المؤلفون: Fernando Cavalcanti, Elena Gonzalez-Rey, Mario Delgado, Clara P. Falo, Leyre Mestre, Carmen Guaza, Francisco O’Valle, Michele M. P. Lufino, Jordi Xaus, Cristina Mascaró, Serena Lunardi, Natalia Sacilotto, Paola Dessanti, David Rotllant, Xavier Navarro, Mireia Herrando-Grabulosa, Carlos Buesa, Tamara Maes

المصدر: Pharmaceutics, Vol 14, Iss 7, p 1420 (2022)

مصطلحات موضوعية: epigenetics, KDM1A, vafidemstat, multiple sclerosis, neuroinflammation, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/7/1420; https://doaj.org/toc/1999-4923

URL الوصول: https://doaj.org/article/df089ff6678843aa91f71f1d603fc7ce

المؤلفون: Natalia Sacilotto (210504), Paola Dessanti (1450990), Michele M. P. Lufino (11687806), Alberto Ortega (2005231), Alejandra Rodríguez-Gimeno (1754389), Jordi Salas (11687809), Tamara Maes (8910419), Carlos Buesa (11687812), Cristina Mascaró (11687815), Robert Soliva (2508724)

مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, transcription silencing complexes, specific demethylase 1, single study exists, seclidemstat ), img, potential anticancer treatments, bomedemstat ), incb059872, reached clinical trials, fundamental scaffolding role, iadademstat ), gsk2879552, lsd1 catalytic activity, lsd1 tool compounds, tool compounds, clinical compounds, key role, low activity, enzymatic activity, lsd1 plays, vitro <

Relation: https://figshare.com/articles/journal_contribution/Comprehensive_i_in_Vitro_i_Characterization_of_the_LSD1_Small_Molecule_Inhibitor_Class_in_Oncology/16999333

الاتاحة: https://doi.org/10.1021/acsptsci.1c00223.s001

المؤلفون: Alberto Ortega, Tamara Maes, Alejandra Rodríguez-Gimeno, Natalia Sacilotto, Michele Matteo Pio Lufino, Cristina Mascaró, Robert Soliva, Carlos Buesa, Paola Dessanti, Jordi Salas

المصدر: ACS Pharmacology & Translational Science. 4:1818-1834

مصطلحات موضوعية: Pharmacology, Class (set theory), Chemistry, Pharmacology (medical), Computational biology, Characterization (mathematics), Small molecule, In vitro

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2e1e90e330dd1cd1dfee5b86029f55bd
https://doi.org/10.1021/acsptsci.1c00223

المؤلفون: Natalia, Sacilotto, Paola, Dessanti, Michele M P, Lufino, Alberto, Ortega, Alejandra, Rodríguez-Gimeno, Jordi, Salas, Tamara, Maes, Carlos, Buesa, Cristina, Mascaró, Robert, Soliva

المصدر: ACS pharmacologytranslational science. 4(6)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::bdb475af769419458a84503ed2b670c4
https://pubmed.ncbi.nlm.nih.gov/34927013

المؤلفون: Dante Rotili, Paola Vianello, Annalisa Romanelli, Stefania Vultaggio, Davide Corinti, Mario Varasi, Oronza A. Botrugno, Claudia Binda, Nicola Mautone, Sergio Valente, Anna Cappa, Antonello Mai, Clemens Zwergel, Elisabetta Di Bello, Paola Dessanti, Andrea Mattevi, Saverio Minucci, Rossella Fioravanti, Annarita Rovere, Ciro Mercurio

المصدر: ChemMedChem

مصطلحات موضوعية: antiproliferative activity, Stereochemistry, Lysine, Antineoplastic Agents, 01 natural sciences, Biochemistry, Article, Structure-Activity Relationship, chemistry.chemical_compound, drug discovery, histone demethylases, lysine specific demethylase 1, structure-activity relationships, Cell Line, Tumor, Drug Discovery, medicine, Humans, Enzyme Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, Benzamide, Cell Proliferation, Histone Demethylases, Pharmacology, Dose-Response Relationship, Drug, biology, 010405 organic chemistry, Drug discovery, Cell growth, Organic Chemistry, Tranylcypromine, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Cell culture, Microsomes, Liver, biology.protein, Molecular Medicine, Demethylase, Growth inhibition, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11fae660195ee471bbc8f39111434524
https://doi.org/10.1002/cmdc.201900730

المؤلفون: Michele M.P. Lufino, Serena Lunardi, Natalia Sacilotto, Tamara Maes, Mireia Herrando-Grabulosa, David Rotllant, Carlos Buesa, Jordi Xaus, Paola Dessanti, Carmen Guaza, Xavier Navarro, Elena Gonzalez-Rey, Cristina Mascaró, Mario Delgado, F. L. Cavalcanti, Leyre Mestre

مصطلحات موضوعية: RCOR1, business.industry, Multiple sclerosis, Experimental autoimmune encephalomyelitis, medicine, KDM1A, Genomics, Epigenetics, Computational biology, medicine.disease, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc502a6fe4bd89e62039ecf96871e3e
https://doi.org/10.21203/rs.3.rs-114482/v4

المؤلفون: Andrea Mattevi, Loris Moretti, Saverio Minucci, Elena Legnaghi, Mario Varasi, Giuseppe Ciossani, Paola Dessanti, Oronza A. Botrugno, Alessia Romussi, Valentina Cecatiello, Elisa Zagarri, Raimondo Fattori, Paola Vianello, Manuela Villa, Florian Thaler, Giovanni Fagà, Giuseppe Meroni, Paolo Trifiro, Anna Cappa, Luca Sartori, Ciro Mercurio, Sebastiano Pasqualato, Federica Amigoni, Stefania Vultaggio

المصدر: Journal of Medicinal Chemistry. 60:1693-1715

مصطلحات موضوعية: 0301 basic medicine, Histone H3 Lysine 4, Stereochemistry, Lysine, Crystallography, X-Ray, 01 natural sciences, Inhibitory Concentration 50, Structure-Activity Relationship, 03 medical and health sciences, Cell Line, Tumor, Drug Discovery, Fluorescence Resonance Energy Transfer, Humans, Structure–activity relationship, Pyrroles, Enzyme Inhibitors, Histone Demethylases, biology, 010405 organic chemistry, Chemistry, KDM1A, Methylation, Ligand (biochemistry), High-Throughput Screening Assays, 0104 chemical sciences, 3. Good health, 030104 developmental biology, Histone, Biochemistry, Drug Design, biology.protein, Molecular Medicine, Demethylase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db43a94fbbdb036bf2b2b03ecbf9f3c2
https://doi.org/10.1021/acs.jmedchem.6b01019

المؤلفون: Roberto Dal Zuffo, Manuela Villa, Biagina Marrocco, Sergio Valente, Paolo Trifiro, Giuseppe Meroni, Mario Varasi, Oronza A. Botrugno, Anna Cappa, Paola Dessanti, Andrea Mattevi, Ciro Mercurio, Giulia Stazi, Saverio Minucci, Paola Vianello, Florian Thaler, Antonello Mai

المصدر: Journal of Medicinal Chemistry. 59:1501-1517

مصطلحات موضوعية: LSD1 epigenetics, monoamine-oxidase-b, breast-cancer, cyclopropylamine derivatives, modifying enzymes, LSD1 inhibition, methylation, cells, proteins, complex, targets, 0301 basic medicine, Acute promyelocytic leukemia, Administration, Oral, Antineoplastic Agents, Pharmacology, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Leukemia, Promyelocytic, Acute, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Humans, Structure–activity relationship, Enzyme Inhibitors, Clonogenic assay, Histone Demethylases, Acute leukemia, Chemistry, KDM1A, Biological activity, medicine.disease, Leukemia, 030104 developmental biology, 030220 oncology & carcinogenesis, Molecular Medicine, Tranylcypromine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae214acac02abb50bd6c6144c38c2d90
https://doi.org/10.1021/acs.jmedchem.5b01209

المؤلفون: Giannamaria Annunziato, Manuela Villa, Claudia Beato, Gabriele Costantino, Marco Pieroni, Elisa Azzali, Mario Varasi, Paolo Trifiro, Paola Vianello, Paola Dessanti, Ciro Mercurio, Giuseppe Meroni

المصدر: European Journal of Medicinal Chemistry. 92:377-386

مصطلحات موضوعية: Cyclopropanes, Models, Molecular, Stereochemistry, Structure-Activity Relationship, Drug Discovery, Histone methylation, medicine, Humans, Epigenetics, Histone Demethylases, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Organic Chemistry, Tranylcypromine, KDM1A, General Medicine, Recombinant Proteins, Histone, Biochemistry, Acetylation, DNA methylation, biology.protein, Demethylase, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9885575cbef72963e8016bda2ca8309
https://doi.org/10.1016/j.ejmech.2014.12.032

المؤلفون: Stefano Rovida, Giulia Stazi, Paola Dessanti, Veronica Rodriguez, Mario Varasi, Oronza A. Botrugno, Dante Rotili, Antonello Mai, Ciro Mercurio, Andrea Mattevi, Saverio Minucci, Giuseppe Ciossani, Sergio Valente, Alessia Lucidi, Paola Vianello

المصدر: MedChemComm. 6:665-670

مصطلحات موضوعية: animal structures, Stereochemistry, tranylcypromine, Pharmaceutical Science, Biochemistry, Residue (chemistry), chemistry.chemical_compound, lysine-specific demethylase 1, Drug Discovery, medicine, stereoisomers, Moiety, Pyrrole, Pharmacology, Indole test, epigenetics, Cell growth, Chemistry, Organic Chemistry, Tranylcypromine, leukemia, Cell culture, Cancer cell, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca844cf9df35f84de1a28b52aa0b200
https://doi.org/10.1039/c4md00507d

المؤلفون: Andrea Mattevi, Marcello Tortorici, Paolo Trifiro, Giuseppe Meroni, Mario Varasi, Paola Dessanti, Oronza A. Botrugno, Florian Thaler, Manuela Villa, Giuseppe Ciossani, Sergio Valente, Paola Vianello, Anna Cappa, Antonello Mai, Ciro Mercurio, Saverio Minucci

المصدر: European Journal of Medicinal Chemistry. 86:352-363

مصطلحات موضوعية: Cyclopropanes, Models, Molecular, Stereochemistry, Crystallography, X-Ray, Structure-Activity Relationship, Drug Discovery, medicine, Humans, Moiety, Enzyme Inhibitors, Monoamine Oxidase, Histone Demethylases, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Organic Chemistry, Tranylcypromine, Biological activity, KDM1A, General Medicine, Histone, Biochemistry, biology.protein, Demethylase, Monoamine oxidase B, Monoamine oxidase A, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957b7b40334eabd9483f42c7d011e753
https://doi.org/10.1016/j.ejmech.2014.08.068

المؤلفون: VALENTE, Sergio, Veronica Rodriguez, Ciro Mercurio, Paola Vianello, Bruna Saponara, Roberto Cirilli, Giuseppe Ciossani, LABELLA, DONATELLA, MARROCCO, BIAGINA, RUOPPOLO, Giovanni, Oronza A. Botrugno, Paola Dessanti, Saverio Minucci, Andrea Mattevi, Mario Varasi, MAI, Antonello

المساهمون: VALENTE, Sergio, Veronica, Rodriguez, Ciro, Mercurio, Paola, Vianello, Bruna, Saponara, Roberto, Cirilli, Giuseppe, Ciossani, LABELLA, DONATELLA, MARROCCO, BIAGINA, RUOPPOLO, Giovanni, Oronza A., Botrugno, Paola, Dessanti, Saverio, Minucci, Andrea, Mattevi, Mario, Varasi, MAI, Antonello

مصطلحات موضوعية: epigenetic, leukemia, lysine-specific demethylase, stereoisomer, tranylcypromine

Relation: info:eu-repo/semantics/altIdentifier/pmid/25699146; info:eu-repo/semantics/altIdentifier/wos/WOS:000349652000012; volume:6; issue:2; firstpage:173; lastpage:177; numberofpages:5; journal:ACS MEDICINAL CHEMISTRY LETTERS; http://hdl.handle.net/11573/781696; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84922867052

الاتاحة: http://hdl.handle.net/11573/781696
https://doi.org/10.1021/ml500424z

المؤلفون: Veronica Rodriguez, Sergio Valente, Dante Rotili, Giulia Stazi, Alessia Lucidi, Oronza A. Botrugno, Paola Dessanti, Ciro Mercurio, Paola Vianello, Saverio Minucci, Mario Varasi, Antonello Mai, ROVIDA, STEFANO, CIOSSANI, GIUSEPPE, MATTEVI, ANDREA

المساهمون: Veronica, Rodriguez, Sergio, Valente, Rovida, Stefano, Dante, Rotili, Giulia, Stazi, Alessia, Lucidi, Ciossani, Giuseppe, Mattevi, Andrea, Oronza A., Botrugno, Paola, Dessanti, Ciro, Mercurio, Paola, Vianello, Saverio, Minucci, Mario, Varasi, Antonello, Mai

مصطلحات موضوعية: epigenetic, Drug design, cancer

وصف الملف: STAMPA

Relation: info:eu-repo/semantics/altIdentifier/wos/000352903400023; volume:6; firstpage:665; lastpage:670; numberofpages:6; journal:MEDCHEMCOMM; http://hdl.handle.net/11571/1097586; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84928004801; http://pubs.rsc.org/en/content/articlehtml/2015/md/c4md00507d

الاتاحة: http://hdl.handle.net/11571/1097586
https://doi.org/10.1039/C4MD00507D
http://pubs.rsc.org/en/content/articlehtml/2015/md/c4md00507d

المؤلفون: Manuela Villa, Elena Legnaghi, Giuseppe Ciossani, Loris Moretti, Valentina Cecatiello, Saverio Minucci, Mario Varasi, Florian Thaler, Oronza A. Botrugno, Paola Dessanti, Giovanni Fagà, Alessia Romussi, Ciro Mercurio, Sebastiano Pasqualato, Stefania Vultaggio, Federica Amigoni, Elisa Zagarri, Anna Cappa, Andrea Mattevi, Daniele Carettoni, Lucia Iuzzolino, Paolo Trifiro, Giuseppe Meroni, Luca Sartori, Paola Vianello, Raimondo Fattori

المصدر: Journal of medicinal chemistry. 60(5)

مصطلحات موضوعية: 0301 basic medicine, Spectrometry, Mass, Electrospray Ionization, Stereochemistry, High-throughput screening, Proton Magnetic Resonance Spectroscopy, Crystallography, X-Ray, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Histone methylation, Structure–activity relationship, Moiety, Humans, Pyrroles, Enzyme Inhibitors, Benzamide, Histone Demethylases, biology, 010405 organic chemistry, Chemistry, Drug discovery, KDM1A, 0104 chemical sciences, 3. Good health, High-Throughput Screening Assays, 030104 developmental biology, Drug Design, biology.protein, Molecular Medicine, Demethylase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318257ca312941ab659dd7b800a0cd31
https://pubmed.ncbi.nlm.nih.gov/28186755

المؤلفون: Francesco Sgarrella, Maria Grazia Tozzi, Paola Dessanti, Yang Zhang, Steven E. Ealick, Simone Allegrini

المصدر: Acta Crystallographica Section D Biological Crystallography. 68:239-248

مصطلحات موضوعية: Models, Molecular, Adenosine, Protein Conformation, Stereochemistry, Purine nucleoside phosphorylase, Crystallography, X-Ray, Substrate Specificity, Structure-Activity Relationship, Bacillus cereus, Structural Biology, medicine, Inosine, Purine metabolism, chemistry.chemical_classification, Binding Sites, biology, Substrate (chemistry), Active site, Glycosidic bond, General Medicine, Research Papers, Purine-Nucleoside Phosphorylase, chemistry, Biochemistry, biology.protein, Nucleoside, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384caaa6f07df0375aaff2ead0b8b9a9
https://doi.org/10.1107/s090744491200073x

المؤلفون: Elena Carceller, Tamara Maes, Alberto Ortega, Raquel Ruiz, Serena Lunardi, Cristina Mascaró Crusat, Paola Dessanti, Natalia Sacilotto, Michele M.P. Lufino, Filippo Ciceri, Jordi Salas

المصدر: Cancer Research. 78:LB-003

مصطلحات موضوعية: Cancer Research, Oncology, Biochemistry, Mechanism of action, Chemistry, Histone Lysine Demethylases, medicine, Cancer, medicine.symptom, medicine.disease

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1a346825e596cb24407083533c18e6e7
https://doi.org/10.1158/1538-7445.am2018-lb-003

المؤلفون: Sergio Valente, Veronica Rodriguez, Ciro Mercurio, Paola Vianello, Bruna Saponara, Roberto Cirilli, Giuseppe Ciossani, Donatella Labella, Biagina Marrocco, Daria Monaldi, Giovanni Ruoppolo, Mats Tilset, Oronza A. Botrugno, Paola Dessanti, Saverio Minucci, Andrea Mattevi, Mario Varasi, Antonello Mai

المساهمون: Valente, Sergio, Veronica, Rodriguez, Mercurio, Ciro, Vianello, Paola, Saponara, Bruna, Cirilli, Roberto, Ciossani, Giuseppe, Labella, Donatella, Marrocco, Biagina, Monaldi, Daria, Ruoppolo, Giovanni, Tilset, Mat, Botrugno, Oronza A., Dessanti, Paola, Minucci, Saverio, Mattevi, Andrea, Varasi, Mario, Mai, Antonello

مصطلحات موضوعية: epigenetic, leukemia, lysine-specific demethylase 1, stereoisomer, tranylcypromine

Relation: info:eu-repo/semantics/altIdentifier/pmid/25768700; info:eu-repo/semantics/altIdentifier/wos/WOS:000353730900016; volume:94; firstpage:163; lastpage:174; numberofpages:12; journal:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; http://hdl.handle.net/11573/781693; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84924406877

الاتاحة: http://hdl.handle.net/11573/781693
https://doi.org/10.1016/j.ejmech.2015.02.060

المؤلفون: Antonello Mai, Daria Monaldi, Donatella Labella, Roberto Cirilli, Bruna Saponara, Mario Varasi, Paola Vianello, Andrea Mattevi, Oronza A. Botrugno, Veronica Rodriguez, Paola Dessanti, Giovanni Ruoppolo, Giuseppe Ciossani, Biagina Marrocco, Mats Tilset, Sergio Valente, Saverio Minucci, Ciro Mercurio

مصطلحات موضوعية: Therapeutic gene modulation, Monoamine Oxidase Inhibitors, animal structures, Stereochemistry, tranylcypromine, Antineoplastic Agents, Mice, Inbred Strains, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Leukemia, Promyelocytic, Acute, lysine-specific demethylase 1, Drug Discovery, medicine, Animals, Humans, Moiety, stereoisomers, Enzyme Inhibitors, Benzamide, Clonogenic assay, Monoamine Oxidase, Histone Demethylases, Pharmacology, chemistry.chemical_classification, epigenetics, Gene Expression Regulation, Leukemic, Chemistry, Organic Chemistry, Tranylcypromine, leukemia, Stereoisomerism, General Medicine, medicine.disease, Leukemia, Enzyme, Drug Screening Assays, Antitumor, Enantiomer, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2619021340ef053fdf0fa9b41160edb
http://hdl.handle.net/11573/781693

المؤلفون: Andrea Mattevi, Giovanni Ruoppolo, Oronza A. Botrugno, Ciro Mercurio, Paola Dessanti, Saverio Minucci, Sergio Valente, Giuseppe Ciossani, Biagina Marrocco, Mario Varasi, Antonello Mai, Donatella Labella, Roberto Cirilli, Veronica Rodriguez, Bruna Saponara, Paola Vianello

مصطلحات موضوعية: chemistry.chemical_classification, Carbamate, animal structures, Hydrochloride, Stereochemistry, medicine.medical_treatment, Organic Chemistry, Tranylcypromine, Diastereomer, Biochemistry, epigenetics, leukemia, lysine-specific demethylase, stereoisomers, tranylcypromine, Chiral column chromatography, chemistry.chemical_compound, Enzyme, chemistry, Drug Discovery, medicine, Separation method, Selectivity, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4351fe8c5c835e50b71e3891d7e2ca86
https://europepmc.org/articles/PMC4329595/

المؤلفون: Giuseppe Meroni, Anna Cappa, Paola Vianello, E.C.W. So, Mario Varasi, Oronza A. Botrugno, Silvia Brambillasca, Maria Rosaria Cera, Ciro Mercurio, R. Dal Zuffo, Paolo Trifiro, Saverio Minucci, Florian Thaler, Paola Dessanti, Manuela Villa

المصدر: European Journal of Cancer. 69:S87

مصطلحات موضوعية: Cancer Research, Oncology, business.industry, Cancer research, Myeloid leukemia, Medicine, KDM1A, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ff51f05f53662307ab783be2d6641800
https://doi.org/10.1016/s0959-8049(16)32854-4