المؤلفون: Yingjuan J. Lu, Leroy W. Wheeler, II, Haiyan Chu, Paul J. Kleindl, Michael Pugh, Fei You, Satish Rao, Gabriela Garcia, Henry Y. Wu, Andre P. da Cunha, Richard Johnson, Elaine Westrick, Vicky Cross, Alex Lloyd, Christina Dircksen, Patrick J. Klein, Iontcho R. Vlahov, Philip S. Low, Christopher P. Leamon

المصدر: Cell Reports Medicine, Vol 2, Iss 10, Pp 100422- (2021)

مصطلحات موضوعية: autoimmunity, inflammation, folate receptor beta, monocyte/macrophage activation, dihydrofolate reductase inhibitor, aminopterin, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666379121002846; https://doaj.org/toc/2666-3791

URL الوصول: https://doaj.org/article/e2fda03da1f14baea081c09735a4dc68

المؤلفون: Philip S. Low, Paul J. Kleindl, Andre P. da Cunha, Satish Rao, Patrick J. Klein, Leroy W Wheeler, Henry Y. Wu, Christopher P. Leamon, Yingjuan J. Lu, Fei You, Alex Lloyd, Christina Dircksen, Chu Haiyan, Michael Pugh, Gabriela E. Garcia, Vicky Cross, Elaine Westrick, Richard J. Johnson, Iontcho R. Vlahov

المصدر: Cell Reports Medicine, Vol 2, Iss 10, Pp 100422-(2021)
Cell Reports Medicine

مصطلحات موضوعية: Medicine (General), Myeloid, T-Lymphocytes, Interleukin-1beta, autoimmune uveitis, Monocytes, folate receptor beta, Mice, Macrophage, education.field_of_study, Receptors, Chimeric Antigen, Chemistry, autoimmunity, monocyte/macrophage activation, Cytokine release syndrome, medicine.anatomical_structure, Female, medicine.symptom, Antigens, CD19, Inflammation, CHO Cells, Models, Biological, Article, General Biochemistry, Genetics and Molecular Biology, adjuvant arthritis, aminopterin, Cricetulus, Folic Acid, R5-920, medicine, Animals, Humans, Folate Receptor 1, Folate Receptor 2, education, Folate receptor beta, Interleukin-6, Macrophages, Monocyte, cytokine release syndrome, Macrophage Activation, medicine.disease, Chimeric antigen receptor, Rats, dihydrofolate reductase inhibitor, RAW 264.7 Cells, Mechanism of action, Rats, Inbred Lew, inflammation, Cancer research, Folic Acid Antagonists, glomerulonephritis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff3f0adb683c62473135f1023e5e206
http://www.sciencedirect.com/science/article/pii/S2666379121002846

المؤلفون: Marilynn Vetzel, Hari Krishna Santhapuram, Christina Dircksen, Alicia Bloomfield, Iontcho Radoslavov Vlahov, Paul J. Kleindl, Melissa Nelson, Joseph A. Reddy, Ryan Dorton, Christopher P. Leamon

المصدر: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)

مصطلحات موضوعية: 0301 basic medicine, Bevacizumab, Paclitaxel, Drug Evaluation, Preclinical, Mice, Nude, lcsh:Medicine, Antineoplastic Agents, Docetaxel, Carboplatin, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Folic Acid, Cell Line, Tumor, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, medicine, Animals, Humans, lcsh:Science, Cisplatin, Vintafolide, Multidisciplinary, business.industry, lcsh:R, Xenograft Model Antitumor Assays, Tumor Burden, 030104 developmental biology, chemistry, Folate receptor, 030220 oncology & carcinogenesis, Pipecolic Acids, Cancer research, Topotecan, lcsh:Q, business, Oligopeptides, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ede75dcf036acc8e8a7c9f4805d63d4
http://link.springer.com/article/10.1038/s41598-018-27320-5

المؤلفون: Jeremy F. Vaughn, Joseph A. Reddy, Hari Krishna Santhapuram, Fei You, Hanna F. Klein, Melissa Nelson, Albert Felten, Longwu Qi, Paul J. Kleindl, Christopher P. Leamon, Iontcho Radoslavov Vlahov, Jeff Nicoson, Spencer Hahn, Marilynn Vetzel, Kevin Wang, Garth L. Parham

المصدر: Bioconjugate Chemistry. 28:2921-2931

مصطلحات موضوعية: 0301 basic medicine, Oxazolidine, Imine, Reactive intermediate, Biomedical Engineering, Pharmaceutical Science, Antineoplastic Agents, Bioengineering, Chemistry Techniques, Synthetic, 01 natural sciences, KB Cells, Benzodiazepines, 03 medical and health sciences, chemistry.chemical_compound, Neoplasms, Humans, Moiety, Prodrugs, Pyrroles, Molecular Targeted Therapy, Pharmacology, chemistry.chemical_classification, 010405 organic chemistry, Organic Chemistry, Aromatic amine, Prodrug, Combinatorial chemistry, 0104 chemical sciences, 030104 developmental biology, Diazepine, chemistry, Drug Design, Linker, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd57ff3b52bd26b3369c3eab77a7d8b3
https://doi.org/10.1021/acs.bioconjchem.7b00476

المؤلفون: Jeff Nicoson, Kevin Wang, Fei You, Hanna F. Klein, Longwu Qi, Jeremy F. Vaughn, Iontcho Radoslavov Vlahov, Hari Krishna Santhapuram, Joe Reddy, Dan Reno, Garth L. Parham, Paul J. Kleindl, Spencer Hahn, Ning Zou, Christopher P. Leamon, Albert Felten

المصدر: Bioorganicmedicinal chemistry letters. 30(7)

مصطلحات موضوعية: Oxazolidine, Clinical Biochemistry, Imine, Pharmaceutical Science, Pyrrolobenzodiazepine, Mice, Nude, behavioral disciplines and activities, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Benzodiazepines, Neoplasms, Drug Discovery, Animals, Humans, Prodrugs, Pyrroles, Molecular Biology, chemistry.chemical_classification, Antibiotics, Antineoplastic, 010405 organic chemistry, Organic Chemistry, Folate Receptors, GPI-Anchored, Aromatic amine, Prodrug, Combinatorial chemistry, Xenograft Model Antitumor Assays, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Diazepine, chemistry, Folate receptor, Drug Design, Molecular Medicine, Female, Conjugate, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001261a0e6c309925872c534e804f39f
https://pubmed.ncbi.nlm.nih.gov/32029324

المؤلفون: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Albert Felten, Paul J. Kleindl

المصدر: Cytotoxic Payloads for Antibody – Drug Conjugates ISBN: 9781788010771

مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Antibody-drug conjugate, Diazepine, chemistry, Reactive intermediate, Imine, Aromatic amine, Prodrug, Combinatorial chemistry, Linker, Conjugate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8b4d57e5829c79e89be44c1b65e10fbf
https://doi.org/10.1039/9781788012898-00279

المؤلفون: Alicia Bloomfield, Iontcho Radoslavov Vlahov, Melissa Nelson, Christopher P. Leamon, Marilynn Vetzel, Kevin Wang, Paul J. Kleindl, Ryan Dorton, Joseph A. Reddy, Spencer Hahn

المصدر: Bioconjugate chemistry. 30(6)

مصطلحات موضوعية: Glutamate Carboxypeptidase II, Male, Biomedical Engineering, Pharmaceutical Science, Mice, Nude, Bioengineering, Antineoplastic Agents, 02 engineering and technology, urologic and male genital diseases, 01 natural sciences, Prostate cancer, Antigen, Cell Line, Tumor, LNCaP, medicine, Glutamate carboxypeptidase II, Animals, Humans, Pharmacology, 010405 organic chemistry, Chemistry, Organic Chemistry, Cancer, Prostatic Neoplasms, 021001 nanoscience & nanotechnology, medicine.disease, Xenograft Model Antitumor Assays, In vitro, 0104 chemical sciences, Docetaxel, Cell culture, Pipecolic Acids, Antigens, Surface, Cancer research, 0210 nano-technology, Oligopeptides, Biotechnology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf3384bbfb6bfe90350c3188a690c09
https://pubmed.ncbi.nlm.nih.gov/31075200

المؤلفون: Jeremy F. Vaughn, Iontcho Radoslavov Vlahov, Kevin Wang, Philip S. Low, Hari Krishna Santhapuram, Patrick J. Klein, Elaine Westrick, Fei You, Yingjuan Lu, Christopher P. Leamon, Mark A Gehrke, Torian W. Stinnette, Paul J. Kleindl, Kristin N. Wollak, Nikki Parker, Spencer Hahn, Vicky A. Cross

المصدر: Molecular Medicine. 21:584-596

مصطلحات موضوعية: Anti-Inflammatory Agents, Inflammation, Biology, Pharmacology, Aminopterin, Arthritis, Rheumatoid, Folic Acid, Pharmacokinetics, In vivo, Genetics, medicine, Animals, Humans, Everolimus, Folate Receptor 2, Molecular Biology, Genetics (clinical), PI3K/AKT/mTOR pathway, Cell Proliferation, Cell growth, TOR Serine-Threonine Kinases, Articles, Arthritis, Experimental, Rats, Folate receptor, Molecular Medicine, medicine.symptom, Signal Transduction, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4dd30ce0aa83391a472ac15048cbcb1
https://doi.org/10.2119/molmed.2015.00040

المؤلفون: Elaine Westrick, Ryan Dorton, Hari Krishna Santhapuram, Jeremy F. Vaughn, Melissa Nelson, Paul J. Kleindl, Alicia Bloomfield, Iontcho Radoslavov Vlahov, Joseph A. Reddy, Fei You, Marilynn Vetzel, Christopher P. Leamon

المصدر: Bioconjugate Chemistry. 25:560-568

مصطلحات موضوعية: Vinca, medicine.drug_class, Molecular Conformation, Biomedical Engineering, Mice, Nude, Pharmaceutical Science, Antineoplastic Agents, Bioengineering, Pharmacology, Vinorelbine, Vinca alkaloid, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Folic Acid, Cell Line, Tumor, medicine, Animals, Humans, Vinca Alkaloids, Cell Proliferation, Vintafolide, Mice, Inbred BALB C, Vinflunine, Dose-Response Relationship, Drug, biology, Alkaloid, Organic Chemistry, Stereoisomerism, Neoplasms, Experimental, biology.organism_classification, chemistry, Biochemistry, Folate receptor, Vindesine, Female, Drug Screening Assays, Antitumor, Biotechnology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c238990b851d5ca4110974eab055a7
https://doi.org/10.1021/bc400441s

المؤلفون: Spencer Hahn, Paul J. Kleindl, Yu Wang, Iontcho Radoslavov Vlahov, Christopher P. Leamon, Marilynn Vetzel, Joseph A. Reddy

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:6778-6781

مصطلحات موضوعية: Cell cycle checkpoint, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Chemistry Techniques, Synthetic, Biochemistry, Ion, Acetic acid, chemistry.chemical_compound, Nucleophile, Drug Discovery, Trifluoroacetic acid, Myxococcales, Cytotoxicity, Molecular Biology, Acetic Acid, Ions, Biological Products, Chemistry, Organic Chemistry, Bond formation, Tubulin Modulators, Pipecolic Acids, Molecular Medicine, Fermentation, Imines, Oligopeptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6404436b442cfb8020693867899d26f6
https://doi.org/10.1016/j.bmcl.2011.09.041

المؤلفون: Iontcho R. Vlahov, Paul J. Kleindl, Fei You

المصدر: Drug Delivery in Oncology: From Basic Research to Cancer Therapy

مصطلحات موضوعية: Drug, Vitamin, media_common.quotation_subject, Growth factor, medicine.medical_treatment, Cancer therapy, chemistry.chemical_compound, Biochemistry, chemistry, Biotin, Folic acid, medicine, media_common, Conjugate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3cac602f563b80e089714ba2bd906db3
https://doi.org/10.1002/9783527634057.ch40

المؤلفون: Albert Felten, Hari Krishna Santhapuram, Spencer Hahn, Ning Zou, Christopher P. Leamon, Kevin K.W. Wang, Jeremy F. Vaughn, Paul J. Kleindl, Iontcho Radoslavov Vlahov

المصدر: Cancer Research. 78:757-757

مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, Imine, Aromatic amine, Prodrug, Oxime, Small molecule, Combinatorial chemistry, chemistry.chemical_compound, Oncology, chemistry, Aminal, Moiety, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5c95fff45c415f05978e90dd9639e797
https://doi.org/10.1158/1538-7445.am2018-757

المؤلفون: Paul J. Kleindl, Longwu Qi, Philip S. Low, Michael J. Hansen, Mini Thomas, Christopher P. Leamon, Sumith A. Kularatne

المصدر: Annals of the New York Academy of Sciences. 1175:32-39

مصطلحات موضوعية: Male, Small interfering RNA, Receptors, Cell Surface, Biology, Ligands, General Biochemistry, Genetics and Molecular Biology, Glutarates, Mice, Folic Acid, History and Philosophy of Science, In vivo, Prostate, Neoplasms, medicine, Animals, Humans, Urea, RNA, Small Interfering, Ligand, General Neuroscience, Folate Receptors, GPI-Anchored, Cancer, medicine.disease, Xenograft Model Antitumor Assays, Mice, Mutant Strains, In vitro, medicine.anatomical_structure, Biochemistry, Folate receptor, Cancer cell, Cancer research, Female, Carrier Proteins, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e799011df41ead288550d7158b24314d
https://doi.org/10.1111/j.1749-6632.2009.04977.x

المؤلفون: Yu Wang, Iontcho Radoslavov Vlahov, Paul J. Kleindl, Christopher P. Leamon

المصدر: Bioorganic & Medicinal Chemistry Letters. 18:4558-4561

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Antineoplastic Agents, Receptors, Cell Surface, Peptide, Biochemistry, Chemical synthesis, Cell Line, Folic Acid, Drug Discovery, Animals, Humans, Disulfides, Cytotoxicity, Molecular Biology, Chromatography, High Pressure Liquid, chemistry.chemical_classification, Chemistry, Folate Receptors, GPI-Anchored, Organic Chemistry, Regioselectivity, Dithiothreitol, Hydrazines, Models, Chemical, Folic acid, Folate receptor, Molecular Medicine, Carrier Proteins, Peptides, Oligopeptides, Linker, Conjugate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea08960fefbea39d258255078048c73
https://doi.org/10.1016/j.bmcl.2008.07.041

المؤلفون: Hari Krishna Santhapuram, Elaine Westrick, Iontcho Radoslavov Vlahov, Christopher P. Leamon, Joseph A. Reddy, Fei You, Paul J. Kleindl, Stephen J. Howard, Yu Wang

المصدر: The Journal of Organic Chemistry. 72:5968-5972

مصطلحات موضوعية: chemistry.chemical_classification, Disulfide Linkage, Ligand, Stereochemistry, Chemistry, Pharmaceutical, Organic Chemistry, Chemistry, Organic, Peptide, Ligands, Drug Delivery Systems, Folic Acid, Models, Chemical, chemistry, Folate receptor, Covalent bond, Drug Design, Thiol, Disulfides, Sulfhydryl Compounds, Carrier Proteins, Peptides, Linker, Conjugate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d2ceb949f7b674076a79050dd2ebd0
https://doi.org/10.1021/jo070411z

المؤلفون: Elaine Westrick, Ryan Dorton, Alicia Dawson, Terri Smith, Paul J. Kleindl, Le-Cun Xu, Christopher P. Leamon, Marilynn Vetzel, Iontcho Radoslavov Vlahov, Joseph A. Reddy

المصدر: Cancer Research. 67:4434-4442

مصطلحات موضوعية: Cancer Research, Vinca, Lymphoma, medicine.drug_class, Antineoplastic Agents, Pharmacology, Drug Administration Schedule, KB Cells, Vinca alkaloid, Mice, chemistry.chemical_compound, Folic Acid, Therapeutic index, Animals, Humans, Medicine, Vinca Alkaloids, Vintafolide, Mice, Inbred BALB C, biology, business.industry, Alkaloid, Cancer, biology.organism_classification, medicine.disease, Xenograft Model Antitumor Assays, Regimen, Oncology, chemistry, Tolerability, Female, Drug Screening Assays, Antitumor, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4cc06e37c8deaa8dd4883d2e3ded347
https://doi.org/10.1158/0008-5472.can-07-0033

المؤلفون: Christopher P. Leamon, Paul J. Kleindl, Jeremy F. Vaughn, Albert Felten, Spencer Hahn, Iontcho Radoslavov Vlahov, Longwu Qi, Hari Krishna Santhapuram, Kevin K.W. Wang

المصدر: Cancer Research. 77:5147-5147

مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, business.industry, Internal medicine, medicine, Cancer, business, medicine.disease

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::62c312fda884f4f5031a0e313b73b10b
https://doi.org/10.1158/1538-7445.am2017-5147

المؤلفون: William A. Donaldson, Paul J. Kleindl

المصدر: The Journal of Organic Chemistry. 62:4176-4179

مصطلحات موضوعية: Chemistry, Organic Chemistry, Diels alder, Organic chemistry, Reactivity (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1ddcdeba6fd7ba598fc24242e2f66809
https://doi.org/10.1021/jo970234+

المؤلفون: Christopher P. Leamon, Paul J. Kleindl, Joseph A. Reddy, Fei You, Iontcho Radoslavov Vlahov, Marilynn Vetzel

المصدر: Cancer Research. 76:4735-4735

مصطلحات موضوعية: Cancer Research, Stereochemistry, Substituent, Biological activity, chemistry.chemical_compound, Oncology, Biochemistry, chemistry, Thioether, Folate receptor, Moiety, Isoleucine, Cytotoxicity, Pipecolic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ca829b9da394d8a3ff98f32dcb0fc414
https://doi.org/10.1158/1538-7445.am2016-4735

المؤلفون: Hari Krishna Santhapuram, Christopher P. Leamon, Spencer Hahn, Mingjin Fan, Fei You, Yu Wang, Jeremy F. Vaughn, Iontcho Radoslavov Vlahov, Paul J. Kleindl

المصدر: Bioorganicmedicinal chemistry letters. 21(4)

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Anti-Inflammatory Agents, Pharmaceutical Science, Peptide, Aminopterin, Hydrazide, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Folic Acid, Drug Discovery, medicine, Humans, Molecular Biology, chemistry.chemical_classification, Inflammation, Organic Chemistry, Stereoisomerism, Glycopeptide, chemistry, Folate receptor, Drug Design, Molecular Medicine, Drug carrier, medicine.drug, Conjugate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b14ed50e2efd99e01d7e7e1bfc9e64
https://pubmed.ncbi.nlm.nih.gov/21236665