المؤلفون: Anna Liao, Gary Probst, Pamela S. Keim, Kang Hu, Roy K. Hom, David A. Quincy, Michael S. Dappen, Grace T. Kwong, Jenifer Smith, Martin L. Neitzel, Ying-zi Xu, Elizabeth F. Brigham, Kevin P. Quinn, Frédérique Bard, Minghua Sun, Jing Wu, John-Michael Sauer, Dora Kholodenko, Hongbin Zhang, William Wallace, Matthew N. Mattson, Patricia Sacayon, Jacek Jagodzinski, Hing L. Sham, Brian T. Peterson, Simeon Bowers, Jennifer Marugg, Guriqbal S. Basi, Lee H. Latimer, Susanna S. Hemphill, Darren B. Dressen, Karina Wong, Kevin Tanaka, Michael P. Bova, Pamela Santiago, Daniel K. Ness, Anh P. Truong, Wes Zmolek, Lany Ruslim, Christopher Willits, Michael K. Lee, Andrei W. Konradi, Xiaocong M. Ye, Lam Nguyen, Chris M. Semko, Ted A. Yednock, Ruth N. Motter, Albert W. Garofalo, Erich Goldbach, Pearl Tanaka, Danielle L. Aubele

المصدر: Journal of Medicinal Chemistry. 56:5261-5274

مصطلحات موضوعية: Trifluoromethyl, biology, Stereochemistry, Quinoline, In vitro, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, biology.protein, medicine, Molecular Medicine, Structure–activity relationship, Chirality (chemistry), Amyloid precursor protein secretase, Semagacestat, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c5b61686f688dd0abd9c5edac66d7201
https://doi.org/10.1021/jm301741t

المؤلفون: Jay Tung, Guriqbal S. Basi, David Davis, Ivan Lieberburg, Russell J. Caccavello, Michael Power, Pamela S. Keim, Donald A. Walker, Kirsten L. Jacobson-Croak, Normand Frigon, Robin Barbour, Susanna Suomensaari, Hua Tan, Lisa McConlogue, John P. Anderson, Gwen Tatsuno, Harry F. Dovey, Shuwen Wang, Minhtam Doan, Dale Schenk, Peter Seubert, Jun Zhao, Nancy Jewett, Jin Hong, Sukanto Sinha, Varghese John, J. Knops

المصدر: Nature. 402:537-540

مصطلحات موضوعية: Multidisciplinary, Beta-secretase 1, biology, Alpha secretase, Biochemistry, biology.protein, Amyloid precursor protein, P3 peptide, Verubecestat, Cleavage (embryo), Amyloid precursor protein secretase, Enzyme assay

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ec9dacb1af91145ab653388836691c6e
https://doi.org/10.1038/990114

المؤلفون: Gary, Probst, Danielle L, Aubele, Simeon, Bowers, Darren, Dressen, Albert W, Garofalo, Roy K, Hom, Andrei W, Konradi, Jennifer L, Marugg, Matthew N, Mattson, Martin L, Neitzel, Chris M, Semko, Hing L, Sham, Jenifer, Smith, Minghua, Sun, Anh P, Truong, Xiaocong M, Ye, Ying-Zi, Xu, Michael S, Dappen, Jacek J, Jagodzinski, Pamela S, Keim, Brian, Peterson, Lee H, Latimer, David, Quincy, Jing, Wu, Erich, Goldbach, Daniel K, Ness, Kevin P, Quinn, John-Michael, Sauer, Karina, Wong, Hongbin, Zhang, Wes, Zmolek, Elizabeth F, Brigham, Dora, Kholodenko, Kang, Hu, Grace T, Kwong, Michael, Lee, Anna, Liao, Ruth N, Motter, Patricia, Sacayon, Pamela, Santiago, Christopher, Willits, Frédérique, Bard, Michael P, Bova, Susanna S, Hemphill, Lam, Nguyen, Lany, Ruslim, Kevin, Tanaka, Pearl, Tanaka, William, Wallace, Ted A, Yednock, Guriqbal S, Basi

المصدر: Journal of medicinal chemistry. 56(13)

مصطلحات موضوعية: Male, Time Factors, Gene Expression, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Dogs, Drug Stability, Basic Helix-Loop-Helix Transcription Factors, Animals, Humans, RNA, Messenger, Enzyme Inhibitors, Homeodomain Proteins, Sulfonamides, Amyloid beta-Peptides, Dose-Response Relationship, Drug, Molecular Structure, Receptors, Notch, Rats, Models, Chemical, Area Under Curve, Drug Design, Microsomes, Liver, Quinolines, Pyrazoles, Transcription Factor HES-1, Amyloid Precursor Protein Secretases, Heterocyclic Compounds, 3-Ring

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::109e2b6e92821a752624dca210f7b056
https://pubmed.ncbi.nlm.nih.gov/23713656

المؤلفون: Guriqbal S. Basi, Hongbin Zhang, Pamela S. Keim, Michael A. Pleiss, Martin L. Neitzel, Erich Goldbach, Semko Christopher M, David A. Quincy, Albert W. Garofalo, Andrei W. Konradi, John-Michael Sauer, Matthew N. Mattson, Hing L. Sham, Elizabeth F. Brigham

المصدر: Bioorganicmedicinal chemistry letters. 20(7)

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Pyrazole, Crystallography, X-Ray, Biochemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Alzheimer Disease, Drug Discovery, Structure–activity relationship, Potency, Animals, Humans, γ secretase, Molecular Biology, chemistry.chemical_classification, Sulfonamides, Organic Chemistry, Metabolic stability, Combinatorial chemistry, In vitro, Rats, chemistry, Molecular Medicine, Pyrazoles, Pharmacophore, Amyloid Precursor Protein Secretases, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0bbae13a02ac5307da21f3ab0837c81
https://pubmed.ncbi.nlm.nih.gov/20206516

المؤلفون: Anh P, Truong, Danielle L, Aubele, Gary D, Probst, Martin L, Neitzel, Chris M, Semko, Simeon, Bowers, Darren, Dressen, Roy K, Hom, Andrei W, Konradi, Hing L, Sham, Albert W, Garofalo, Pamela S, Keim, Jing, Wu, Michael S, Dappen, Karina, Wong, Erich, Goldbach, Kevin P, Quinn, John-Michael, Sauer, Elizabeth F, Brigham, William, Wallace, Lan, Nguyen, Susanna S, Hemphill, Michael P, Bova, Frédérique, Bard, Ted A, Yednock, Guriqbal, Basi

المصدر: Bioorganicmedicinal chemistry letters. 19(17)

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Pyrazole, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, Oral administration, Drug Discovery, Amyloid precursor protein, medicine, Structure–activity relationship, Animals, Protease Inhibitors, Molecular Biology, Sulfonamides, biology, Chemistry, Organic Chemistry, Sulfonamide (medicine), Enzyme inhibitor, Drug Design, biology.protein, Quinolines, Molecular Medicine, Pyrazoles, Amyloid Precursor Protein Secretases, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c351bc65695ea36d488b1e5c084234d
https://pubmed.ncbi.nlm.nih.gov/19660943

المؤلفون: Frederick Esch, Nikolaos K. Robakis, Kumar Sambamurti, Pamela S. Keim, John P. Anderson, Ivan Lieberburg

المصدر: Neuroscience Letters. 128:126-128

مصطلحات موضوعية: Neurons, biology, medicine.diagnostic_test, General Neuroscience, Proteolysis, P3 peptide, Cleavage (embryo), medicine.disease, PC12 Cells, Carboxypeptidase, Amyloid beta-Protein Precursor, chemistry.chemical_compound, chemistry, Biochemistry, Alzheimer Disease, Cell culture, mental disorders, Chromatography, Gel, biology.protein, Amyloid precursor protein, medicine, Animals, Cyanogen bromide, Alzheimer's disease

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4696f12e642b072b81445be79c19fc8a
https://doi.org/10.1016/0304-3940(91)90775-o

المؤلفون: Jeffrey P. Shapiros, Pamela S. Keim, John H. Law

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.ars.usda.gov/SP2UserFiles/person/5083/structural studies.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.518.8328; http://www.ars.usda.gov/SP2UserFiles/person/5083/structural studies.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.518.8328
http://www.ars.usda.gov/SP2UserFiles/person/5083/structural studies.pdf

المؤلفون: Ted Yednock, Chris M. Semko, Hing L. Sham, Darren B. Dressen, Gary Probst, John-Michael Sauer, Albert W. Garofalo, Kevin P. Quinn, Michael P. Bova, Jing Wu, Michael S. Dappen, Simeon Bowers, Martin L. Neitzel, Pamela S. Keim, Karina Wong, Guriqbal S. Basi, Roy K. Hom, Erich Goldbach, Anh P. Truong, Andrei W. Konradi, Susanna S. Hemphill, William A Wallace, Lan K. Nguyen, Elizabeth F. Brigham, Danielle L. Aubele, Frederique Bard

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:7553

مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pyrazole, Biochemistry, Sulfonamide, chemistry.chemical_compound, chemistry, Design synthesis, Drug Discovery, Molecular Medicine, Structure–activity relationship, γ secretase, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::49d496068a972d5629e4dba9b9fa5644
https://doi.org/10.1016/j.bmcl.2010.10.090

المؤلفون: Albert W. Garofalo, Stephen B. Freedman, Balazs Szoke, Ferdie Soriano, Lee H. Latimer, George Shopp, Ruth N. Motter, Terence Hui, Kevin P. Quinn, Jenifer Smith, Jeanne Baker, Mei Yu, Michael K. Lee, Michael P. Bova, Pamela S. Keim, Elizabeth F. Brigham, John A Tucker, Andrei W. Konradi, Guriqbal S. Basi, Pearl Tang, Jon Hawkinson, Xiao-Hua Chen, Matthew N. Mattson, Kang Hu, Danielle L. Aubele, Martin L. Neitzel, Jennifer Marugg, Daniel K. Ness, Rose Lawler-Herbold, Christopher M Semko, Dora Kholodenko, Ying-zi Xu, Paul Shapiro, Kevin Tanaka, Michael S. Dappen, Tovah Eichenbaum, James L Miller, Lany Ruslim, Jing Wu, Robin Barbour, Linda Mutter, Jacek Jagodzinski, Erich Goldbach, Xiacong Michael Ye, Dale Schenk, Scott McCauley, Susanna S. Hemphill, John Michael Sauer, Anna Liao, Huifang Ni, Lan K. Nguyen, Michael A Pleiss

المصدر: Alzheimer's Research & Therapy

مصطلحات موضوعية: Genetically modified mouse, biology, business.industry, Research, Cognitive Neuroscience, Transgene, Clinical Neurology, Notch signaling pathway, P3 peptide, Pharmacology, Bioinformatics, Neurology, In vivo, Toxicity, Amyloid precursor protein, biology.protein, Medicine, Neurology (clinical), business, Gamma secretase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57cfce5191b5c22ca3906348025bc9ba
https://doi.org/10.1186/alzrt60

المؤلفون: Russell W. Blacher, Donald McClure, Eric C. Beattie, Tilman Oltersdorf, Frederick Esch, Pamela S. Keim, Alan R. Culwell, Pamela J. Ward

المصدر: Science (New York, N.Y.). 248(4959)

مصطلحات موضوعية: medicine.medical_specialty, Amyloid, Amyloid beta, BACE1-AS, Molecular Sequence Data, Transfection, Amyloid beta-Protein Precursor, Internal medicine, mental disorders, medicine, Amyloid precursor protein, Humans, Senile plaques, Amino Acid Sequence, Protein Precursors, Multidisciplinary, biology, P3 peptide, medicine.disease, Peptide Fragments, Cell biology, Biochemistry of Alzheimer's disease, Endocrinology, Alpha secretase, biology.protein, Alzheimer's disease, Protein Processing, Post-Translational

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d919fa82f1eaa7e414e53db86a5011
https://pubmed.ncbi.nlm.nih.gov/2111583

المؤلفون: Sukanto Sinha, Varghese John, Tamie J. Chilcote, Kang Hu, Russell J. Caccavello, Pamela S. Keim, Kirsten L. Jacobson-Croak, Susanna Suomensaari, Shuwen Wang, Lisa McConlogue, Norman Frigon, Minhtam Doan, Gwen Tatsuno, John P. Anderson, Donald A. Walker, Guriqbal S. Basi

المصدر: Neurobiology of Aging. 25:S527

مصطلحات موضوعية: chemistry.chemical_classification, Aging, Protease, Amyloid, Chemistry, General Neuroscience, medicine.medical_treatment, P3 peptide, Substrate recognition, Peptide, Biochemistry, medicine, β secretase, Neurology (clinical), Geriatrics and Gerontology, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::74b3be693bfb31320884eb4391ab480d
https://doi.org/10.1016/s0197-4580(04)81741-x

المؤلفون: Pamela S. Keim, Donald F. Steiner, T.H. Claus, Robert L. Heinrikson, Simon J. Pilkis, B Coven, M R El-Maghrabi, H S Tager

المصدر: Journal of Biological Chemistry. 255:2770-2775

مصطلحات موضوعية: Pyruvate decarboxylation, Pyruvate dehydrogenase lipoamide kinase isozyme 1, Pyruvate dehydrogenase kinase, Fructose 1,6-bisphosphatase, Cell Biology, PKM2, Biology, Pyruvate dehydrogenase phosphatase, Biochemistry, Molecular biology, biology.protein, Protein kinase A, Molecular Biology, Pyruvate kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::61fefa46775c1cafb4fbac36a0df0400
https://doi.org/10.1016/s0021-9258(19)85805-2

المؤلفون: Pamela S. Keim, Leo J. Saidel, Ida Edelstein, Robert L. Heinrikson, Frank Marcus

المصدر: Archives of Biochemistry and Biophysics. 209:687-696

مصطلحات موضوعية: Swine, Allosteric regulation, Biophysics, Fructose 1,6-bisphosphatase, Peptide, Kidney, Biochemistry, chemistry.chemical_compound, Species Specificity, Tetramer, Animals, Amino Acid Sequence, Subtilisins, Molecular Biology, Peptide sequence, chemistry.chemical_classification, biology, Photoaffinity labeling, Chemistry, Subtilisin, Fructose, Adenosine Monophosphate, Peptide Fragments, Fructose-Bisphosphatase, Molecular Weight, Liver, biology.protein, Rabbits, Bacillus subtilis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cacc32f539d0ab18f1e4a83964c759d8
https://doi.org/10.1016/0003-9861(81)90330-1

المؤلفون: Pamela S. Keim, C T Riley, Robert L. Heinrikson, B K Barbeau, Ferenc J. Kezdy, John H. Law

المصدر: Journal of Biological Chemistry. 259:13159-13165

مصطلحات موضوعية: chemistry.chemical_classification, animal structures, Chromatography, Chymotrypsin, Edman degradation, biology, fungi, Cell Biology, biology.organism_classification, Trypsin, Biochemistry, Amino acid, chemistry.chemical_compound, chemistry, Manduca sexta, Hemolymph, biology.protein, medicine, Cyanogen bromide, Molecular Biology, Peptide sequence, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5eff3414acda2236c5b416741ae8bac6
https://doi.org/10.1016/s0021-9258(18)90671-x

المؤلفون: Pamela S. Keim, Howard Zalkin, Robert L. Heinrikson, Yoshitaka Goto

المصدر: Journal of Biological Chemistry. 251:941-949

مصطلحات موضوعية: chemistry.chemical_classification, biology, Stereochemistry, Cell Biology, Alkylation, biology.organism_classification, Biochemistry, Glutaminase activity, Pseudomonas putida, Amino acid, Glutamine, chemistry.chemical_compound, chemistry, Covalent bond, Anthranilic acid, Iodoacetamide, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8634495d220b378535131b5e005a9017
https://doi.org/10.1016/s0021-9258(17)33784-5

المؤلفون: Frank Marcus, Pamela S. Keim, M M Hosey, Robert L. Heinrikson

المصدر: Journal of Biological Chemistry. 256:12208-12212

مصطلحات موضوعية: chemistry.chemical_classification, biology, Fructose 1,6-bisphosphatase, Peptide, Cell Biology, Biochemistry, Serine, PEST sequence, chemistry.chemical_compound, chemistry, biology.protein, Phosphorylation, Cyanogen bromide, Protein kinase A, Molecular Biology, Peptide sequence

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7519b9577cf990e4cf59188c07388cea
https://doi.org/10.1016/s0021-9258(18)43255-3

المؤلفون: John H. Law, Hidelisa L. Seballos, Pamela S. Keim, Ronald C. Peterson, Barbara K. Barbeau, Clark T. Riley, Peter E. Dunn, Robert L. Heinrikson

المصدر: Insect Biochemistry. 12:643-650

مصطلحات موضوعية: chemistry.chemical_classification, Biology, Tetranitromethane, biology.organism_classification, Biochemistry, Gel permeation chromatography, chemistry.chemical_compound, chemistry, Manduca sexta, Insect Science, Yield (chemistry), Juvenile hormone, Hemolymph, Propionate, Side chain, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::746db1fc1e60753ceb85cb5e232743c8
https://doi.org/10.1016/0020-1790(82)90051-8

المؤلفون: Pamela S. Keim, William H. Telfer, John H. Law

المصدر: Insect Biochemistry. 13:601-613

مصطلحات موضوعية: chemistry.chemical_classification, Gel electrophoresis, animal structures, biology, Apolysis, biology.organism_classification, Biochemistry, Calliphora, Hyalophora, chemistry, Insect Science, Ecdysis, Hemolymph, Hyalophora cecropia, Storage protein, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fb10fe500c20973d5b7c35818740f901
https://doi.org/10.1016/0020-1790(83)90034-3

المؤلفون: Yoshitaka Goto, Howard Zalkin, Robert L. Heinrikson, Pamela S. Keim, M. Kawamura

المصدر: Journal of Biological Chemistry. 253:4659-4668

مصطلحات موضوعية: biology, Active site, Cell Biology, biology.organism_classification, Biochemistry, Pseudomonas putida, Glutamine, chemistry.chemical_compound, Residue (chemistry), chemistry, Iodoacetamide, biology.protein, Cyanogen bromide, Molecular Biology, Peptide sequence, Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f1de06877be0f77b6bcfc28ab5cc8684
https://doi.org/10.1016/s0021-9258(17)30440-4

المؤلفون: Robert E. Fellows, Celina Edelstein, Robert L. Heinrikson, Pamela S. Keim, Claudia M. Noyes, Angelo M. Scanu

المصدر: Biochemistry. 15:1262-1268

مصطلحات موضوعية: chemistry.chemical_classification, Apolipoprotein B, biology, Stereochemistry, Apolipoprotein A-II, Haplorhini, Macaca mulatta, Biochemistry, Peptide Fragments, Amino acid, Serine, Blood serum, chemistry, biology.protein, Animals, Macaca, Trypsin, Amino Acid Sequence, Amino Acids, Apoproteins, Peptide sequence, Cysteine, Lipoprotein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c94a911ccc1e48077edb741c630938
https://doi.org/10.1021/bi00651a014