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1
المؤلفون: Xu Min Zhao, Bo Wei, George J. Hanna, Zhong Ping Duan, Sheng Mei Mu, Ji Dong Jia, Lai Wei, Paul Ingravallo, Peggy Hwang, Zhan Sheng Jia, Li Wen Liang, Michael N. Robertson, Wen Xie, Ying Ren Zhao, Shan Ming Wu, Rohit Talwani, Wen Xiang Huang, Amy Puenpatom, Yan Huang, Ernest Asante-Appiah, Barbara Evans, Ming Xiang Zhang, Mao Rong Wang, Jun Qi Niu, Fu-Sheng Wang, Zaiqi Wang
المصدر: JGH Open: An Open Access Journal of Gastroenterology and Hepatology
مصطلحات موضوعية: Elbasvir, medicine.medical_specialty, Hepatitis C virus, viral hepatitis, Placebo, medicine.disease_cause, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, virology, hepatitis C virus treatment, hepatitis C virus clinical trials, Medicine, Elbasvir, Grazoprevir, Adverse effect, hepatitis C clinical, Hepatology, business.industry, Gastroenterology, Original Articles, medicine.disease, Grazoprevir, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Original Article, business, Viral hepatitis
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2
المؤلفون: Ying Zhai, De-Yi Yang, Ernest Asante-Appiah, Lei Chen, Haiqun Tang, Paul Ingravallo, Amin A. Nomeir, John P. Caldwell, Ling Tong, Guowei Zhou, Wensheng Yu, Yueheng Jiang, Oleg Selyutin, Anilkumar G. Nair, Seong Heon Kim, Rong Liu, Joseph A. Kozlowski, Qingbei Zeng, Stuart B. Rosenblum, Michael P. Dwyer, Rong Kong, Ellen Xia, Sony Agrawal, Robert Mazzola, Bandarpalle B. Shankar, Kerry Keertikar
المصدر: Bioorganic & Medicinal Chemistry Letters. 28:1954-1957
مصطلحات موضوعية: 0301 basic medicine, Genotype, Proline, Silylation, viruses, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Pharmacology, Virus Replication, Antiviral Agents, Heterocyclic Compounds, 4 or More Rings, Biochemistry, 03 medical and health sciences, Dogs, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Pharmacokinetics, Drug Discovery, Animals, Humans, Potency, NS5A, Molecular Biology, Chemistry, Organic Chemistry, virus diseases, Haplorhini, biochemical phenomena, metabolism, and nutrition, digestive system diseases, In vitro, Rats, Regimen, 030104 developmental biology, Molecular Medicine, 030211 gastroenterology & hepatology, Half-Life
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3
المؤلفون: Janice Wahl, Joy Ginanni, Svetlana Kizhlo, Liwen Liang, Pauline A. Lindore, Nguyen Van Kinh, Rohit Talwani, Bach-Yen Nguyen, Michael N. Robertson, Paul Ingravallo, K. V. Zhdanov, Eduard Burnevich, C‐Coral Study Investigators, Jacob George, Won Young Tak, Tawesak Tanwandee, I-Shyan Sheen, Pin-Nan Cheng, Jeong Heo, Do Young Kim, Eliav Barr, Vasily Isakov
المصدر: Hepatology Communications
مصطلحات موضوعية: 0301 basic medicine, Elbasvir, medicine.medical_specialty, Hepatology, business.industry, Incidence (epidemiology), 030106 microbiology, Original Articles, Placebo, 03 medical and health sciences, Regimen, 0302 clinical medicine, Grazoprevir, Internal medicine, medicine, Elbasvir, Grazoprevir, 030211 gastroenterology & hepatology, Original Article, Adverse effect, business
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4Academic Journal
المؤلفون: Rong Liu, Karim Abid, John Pichardo, Valerio Pazienza, Paul Ingravallo, Rong Kong, Sony Agrawal, Stephane Bogen, Anil Saksena, Kuo-chi Cheng, Andrew Prongay, F. George Njoroge, Bahige M. Baroudy, Francesco Negro
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.624.4142; http://jac.oxfordjournals.org/content/59/1/51.full.pdf
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5
المؤلفون: Zhuyan Guo, Yuan Hu, Patricia McMonagle, Ernest Asante-Appiah, Paul Ingravallo, Stuart Black, Stephanie Curry, Robert Chase
المصدر: Journal of Biological Chemistry. 292:6202-6212
مصطلحات موضوعية: Cyclopropanes, 0301 basic medicine, Simeprevir, Elbasvir, viruses, medicine.medical_treatment, Hepatitis C virus, 030106 microbiology, Mutation, Missense, Hepacivirus, Molecular Dynamics Simulation, Viral Nonstructural Proteins, Biology, medicine.disease_cause, Biochemistry, 03 medical and health sciences, Cell Line, Tumor, Quinoxalines, medicine, Humans, Potency, NS5A, Molecular Biology, Sulfonamides, NS3, Protease, Computational Biology, virus diseases, Cell Biology, Amides, Hepatitis C, Virology, digestive system diseases, 030104 developmental biology, Amino Acid Substitution, Grazoprevir, Carbamates
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6
المؤلفون: Stephanie Curry, Frederick C. Lahser, Ping Qiu, Karin Bystol, Ernest Asante-Appiah, Stuart Black, Rong Liu, Ellen Xia, Patricia McMonagle, Paul Ingravallo, Robert Chase
المصدر: Antimicrobial Agents and Chemotherapy. 63
مصطلحات موضوعية: Elbasvir, viruses, Hepatitis C virus, medicine.disease_cause, law.invention, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, law, medicine, Pharmacology (medical), NS5A, Pharmacology, chemistry.chemical_classification, 0303 health sciences, NS3, Methionine, 030306 microbiology, Chemistry, biochemical phenomena, metabolism, and nutrition, Virology, Amino acid, Infectious Diseases, Grazoprevir, Recombinant DNA, 030211 gastroenterology & hepatology
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7
المؤلفون: Ernest, Asante-Appiah, Paul, Ingravallo, Patricia, McMonagle, Karin, Bystol, Ellen, Xia, Stephanie, Curry, Ping, Qiu, Stuart, Black, Robert, Chase, Rong, Liu, Fred, Lahser
المصدر: Antimicrob Agents Chemother
مصطلحات موضوعية: viruses, biochemical phenomena, metabolism, and nutrition, Antiviral Agents
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8Academic Journal
المساهمون: The Pennsylvania State University CiteSeerX Archives
المصدر: http://iah.iec.pa.gov.br/iah/fulltext/pc/artigos/2001/Mol Biochem Parasitol 2001 115 41-53.pdf.
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.331.2378; http://iah.iec.pa.gov.br/iah/fulltext/pc/artigos/2001/Mol Biochem Parasitol 2001 115 41-53.pdf
الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.331.2378
http://iah.iec.pa.gov.br/iah/fulltext/pc/artigos/2001/Mol Biochem Parasitol 2001 115 41-53.pdf -
9Academic Journal
المؤلفون: Vicky C. H. Lai, Weidong Zhong, Angela Skelton, Venteislav Vassilev, Ruben O. Donis, Zhi Hong, Johnson Y. N. Lau, Paul Ingravallo
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.325.1726; http://jvi.asm.org/content/74/14/6339.full.pdf
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10Academic Journal
المؤلفون: Nancy Butkiewicz, Nanhua Yao, Weidong Zhong, Paul Ingravallo, Rumin Zhang, David N. St, Bahige M. Baroudy, David V, Stanley M. Lemon, Johnson Y. N. Lau, Zhi Hong, Jacquelyn Wright-minogue, James Durkin, David N. Standring, David V. Sangar
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.319.6395; http://jvi.asm.org/content/74/9/4291.full.pdf
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11
المؤلفون: Lei Chen, Ling Tong, Joseph A. Kozlowski, Sony Agrawal, Christian L. Holst, Bin Zhong, Yueheng Jiang, Oleg Selyutin, Craig A. Coburn, A. Samuel Vellekoop, Frederick C. Lahser, James I. Fells, Bin Hu, Patricia McMonagle, Donna Carr, Ernest Asante-Appiah, Laura Rokosz, Rong Liu, Gregory Scott Martin, Anilkumar G. Nair, Michael P. Dwyer, Stuart B. Rosenblum, Paul Ingravallo, Michael Wong, Tao Ji, Wensheng Yu, Bancha Vibulbhan, Stephanie Curry, Qingbei Zeng
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:3793-3799
مصطلحات موضوعية: 0301 basic medicine, Macrocyclic Compounds, Stereochemistry, Hepacivirus, 030106 microbiology, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, Viral Nonstructural Proteins, Virus Replication, Antiviral Agents, Heterocyclic Compounds, 4 or More Rings, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, medicine, NS5A, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, Drug discovery, Organic Chemistry, virus diseases, Hepatitis C, medicine.disease, biology.organism_classification, Virology, digestive system diseases, In vitro, Titer, Regimen, 030104 developmental biology, Viral replication, Molecular Medicine
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12
المؤلفون: Ling Tong, Craig A. Coburn, Michael P. Dwyer, Paul Ingravallo, Stephanie Curry, Mingxiang Lin, Guowei Zhou, Stuart B. Rosenblum, Shuai Zan, Wensheng Yu, Joseph A. Kozlowski, Ying Zhai, Oleg Selyutin, Bin Hu, Michael Wong, Lei Chen, Rong Liu, Ernest Asante-Appiah, Qingbei Zeng, Jinglai Hao, Seong Heon Kim, Anilkumar G. Nair, Ellen Xia, Tao Ji, Patricia McMonagle, Frédéric Massé, Bin Zhong, Sony Agrawal
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:3414-3420
مصطلحات موضوعية: Male, 0301 basic medicine, Elbasvir, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Microbial Sensitivity Tests, Viral Nonstructural Proteins, Antiviral Agents, 01 natural sciences, Biochemistry, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Animals, Potency, Structure–activity relationship, HCV NS5A Inhibitor, NS5A, Molecular Biology, Benzofurans, Indole test, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Aryl, Organic Chemistry, Imidazoles, virus diseases, digestive system diseases, Rats, 0104 chemical sciences, 030104 developmental biology, chemistry, Aminal, Molecular Medicine
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13
المؤلفون: Daria J. Hazuda, Robert Chase, Rong Liu, Karin Bystol, Ernest Asante-Appiah, Paul Ingravallo, Anita Y. M. Howe, Ellen Xia, Patricia McMonagle, Stephanie Curry, Frederick C. Lahser, Todd A. Black
المصدر: Antimicrobial Agents and Chemotherapy. 60:2954-2964
مصطلحات موضوعية: Cyclopropanes, 0301 basic medicine, Elbasvir, Genotype, viruses, Hepacivirus, Hepatitis C virus, 030106 microbiology, medicine.disease_cause, Antiviral Agents, 03 medical and health sciences, Quinoxalines, Ribavirin, medicine, Protease Inhibitors, Pharmacology (medical), Protease inhibitor (pharmacology), Replicon, NS5A, Benzofurans, Pharmacology, Sulfonamides, NS3, biology, Imidazoles, biology.organism_classification, Amides, Virology, Infectious Diseases, Grazoprevir, Mutation, Drug Therapy, Combination, Carbamates
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14
المؤلفون: Xu Min Zhao, Jacob George, Peggy Hwang, Jeong Heo, Paul Ingravallo, Zhong Ping Duan, Tawesak Tanwandee, Ernest Asante-Appiah, Barbara Evans, Zaiqi Wang, Van Kinh Nguyen, Vasily Isakov, Shengmei Mu, George J. Hanna, Jun Qi Niu, K. V. Zhdanov, Lai Wei, Bo Wei, Michael N. Robertson, Fu-Sheng Wang, Rohit Talwani, Pin-Nan Cheng, Ji Dong Jia, Li Wen Liang
المصدر: Journal of Gastroenterology and Hepatology.
مصطلحات موضوعية: Adult, Male, Elbasvir, medicine.medical_specialty, Genotype, Sustained Virologic Response, Hepatitis C virus, Hepacivirus, Viral Nonstructural Proteins, Placebo, medicine.disease_cause, Antiviral Agents, Virus, Russia, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Quinoxalines, Internal medicine, Drug Resistance, Viral, Humans, Medicine, Elbasvir, Grazoprevir, Aspartate Aminotransferases, 030212 general & internal medicine, Adverse effect, Benzofurans, Hepatology, Asia, Eastern, business.industry, Australia, Imidazoles, Gastroenterology, Alanine Transaminase, Hepatitis C, Chronic, Middle Aged, Thailand, Drug Combinations, Vietnam, Grazoprevir, Female, 030211 gastroenterology & hepatology, business
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15In Vitro Antiviral Profile of Ruzasvir, a Potent and Pangenotype Inhibitor of Hepatitis C Virus NS5A
المؤلفون: Wensheng Yu, Joseph A. Kozlowski, Stuart Black, Robert Chase, Paul Ingravallo, Ling Tong, Sony Agrawal, Eric Ferrari, Patricia McMonagle, Karin Bystol, Donna Carr, Ernest Asante-Appiah, Frederick C. Lahser, Laura Rokosz, Rong Liu, Stephanie Curry
المصدر: Antimicrobial Agents and Chemotherapy. 62
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, NS3, Chemistry, viruses, Hepatitis C virus, 030106 microbiology, biochemical phenomena, metabolism, and nutrition, Prodrug, medicine.disease_cause, Antiviral Agents, Virology, digestive system diseases, 03 medical and health sciences, Infectious Diseases, Grazoprevir, medicine, Potency, Pharmacology (medical), Protease inhibitor (pharmacology), Replicon, NS5A
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16
المؤلفون: Robert Chase, David A. Smith, Eleanor Barnes, Paul Ingravallo, David Bonsall, Anita Y. M. Howe, Rory Bowden, Anthony Brown, Stuart Black, Irene Pak
المصدر: Infection and Drug Resistance
Infection and Drug Resistance, Vol Volume 11, Pp 1119-1135 (2018)مصطلحات موضوعية: 0301 basic medicine, Hepatitis C virus, viruses, 030106 microbiology, Viral quasispecies, Biology, medicine.disease_cause, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, chemistry.chemical_compound, medicine, virologic failure, Pharmacology (medical), Protease inhibitor (pharmacology), lcsh:RC109-216, Gene, Original Research, Pharmacology, resistance-associated substitution, NS3, Ribavirin, virus diseases, Virology, 3. Good health, Infectious Diseases, chemistry, Grazoprevir, NS3/4A protease inhibitor, Infection and Drug Resistance, Viral evolution, next-generation sequencing
وصف الملف: text/html
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17
المؤلفون: Christina L. Burch, Shuntai Zhou, Paul Ingravallo, Ernest Asante-Appiah, Ronald Swanstrom, Tiffany Benzine, Anita Y. M. Howe, David R. McGivern, Stanley M. Lemon, Sara E. Williford, Fengyu Hu
مصطلحات موضوعية: 0301 basic medicine, Elbasvir, Genotype, Sustained Virologic Response, Hepatitis C virus, viruses, Population, Viremia, Drug resistance, Hepacivirus, Biology, Viral Nonstructural Proteins, medicine.disease_cause, Virus Replication, Antiviral Agents, Virus, Article, 03 medical and health sciences, Virology, Drug Resistance, Viral, medicine, Humans, NS5A, education, Phylogeny, Benzofurans, Pharmacology, education.field_of_study, Imidazoles, High-Throughput Nucleotide Sequencing, medicine.disease, Hepatitis C, 030104 developmental biology, Treatment Outcome, Viral evolution, Replicon, Genetic Fitness
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18
المؤلفون: Shiying Chen, Mark Cartwright, Joseph A. Kozlowski, Lei Chen, Tao Ji, Ling Tong, Patricia McMonagle, Wensheng Yu, Frederick C. Lahser, Laura L. Rokosz, Rong Liu, Kung-I Feng, Bin Hu, Jingjun Yin, Jinglai Hao, Shuai Zan, Oleg Selyutin, Sony Agrawal, Paul Ingravallo, Rebecca T. Ruck, Bin Zhong, Karin Bystol, Donna Carr, Ernest Asante-Appiah, Stephanie Curry
المصدر: Journal of medicinal chemistry. 61(9)
مصطلحات موضوعية: Male, Elbasvir, Genotype, Drug resistance, Hepacivirus, Viral Nonstructural Proteins, 01 natural sciences, Antiviral Agents, chemistry.chemical_compound, Dogs, Pharmacokinetics, Valine, Drug Discovery, Drug Resistance, Viral, Potency, Animals, Tissue Distribution, 010405 organic chemistry, Chemistry, Drug discovery, Virology, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, Aminal, Molecular Medicine
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19
المؤلفون: Song Huang, Jason D. Graci, Paul Ingravallo, Anthony Turpoff, Neil Gregory Almstead, John Pichardo, Nanjing Zhang, Joseph M. Colacino, F. George Njoroge, Yalei Liu, Zhengxian Gu, Marla Weetall, Frederick C. Lahser, Stephen P. Jung, Gary Mitchell Karp, Amin A. Nomeir, Xiaoyan Zhang
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:594-601
مصطلحات موضوعية: 0301 basic medicine, Indoles, viruses, Hepacivirus, Molecular Sequence Data, 030106 microbiology, Clinical Biochemistry, Pharmaceutical Science, Viral Nonstructural Proteins, medicine.disease_cause, Antiviral Agents, Biochemistry, 03 medical and health sciences, Hepatitis C virus genotype, Drug Discovery, medicine, Humans, Coding region, Amino Acid Sequence, Replicon, Molecular Biology, Peptide sequence, Indole test, Sulfonamides, Mutation, biology, Organic Chemistry, Hepatitis C, medicine.disease, biology.organism_classification, Virology, Molecular biology, Molecular Medicine
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20
المؤلفون: Sony Agrawal, Bin Hu, Deyou Sha, Rebecca T. Ruck, Tao Ji, Rong Liu, Bin Zhong, Wensheng Yu, Ian W. Davies, Kung-I Feng, Patricia McMonagle, Shuai Zan, Lei Chen, Ellen Xia, Laura L. Rokosz, Robert Mazzola, Frederick C. Lahser, Jingjun Yin, Stephanie Curry, Karin Bystol, Donna Carr, Ernest Asante-Appiah, Oleg Selyutin, Shiying Chen, Anilkumar G. Nair, Mark Cartwright, Jae-Hun Kim, Jinglai Hao, Paul Ingravallo, Ling Tong, Joseph A. Kozlowski, Michael P. Dwyer
المصدر: Journal of medicinal chemistry. 60(1)
مصطلحات موضوعية: 0301 basic medicine, Pyrrolidines, viruses, Mutant, Hepacivirus, Pharmacology, Viral Nonstructural Proteins, Bioinformatics, Antiviral Agents, Heterocyclic Compounds, 4 or More Rings, Cell Line, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Dogs, Drug Discovery, Genotype, Animals, Humans, HCV NS5A Inhibitor, NS5A, Indole test, Polymorphism, Genetic, Chemistry, virus diseases, Haplorhini, biochemical phenomena, metabolism, and nutrition, digestive system diseases, Rats, Regimen, Thiazoles, 030104 developmental biology, Molecular Medicine, 030211 gastroenterology & hepatology