-
1
المؤلفون: Lalit Kalra, Mohammad Reza Amiri-Nikpour, Fabrizio A. DeFalco, Jeffrey A. Switzer, Ángel Chamorro, Marcel G. W. Dijkgraaf, Jan Dirk Vermeij, John Hodsoll, Craig J. Smith, Amit Kishore, Jason J. Chang, Willeke F. Westendorp, Diederik van de Beek, David Blacker, Paul H. J. Nederkoorn, Yousef Rezaei, Andreas Meisel
المساهمون: Neurology, ACS - Atherosclerosis & ischemic syndromes, Amsterdam Neuroscience - Neuroinfection & -inflammation, Amsterdam Neuroscience - Neurovascular Disorders, Epidemiology and Data Science, APH - Methodology
المصدر: European Stroke Journal, 6(4), 385-394. SAGE Publications Inc.
Westendorp, W F, Vermeij, J, Smith, C J, Kishore, A K, Hodsoll, J, Kalra, L, Meisel, A, Chamorro, A, Chang, J J, Rezaei, Y, Amiri-nikpour, M R, Defalco, F A, Switzer, J A, Blacker, D J, Dijkgraaf, M G, Nederkoorn, P J & Van De Beek, D 2021, ' Preventive antibiotic therapy in acute stroke patients: A systematic review and meta-analysis of individual patient data of randomized controlled trials ', European Stroke Journal . https://doi.org/10.1177/23969873211056445مصطلحات موضوعية: medicine.medical_specialty, Lydia Becker Institute, business.industry, Patient data, medicine.disease, stroke, infection, law.invention, Randomized controlled trial, law, ResearchInstitutes_Networks_Beacons/lydia_becker_institute_of_immunology_and_inflammation, Internal medicine, Meta-analysis, Antibiotic therapy, antibiotic therapy, medicine, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, Stroke, Acute stroke
-
2
المؤلفون: Anthony James Wilkinson, David Timms, Henk Timmerman, David R. Kelly, R. H. Davies, Paul H. J. Nederkoorn, Kenneth J. Broadley
المصدر: Journal of Molecular Structure: THEOCHEM. 452:25-47
مصطلحات موضوعية: GTP', ATP synthase, biology, Chemistry, Stereochemistry, Phosphoramidate, Condensed Matter Physics, Ligand (biochemistry), Biochemistry, GDP phosphorylation, biology.protein, Phosphorylation, Physical and Theoretical Chemistry, Ternary complex, Histidine
-
3
المساهمون: Medicinal chemistry
المصدر: Bioorganic and Medicinal Chemistry Letters, 7, 1331-1336. Elsevier Limited
Zhang, M Q, Zwaagstra, M E, Nederkoorn, P H J & Timmerman, H 1997, ' The role of arginine in the binding of LTD4 antagonists to Cys LT1 receptors of guinea pig ileum. ', Bioorganic and Medicinal Chemistry Letters, vol. 7, pp. 1331-1336 . https://doi.org/10.1016/S0960-894X(97)00219-9مصطلحات موضوعية: Leukotriene, Phenylglyoxal, Leukotriene D4, Arginine, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, respiratory system, Biochemistry, Pranlukast, Guinea pig, chemistry.chemical_compound, Drug Discovery, medicine, Molecular Medicine, lipids (amino acids, peptides, and proteins), Binding site, Receptor, SDG 6 - Clean Water and Sanitation, Molecular Biology, medicine.drug
-
4
المؤلفون: Hendrik Timmerman, Anton M. Ter Laak, Paul H. J. Nederkoorn, Rob Leurs, Gabriëlle M. Donné-Op den Kelder, Martine J. Smit
المصدر: Journal of Computer-Aided Molecular Design. 9:319-330
مصطلحات موضوعية: Models, Molecular, Agonist, Protein Conformation, medicine.drug_class, Stereochemistry, Molecular Sequence Data, Histamine H1 receptor, Histamine agonist, Histamine Agonists, chemistry.chemical_compound, Histamine receptor, Histamine H2 receptor, Drug Discovery, medicine, Animals, Humans, Computer Simulation, Amino Acid Sequence, Receptors, Histamine H1, Physical and Theoretical Chemistry, Binding site, Binding Sites, Chemistry, Computer Science Applications, Mutagenesis, Site-Directed, Histamine, Binding domain
-
5
المساهمون: Medicinal chemistry
المصدر: Trends in Pharmacological Sciences, 16, 156-161. Elsevier Limited
Nederkoorn, P H J, Timmerman, H & Donné-Op den Kelder, G M 1995, ' Does the tenary complex act as a secondary proton pump and a GTP synthase? ', Trends in Pharmacological Sciences, vol. 16, pp. 156-161 . https://doi.org/10.1016/S0165-6147(00)89008-2مصطلحات موضوعية: Pharmacology, G protein-coupled receptor kinase, ATP synthase, biology, GTP', G protein, Hydrolysis, fungi, food and beverages, Proton Pumps, Toxicology, Guanosine Diphosphate, Ligases, Biochemistry, GTP-Binding Proteins, Heterotrimeric G protein, biology.protein, Guanosine Triphosphate, Receptor, Ternary complex, Signal Transduction, G protein-coupled receptor
-
6
المؤلفون: Hendrik Timmerman, Paul H. J. Nederkoorn, Gabriëlle M. Donné-Op den Kelder, Pieter Vernooijs, E. J. Baerends
المصدر: Journal of Molecular Graphics. 12:242-256
مصطلحات موضوعية: Serine protease, biology, Stereochemistry, Biophysics, Biochemistry, Dimaprit, Serine, chemistry.chemical_compound, chemistry, Histamine H2 receptor, Catalytic triad, biology.protein, Imidazole, Binding site, Histamine
-
7
المصدر: Integrated Analytical Systems ISBN: 9780387980607
مصطلحات موضوعية: Interferometry, Phase change, Computer science, Electronic engineering, Current sensor, Key features, Biosensor, Label free
-
8
المؤلفون: Paul H. J. Nederkoorn, Henk Timmerman
المصدر: Computer-Assisted Lead Finding and Optimization: Current Tools for Medicinal Chemistry
مصطلحات موضوعية: Biochemistry, GTP', Chemistry, Signal transduction, Ternary operation, Receptor, Proton pump, G protein-coupled receptor
-
9
المؤلفون: Jacobus D. M. Herscheid, Wiro M. P. B. Menge, Edward A. Worthington, Henk Timmerman, Greetje J. Bijloo, Albert D. Windhorst, Rob Leurs, Paul H. J. Nederkoorn
المساهمون: Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, CCA - Cancer Treatment and quality of life, Medicinal chemistry
المصدر: Journal of Medicinal Chemistry, 43(9), 1754-1761. American Chemical Society
Windhorst, A D, Timmerman, H, Worthington, E A, Bijloo, G J, Nederkoorn, P H J, Menge, W M P B, Leurs, R & Herscheid, J D M 2000, ' Characterization of the binding site of the histamine H 3 receptor. 2. Synthesis, in vitro pharmacology, and QSAR of a series of monosubstituted benzyl analogues of thioperamide ', Journal of Medicinal Chemistry, vol. 43, no. 9, pp. 1754-1761 . https://doi.org/10.1021/jm981106w
Journal of Medicinal Chemistry, 43, 1754-1761. American Chemical Society
Windhorst, A D, Timmerman, H, Worthington, E A, Bijloo, G J, Nederkoorn, P H J, Menge, W M P B, Leurs, R & Herscheid, J D M 2000, ' Characterization of the binding site of the Histamine H3 receptor. 2. Synthesis in Vitro Pharmacology, and QSAR of a series of Monosubstituted Benzyl analogues of Thioperamide ', Journal of Medicinal Chemistry, vol. 43, pp. 1754-1761 . https://doi.org/10.1021/jm981106wمصطلحات موضوعية: Models, Molecular, inorganic chemicals, Quantitative structure–activity relationship, Molecular model, Stereochemistry, Histamine Antagonists, Substituent, Dihedral angle, urologic and male genital diseases, Structure-Activity Relationship, chemistry.chemical_compound, Piperidines, Benzyl Compounds, Drug Discovery, polycyclic compounds, medicine, Receptors, Histamine H3, Moiety, heterocyclic compounds, Thioperamide, Binding Sites, Chemistry, organic chemicals, Muscle, Smooth, Jejunum, Thiourea, Molecular Medicine, Radiopharmaceuticals, Histamine H3 receptor, SDG 6 - Clean Water and Sanitation, Muscle Contraction, medicine.drug
-
10
المساهمون: Medicinal chemistry
المصدر: Broadley, K J, Nederkoorn, P H J, Timmerman, H, Timms, D & Davies, R H 2000, ' The Ligand-Receptor-G-Protein Ternary Complex as a GTP-Synthase. Steady-state Proton Pumping and Dose-Response relationships for eta Adrenoceptors ', Journal of Theoretical Biology, vol. 205, pp. 297-320 . https://doi.org/10.1006/jtbi.2000.2067
Journal of Theoretical Biology, 205, 297-320. Academic Press Inc.مصطلحات موضوعية: Statistics and Probability, GTP', G protein, General Biochemistry, Genetics and Molecular Biology, GTP-Binding Proteins, Receptors, Adrenergic, beta, Humans, Receptor, Ternary complex, Equilibrium constant, General Immunology and Microbiology, ATP synthase, biology, Dose-Response Relationship, Drug, Chemistry, Applied Mathematics, General Medicine, Proton Pumps, Binding constant, Biochemistry, Models, Chemical, Modeling and Simulation, Biophysics, biology.protein, Steady state (chemistry), Guanosine Triphosphate, General Agricultural and Biological Sciences, Protein Binding
-
11
المساهمون: Medicinal chemistry
المصدر: de Esch, I J P, Timmerman, H, Menge, W M P B & Nederkoorn, P H J 2000, ' A qualitative Model for the Histamine H3 receptor explaining agonistic and antagonistic activity simultaneously ', Archiv der Pharmazie, vol. 333, pp. 254-261 . https://doi.org/10.1002/1521-4184(20008)333:8<254::aid-ardp254>3.0.co;2-g
Archiv der Pharmazie, 333, 254-261. Wiley-VCH Verlagمصطلحات موضوعية: Agonist, Molecular model, medicine.drug_class, Stereochemistry, Pharmaceutical Science, Histamine agonist, chemistry.chemical_compound, chemistry, SDG 3 - Good Health and Well-being, Drug Discovery, medicine, Structure–activity relationship, Pharmacophore, Binding site, Histamine H3 receptor, Histamine
-
12
المؤلفون: Saskia H. H. F. Schoenmakers, Edith Gelens, M. E. Zwaagstra, Henk Timmerman, Mingqiang Zhang, Paul H. J. Nederkoorn
المساهمون: Medicinal chemistry
المصدر: Zwaagstra, M E, Schoenmaker, S H H F, Nederkoorn, P H J, Gelens, E, Timmerman, H & Zhang, M Q 1998, ' Development of a three-dimensional CysLT1 (LTD4) antagonist model with an incorporated amino acid residue from the receptor. ', Journal of Medicinal Chemistry, vol. 41, pp. 1439-1445 . https://doi.org/10.1021/jm970180w
Journal of Medicinal Chemistry, 41, 1439-1445. American Chemical Societyمصطلحات موضوعية: chemistry.chemical_classification, Flavonoids, Models, Molecular, Receptors, Leukotriene, Molecular model, Arginine, Stereochemistry, Carboxylic acid, Quinoline, Antagonist, Molecular Conformation, Membrane Proteins, chemistry.chemical_compound, Residue (chemistry), chemistry, Drug Discovery, Quinolines, Molecular Medicine, Leukotriene Antagonists, Pharmacophore, Guanidine
-
13
المؤلفون: Iwan J. P. de Esch, Henk Timmerman, Paul H. J. Nederkoorn
مصطلحات موضوعية: Biochemistry, Histamine h, Histamine H3 receptor, Biology, Receptor, Receptor stimulation, Receptor activation
-
14
المصدر: Signal Transduction by G Protein-Coupled Receptors ISBN: 9781468414097
مصطلحات موضوعية: chemistry.chemical_classification, Chemistry, Effector, G protein, Mechanism (biology), Biophysics, Phosphorylation, Nucleotide, Transducin, Guanine nucleotide exchange factor, Rod Outer Segments
-
15
المصدر: Signal Transduction by G Protein-Coupled Receptors ISBN: 9781468414097
-
16
المصدر: Signal Transduction by G Protein-Coupled Receptors ISBN: 9781468414097
مصطلحات موضوعية: Cognitive science, Proton translocation, Classical theory, Computer science, Molecular mechanism, Signal transduction, G protein-coupled receptor
-
17
المصدر: Signal Transduction by G Protein-Coupled Receptors ISBN: 9781468414097
مصطلحات موضوعية: G protein-coupled receptor kinase, Biochemistry, G protein, Metabotropic glutamate receptor, Chemistry, Heterotrimeric G protein, Receptor, Rhodopsin-like receptors, 5-HT receptor, G protein-coupled receptor
-
18
المصدر: Signal Transduction by G Protein-Coupled Receptors ISBN: 9781468414097
مصطلحات موضوعية: Hydrolysis, ATP synthase, biology, Chemiosmosis, ATP hydrolysis, Chemistry, ATPase, biology.protein, Biophysics, Paracoccus denitrificans, biology.organism_classification, Reversible reaction, Catalysis
-
19
المصدر: Signal Transduction by G Protein-Coupled Receptors ISBN: 9781468414097
مصطلحات موضوعية: chemistry.chemical_classification, chemistry, GTP', G protein, Biophysics, Nucleotide, Rate-determining step, Dissociation (chemistry)
-
20
المصدر: Molecular Biology Intelligence Unit ISBN: 9781468414097
Signal Transduction by G Protein-Coupled Receptorsمصطلحات موضوعية: Metabotropic receptor, Chemistry, G protein, Signal transducing adaptor protein, Signal transduction, G protein-coupled receptor, Cell biology