المؤلفون: Fu, Xudong, Chin, Randall M, Vergnes, Laurent, Hwang, Heejun, Deng, Gang, Xing, Yanpeng, Pai, Melody Y, Li, Sichen, Ta, Lisa, Fazlollahi, Farbod, Chen, Chuo, Prins, Robert M, Teitell, Michael A, Nathanson, David A, Lai, Albert, Faull, Kym F, Jiang, Meisheng, Clarke, Steven G, Cloughesy, Timothy F, Graeber, Thomas G, Braas, Daniel, Christofk, Heather R, Jung, Michael E, Reue, Karen, Huang, Jing

المصدر: Cell metabolism. 22(3)

مصطلحات موضوعية: Animals, Humans, Caenorhabditis elegans, Glioblastoma, Glutarates, Isocitrate Dehydrogenase, Signal Transduction, Cell Proliferation, Longevity, Mutation, Adenosine Triphosphatases, TOR Serine-Threonine Kinases, Brain Disorders, Aging, Cancer, Brain Cancer, Rare Diseases, Biochemistry and Cell Biology, Medical Biochemistry and Metabolomics, Endocrinology & Metabolism

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/2120303x

المؤلفون: Pai, Melody Y, Lomenick, Brett, Hwang, Heejun, Schiestl, Robert, McBride, William, Loo, Joseph A, Huang, Jing

مصطلحات موضوعية: Medicinal and Biomolecular Chemistry, Chemical Sciences, 5.1 Pharmaceuticals, Ligands, Protein Binding, Proteins, Proteomics, Reproducibility of Results, Small Molecule Libraries, Small molecules, Drugs, Target identification, Metabolites, Natural products, Mass spectrometry, Immunoblotting, Other Chemical Sciences, Biochemistry and Cell Biology, Developmental Biology, Biochemistry and cell biology, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6234n5h8
https://escholarship.org/content/qt6234n5h8/qt6234n5h8.pdf

المؤلفون: Chin, Randall M, Fu, Xudong, Pai, Melody Y, Vergnes, Laurent, Hwang, Heejun, Deng, Gang, Diep, Simon, Lomenick, Brett, Meli, Vijaykumar S, Monsalve, Gabriela C, Hu, Eileen, Whelan, Stephen A, Wang, Jennifer X, Jung, Gwanghyun, Solis, Gregory M, Fazlollahi, Farbod, Kaweeteerawat, Chitrada, Quach, Austin, Nili, Mahta, Krall, Abby S, Godwin, Hilary A, Chang, Helena R, Faull, Kym F, Guo, Feng, Jiang, Meisheng, Trauger, Sunia A, Saghatelian, Alan, Braas, Daniel, Christofk, Heather R, Clarke, Catherine F, Teitell, Michael A, Petrascheck, Michael, Reue, Karen, Jung, Michael E, Frand, Alison R, Huang, Jing

المصدر: Nature. 510(7505)

مصطلحات موضوعية: Medical Biochemistry and Metabolomics, Biological Sciences, Biomedical and Clinical Sciences, Aging, Generic health relevance, Animals, Caenorhabditis elegans, Cell Line, Enzyme Activation, Enzyme Inhibitors, Gene Knockdown Techniques, HEK293 Cells, Humans, Jurkat Cells, Ketoglutaric Acids, Longevity, Mice, Mitochondrial Proton-Translocating ATPases, Protein Binding, TOR Serine-Threonine Kinases, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/88j0f0k8

المؤلفون: Chin, Randall M., Fu, Xudong, Pai, Melody Y., Vergnes, Laurent, Hwang, Heejun, Deng, Gang, Diep, Simon, Lomenick, Brett, Meli, Vijaykumar S., Monsalve, Gabriela C., Hu, Eileen, Whelan, Stephen A., Wang, Jennifer X, Jung, Gwanghyun, Solis, Gregory M., Fazlollahi, Farbod, Kaweeteerawat, Chitrada, Quach, Austin, Nili, Mahta, Krall, Abby S., Godwin, Hilary A., Chang, Helena R., Faull, Kym F., Guo, Feng, Jiang, Meisheng, Trauger, Sunia A, Saghatelian, Alan, Braas, Daniel, Christofk, Heather R., Clarke, Catherine F., Teitell, Michael A., Petrascheck, Michael, Reue, Karen, Jung, Michael E., Frand, Alison R., Huang, Jing

مصطلحات موضوعية: Biochemistry, Chemical biology, Genetics

وصف الملف: application/pdf

Relation: Nature; Chin, Randall M., Xudong Fu, Melody Y. Pai, Laurent Vergnes, Heejun Hwang, Gang Deng, Simon Diep, et al. 2014. The Metabolite α-Ketoglutarate Extends Lifespan by Inhibiting ATP Synthase and TOR. Nature 510, no. 7505: 397–401.; https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37374400

الاتاحة: https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37374400
https://doi.org/10.1038/nature13264

المؤلفون: Pai, Melody Y., Lomenick, Brett, Hwang, Heejun, Schiestl, Robert, McBride, William, Loo, Joseph A., Huang, Jing

المصدر: Chemical Biology Methods & Protocols; 2015, p287-298, 12p

المؤلفون: Chin, Randall M., Fu, Xudong, Pai, Melody Y., Vergnes, Laurent, Hwang, Heejun, Deng, Gang, Diep, Simon, Lomenick, Brett, Meli, Vijaykumar S., Monsalve, Gabriela C., Hu, Eileen, Whelan, Stephen A., Wang, Jennifer X., Jung, Gwanghyun, Solis, Gregory M., Fazlollahi, Farbod, Kaweeteerawat, Chitrada, Quach, Austin, Nili, Mahta, Krall, Abby S.

المصدر: Nature; 6/19/2014, Vol. 510 Issue 7505, p397-401, 5p

مصطلحات موضوعية: METABOLITES, ANIMAL life spans, ADENOSINE triphosphatase, TOR proteins, ENERGY metabolism, AGING prevention