المؤلفون: Awalt, Jon, Su, Wenyin, Nguyen, William, Loi, Katie, Jarman, Kate, Penington, Jocelyn, Ramesh, Saishyam, Fairhurst, Kate, Yeo, Tomas, Park, Heekuk, Uhlemann, Anne-Catrin, Chandra Maity, Bikash, De, Nirupam, Mukherjee, Partha, Chakraborty, Arnish, Churchyard, Alisje, Famodimu, Mufuliat, Delves, Michael, Baum, Jake, Mittal, Nimisha, Winzeler, Elizabeth, Papenfuss, Anthony, Chowdury, Mrittika, de Koning-Ward, Tania, Maier, Alexander, van Dooren, Giel, Baud, Delphine, Brand, Stephen, Fidock, David, Jackson, Paul, Cowman, Alan, Dans, Madeline, Sleebs, Brad

مصطلحات موضوعية: Antimalarial, Cytochrome b, Malaria, Mitochondria, Plasmodium, Antimalarials, Plasmodium falciparum, Structure-Activity Relationship, Cytochromes b, Humans, Animals, Molecular Structure, Dose-Response Relationship, Drug, Parasitic Sensitivity Tests, Mice, Cyclopropanes, Amides, Drug Resistance

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4zc6q4nb
https://escholarship.org/content/qt4zc6q4nb/qt4zc6q4nb.pdf

المؤلفون: Barnes, Griffin, Magann, Nicholas, Perrotta, Daniele, Hörmann, Fabian, Fernandez, Sebastian, Vydyam, Pratap, Choi, Jae-Yeon, Prudhomme, Jacques, Neal, Armund, Le Roch, Karine, Ben Mamoun, Choukri, Vanderwal, Christopher

المصدر: Journal of the American Chemical Society. 146(43)

مصطلحات موضوعية: Alkaloids, Plasmodium falciparum, Antiprotozoal Agents, Pyrroloiminoquinones, Humans, Parasitic Sensitivity Tests, Molecular Structure, Antimalarials, Pyrroles, Structure-Activity Relationship

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0fz1787r
https://escholarship.org/content/qt0fz1787r/qt0fz1787r.pdf

المؤلفون: Taylor, Annie E, Hering, Moritz, Elsegood, Mark RJ, Teat, Simon J, Weaver, George W, Arroo, Randolph RJ, Kaiser, Marcel, Maeser, Pascal, Bhambra, Avninder S

مصطلحات موضوعية: Medicinal and Biomolecular Chemistry, Chemical Sciences, Orphan Drug, Vector-Borne Diseases, Rare Diseases, Infectious Diseases, 5.1 Pharmaceuticals, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Pyrimidines, Trypanocidal Agents, Structure-Activity Relationship, Parasitic Sensitivity Tests, Molecular Structure, Trypanosoma brucei brucei, Humans, Trypanosoma brucei rhodesiense, Dose-Response Relationship, Drug, Trypanosomiasis, African, Antiparasitic, Antitrypanosomal, Kinetoplastid, Neglected tropical diseases, T.brucei, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, Medicinal and biomolecular chemistry, Organic chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4tm697wf
https://escholarship.org/content/qt4tm697wf/qt4tm697wf.pdf

المؤلفون: Summers, Robert, Pasaje, Charisse, Pisco, Joao, Striepen, Josefine, Luth, Madeline, Kumpornsin, Krittikorn, Carpenter, Emma, Munro, Justin, Lin, De, Plater, Andrew, Punekar, Avinash, Shepherd, Andrew, Shepherd, Sharon, Vanaerschot, Manu, Murithi, James, Rubiano, Kelly, Akidil, Aslı, Ottilie, Sabine, Mittal, Nimisha, Dilmore, A, Won, Madalyn, Mandt, Rebecca, McGowen, Kerry, Owen, Edward, Walpole, Chris, Llinás, Manuel, Lee, Marcus, Fidock, David, Gilbert, Ian, Wirth, Dyann, Niles, Jacquin, Baragaña, Beatriz, Lukens, Amanda, Winzeler, Elizabeth

المصدر: Cell Chemical Biology. 29(2)

مصطلحات موضوعية: Plasmodium falciparum, acetyl-CoA synthetase, antimalarial, drug development, drug target identification, histone acetylation, malaria, mechanism of action, Acetate-CoA Ligase, Antimalarials, Enzyme Inhibitors, Humans, Malaria, Models, Molecular, Molecular Structure, Parasitic Sensitivity Tests, Plasmodium falciparum

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/2t51p0mx
https://escholarship.org/content/qt2t51p0mx/qt2t51p0mx.pdf

المؤلفون: Miyamoto, Yukiko, Aggarwal, Shubhangi, Celaje, Jeff Joseph A, Ihara, Sozaburo, Ang, Jonathan, Eremin, Dmitry B, Land, Kirkwood M, Wrischnik, Lisa A, Zhang, Liangfang, Fokin, Valery V, Eckmann, Lars

المصدر: Journal of Medicinal Chemistry. 64(10)

مصطلحات موضوعية: Inorganic Chemistry, Biomedical and Clinical Sciences, Chemical Sciences, Urologic Diseases, Sexually Transmitted Infections, Infectious Diseases, 5.1 Pharmaceuticals, Good Health and Well Being, Animals, Antiprotozoal Agents, Cell Survival, Coordination Complexes, Disease Models, Animal, Drug Resistance, Female, Gold, HeLa Cells, Humans, Mice, Mice, Inbred BALB C, Parasitic Sensitivity Tests, Phosphines, Protein Isoforms, Structure-Activity Relationship, Thioredoxin-Disulfide Reductase, Trichomonas Infections, Trichomonas vaginalis, Trophozoites, Hela Cells, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, Pharmacology and pharmaceutical sciences, Medicinal and biomolecular chemistry, Organic chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/99v254ct
https://escholarship.org/content/qt99v254ct/qt99v254ct.pdf

المؤلفون: Sauvey, Conall, Ehrenkaufer, Gretchen, Shi, Da, Debnath, Anjan, Abagyan, Ruben

المصدر: PLOS Neglected Tropical Diseases. 15(2)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Digestive Diseases, Orphan Drug, Infectious Diseases, Emerging Infectious Diseases, Biodefense, Rare Diseases, 5.1 Pharmaceuticals, Good Health and Well Being, Animals, Antineoplastic Agents, Cell Survival, Drug Evaluation, Preclinical, Entamoeba histolytica, Parasitic Sensitivity Tests, Trophozoites, Biological Sciences, Medical and Health Sciences, Tropical Medicine, Biological sciences, Biomedical and clinical sciences, Health sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0tz4754w
https://escholarship.org/content/qt0tz4754w/qt0tz4754w.pdf

المؤلفون: Patra, Alok Tanala, Hingamire, Tejashri, Belekar, Meenakshi A, Xiong, Aoli, Subramanian, Gowtham, Bozdech, Zbynek, Preiser, Peter, Shanmugam, Dhanasekaran, Chandramohanadas, Rajesh

المصدر: Antimicrobial Agents and Chemotherapy. 64(5)

مصطلحات موضوعية: Vector-Borne Diseases, Emerging Infectious Diseases, Infectious Diseases, Malaria, Orphan Drug, Rare Diseases, Aetiology, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Antimalarials, DNA Fragmentation, Drug Evaluation, Preclinical, Humans, Malaria, Falciparum, Merozoites, Parasitic Sensitivity Tests, Plasmodium falciparum, Schizonts, Trophozoites, phenotypic screening, Medicines for Malaria Venture, Pathogen Box, stage-specific inhibition, egress, DNA fragmentation, MMV, schizonts, Plasmodium falciparum, Microbiology, Medical Microbiology, Pharmacology and Pharmaceutical Sciences

URL الوصول: https://escholarship.org/uc/item/33s180ss

المؤلفون: Tiash, Snigdha, Saunders, Jake, Ryan, John, Riches, Andrew, Skinner-Adams, Tina, Hart, Christopher

مصطلحات موضوعية: Drug discovery, Giardia duodenalis, Pathogen box, Antiparasitic Agents, Biological Assay, Drug Discovery, Giardia, Giardia lamblia, Giardiasis, Humans, Inhibitory Concentration 50, Parasitic Sensitivity Tests, Prevalence

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4sz0z0wm

المؤلفون: Keller, Lena, Siqueira-Neto, Jair L, Souza, Julia M, Eribez, Korina, LaMonte, Gregory M, Smith, Jennifer E, Gerwick, William H

المصدر: Molecules (Basel, Switzerland). 25(7)

مصطلحات موضوعية: Cyanobacteria, Macrolides, Antimalarials, Magnetic Resonance Spectroscopy, Parasitic Sensitivity Tests, Molecular Structure, Structure-Activity Relationship, Aquatic Organisms, antimalarial agents, cyanobacteria, leishmaniosis, macrolide, malaria, natural products, Medicinal and Biomolecular Chemistry, Organic Chemistry, Theoretical and Computational Chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/14s5000t

المؤلفون: Ehrenkaufer, Gretchen, Li, Pengyang, Stebbins, Erin E, Kangussu-Marcolino, Monica M, Debnath, Anjan, White, Corin V, Moser, Matthew S, DeRisi, Joseph, Gisselberg, Jolyn, Yeh, Ellen, Wang, Steven C, Company, Ana Hervella, Monti, Ludovica, Caffrey, Conor R, Huston, Christopher D, Wang, Bo, Singh, Upinder

المصدر: PLoS neglected tropical diseases. 14(3)

مصطلحات موضوعية: Cell Line, Fibroblasts, Animals, Humans, Mice, Rats, Parasites, Pyrroles, Prodigiosin, Anisomycin, Antiparasitic Agents, Parasitic Sensitivity Tests, Cell Survival, Drug Repositioning, Biological Sciences, Medical and Health Sciences, Tropical Medicine

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9qz9r8pc

المؤلفون: Maccesi, Martina, Aguiar, Pedro HN, Pasche, Valérian, Padilla, Melody, Suzuki, Brian M, Montefusco, Sandro, Abagyan, Ruben, Keiser, Jennifer, Mourão, Marina M, Caffrey, Conor R

المصدر: Parasites & Vectors. 12(1)

مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Vector-Borne Diseases, Infectious Diseases, Rare Diseases, Orphan Drug, Infection, Good Health and Well Being, Animals, Biomphalaria, Cricetinae, Drug Discovery, Female, Larva, Life Cycle Stages, Mesocricetus, Parasitic Sensitivity Tests, Phenotype, Schistosoma mansoni, Schistosomiasis mansoni, Schistosomicides, Schistosoma, Schistosomiasis, Drug discovery, Phenotypic screen, Pathogen Box, MMV, Public Health and Health Services, Mycology & Parasitology, Tropical Medicine, Microbiology, Medical microbiology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3937v5z0
https://escholarship.org/content/qt3937v5z0/qt3937v5z0.pdf

المؤلفون: O’Donoghue, Anthony J, Bibo-Verdugo, Betsaida, Miyamoto, Yukiko, Wang, Steven C, Yang, Justin Z, Zuill, Douglas E, Matsuka, Shoun, Jiang, Zhenze, Almaliti, Jehad, Caffrey, Conor R, Gerwick, William H, Eckmann, Lars

المصدر: Antimicrobial Agents and Chemotherapy. 63(11)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Biotechnology, Women's Health, Sexually Transmitted Infections, Infectious Diseases, 5.1 Pharmaceuticals, Good Health and Well Being, Amino Acid Sequence, Animals, Anti-Infective Agents, Antitrichomonal Agents, Cytoplasm, Drug Resistance, Female, Humans, Mice, Mice, Inbred BALB C, Parasitic Sensitivity Tests, Proteasome Endopeptidase Complex, Proteomics, Sexually Transmitted Diseases, Trichomonas Infections, Trichomonas Vaginitis, Trichomonas vaginalis, proteasome, protozoa, Microbiology, Medical Microbiology, Pharmacology and Pharmaceutical Sciences, Medical microbiology, Pharmacology and pharmaceutical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/2bk3t711
https://escholarship.org/content/qt2bk3t711/qt2bk3t711.pdf

المؤلفون: Laurie, Matthew T, White, Corin V, Retallack, Hanna, Wu, Wesley, Moser, Matthew S, Sakanari, Judy A, Ang, Kenny, Wilson, Christopher, Arkin, Michelle R, DeRisi, Joseph L, Ali, Ibne, Geary, Timothy

المصدر: mBio. 9(5)

مصطلحات موضوعية: Vaccine Related, Prevention, Biodefense, Orphan Drug, Infectious Diseases, Rare Diseases, Brain Disorders, Antimicrobial Resistance, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Infection, Good Health and Well Being, Amebiasis, Amebicides, Balamuthia mandrillaris, Brain, Cell Line, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Fibroblasts, Humans, Models, Biological, Nitroquinolines, Parasitic Sensitivity Tests, amoeba, antiparasitic agents, balamuthia, encephalitis, nitroxoline, Microbiology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4jv0t9k1
https://escholarship.org/content/qt4jv0t9k1/qt4jv0t9k1.pdf

المؤلفون: Monti, Ludovica, Wang, Steven C, Oukoloff, Killian, Smith, Amos B, Brunden, Kurt R, Caffrey, Conor R, Ballatore, Carlo

المصدر: ChemMedChem. 13(17)

مصطلحات موضوعية: Neurosciences, Vector-Borne Diseases, Rare Diseases, Infectious Diseases, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Good Health and Well Being, Brain, Dose-Response Relationship, Drug, Humans, Microtubules, Molecular Structure, Parasitic Sensitivity Tests, Pyrimidines, Structure-Activity Relationship, Trypanocidal Agents, Trypanosoma brucei brucei, Trypanosomiasis, African, human African trypanosomiasis, microtubules, phenylpyrimidines, triazolopyrimidines, Trypanosoma brucei, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/7hs264h0

المؤلفون: Kumar, Sumit, Bains, Trpta, Won Kim, Ashley, Tam, Christina, Kim, Jong, Cheng, Luisa, Land, Kirkwood, Debnath, Anjan, Kumar, Vipan

مصطلحات موضوعية: Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, Tritrichomonas foetus, cytotoxicity, isatin-metronidazole conjugates, metronidazole, Anaerobiosis, Antiprotozoal Agents, Entamoeba histolytica, Foodborne Diseases, Giardia lamblia, Humans, Inhibitory Concentration 50, Isatin, Metronidazole, Parasitic Diseases, Parasitic Sensitivity Tests, Sexually Transmitted Diseases, Triazoles, Trichomonas vaginalis, Tritrichomonas foetus

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9918c7g2
https://escholarship.org/content/qt9918c7g2/qt9918c7g2.pdf

المؤلفون: Kim, Wan Jung, Korthals, Keith A, Li, Suhua, Le, Christine, Kalisiak, Jarosław, Sharpless, K Barry, Fokin, Valery V, Miyamoto, Yukiko, Eckmann, Lars

المصدر: Antimicrobial Agents and Chemotherapy. 61(6)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Medical Microbiology, Biomedical and Clinical Sciences, Emerging Infectious Diseases, Infectious Diseases, Biodefense, Vaccine Related, Prevention, Antimicrobial Resistance, Digestive Diseases, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Good Health and Well Being, Anti-Infective Agents, Antiprotozoal Agents, Click Chemistry, Giardia lamblia, Nitrofurans, Parasitic Sensitivity Tests, Pyrroles, Structure-Activity Relationship, Thiazoles, antimicrobial agents, drug screening, Microbiology, Medical microbiology, Pharmacology and pharmaceutical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0h83n19g

المؤلفون: Munro, Taylah, Andrews, Katherine, Ryan, John, Riches, Andrew, Skinner-Adams, Tina, Hart, Christopher

المصدر: International Journal for Parasitology: Drugs and Drug Resistance. 7(1)

مصطلحات موضوعية: Drug discovery, Giardia, Image-based assay, Malaria Box, Antiprotozoal Agents, Automation, Drug Discovery, Drug Resistance, Giardia lamblia, Image Processing, Computer-Assisted, Life Cycle Stages, Parasitic Sensitivity Tests

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5h84h900

المؤلفون: Lamy, Ricardo, Chan, Elliot, Good, Samuel D, Cevallos, Vicky, Porco, Travis C, Stewart, Jay M

المصدر: Clinical and Experimental Ophthalmology. 44(3)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Ophthalmology and Optometry, Acanthamoeba, Biguanides, Chlorhexidine, Disinfectants, Drug Synergism, Humans, Parasitic Sensitivity Tests, Photochemotherapy, Photosensitizing Agents, Riboflavin, Ultraviolet Rays, photochemotherapy, riboflavin, ultraviolet, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry, Ophthalmology and optometry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/028249c4
https://escholarship.org/content/qt028249c4/qt028249c4.pdf

المؤلفون: Kuhlenschmidt, Theresa B, Rutaganira, Florentine U, Long, Shaojun, Tang, Keliang, Shokat, Kevan M, Kuhlenschmidt, Mark S, Sibley, L David

المصدر: Antimicrobial Agents and Chemotherapy. 60(1)

مصطلحات موضوعية: Biological Sciences, Biomedical and Clinical Sciences, Microbiology, Medical Microbiology, Pharmacology and Pharmaceutical Sciences, Emerging Infectious Diseases, Foodborne Illness, Digestive Diseases, Biodefense, Vaccine Related, Prevention, Infectious Diseases, Biotechnology, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Animals, Antiprotozoal Agents, Cattle, Cell Line, Cryptosporidium parvum, Epithelial Cells, Feces, Gene Expression, Humans, Inhibitory Concentration 50, Male, Parasitic Sensitivity Tests, Protein Kinases, Protozoan Proteins, Pyrazoles, Pyrimidines, Sporozoites, Structure-Activity Relationship, Medical microbiology, Pharmacology and pharmaceutical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/75w4n19n

المؤلفون: Saraiva, Raul G., Huitt-Roehl, Callie R., Tripathi, Abhai, Cheng, Yi-Qiang, Bosch, Jurgen, Townsend, Craig A., Dimopoulos, George

المصدر: Scientific Reports

مصطلحات موضوعية: Antibiosis, Antimalarials / chemistry, Antimalarials / metabolism, Antimalarials / pharmacology, Chromobacterium / classification, Chromobacterium / physiology, Depsipeptides / biosynthesis, Depsipeptides / chemistry, Depsipeptides / pharmacology, Genome, Bacterial, Genome-Wide Association Study, Genomics / methods, Histone Deacetylase Inhibitors / chemistry, Histone Deacetylase Inhibitors / metabolism, Histone Deacetylase Inhibitors / pharmacology, Parasitic Sensitivity Tests, Phylogeny, Plasmodium / drug effects, Plasmodium / physiology

وصف الملف: application/pdf

Relation: https://doi.org/10.1038/s41598-018-24296-0; Saraiva, R. G., Huitt-Roehl, C. R., Tripathi, A., Cheng, Y. Q., Bosch, J., Townsend, C. A., & Dimopoulos, G. (2018). Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin. Scientific reports, 8(1), 6176. https://doi.org/10.1038/s41598-018-24296-0; https://hdl.handle.net/20.500.12503/31656

الاتاحة: https://hdl.handle.net/20.500.12503/31656