogenase complex, OCR, oxygen consumption rates, 3. Good health, Pyruvate carboxylase, Mitochondria, Biochemistry, oxygen consumption rates, GTT, glucose tolerance test, beta-Cell, Original Article, Drosophila, DILP2, Drosophila insulin-like peptide 2, IMM, inner mitochondrial membrane, β-Cell, IPCs, Insulin-producing Cells, Pyruvate decarboxylation, Pyruvate, lcsh:Internal medicine, Pyruvate dehydrogenase kinase, RESPYR, RESPYR, REporter Sensitive to PYRuvate, glucose tolerance test, PKM2, Biology, Drosophila insulin-like peptide 2, GSIS, glucose-stimulated insulin secretion, 03 medical and health sciences, Dihydrolipoyl transacetylase, lcsh:RC31-1245, Molecular Biology, inner mitochondrial membrane, ITT, insulin tolerance test, 030102 biochemistry & molecular biology, Cell Biology, pancreatic and duodenal homeobox 1, REporter Sensitive to PYRuvate, GSIS, DILP2, MPC1 and MPC2, Mitochondrial Pyruvate Carrier 1 and 2, OCR, 030104 developmental biology, IPCs, GTT, b-Cell, Pdx1, pancreatic and duodenal homeobox 1, Mitochondrial Pyruvate Carrier 1 and 2
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المؤلفون: Takanori Takebe, Hideki Taniguchi, Yoshinobu Takahashi
المصدر: Regenerative Therapy, Vol 3, Iss C, Pp 15-23 (2016)
Regenerative Therapyمصطلحات موضوعية: 0301 basic medicine, Ptf1a, pancreatic transcription factor 1a, Heterotypic cellular interaction, Biomedical Engineering, IBMIR, instant blood-mediated reaction, Review Article, ILV, indolactam V, Biology, Regenerative medicine, PVA, polyvinyl alcohol, Biomaterials, 03 medical and health sciences, Directed differentiation, iPS/ES cell, medicine, 2D, two-dimensional, lcsh:QH573-671, Induced pluripotent stem cell, FGF, fibroblast growth factors, iPS, induced pluripotent stem, Pancreas, PEG, polyethylene glycol, PI3K, phosphatidylinositol-3 kinase, lcsh:R5-920, lcsh:Cytology, 3D, three-dimensional, PIPAAm, poly-N-isopropylacrylamide, Vascularization, Diabetes, ES, embryonic stem, VEGF, vascular endothelial growth factor, Embryonic stem cell, Transplantation, 030104 developmental biology, medicine.anatomical_structure, Immunology, BMP, bone morphogenic protein, Ngn3, neurogenin 3, Cancer research, Pancreatic islet transplantation, Stem cell, lcsh:Medicine (General), Pdx1, pancreatic and duodenal homeobox 1, Developmental Biology
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المؤلفون: Marshall H. Montrose, Eitaro Aihara, Rebekah Karns, Kristen A. Engevik, Bruce R. Yacyshyn, Jiang Wang, Andrea L. Matthis, Peihua Jiang
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 5, Pp 625-647 (2016)
BASE-Bielefeld Academic Search Engineمصطلحات موضوعية: 0301 basic medicine, WT, wild type, Pathology, NHE2, sodium hydrogen exchanger 2, Gastric Ulcer Healing, PCR, polymerase chain reaction, Metaplasia, Gastric glands, TFF2, trefoil factor 2, GSII, Griffonia simplicifolia lectin II, HK-ATPase, hydrogen potassium exchanger adenosine triphosphatase, TFF2, Original Research, education.field_of_study, H pylori, SPEM, spasmolytic polypeptide-expressing metaplasia, NHE2, Gastroenterology, Trefoil factor 2, UEA-1, ulex europaeus, Anatomy, SOX2, (sex-determining region Y)-box 2, mRNA, messenger RNA, 3. Good health, medicine.anatomical_structure, DCLK1, doublecortin-like kinase 1, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, medicine.symptom, SOX9, medicine.medical_specialty, Cell type, MUC, Mucin, Biology, CXCR4, C-X-C chemokine receptor type 4, 03 medical and health sciences, cDNA, complementary DNA, Lgr5, Leucine-rich repeat-containing G protein-coupled receptor5, medicine, lcsh:RC799-869, Progenitor cell, education, KO, knockout, Hepatology, Mucin, Helicobacter pylori, PDX1, pancreatic and duodenal homeobox 1, biology.organism_classification, Epithelium, digestive system diseases, 030104 developmental biology, lcsh:Diseases of the digestive system. Gastroenterology, GIF, gastric intrinsic factor