المؤلفون: Petra Lukacik (11570623), C. David Owen (11570626), Gemma Harris (5814209), Jani Reddy Bolla (11570629), Sarah Picaud (1280562), Irfan Alibay (4490764), Joanne E. Nettleship (740116), Louise E. Bird (3331530), Raymond J. Owens (29766), Philip C. Biggin (122818), Panagis Filippakopoulos (1280556), Carol V. Robinson (244129), Martin A. Walsh (11570632)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Cell Biology, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Infectious Diseases, Virology, Computational Biology, surface exposed histidine, div >< p, coordinated via residues, abc transporter system, 282 &# 956, ligand bound conformation, haemophilus influenzae <, identified surface interactions, current models propose, closed conformation reveals, 4 &# 956, p , sap (< u, , constricted ligand, vivo <, hi <,

Relation: https://figshare.com/articles/journal_contribution/Supporting_methods_Expression_and_purification_of_human_beta_defensins_and_isothermal_titration_calorimetry_of_AMPs_/16820125

الاتاحة: https://doi.org/10.1371/journal.pone.0256070.s001

المؤلفون: Petra Lukacik (11570623), C. David Owen (11570626), Gemma Harris (5814209), Jani Reddy Bolla (11570629), Sarah Picaud (1280562), Irfan Alibay (4490764), Joanne E. Nettleship (740116), Louise E. Bird (3331530), Raymond J. Owens (29766), Philip C. Biggin (122818), Panagis Filippakopoulos (1280556), Carol V. Robinson (244129), Martin A. Walsh (11570632)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Cell Biology, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Infectious Diseases, Virology, Computational Biology, surface exposed histidine, div >< p, coordinated via residues, abc transporter system, 282 &# 956, ligand bound conformation, haemophilus influenzae <, identified surface interactions, current models propose, closed conformation reveals, 4 &# 956, p , sap (< u, , constricted ligand, vivo <, hi <,

Relation: https://figshare.com/articles/journal_contribution/Surface_representations_of_SapA_structures_/16820128

الاتاحة: https://doi.org/10.1371/journal.pone.0256070.s002

المؤلفون: Petra Lukacik (11570623), C. David Owen (11570626), Gemma Harris (5814209), Jani Reddy Bolla (11570629), Sarah Picaud (1280562), Irfan Alibay (4490764), Joanne E. Nettleship (740116), Louise E. Bird (3331530), Raymond J. Owens (29766), Philip C. Biggin (122818), Panagis Filippakopoulos (1280556), Carol V. Robinson (244129), Martin A. Walsh (11570632)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Cell Biology, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Infectious Diseases, Virology, Computational Biology, surface exposed histidine, div >< p, coordinated via residues, abc transporter system, 282 &# 956, ligand bound conformation, haemophilus influenzae <, identified surface interactions, current models propose, closed conformation reveals, 4 &# 956, p , sap (< u, , constricted ligand, vivo <, hi <,

Relation: https://figshare.com/articles/journal_contribution/Alignment_of_amino_acid_sequences_of_NT_i_Hi_i_SapA_UNIPROT_Q4QL73_with_its_closest_structural_homologs_i_Hp_i_HbpA_UNIPROT_B8F653_i_Ec_i_DppA_UNIPROT_P23847_and_i_Pseudoaltermonas_i_sp_SM9913_DppA_UNIPROT_A7Y7W1_/16820134

الاتاحة: https://doi.org/10.1371/journal.pone.0256070.s004

المؤلفون: Serena G. Piticchio (11831405), Míriam Martínez-Cartró (11831408), Salvatore Scaffidi (1340703), Moira Rachman (11831411), Sergio Rodriguez-Arevalo (11831414), Ainoa Sanchez-Arfelis (11831417), Carmen Escolano (2393860), Sarah Picaud (1280562), Tobias Krojer (1385454), Panagis Filippakopoulos (1280556), Frank von Delft (7879808), Carles Galdeano (1305135), Xavier Barril (550048)

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Pharmacology, Biotechnology, Plant Biology, Computational Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, rapidly finding analogues, outcome depends crucially, containing protein 4, common interaction motif, corresponding chemical space, chemical space rather, chemical space around, brd4 ), starting, actual starting points, nonobvious scaffold changes, automated computational pipeline, specific fragment hit, based drug discovery, starting fragment, chemical structure, often scaffold, automated navigation, known fragment, structurally novel

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Novel_BRD4_Ligand_Scaffolds_by_Automated_Navigation_of_the_Fragment_Chemical_Space/17190215

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01108.s001

المؤلفون: João Conde (1424986), Ruth A. Pumroy (10647971), Charlotte Baker (3074619), Tiago Rodrigues (468531), Ana Guerreiro (198740), Bárbara B. Sousa (10647974), Marta C. Marques (5006471), Bernardo P. de Almeida (6443921), Sohyon Lee (10647977), Elvira P. Leites (10647980), Daniel Picard (3508178), Amrita Samanta (10647983), Sandra H. Vaz (4543093), Florian Sieglitz (10647986), Maike Langini (10647989), Marc Remke (3508145), Rafael Roque (10647992), Tobias Weiss (2092234), Michael Weller (329740), Yuhang Liu (507131), Seungil Han (1811221), Francisco Corzana (1470730), Vanessa A. Morais (10647995), Cláudia C. Faria (10647998), Tânia Carvalho (10648001), Panagis Filippakopoulos (1280556), Berend Snijder (569807), Nuno L. Barbosa-Morais (9747023), Vera Y. Moiseenkova-Bell (10648004), Gonçalo J. L. Bernardes (7319006)

مصطلحات موضوعية: Medicine, Genetics, Neuroscience, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, calcium influx modulation, Calcium imaging experiments, decreases ROS production, rat TRPV 2 channel, Extensive tumor abrogation, Allosteric Antagonist Modulation, PL, Piperlongumine Impairs Glioblastoma., data-motivated research hypotheses, hTRPV 2, Thr 522 residues, GBM patient samples associates hTRP., TRPV 2 channel

Relation: https://figshare.com/articles/journal_contribution/Allosteric_Antagonist_Modulation_of_TRPV2_by_Piperlongumine_Impairs_Glioblastoma_Progression/14417666

الاتاحة: https://doi.org/10.1021/acscentsci.1c00070.s001

المؤلفون: João Conde (1424986), Ruth A. Pumroy (10647971), Charlotte Baker (3074619), Tiago Rodrigues (468531), Ana Guerreiro (198740), Bárbara B. Sousa (10647974), Marta C. Marques (5006471), Bernardo P. de Almeida (6443921), Sohyon Lee (10647977), Elvira P. Leites (10647980), Daniel Picard (3508178), Amrita Samanta (10647983), Sandra H. Vaz (4543093), Florian Sieglitz (10647986), Maike Langini (10647989), Marc Remke (3508145), Rafael Roque (10647992), Tobias Weiss (2092234), Michael Weller (329740), Yuhang Liu (507131), Seungil Han (1811221), Francisco Corzana (1470730), Vanessa A. Morais (10647995), Cláudia C. Faria (10647998), Tânia Carvalho (10648001), Panagis Filippakopoulos (1280556), Berend Snijder (569807), Nuno L. Barbosa-Morais (9747023), Vera Y. Moiseenkova-Bell (10648004), Gonçalo J. L. Bernardes (7319006)

مصطلحات موضوعية: Medicine, Genetics, Neuroscience, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, calcium influx modulation, Calcium imaging experiments, decreases ROS production, rat TRPV 2 channel, Extensive tumor abrogation, Allosteric Antagonist Modulation, PL, Piperlongumine Impairs Glioblastoma., data-motivated research hypotheses, hTRPV 2, Thr 522 residues, GBM patient samples associates hTRP., TRPV 2 channel

Relation: https://figshare.com/articles/journal_contribution/Allosteric_Antagonist_Modulation_of_TRPV2_by_Piperlongumine_Impairs_Glioblastoma_Progression/14417669

الاتاحة: https://doi.org/10.1021/acscentsci.1c00070.s002

المؤلفون: João Conde (1424986), Ruth A. Pumroy (10647971), Charlotte Baker (3074619), Tiago Rodrigues (468531), Ana Guerreiro (198740), Bárbara B. Sousa (10647974), Marta C. Marques (5006471), Bernardo P. de Almeida (6443921), Sohyon Lee (10647977), Elvira P. Leites (10647980), Daniel Picard (3508178), Amrita Samanta (10647983), Sandra H. Vaz (4543093), Florian Sieglitz (10647986), Maike Langini (10647989), Marc Remke (3508145), Rafael Roque (10647992), Tobias Weiss (2092234), Michael Weller (329740), Yuhang Liu (507131), Seungil Han (1811221), Francisco Corzana (1470730), Vanessa A. Morais (10647995), Cláudia C. Faria (10647998), Tânia Carvalho (10648001), Panagis Filippakopoulos (1280556), Berend Snijder (569807), Nuno L. Barbosa-Morais (9747023), Vera Y. Moiseenkova-Bell (10648004), Gonçalo J. L. Bernardes (7319006)

مصطلحات موضوعية: Medicine, Genetics, Neuroscience, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, calcium influx modulation, Calcium imaging experiments, decreases ROS production, rat TRPV 2 channel, Extensive tumor abrogation, Allosteric Antagonist Modulation, PL, Piperlongumine Impairs Glioblastoma., data-motivated research hypotheses, hTRPV 2, Thr 522 residues, GBM patient samples associates hTRP., TRPV 2 channel

Relation: https://figshare.com/articles/journal_contribution/Allosteric_Antagonist_Modulation_of_TRPV2_by_Piperlongumine_Impairs_Glioblastoma_Progression/14417672

الاتاحة: https://doi.org/10.1021/acscentsci.1c00070.s003

المؤلفون: João Conde (1424986), Ruth A. Pumroy (10647971), Charlotte Baker (3074619), Tiago Rodrigues (468531), Ana Guerreiro (198740), Bárbara B. Sousa (10647974), Marta C. Marques (5006471), Bernardo P. de Almeida (6443921), Sohyon Lee (10647977), Elvira P. Leites (10647980), Daniel Picard (3508178), Amrita Samanta (10647983), Sandra H. Vaz (4543093), Florian Sieglitz (10647986), Maike Langini (10647989), Marc Remke (3508145), Rafael Roque (10647992), Tobias Weiss (2092234), Michael Weller (329740), Yuhang Liu (507131), Seungil Han (1811221), Francisco Corzana (1470730), Vanessa A. Morais (10647995), Cláudia C. Faria (10647998), Tânia Carvalho (10648001), Panagis Filippakopoulos (1280556), Berend Snijder (569807), Nuno L. Barbosa-Morais (9747023), Vera Y. Moiseenkova-Bell (10648004), Gonçalo J. L. Bernardes (7319006)

مصطلحات موضوعية: Medicine, Genetics, Neuroscience, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, calcium influx modulation, Calcium imaging experiments, decreases ROS production, rat TRPV 2 channel, Extensive tumor abrogation, Allosteric Antagonist Modulation, PL, Piperlongumine Impairs Glioblastoma., data-motivated research hypotheses, hTRPV 2, Thr 522 residues, GBM patient samples associates hTRP., TRPV 2 channel

Relation: https://figshare.com/articles/journal_contribution/Allosteric_Antagonist_Modulation_of_TRPV2_by_Piperlongumine_Impairs_Glioblastoma_Progression/14417675

الاتاحة: https://doi.org/10.1021/acscentsci.1c00070.s004

المؤلفون: Petra Lukacik (11570623), C. David Owen (11570626), Gemma Harris (5814209), Jani Reddy Bolla (11570629), Sarah Picaud (1280562), Irfan Alibay (4490764), Joanne E. Nettleship (740116), Louise E. Bird (3331530), Raymond J. Owens (29766), Philip C. Biggin (122818), Panagis Filippakopoulos (1280556), Carol V. Robinson (244129), Martin A. Walsh (11570632)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Cell Biology, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Infectious Diseases, Virology, Computational Biology, surface exposed histidine, div >< p, coordinated via residues, abc transporter system, 282 &# 956, ligand bound conformation, haemophilus influenzae <, identified surface interactions, current models propose, closed conformation reveals, 4 &# 956, p , sap (< u, , constricted ligand, vivo <, hi <,

Relation: https://figshare.com/articles/figure/Superimposition_of_the_NT_i_Hi_i_SapA_sub_closed_sub_structure_green_with_its_closest_structural_homologs_/16820143

الاتاحة: https://doi.org/10.1371/journal.pone.0256070.g002

المؤلفون: Petra Lukacik (11570623), C. David Owen (11570626), Gemma Harris (5814209), Jani Reddy Bolla (11570629), Sarah Picaud (1280562), Irfan Alibay (4490764), Joanne E. Nettleship (740116), Louise E. Bird (3331530), Raymond J. Owens (29766), Philip C. Biggin (122818), Panagis Filippakopoulos (1280556), Carol V. Robinson (244129), Martin A. Walsh (11570632)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Cell Biology, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Infectious Diseases, Virology, Computational Biology, surface exposed histidine, div >< p, coordinated via residues, abc transporter system, 282 &# 956, ligand bound conformation, haemophilus influenzae <, identified surface interactions, current models propose, closed conformation reveals, 4 &# 956, p , sap (< u, , constricted ligand, vivo <, hi <,

Relation: https://figshare.com/articles/figure/The_SapA_ligand-binding_cavity_/16820149

الاتاحة: https://doi.org/10.1371/journal.pone.0256070.g003

المؤلفون: Petra Lukacik (11570623), C. David Owen (11570626), Gemma Harris (5814209), Jani Reddy Bolla (11570629), Sarah Picaud (1280562), Irfan Alibay (4490764), Joanne E. Nettleship (740116), Louise E. Bird (3331530), Raymond J. Owens (29766), Philip C. Biggin (122818), Panagis Filippakopoulos (1280556), Carol V. Robinson (244129), Martin A. Walsh (11570632)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Cell Biology, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Infectious Diseases, Virology, Computational Biology, surface exposed histidine, div >< p, coordinated via residues, abc transporter system, 282 &# 956, ligand bound conformation, haemophilus influenzae <, identified surface interactions, current models propose, closed conformation reveals, 4 &# 956, p , sap (< u, , constricted ligand, vivo <, hi <,

Relation: https://figshare.com/articles/figure/SapA_interaction_with_heme_/16820155

الاتاحة: https://doi.org/10.1371/journal.pone.0256070.g005

المؤلفون: Petra Lukacik (11570623), C. David Owen (11570626), Gemma Harris (5814209), Jani Reddy Bolla (11570629), Sarah Picaud (1280562), Irfan Alibay (4490764), Joanne E. Nettleship (740116), Louise E. Bird (3331530), Raymond J. Owens (29766), Philip C. Biggin (122818), Panagis Filippakopoulos (1280556), Carol V. Robinson (244129), Martin A. Walsh (11570632)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Cell Biology, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Infectious Diseases, Virology, Computational Biology, surface exposed histidine, div >< p, coordinated via residues, abc transporter system, 282 &# 956, ligand bound conformation, haemophilus influenzae <, identified surface interactions, current models propose, closed conformation reveals, 4 &# 956, p , sap (< u, , constricted ligand, vivo <, hi <,

Relation: https://figshare.com/articles/figure/SapA_interaction_with_RNA_/16820158

الاتاحة: https://doi.org/10.1371/journal.pone.0256070.g006

المؤلفون: Petra Lukacik (11570623), C. David Owen (11570626), Gemma Harris (5814209), Jani Reddy Bolla (11570629), Sarah Picaud (1280562), Irfan Alibay (4490764), Joanne E. Nettleship (740116), Louise E. Bird (3331530), Raymond J. Owens (29766), Philip C. Biggin (122818), Panagis Filippakopoulos (1280556), Carol V. Robinson (244129), Martin A. Walsh (11570632)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Cell Biology, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Infectious Diseases, Virology, Computational Biology, surface exposed histidine, div >< p, coordinated via residues, abc transporter system, 282 &# 956, ligand bound conformation, haemophilus influenzae <, identified surface interactions, current models propose, closed conformation reveals, 4 &# 956, p , sap (< u, , constricted ligand, vivo <, hi <,

Relation: https://figshare.com/articles/dataset/Crystallographic_data_collection_and_refinement_statistics_/16820161

الاتاحة: https://doi.org/10.1371/journal.pone.0256070.t001

المؤلفون: Serena G. Piticchio (11831405), Míriam Martínez-Cartró (11831408), Salvatore Scaffidi (1340703), Moira Rachman (11831411), Sergio Rodriguez-Arevalo (11831414), Ainoa Sanchez-Arfelis (11831417), Carmen Escolano (2393860), Sarah Picaud (1280562), Tobias Krojer (1385454), Panagis Filippakopoulos (1280556), Frank von Delft (7879808), Carles Galdeano (1305135), Xavier Barril (550048)

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Pharmacology, Biotechnology, Plant Biology, Computational Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, rapidly finding analogues, outcome depends crucially, containing protein 4, common interaction motif, corresponding chemical space, chemical space rather, chemical space around, brd4 ), starting, actual starting points, nonobvious scaffold changes, automated computational pipeline, specific fragment hit, based drug discovery, starting fragment, chemical structure, often scaffold, automated navigation, known fragment, structurally novel

Relation: https://figshare.com/articles/dataset/Discovery_of_Novel_BRD4_Ligand_Scaffolds_by_Automated_Navigation_of_the_Fragment_Chemical_Space/17190218

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01108.s002

المؤلفون: Serena G. Piticchio (11831405), Míriam Martínez-Cartró (11831408), Salvatore Scaffidi (1340703), Moira Rachman (11831411), Sergio Rodriguez-Arevalo (11831414), Ainoa Sanchez-Arfelis (11831417), Carmen Escolano (2393860), Sarah Picaud (1280562), Tobias Krojer (1385454), Panagis Filippakopoulos (1280556), Frank von Delft (7879808), Carles Galdeano (1305135), Xavier Barril (550048)

مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Pharmacology, Biotechnology, Plant Biology, Computational Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, rapidly finding analogues, outcome depends crucially, containing protein 4, common interaction motif, corresponding chemical space, chemical space rather, chemical space around, brd4 ), starting, actual starting points, nonobvious scaffold changes, automated computational pipeline, specific fragment hit, based drug discovery, starting fragment, chemical structure, often scaffold, automated navigation, known fragment, structurally novel

Relation: https://figshare.com/articles/dataset/Discovery_of_Novel_BRD4_Ligand_Scaffolds_by_Automated_Navigation_of_the_Fragment_Chemical_Space/17190221

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01108.s003

المؤلفون: João Conde (1424986), Ruth A. Pumroy (10647971), Charlotte Baker (3074619), Tiago Rodrigues (468531), Ana Guerreiro (198740), Bárbara B. Sousa (10647974), Marta C. Marques (5006471), Bernardo P. de Almeida (6443921), Sohyon Lee (10647977), Elvira P. Leites (10647980), Daniel Picard (3508178), Amrita Samanta (10647983), Sandra H. Vaz (4543093), Florian Sieglitz (10647986), Maike Langini (10647989), Marc Remke (3508145), Rafael Roque (10647992), Tobias Weiss (2092234), Michael Weller (329740), Yuhang Liu (507131), Seungil Han (1811221), Francisco Corzana (1470730), Vanessa A. Morais (10647995), Cláudia C. Faria (10647998), Tânia Carvalho (10648001), Panagis Filippakopoulos (1280556), Berend Snijder (569807), Nuno L. Barbosa-Morais (9747023), Vera Y. Moiseenkova-Bell (10648004), Gonçalo J. L. Bernardes (7319006)

مصطلحات موضوعية: Medicine, Genetics, Neuroscience, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, calcium influx modulation, Calcium imaging experiments, decreases ROS production, rat TRPV 2 channel, Extensive tumor abrogation, Allosteric Antagonist Modulation, PL, Piperlongumine Impairs Glioblastoma., data-motivated research hypotheses, hTRPV 2, Thr 522 residues, GBM patient samples associates hTRP., TRPV 2 channel

Relation: https://figshare.com/articles/dataset/Allosteric_Antagonist_Modulation_of_TRPV2_by_Piperlongumine_Impairs_Glioblastoma_Progression/14417678

الاتاحة: https://doi.org/10.1021/acscentsci.1c00070.s005

المؤلفون: Adam P. Cribbs (7500821), Panagis Filippakopoulos (1280556), Martin Philpott (1280565), Graham Wells (7500815), Henry Penn (10202699), Henrik Oerum (10202702), Viia Valge-Archer (9373908), Marc Feldmann (28329), Udo Oppermann (236766)

مصطلحات موضوعية: Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, BET bromodomain, BRD2, BRD4, NK cell, epigenetics (DNA methylation histone modifications)

Relation: https://figshare.com/articles/dataset/DataSheet_1_Dissecting_the_Role_of_BET_Bromodomain_Proteins_BRD2_and_BRD4_in_Human_NK_Cell_Function_csv/14125085

الاتاحة: https://doi.org/10.3389/fimmu.2021.626255.s001

المؤلفون: Adam P. Cribbs (7500821), Panagis Filippakopoulos (1280556), Martin Philpott (1280565), Graham Wells (7500815), Henry Penn (10202699), Henrik Oerum (10202702), Viia Valge-Archer (9373908), Marc Feldmann (28329), Udo Oppermann (236766)

مصطلحات موضوعية: Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, BET bromodomain, BRD2, BRD4, NK cell, epigenetics (DNA methylation histone modifications)

Relation: https://figshare.com/articles/dataset/DataSheet_2_Dissecting_the_Role_of_BET_Bromodomain_Proteins_BRD2_and_BRD4_in_Human_NK_Cell_Function_csv/14125088

الاتاحة: https://doi.org/10.3389/fimmu.2021.626255.s002

المؤلفون: Michael Brand (186270), James Clayton (11128178), Mustafa Moroglu (11128181), Matthias Schiedel (1399321), Sarah Picaud (1280562), Joseph P. Bluck (9653382), Anna Skwarska (8275659), Hannah Bolland (11128184), Anthony K. N. Chan (4332478), Corentine M. C. Laurin (11128187), Amy R. Scorah (9653388), Larissa See (11128190), Timothy P. C. Rooney (8946380), Katrina H. Andrews (11128193), Oleg Fedorov (244326), Gabriella Perell (11128196), Prakriti Kalra (8823092), Kayla B. Vinh (11128199), Wilian A. Cortopassi (7181453), Pascal Heitel (3863806), Kirsten E. Christensen (1711261), Richard I. Cooper (3377774), Robert S. Paton (1281666), William C. K. Pomerantz (8053445), Philip C. Biggin (122818), Ester M. Hammond (233098), Panagis Filippakopoulos (1280556), Stuart J. Conway (1280553)

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Developmental Biology, Cancer, Inorganic Chemistry, Hematology, Chemical Sciences not elsewhere classified, transcriptional co-activators, HIF, 2F, Controlling Intramolecular Interactions, BET bromodomains, HCT 116 colon cancer cells results, paralogue EP 300, H 3K acetylation, CREBBP Bromodomain CREBBP, GATA 1, KAT 3B, CBP, acetylated lysine residues, lysine acetyltransferases, EP 300, H 3K, small-molecule ligand, 10 domains, High-Affinity Ligands

Relation: https://figshare.com/articles/dataset/Controlling_Intramolecular_Interactions_in_the_Design_of_Selective_High-Affinity_Ligands_for_the_CREBBP_Bromodomain/14976959

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00348.s002