المؤلفون: Afjal H. Miah (11332004), Ian E. D. Smith (10891097), Mark Rackham (11332007), Alina Mares (11332010), Aditya R. Thawani (9460156), Rakesh Nagilla (1871794), Pamela A. Haile (440598), Bartholomew J. Votta (2638426), Laurie J. Gordon (1343442), Gillian Watt (9240067), Jane Denyer (9240058), Don T. Fisher (11332013), Phoebe Dace (11332016), Paul Giffen (11332019), Andrea Goncalves (11332022), Ian Churcher (1523551), Paul Scott-Stevens (6321608), John D. Harling (1545550)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, PROTAC optimization strategy, RIPK 2 PROTACs, proof-of-concept study, parenteral formulation, release matrix, pharmacokinetic profiles, kinase, TNF α release, solubility, Compound 20, E 3 ligases, IAP binders, alternative dosing paradigm

Relation: https://figshare.com/articles/journal_contribution/Optimization_of_a_Series_of_RIPK2_PROTACs/16441697

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01118.s001

المؤلفون: Afjal H. Miah (11332004), Ian E. D. Smith (10891097), Mark Rackham (11332007), Alina Mares (11332010), Aditya R. Thawani (9460156), Rakesh Nagilla (1871794), Pamela A. Haile (440598), Bartholomew J. Votta (2638426), Laurie J. Gordon (1343442), Gillian Watt (9240067), Jane Denyer (9240058), Don T. Fisher (11332013), Phoebe Dace (11332016), Paul Giffen (11332019), Andrea Goncalves (11332022), Ian Churcher (1523551), Paul Scott-Stevens (6321608), John D. Harling (1545550)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, PROTAC optimization strategy, RIPK 2 PROTACs, proof-of-concept study, parenteral formulation, release matrix, pharmacokinetic profiles, kinase, TNF α release, solubility, Compound 20, E 3 ligases, IAP binders, alternative dosing paradigm

Relation: https://figshare.com/articles/dataset/Optimization_of_a_Series_of_RIPK2_PROTACs/16441700

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01118.s002