المؤلفون: Mowday, Alexandra M, van de Laak, Jella M, Fu, Zhe, Henare, Kimiora L, Dubois, Ludwig, Lambin, Philippe, Theys, Jan, Patterson, Adam V

المصدر: Mowday , A M , van de Laak , J M , Fu , Z , Henare , K L , Dubois , L , Lambin , P , Theys , J & Patterson , A V 2024 , ' Tumor-targeting bacteria as immune stimulants - the future of cancer immunotherapy? ' , Critical Reviews in Microbiology , vol. 50 , no. 6 , pp. 955-970 . https://doi.org/10.1080/1040841X.2024.2311653

مصطلحات موضوعية: Tumor-targeting bacteria, cancer, immune response, immune stimulant, immunotherapy

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/4e23fbea-89e1-4487-995e-09f0199588d8
https://doi.org/10.1080/1040841X.2024.2311653

المؤلفون: Theys, Jan, Patterson, Adam V., Mowday, Alexandra M.

المصدر: Theys , J , Patterson , A V & Mowday , A M 2024 , ' Clostridium Bacteria : Harnessing Tumour Necrosis for Targeted Gene Delivery ' , Molecular Diagnosis & Therapy , vol. 28 , no. 2 , pp. 141-151 . https://doi.org/10.1007/s40291-024-00695-0

مصطلحات موضوعية: ENZYME PRODRUG THERAPY, NOVYI-NT SPORES, ANAEROBIC-BACTERIA, RECOMBINANT INTERLEUKIN-2, INTRATUMORAL INJECTION, NITROREDUCTASE ENZYME, CYTOSINE DEAMINASE, ANTITUMOR-ACTIVITY, ESCHERICHIA-COLI, PHASE-I

Relation: https://cris.maastrichtuniversity.nl/en/publications/9011784f-304c-4be0-9e4a-4dbbaf9da42c

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/9011784f-304c-4be0-9e4a-4dbbaf9da42c
https://doi.org/10.1007/s40291-024-00695-0

المؤلفون: Jackson-Patel, Victoria, Liu, Emily, Bull, Matthew R, Ashoorzadeh, Amir, Bogle, Gib, Wolfram, Anna, Hicks, Kevin O, Smaill, Jeff B, Patterson, Adam V

مصطلحات موضوعية: CP-506, PR-104 (PubChem CID: 11455973), PR-104A (PubChem CID: 9848786), SN36506, agent-based modelling (ABM), bystander effect, hypoxia-activated prodrug, multicellular spheroids, 2 Aetiology, 2.1 Biological and endogenous factors, Cancer, Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, PR-104 (PubChem CID, 11455973), PR-104A (PubChem CID, 9848786), EXTRAVASCULAR TRANSPORT, CANCER-THERAPY, PR-104A, TIRAPAZAMINE, OXIDOREDUCTASE, SORAFENIB, 1115 Pharmacology and Pharmaceutical Sciences

جغرافية الموضوع: Switzerland

وصف الملف: Electronic-eCollection; application/pdf

Relation: Frontiers in pharmacology; (2022). Frontiers in Pharmacology, 13, 803602-.; https://hdl.handle.net/2292/62944; 35211015 (pubmed); 803602

الاتاحة: https://hdl.handle.net/2292/62944
https://doi.org/10.3389/fphar.2022.803602

المؤلفون: Chen, Hao, Hu, Shiliang, Patterson, Adam V., Smaill, Jeff B., Ding, Ke, Lu, Xiaoyun

المساهمون: State Key Laboratory of Respiratory Disease, Basic and Applied Basic Research Foundation of Guangdong Province, Jinan University, National Natural Science Foundation of China

المصدر: Journal of Medicinal Chemistry ; volume 66, issue 17, page 11656-11671 ; ISSN 0022-2623 1520-4804

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c00875
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00875

المؤلفون: Mowday, Alexandra M., van de Laak, Jella M., Fu, Zhe, Henare, Kimiora L., Dubois, Ludwig, Lambin, Philippe, Theys, Jan, Patterson, Adam V.

المصدر: Critical Reviews in Microbiology; Nov2024, Vol. 50 Issue 6, p955-970, 16p

مصطلحات موضوعية: TYPE I interferons, TUMOR-infiltrating immune cells, TREATMENT effectiveness, TUMOR microenvironment, IMMUNE response

المؤلفون: Mowday, Alexandra M., Dubois, Ludwig J., Kubiak, Aleksandra M., Chan-Hyams, Jasmine V. E., Guise, Christopher P., Ashoorzadeh, Amir, Lambin, Philippe, Ackerley, David F., Smaill, Jeff B., Minton, Nigel P., Theys, Jan, Patterson, Adam V.

المصدر: Mowday , A M , Dubois , L J , Kubiak , A M , Chan-Hyams , J V E , Guise , C P , Ashoorzadeh , A , Lambin , P , Ackerley , D F , Smaill , J B , Minton , N P , Theys , J & Patterson , A V 2022 , ' Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours ' , Cancer Gene Therapy , vol. 29 , no. 2 , pp. 178-188 . https://doi.org/10.1038/s41417-021-00296-7

وصف الملف: application/pdf

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/df7cb783-c7d9-475e-9337-a77f79540da8
https://doi.org/10.1038/s41417-021-00296-7
https://cris.maastrichtuniversity.nl/ws/files/63828225/Dubois_2021_Use_of_an_optimised_enzymeprodrug_combination_for_Clostridia.pdf

المؤلفون: Patterson, Adam V.

مصطلحات موضوعية: 615.1, Reductive metabolism, Gene therapy

الاتاحة: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267352

المؤلفون: Sharrock, Abigail V., Mumm, Jeff S., Williams, Elsie M., Čėnas, Narimantas, Smaill, Jeff B., Patterson, Adam V., Ackerley, David F., Bagdžiūnas, Gintautas, Arcus, Vickery L.

المصدر: International Journal of Molecular Sciences; Jun2024, Vol. 25 Issue 12, p6593, 16p

مصطلحات موضوعية: PRODRUGS, BACTERIAL enzymes, ESCHERICHIA coli, HYDROGEN bonding interactions, BIOCHEMICAL substrates, GROUP 15 elements

المؤلفون: Yang, Fang, Lin, Qianmeng, Song, Xiaojuan, Huang, Huisi, Chen, Xiaojuan, Tan, Jianwen, Li, Yun, Zhou, Yang, Tu, Zhengchao, Du, Hongli, Zhang, Zhi-min, Ortega, Raquel, Lin, Xiaojing, Patterson, Adam V., Smaill, Jeff B., Chen, Yongheng, Lu, Xiaoyun

المساهمون: State Key Laboratory of Respiratory Disease, Basic and Applied Basic Research Foundation of Guangdong Province, Health Research Council of New Zealand, Jinan University, National Natural Science Foundation of China, Cancer Society Auckland Northland, China–Maurice Wilkins Centre Collaborative Research Programme

المصدر: Journal of Medicinal Chemistry ; volume 67, issue 4, page 2667-2689 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.3c01810
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01810

المؤلفون: van der Wiel, Alexander M A, Jackson-Patel, Victoria, Niemans, Raymon, Yaromina, Ala, Liu, Emily, Marcus, Damiënne, Mowday, Alexandra M, Lieuwes, Natasja G, Biemans, Rianne, Lin, Xiaojing, Fu, Zhe, Kumara, Sisira, Jochems, Arthur, Ashoorzadeh, Amir, Anderson, Robert F, Hicks, Kevin O, Bull, Matthew R, Abbattista, Maria R, Guise, Christopher P, Deschoemaeker, Sofie, Thiolloy, Sophie, Heyerick, Arne, Solivio, Morwena J, Balbo, Silvia, Smaill, Jeff B, Theys, Jan, Dubois, Ludwig J, Patterson, Adam V, Lambin, Philippe

المصدر: van der Wiel , A M A , Jackson-Patel , V , Niemans , R , Yaromina , A , Liu , E , Marcus , D , Mowday , A M , Lieuwes , N G , Biemans , R , Lin , X , Fu , Z , Kumara , S , Jochems , A , Ashoorzadeh , A , Anderson , R F , Hicks , K O , Bull , M R , Abbattista , M R , Guise , C P , Deschoemaeker , S , Thiolloy , S , Heyerick , A , ....

مصطلحات موضوعية: PHASE-I, MUSTARD, PR-104A, COMBINATION, TH-302, IDENTIFICATION, REPAIR, OXIDOREDUCTASE, EVOFOSFAMIDE, DOXORUBICIN

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/88b13f8c-1c7d-4e61-8dfc-034eda5a4a38
https://doi.org/10.1158/1535-7163.MCT-21-0406

المؤلفون: Abbattista, Maria R., Ashoorzadeh, Amir, Guise, Christopher P., Mowday, Alexandra M., Mittra, Rituparna, Silva, Shevan, Hicks, Kevin O., Bull, Matthew R., Jackson-Patel, Victoria, Lin, Xiaojing, Prosser, Gareth A., Lambie, Neil K., Dachs, Gabi U., Ackerley, David F., Smaill, Jeff B., Patterson, Adam V.

المصدر: Abbattista , M R , Ashoorzadeh , A , Guise , C P , Mowday , A M , Mittra , R , Silva , S , Hicks , K O , Bull , M R , Jackson-Patel , V , Lin , X , Prosser , G A , Lambie , N K , Dachs , G U , Ackerley , D F , Smaill , J B & Patterson , A V 2021 , ' Restoring tumour selectivity of the bioreductive prodrug pr-104 by developing an analogue resistant to aerobic metabolism by human aldo-keto reductase 1c3 ' ....

مصطلحات موضوعية: Aldo-keto reductase 1C3, Bioreductive prodrug, Cytochrome P450 oxidoreductase, Hypoxia-activated prodrug, Myelotoxicity, Orthologues, PR-104, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/3000/3003, name=Pharmaceutical Science, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery

وصف الملف: application/pdf

Relation: https://discovery.dundee.ac.uk/en/publications/c3a01da2-b52f-47d5-bf2b-f3e135947b21

الاتاحة: https://discovery.dundee.ac.uk/en/publications/c3a01da2-b52f-47d5-bf2b-f3e135947b21
https://doi.org/10.3390/ph14121231
https://discovery.dundee.ac.uk/ws/files/70864772/pharmaceuticals_14_01231_v2.pdf
http://www.scopus.com/inward/record.url?scp=85120404060&partnerID=8YFLogxK

المؤلفون: Kavianinia, Iman, Brimble, Margaret A., Kasim, Johanes K., Bull, Matthew, Harris, Paul W. R., Smaill, Jeff B., Patterson, Adam V.

المساهمون: Health Research Council of New Zealand, Maurice Wilkins Centre for Molecular Biodiscovery

المصدر: Synthesis ; volume 53, issue 22, page 4239-4245 ; ISSN 0039-7881 1437-210X

الاتاحة: http://dx.doi.org/10.1055/s-0040-1706264
http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1706264.pdf

المؤلفون: Theys, Jan, Patterson, Adam V., Mowday, Alexandra M.

المصدر: Molecular Diagnosis & Therapy; Mar2024, Vol. 28 Issue 2, p141-151, 11p

مصطلحات موضوعية: CLOSTRIDIUM, CLOSTRIDIUM acetobutylicum, CLOSTRIDIA, IMMUNE checkpoint inhibitors, ANAEROBIC bacteria, GENETIC techniques, GENE expression

المؤلفون: Guo, Jing, Chen, Xiaojuan, Li, Xiaofei, Shao, Min, Song, Xiaojuan, Zhang, Lin, Huang, Shengjie, Patterson, Adam V., Smaill, Jeff B., Zhou, Yang, Yu, Xiangrong, Chen, Yongheng, Lu, Xiaoyun

الاتاحة: https://doi.org/10.2139/ssrn.5096059

المؤلفون: Spiegelberg, Linda, Houben, Ruud, Niemans, Raymon, de Ruysscher, Dirk, Yaromina, Ala, Theys, Jan, Guise, Christopher P., Smaill, Jeffrey B., Patterson, Adam V., Lambin, Philippe, Dubois, Ludwig J.

المصدر: Spiegelberg , L , Houben , R , Niemans , R , de Ruysscher , D , Yaromina , A , Theys , J , Guise , C P , Smaill , J B , Patterson , A V , Lambin , P & Dubois , L J 2019 , ' Hypoxia-activated prodrugs and (lack of) clinical progress : The need for hypoxia-based biomarker patient selection in phase III clinical trials ' , Clinical and Translational Radiation Oncology , vol. 15 , pp. 62-69 . https://doi.org/10.1016/j.ctro.2019.01.005

مصطلحات موضوعية: Hypoxia-activated prodrugs, Phase III clinical trial, Biomarker, Hypoxia, C P450 REDUCTASE, POSITRON-EMISSION-TOMOGRAPHY, SQUAMOUS-CELL CARCINOMAS, OXYGEN-ENHANCED MRI, TUMOR HYPOXIA, ANTITUMOR-ACTIVITY, NECK-CANCER, LUNG-CANCER, EXTRAVASCULAR TRANSPORT, EVOFOSFAMIDE TH-302

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/1fbf9033-8075-4655-9efb-1632d138d1a5
https://doi.org/10.1016/j.ctro.2019.01.005

المؤلفون: Ashoorzadeh, Amir, Mowday, Alexandra M., Abbattista, Maria R., Guise, Christopher P., Bull, Matthew R., Silva, Shevan, Patterson, Adam V., Smaill, Jeff B.

المساهمون: Health Research Council of New Zealand, Faculty of Medical and Health Sciences, University of Auckland

المصدر: ACS Medicinal Chemistry Letters ; volume 14, issue 11, page 1517-1523 ; ISSN 1948-5875 1948-5875

الاتاحة: http://dx.doi.org/10.1021/acsmedchemlett.3c00321
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00321

المؤلفون: Copp, Janine N., Mowday, Alexandra M., Williams, Elsie M., Guise, Christopher P., Ashoorzadeh, Amir, Sharrock, Abigail V., Flanagan, Jack U., Smaill, Jeff B., Patterson, Adam V., Ackerley, David F.

المساهمون: Royal Society of New Zealand, Health Research Council of New Zealand, Genesis Oncology Trust, Cancer Society of New Zealand, Tertiary Education Commission, University of Auckland

المصدر: Cell Chemical Biology ; volume 24, issue 3, page 391-403 ; ISSN 2451-9456

الاتاحة: http://dx.doi.org/10.1016/j.chembiol.2017.02.005
https://api.elsevier.com/content/article/PII:S2451945617300351?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2451945617300351?httpAccept=text/plain

المؤلفون: Xu, Fang, Zhang, Xin, Chen, Zhipeng, He, Sheng, Guo, Jing, Yu, Lei, Wang, Yongjin, Hou, Caiyun, AI-furas, Hawaa, Zheng, Zongyao, Smaill, Jeff B., Patterson, Adam V., Zhang, Zhi-Min, Chen, Liang, Ren, Xiaomei, Ding, Ke

المساهمون: Shenzhen Bay Laboratory, National Natural Science Foundation of China, Guangdong Province

المصدر: Journal of Medicinal Chemistry ; volume 65, issue 20, page 14032-14048 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.2c01246
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01246

المؤلفون: Shao, Min, Chen, Xiaojuan, Yang, Fang, Song, Xiaojuan, Zhou, Yang, Lin, Qianmeng, Fu, Ying, Ortega, Raquel, Lin, Xiaojing, Tu, Zhengchao, Patterson, Adam V., Smaill, Jeff B., Chen, Yongheng, Lu, Xiaoyun

المساهمون: Ministry of Science and Technology of the People's Republic of China, Health Research Council of New Zealand, Maurice Wilkins Centre for Molecular Biodiscovery, National Natural Science Foundation of China, Chinese Academy of Sciences, Cancer Society Auckland

المصدر: Journal of Medicinal Chemistry ; volume 65, issue 6, page 5113-5133 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.2c00096
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c00096

المؤلفون: Yang, Fang, Chen, Xiaojuan, Song, Xiaojuan, Ortega, Raquel, Lin, Xiaojing, Deng, Wuqing, Guo, Jing, Tu, Zhengchao, Patterson, Adam V., Smaill, Jeff B., Chen, Yongheng, Lu, Xiaoyun

المساهمون: Ministry of Science and Technology of the People's Republic of China, Health Research Council of New Zealand, Jinan University, National Natural Science Foundation of China, Guangdong Province Science and Technology Program, Cancer Society Auckland Northland, China Maurice Wilkins Centre Collaborative Research Program

المصدر: Journal of Medicinal Chemistry ; volume 65, issue 21, page 14809-14831 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.2c01319
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.2c01319